Nanoparticle-Mediated Active and Passive Drug Targeting in Oral Squamous Cell Carcinoma: Current Trends and Advances

References

• Kontos CK . Surrogate prognostic biomarkers in OSCC: the paradigm of PA28γ overexpression. EBioMedicine 2(8), 784–785 (2015).
   PubMed Web of Science ®Google Scholar
• Yang Z , Liang X , Fu Y et al. Identification of AUNIP as a candidate diagnostic and prognostic biomarker for oral squamous cell carcinoma. EBioMedicine 47, 44–57 (2019).
   PubMed Web of Science ®Google Scholar
• Capik O , Gumus R , Karatas OF . Hypoxia-induced tumor exosomes promote angiogenesis through miR-1825/TSC2/mTOR axis in oral squamous cell carcinoma. Head Neck 45(9), 2259–2273 (2023).
   PubMed Web of Science ®Google Scholar
• Chen SH , Yuan TM , Zhang J et al. Remimazolam tosilate in upper gastrointestinal endoscopy: a multicenter, randomized, non-inferiority, phase III trial. J. Gastroenterol. Hepatol. 36(2), 474–481 (2021).
   PubMed Web of Science ®Google Scholar
• Manikkath J , Jishnu PV , Wich PR , Manikkath A , Radhakrishnan R . Nanoparticulate strategies for the delivery of miRNA mimics and inhibitors in anticancer therapy and its potential utility in oral submucous fibrosis. Nanomedicine 17(3), 181–195 (2022).
   PubMed Web of Science ®Google Scholar
• Yasin MM , Abbas Z , Hafeez A . Correlation of histopathological patterns of OSCC patients with tumor site and habits. BMC Oral Health 22(1), 305 (2022).
   PubMed Web of Science ®Google Scholar
• Ali K . Oral cancer – the fight must go on against all odds. Evid. Based Dent. 23(1), 4–5 (2022).
   PubMedGoogle Scholar
• Farooq I , Bugshan A . Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis. F1000 Res. 9, 229 (2020).
   PubMedGoogle Scholar
• Chi AC , Day TA , Neville BW . Oral cavity and oropharyngeal squamous cell carcinoma – an update. CA Cancer J. Clin. 65(5), 401–421 (2015).
   PubMed Web of Science ®Google Scholar
• Sun J , Tang Q , Yu S et al. F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. EBioMedicine 88, 104444 (2023).
   PubMedGoogle Scholar
• Rivera C , Venegas B . Histological and molecular aspects of oral squamous cell carcinoma. Oncol. Lett. 8(1), 7 (2014).
   PubMed Web of Science ®Google Scholar
• Cui S , Liu H , Cui G . Nanoparticles as drug delivery systems in the treatment of oral squamous cell carcinoma: current status and recent progression. Front. Pharmacol. 14, 1176422 (2023).
   PubMed Web of Science ®Google Scholar
• Yang G , Yang Y , Tang H , Yang K . Loss of the clock gene Per1 promotes oral squamous cell carcinoma progression via the AKT/mTOR pathway. Cancer Sci. 111(5), 1542–1554 (2020).
   PubMed Web of Science ®Google Scholar
• Shi J , Kantoff PW , Wooster R , Farokhzad OC . Cancer nanomedicine: progress, challenges and opportunities. Nat. Rev. Cancer 17(1), 20–37 (2016).
   PubMed Web of Science ®Google Scholar
• Cheng Z , Li M , Dey R , Chen Y . Nanomaterials for cancer therapy: current progress and perspectives. J. Hematol. Oncol. 14(1), 1–27 (2021).
   PubMed Web of Science ®Google Scholar
• Yao Y , Zhou Y , Liu L et al. Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance. Front. Mol. Biosci. 7, 558493 (2020).
   Web of Science ®Google Scholar
• Lu Y , Zheng Z , Yuan Y et al. The emerging role of exosomes in oral squamous cell carcinoma. Front. Cell Dev. Biol. 9, 628103 (2021).
   PubMed Web of Science ®Google Scholar
• Bai YT , Zhang XQ , Chen XJ , Zhou G . Nanomedicines in oral cancer: inspiration comes from extracellular vesicles and biomimetic nanoparticles. Nanomedicine 17(23), 1761–1778 (2023).
   Web of Science ®Google Scholar
• Pires FR , Ramos AB , de Oliveira JBC , Tavares AS , da Luz PSR , dos Santos TCRB . Oral squamous cell carcinoma: clinicopathological features from 346 cases from a single oral pathology service during an 8-year period. J. Appl. Oral Sci. 21(5), 460 (2013).
   PubMed Web of Science ®Google Scholar
• Larsen SR , Johansen J , SØrensen JA , Krogdahl A . The prognostic significance of histological features in oral squamous cell carcinoma. J. Oral Pathol. Med. 38(8), 657–662 (2009).
   PubMed Web of Science ®Google Scholar
• Marocchio LS , Lima J , Sperandio FF , Corrêa L , de Sousa SOM . Oral squamous cell carcinoma: an analysis of 1564 cases showing advances in early detection. J. Oral Sci. 52(2), 267–273 (2010).
   PubMedGoogle Scholar
• Lawal AO , Adisa AO , Effiom OA . A review of 640 oral squamous cell carcinoma cases in Nigeria. J. Clin. Exp. Dent. 9(6), e767 (2017).
   PubMedGoogle Scholar
• Singh MP , Kumar V , Agarwal A , Kumar R , Bhatt MLB , Misra S . Clinico-epidemiological study of oral squamous cell carcinoma: a tertiary care centre study in North India. J. Oral Biol. Craniofac. Res. 6(1), 31 (2016).
   PubMedGoogle Scholar
• Borse V , Konwar AN , Buragohain P . Oral cancer diagnosis and perspectives in India. Sensors Int. 1, 100046 (2020).
   PubMedGoogle Scholar
• Deshmukh V , Shekar K . Oral squamous cell carcinoma: diagnosis and treatment planning. Oral Maxillofac. Surg. Clin. 1853–1867 (2021).
   Google Scholar
• Kaing L , Manchella S , Love C , Nastri A , Wiesenfeld D . Referral patterns for oral squamous cell carcinoma in Australia: 20 years progress. Aust. Dent. J. 61(1), 29–34 (2016).
   PubMed Web of Science ®Google Scholar
• Tanaka T , Ishigamori R . Understanding carcinogenesis for fighting oral cancer. J. Oncol. 2011, doi:10.1155/2011/603740 (2011).
   Google Scholar
• Attia MF , Anton N , Wallyn J , Omran Z , Vandamme TF . An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites. J. Pharm. Pharmacol. 71(8), 1185–1198 (2019).
   PubMed Web of Science ®Google Scholar
• Tanaka T , Ishigamori R . Understanding carcinogenesis for fighting oral cancer. J. Oncol. 2011, 603740 (2011).
   PubMedGoogle Scholar
• Manikkath J , Sumathy T , Manikkath A , Mutalik S . Delving deeper into dermal and transdermal drug delivery: factors and mechanisms associated with nanocarrier-mediated strategies. Curr. Pharm. Des. 24(27), 3210–3222 (2018).
   PubMed Web of Science ®Google Scholar
• Ding Y , Xu Y , Yang W et al. Investigating the EPR effect of nanomedicines in human renal tumors via ex vivo perfusion strategy. Nano Today 35, 100970 (2020).
   Web of Science ®Google Scholar
• Gu FX , Karnik R , Wang AZ et al. Targeted nanoparticles for cancer therapy. Nano Today 2(3), 14–21 (2007).
   Web of Science ®Google Scholar
• Lee H , Shields AF , Siegel BA et al. 64Cu-MM-302 positron emission tomography quantifies variability of enhanced permeability and retention of nanoparticles in relation to treatment response in patients with metastatic breast cancer. Clin. Cancer Res. 23(15), 4190 (2017).
   PubMed Web of Science ®Google Scholar
• Desai DD , Manikkath J , Lad H , Kulkarni M , Manikkath A , Radhakrishnan R . Nanotechnology-based mucoadhesive and mucus-penetrating drug-delivery systems for transbuccal drug delivery. Nanomedicine 18(21), 1495–1514 (2023).
   PubMed Web of Science ®Google Scholar
• Manikkath J , Parekh HS , Mutalik S . Surface-engineered nanoliposomes with lipidated and non-lipidated peptide-dendrimeric scaffold for efficient transdermal delivery of a therapeutic agent: development, characterization, toxicological and preclinical performance analyses. Eur. J. Pharm. Biopharm. 156, 97–113 (2020).
   PubMed Web of Science ®Google Scholar
• Mitchell MJ , Billingsley MM , Haley RM , Wechsler ME , Peppas NA , Langer R . Engineering precision nanoparticles for drug delivery. Nat. Rev. Drug Discov. 20(2), 101–124 (2020).
   PubMed Web of Science ®Google Scholar
• Singh R , Lillard JW . Nanoparticle-based targeted drug delivery. Exp. Mol. Pathol. 86(3), 215 (2009).
   PubMed Web of Science ®Google Scholar
• Radaic A , Malone E , Kamarajan P , Kapila YL . Solid lipid nanoparticles loaded with nisin (SLN-nisin) are more effective than free nisin as antimicrobial, antibiofilm, and anticancer agents. J. Biomed. Nanotechnol. 18(4), 1227–1235 (2022).
   PubMed Web of Science ®Google Scholar
• Müller RH , Radtke M , Wissing SA . Nanostructured lipid matrices for improved microencapsulation of drugs. Int. J. Pharm. 242(1–2), 121–128 (2002).
   PubMed Web of Science ®Google Scholar
• Felimban RI , Tayeb HH , Chaudhary AG et al. Utilization of a nanostructured lipid carrier encapsulating pitavastatin–Pinus densiflora oil for enhancing cytotoxicity against the gingival carcinoma HGF-1 cell line. Drug Deliv. 30(1), 83–96 (2023).
   PubMed Web of Science ®Google Scholar
• Chaudhari VS , Gawali B , Saha P , Naidu VGM , Murty US , Banerjee S . Quercetin and piperine enriched nanostructured lipid carriers (NLCs) to improve apoptosis in oral squamous cellular carcinoma (FaDu cells) with improved biodistribution profile. Eur. J. Pharmacol. 909, 174400 (2021).
   PubMed Web of Science ®Google Scholar
• El-Hamid ESA , Gamal-Eldeen AM , Sharaf Eldeen AM . Liposome-coated nano doxorubicin induces apoptosis on oral squamous cell carcinoma CAL-27 cells. Arch. Oral Biol. 103, 47–54 (2019).
   PubMed Web of Science ®Google Scholar
• Wei X-Q . Effect of transferrin-modified liposomal curcumin on proliferation inhibition of oral squamous cell carcinoma (2022). doi:10.21203/rs.3.rs-1632957/v2
   Google Scholar
• Hariharan K , Mehta T , Shah J , Dave H , Sami A , Omri A . Localized delivery of erlotinib using liposomal gel formulations for the treatment of oral squamous cell carcinoma. Int. J. Pharm. 642, 123144 (2023).
   PubMedGoogle Scholar
• Mabrouk AA , El-Mezayen NS , Tadros MI , El-Gazayerly ON , El-Refaie WM . Novel mucoadhesive celecoxib-loaded cubosomal sponges: anticancer potential and regulation of myeloid-derived suppressor cells in oral squamous cell carcinoma. Eur. J. Pharm. Biopharm. 182, 62–80 (2023).
   PubMed Web of Science ®Google Scholar
• Habibi N , Bissonnette C , Pei P et al. Mucopenetrating Janus nanoparticles for field-coverage oral cancer chemoprevention. Pharm. Res. 40(3), 749–764 (2023).
   PubMed Web of Science ®Google Scholar
• Li X , Li L , Huang Y et al. Synergistic therapy of chemotherapeutic drugs and MTH1 inhibitors using a pH-sensitive polymeric delivery system for oral squamous cell carcinoma. Biomater. Sci. 5(10), 2068–2078 (2017).
   PubMed Web of Science ®Google Scholar
• Zhao H , Feng H , Liu D et al. Self-assembling monomeric nucleoside molecular nanoparticles loaded with 5-FU enhancing therapeutic efficacy against oral cancer. ACS Nano 9(10), 9638–9651 (2015).
   PubMed Web of Science ®Google Scholar
• de Souza Ferreira SB , Slowik KM , de Castro Hoshino LV et al. Mucoadhesive emulgel systems containing curcumin for oral squamous cell carcinoma treatment: from pre-formulation to cytotoxicity in tissue-engineering oral mucosa. Eur. J. Pharm. Sci. 151, 105372 (2020).
   PubMed Web of Science ®Google Scholar
• Uram Ł , Filipowicz-Rachwał A , Misiorek M , Winiarz A , Wałajtys-Rode E , Wołowiec S . Synthesis and different effects of biotinylated PAMAM G3 dendrimer substituted with nimesulide in human normal fibroblasts and squamous carcinoma cells. Biomolecules 9(9), 437 (2019).
   PubMed Web of Science ®Google Scholar
• Xu L , Kittrell S , Yeudall WA , Yang H . Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells. Nanomedicine 11(22), 2959–2973 (2016).
   PubMed Web of Science ®Google Scholar
• Ma Y , Liu Y , Wang Y et al. The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma. Mater. Des. 220, 110838 (2022).
   Web of Science ®Google Scholar
• Mousavi SM , Hashemi SA , Ghahramani Y et al. Antiproliferative and apoptotic effects of graphene oxide @AlFu MOF based saponin natural product on OSCC line. Pharmaceuticals 15(9), 1137 (2022).
   Web of Science ®Google Scholar
• Zur Mühlen A , Schwarz C , Mehnert W . Solid lipid nanoparticles (SLN) for controlled drug delivery – drug release and release mechanism. Eur. J. Pharm. Biopharm. 45(2), 149–155 (1998).
   PubMed Web of Science ®Google Scholar
• Xu L , Wang X , Liu Y , Yang G , Falconer RJ , Zhao C-X . Lipid nanoparticles for drug delivery. Adv. Nanobiomed. Res. 2(2), 2100109 (2022).
   Google Scholar
• Bharadwaj R , Sahu BP , Haloi J et al. Combinatorial therapeutic approach for treatment of oral squamous cell carcinoma. Artif. Cells Nanomed. Biotechnol. 47(1), 572–585 (2019).
   PubMed Web of Science ®Google Scholar
• Okazaki S , Yokoyama T , Miyauchi K et al. Early statin treatment in patients with acute coronary syndrome. Circulation 110(9), 1061–1068 (2004).
   PubMed Web of Science ®Google Scholar
• Di Bello E , Zwergel C , Mai A , Valente S . The innovative potential of statins in cancer: new targets for new therapies. Front. Chem. 8, 553677 (2020).
   Web of Science ®Google Scholar
• Tsubaki M , Fujiwara D , Takeda T et al. The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways. Clin. Exp. Pharmacol. Physiol. 44(2), 222–234 (2017).
   PubMed Web of Science ®Google Scholar
• Barenholz Y . Doxil®– The first FDA-approved nano-drug: lessons learned. J. Control. Rel. 160(2), 117–134 (2012).
   PubMed Web of Science ®Google Scholar
• Shah S , Famta P , Raghuvanshi RS , Singh SB , Srivastava S . Lipid polymer hybrid nanocarriers: insights into synthesis aspects, characterization, release mechanisms, surface functionalization and potential implications. Colloid Interface Sci. Commun. 46, 100570 (2022).
   Web of Science ®Google Scholar
• Mabrouk AA , El-Mezayen NS , Tadros MI , El-Gazayerly ON , El-Refaie WM . Novel mucoadhesive celecoxib-loaded cubosomal sponges: anticancer potential and regulation of myeloid-derived suppressor cells in oral squamous cell carcinoma. Eur. J. Pharm. Biopharm. 182, 62–80 (2023).
   PubMed Web of Science ®Google Scholar
• Liu W , Wang J , Zhang C , Bao Z , Wu L . Curcumin nanoemulsions inhibit oral squamous cell carcinoma cell proliferation by PI3K/Akt/mTOR suppression and miR-199a upregulation: a preliminary study. Oral Dis. (2022). doi:10.1111/odi.14271
   Web of Science ®Google Scholar
• Fernandes AS , de Souza Ferreira SB , de Oliveira MC , Caetano W , Bruschi ML . The influence of different bioadhesive polymers on physicochemical properties of thermoresponsive emulgels containing Amazonian andiroba oil. J. Mol. Liq. 365, 120102 (2022).
   Web of Science ®Google Scholar
• de Souza Ferreira SB , Slowik KM , de Castro Hoshino LV et al. Mucoadhesive emulgel systems containing curcumin for oral squamous cell carcinoma treatment: from pre-formulation to cytotoxicity in tissue-engineering oral mucosa. Eur. J. Pharm. Sci. 151, 105372 (2020).
   PubMed Web of Science ®Google Scholar
• Abdihaji M , Chegeni MM , Hadizadeh A et al. Polyvinyl alcohol (PVA)-based nanoniosome for enhanced in vitro delivery and anticancer activity of thymol. Int. J. Nanomed. 18, 3459–3488 (2023).
   PubMed Web of Science ®Google Scholar
• Motlagh MZ , Mahdavi N , Miri-Lavasani Z et al. Disulfiram-loaded niosomes reduces cancerous phenotypes in oral squamous cell carcinoma cells. Cell J. 25(6), 407 (2023).
   PubMed Web of Science ®Google Scholar
• Fazli B , Irani S , Bardania H , Moosavi MS , Rohani B . Prophylactic effect of topical (slow-release) and systemic curcumin nano-niosome antioxidant on oral cancer in rat. BMC Complement. Med. Ther. 22(1), 109 (2022).
   PubMedGoogle Scholar
• Elsaady SA , Aboushelib MN , Al-Wakeel E , Badawi MF . A novel intra-tumoral drug delivery carrier for treatment of oral squamous cell carcinoma. Sci. Rep. 13(1), 11984 (2023).
   PubMed Web of Science ®Google Scholar
• Goldberg M , Manzi A , Conway P et al. A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer. Nat. Commun. 13(1), 4829 (2022).
   PubMed Web of Science ®Google Scholar
• Rothemund PWK . Folding DNA to create nanoscale shapes and patterns. Nature 440(7082), 297–302 (2006).
   PubMed Web of Science ®Google Scholar
• Yadav S , Sharma AK , Kumar P . Nanoscale self-assembly for therapeutic delivery. Front. Bioeng. Biotechnol. 8, 500966 (2020).
   Web of Science ®Google Scholar
• Zhang H , Ji Y , Yuan C et al. Fabrication of astaxanthin-loaded electrospun nanofiber-based mucoadhesive patches with water-insoluble backing for the treatment of oral premalignant lesions. Mater. Des. 223, 111131 (2022).
   Web of Science ®Google Scholar
• Nam S , Lee SY , Cho HJ . Phloretin-loaded fast dissolving nanofibers for the locoregional therapy of oral squamous cell carcinoma. J. Colloid Interface Sci. 508, 112–120 (2017).
   PubMed Web of Science ®Google Scholar
• Geng Q , Wang J , Zhang W , Zhou W , Tang G , Gu M . Oncostatin M receptor is overexpressed in oral squamous cell carcinoma and connected to poor prognosis. J. Oral Pathol. Med. 52(2), 136–144 (2023).
   PubMed Web of Science ®Google Scholar
• Liu X , Qing S , Che K , Li L , Liao X . Androgen receptor promotes oral squamous cell carcinoma cell migration by increasing EGFR phosphorylation. Onco Targets Ther. 12, 4245 (2019).
   PubMed Web of Science ®Google Scholar
• Batelja-Vuletic L , Tomasovic-Loncaric C , Ceppi M et al. Comparison of androgen receptor, VEGF, HIF-1, Ki67 and MMP9 expression between non-metastatic and metastatic stages in stromal and tumor cells of oral squamous cell carcinoma. Life 11(4), 336 (2021).
   PubMedGoogle Scholar
• Lin YT , Chuang HC , Chen CH et al. Clinical significance of erythropoietin receptor expression in oral squamous cell carcinoma. BMC Cancer 12(1), 194 (2012).
   PubMedGoogle Scholar
• Tarle M , Raguž M , Muller D , Lukšić I . Nuclear epidermal growth factor receptor overexpression as a survival predictor in oral squamous cell carcinoma. Int. J. Mol. Sci. 24(6), 5816 (2023).
   PubMed Web of Science ®Google Scholar
• Magnussen S , Rikardsen OG , Hadler-Olsen E , Uhlin-Hansen L , Steigen SE , Svineng G . Urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage oral squamous cell carcinomas (OSCC). PLOS ONE 9(7), e101895 (2014).
   PubMed Web of Science ®Google Scholar
• Sun JY , Shen J , Thibodeaux J et al. In vivo optical imaging of folate receptor-β in head and neck squamous cell carcinoma. Laryngoscope 124(8), E312–E319 (2014).
   PubMed Web of Science ®Google Scholar
• Egloff AM , Liu X , Davis ALG et al. Elevated gastrin-releasing peptide receptor mRNA expression in buccal mucosa: association with head and neck squamous cell carcinoma. Head Neck 35(2), 270 (2013).
   PubMed Web of Science ®Google Scholar
• Kimura I , Kitahara H , Ooi K et al. Loss of epidermal growth factor receptor expression in oral squamous cell carcinoma is associated with invasiveness and epithelial–mesenchymal transition. Oncol. Lett. 11(1), 201 (2016).
   PubMed Web of Science ®Google Scholar
• Bhattacharya D , Sakhare K , Dhiman C et al. Delivery of chemotherapeutic drug targeting folate receptor to oral cancer cells using functionalized carbon nanospheres. Biomed. Mater. 18(5), 10.1088/1748-605X/ace8de (2023).
   Web of Science ®Google Scholar
• Bharadwaj R , Medhi S . Effectual nanotherapy against oral squamous cell carcinoma. Drug Dev. Ind. Pharm. 47(5), 711–724 (2021).
   PubMed Web of Science ®Google Scholar
• Li R , Gao R , Wang Y et al. Gastrin releasing peptide receptor targeted nano-graphene oxide for near-infrared fluorescence imaging of oral squamous cell carcinoma. Sci. Rep. 10(1), 11434 (2020).
   PubMed Web of Science ®Google Scholar
• Li R , Liu C , Wan C et al. A targeted and pH-responsive nano-graphene oxide nanoparticle loaded with doxorubicin for synergetic chemo-photothermal therapy of oral squamous cell carcinoma. Int. J. Nanomed. 18, 3309–3324 (2023).
   PubMed Web of Science ®Google Scholar
• Zuo J , Huo M , Wang L , Li J , Chen Y , Xiong P . Photonic hyperthermal and sonodynamic nanotherapy targeting oral squamous cell carcinoma. J. Mater. Chem. B 8(39), 9084–9093 (2020).
   Web of Science ®Google Scholar
• Chen S , Zhao X , Chen J et al. Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release. Bioconjug. Chem. 21(5), 979 (2010).
   PubMed Web of Science ®Google Scholar
• Abbasi E , Aval SF , Akbarzadeh A et al. Dendrimers: synthesis, applications, and properties. Nanoscale Res. Lett. 9(1), 247 (2014).
   PubMed Web of Science ®Google Scholar
• Manikkath J , Hegde AR , Parekh HS , Mutalik S . Peptide dendrimers in delivery of bioactive molecules to skin. In: Nanoscience in Dermatology. Hamblin MR , Avci P , Prow TW ( Eds). Academic Press, MA, USA, 89–97 (2016).
   Google Scholar
• Manikkath J , Manikkath A , Shavi GV , Bhat K , Mutalik S . Low frequency ultrasound and PAMAM dendrimer facilitated transdermal delivery of ketoprofen. J. Drug Deliv. Sci. Technol. 41, 334–343 (2017).
   Web of Science ®Google Scholar
• Shen J , Hu Y , Putt KS et al. Assessment of folate receptor alpha and beta expression in selection of lung and pancreatic cancer patients for receptor targeted therapies. Oncotarget 9(4), 4485–4495 (2018).
   PubMedGoogle Scholar
• Sun JY , Shen J , Thibodeaux J et al. In vivo optical imaging of folate receptor-β in head and neck squamous cell carcinoma. Laryngoscope 124(8), E312 (2014).
   PubMed Web of Science ®Google Scholar
• Scaranti M , Cojocaru E , Banerjee S , Banerji U . Exploiting the folate receptor α in oncology. Nat. Rev. Clin. Oncol. 17(6), 349–359 (2020).
   PubMed Web of Science ®Google Scholar
• Lango MN , Dyer KF , Lui VWY et al. Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck. J. Natl Cancer Inst. 94(5), 375–383 (2002).
   PubMed Web of Science ®Google Scholar
• Linz C , Brands RC , Kertels O et al. Targeting fibroblast activation protein in newly diagnosed squamous cell carcinoma of the oral cavity – initial experience and comparison to [18F]FDG PET/CT and MRI. Eur. J. Nucl. Med. Mol. Imaging 48(12), 3951–3960 (2021).
   PubMed Web of Science ®Google Scholar
• Ma P , Li J , Gao Y et al. Local and systemic delivery of the BimS gene nano-complex for efficient oral squamous cell carcinoma therapy. Int. J. Nanomed. 17, 2925–2941 (2022).
   PubMed Web of Science ®Google Scholar
• Miao L , Liu C , Ge J et al. Antitumor effect of TRAIL on oral squamous cell carcinoma using magnetic nanoparticle-mediated gene expression. Cell Biochem Biophys. 69, 663–672 (2014).
   PubMed Web of Science ®Google Scholar
• Ou L , Sun T , Liu M et al. Efficient miRNA inhibitor delivery with graphene oxide–polyethylenimine to inhibit oral squamous cell carcinoma. Int. J. Nanomed. 15, 1569–1583 (2020).
   PubMed Web of Science ®Google Scholar
• Surekha B , Kommana NS , Dubey SK , Kumar AVP , Shukla R , Kesharwani P . PAMAM dendrimer as a talented multifunctional biomimetic nanocarrier for cancer diagnosis and therapy. Colloids Surf. B Biointerfaces 204, 10.1016/j.colsurfb.2021.111837 (2021).
   PubMed Web of Science ®Google Scholar
• Clemons TD , Singh R , Sorolla A , Chaudhari N , Hubbard A , Iyer KS . Distinction between active and passive targeting of nanoparticles dictate their overall therapeutic efficacy. Langmuir 34(50), 15343–15349 (2018).
   PubMed Web of Science ®Google Scholar
• Decuzzi P , Cook AB . Harnessing endogenous stimuli for responsive materials in theranostics. ACS Nano 15(2), 2068–2098 (2021).
   PubMed Web of Science ®Google Scholar
• Mura S , Nicolas J , Couvreur P . Stimuli-responsive nanocarriers for drug delivery. Nat. Mater. 12(11), 991–1003 (2013).
   PubMed Web of Science ®Google Scholar
• Liang J , Yang B , Zhou X , Han Q , Zou J , Cheng L . Stimuli-responsive drug delivery systems for head and neck cancer therapy. Drug Deliv. 28(1), 272 (2021).
   PubMed Web of Science ®Google Scholar
• Li B , Ding Y , Huo C et al. Targeting circ-OCAC suppress oral squamous cell carcinoma progression. Oral Dis. (2023). doi:10.1111/odi.14687
   Web of Science ®Google Scholar
• Lo YL , Lin HC , Tseng WH . Tumor pH-functionalized and charge-tunable nanoparticles for the nucleus/cytoplasm-directed delivery of oxaliplatin and miRNA in the treatment of head and neck cancer. Acta Biomater. 153, 465–480 (2022).
   PubMed Web of Science ®Google Scholar
• Zhou ZH , Liang SY , Zhao TC et al. Overcoming chemotherapy resistance using pH-sensitive hollow MnO2 nanoshells that target the hypoxic tumor microenvironment of metastasized oral squamous cell carcinoma. J. Nanobiotechnol. 19(1), 157 (2021).
   PubMed Web of Science ®Google Scholar
• Shokrollahi H , Khorramdin A , Isapour G . Magnetic resonance imaging by using nano-magnetic particles. J. Magnetism Magnetic Mater. 369, 176–183 (2014).
   Web of Science ®Google Scholar
• Wu YN , Yang LX , Shi XY et al. The selective growth inhibition of oral cancer by iron core–gold shell nanoparticles through mitochondria-mediated autophagy. Biomaterials 32(20), 4565–4573 (2011).
   PubMed Web of Science ®Google Scholar
• Zhang S , Li Z , Xu Z et al. Reactive oxygen species-based nanotherapeutics for head and neck squamous cell carcinoma. Mater. Des. 223, 111194 (2022).
   Web of Science ®Google Scholar
• Zhang Y , Bi L , Hu Z , Cao W , Zhuang D . Hematoporphyrin monomethyl ether-mediated sonodynamic therapy induces A-253 cell apoptosis. Oncol. Lett. 19(4), 3223–3228 (2020).
   PubMed Web of Science ®Google Scholar
• Moosavi Nejad S , Takahashi H , Hosseini H et al. Acute effects of sono-activated photocatalytic titanium dioxide nanoparticles on oral squamous cell carcinoma. Ultrason. Sonochem. 32, 95–101 (2016).
   PubMed Web of Science ®Google Scholar
• Sun L , Xu Y , Zhang X et al. Mesenchymal stem cells functionalized sonodynamic treatment for improving therapeutic efficacy and compliance of orthotopic oral cancer. Adv. Mater. 32(48), 2005295 (2020).
   Web of Science ®Google Scholar
• Bilmin K , Kujawska T , Secomski W , Nowicki A , Grieb P . 5-Aminolevulinic acid-mediated sonosensitization of rat RG2 glioma cells in vitro . Folia Neuropathol. 54(3), 234–240 (2016).
   PubMed Web of Science ®Google Scholar
• Lv Y , Zheng J , Zhou Q et al. Antiproliferative and apoptosis-inducing effect of exo-protoporphyrin IX based sonodynamic therapy on human oral squamous cell carcinoma. Sci. Rep. 7(1), 40967 (2017).
   PubMedGoogle Scholar
• Fan HY , Zhu ZL , Zhang WL et al. Light stimulus responsive nanomedicine in the treatment of oral squamous cell carcinoma. Eur. J. Med. Chem. 199, 112394 (2020).
   PubMed Web of Science ®Google Scholar
• Shalhout SZ , Miller DM , Emerick KS , Kaufman HL . Therapy with oncolytic viruses: progress and challenges. Nat. Rev. Clin. Oncol. 20(3), 160–177 (2023).
   PubMed Web of Science ®Google Scholar
• Pol J , Kroemer G , Galluzzi L . First oncolytic virus approved for melanoma immunotherapy. Oncoimmunology 5(1), e1115641 (2016).
   PubMed Web of Science ®Google Scholar
• Dolgin E . Oncolytic viruses get a boost with first FDA-approval recommendation. Nat. Rev. Drug Discov. 14(6), 369–371 (2015).
   PubMed Web of Science ®Google Scholar
• Uchihashi T , Nakahara H , Fukuhara H et al. Oncolytic herpes virus G47Δ injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis. Mol. Ther. Oncolytics 22, 388–398 (2021).
   PubMed Web of Science ®Google Scholar
• Inoue K , Ito H , Iwai M , Tanaka M , Mori Y , Todo T . Neoadjuvant use of oncolytic herpes virus G47Δ prevents local recurrence after insufficient resection in tongue cancer models. Mol. Ther. Oncolytics 30, 72–85 (2023).
   PubMed Web of Science ®Google Scholar
• Zhang CX , Ye LW , Liu Y et al. Antineoplastic activity of Newcastle disease virus strain D90 in oral squamous cell carcinoma. Tumor Biol. 36(9), 7121–7131 (2015).
   PubMedGoogle Scholar
• Lu R , Wu G , Chen M et al. USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells. Mol. Ther. Oncolytics 23, 477–487 (2021).
   PubMed Web of Science ®Google Scholar
• Woo Y , Reid V , Kelly KJ , Carlson D , Yu Z , Fong Y . Oncolytic herpes simplex virus prevents premalignant lesions from progressing to cancer. Mol. Ther. Oncolytics 16, 1–6 (2019).
   PubMed Web of Science ®Google Scholar
• Lee SY , Park HR , Rhee J , Park YM , Kim SH . Therapeutic effect of oncolytic adenovirus expressing relaxin in radioresistant oral squamous cell carcinoma. Oncol. Res. 20(9), 419–425 (2013).
   PubMed Web of Science ®Google Scholar
• Zhang T , Hamada K , Hyodo M et al. Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells. Oncol. Rep. 25(3), 795–802 (2011).
   PubMed Web of Science ®Google Scholar
• Saito K , Uzawa K , Kasamatsu A et al. Oncolytic activity of Sindbis virus in human oral squamous carcinoma cells. Br. J. Cancer 101(4), 684–690 (2009).
   PubMed Web of Science ®Google Scholar