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Nanomedicine Volume 5, 2010 - Issue 3
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Research Article

Imatinib-Loaded Polyelectrolyte Microcapsules for Sustained Targeting of BCR-ABL+ Leukemia Stem Cells

Ilaria E Palamà1 National Nanotechnology Laboratory of CNR-INFM, IIT Research Unit, Scuola Superiore ISUFI, University of Salento, Via Arnesano 73100 Lecce, Italy.View further author information
,
Stefano Leporatti1 National Nanotechnology Laboratory of CNR-INFM, IIT Research Unit, Scuola Superiore ISUFI, University of Salento, Via Arnesano 73100 Lecce, Italy.View further author information
,
Emanuela de Luca2 ‘Vito Fazzi’ Hospital, ItalyView further author information
,
Nicola Di Renzo2 ‘Vito Fazzi’ Hospital, ItalyView further author information
,
Michele Maffia2 ‘Vito Fazzi’ Hospital, ItalyView further author information
,
Carlo Gambacorti-Passerini3 University of Milano-Bicocca, ItalyView further author information
,
Ross Rinaldi1 National Nanotechnology Laboratory of CNR-INFM, IIT Research Unit, Scuola Superiore ISUFI, University of Salento, Via Arnesano 73100 Lecce, Italy.View further author information
,
Giuseppe Gigli1 National Nanotechnology Laboratory of CNR-INFM, IIT Research Unit, Scuola Superiore ISUFI, University of Salento, Via Arnesano 73100 Lecce, Italy.View further author information
,
Roberto Cingolani1 National Nanotechnology Laboratory of CNR-INFM, IIT Research Unit, Scuola Superiore ISUFI, University of Salento, Via Arnesano 73100 Lecce, Italy.View further author information
&
Addolorata ML Coluccia1 National Nanotechnology Laboratory of CNR-INFM, IIT Research Unit, Scuola Superiore ISUFI, University of Salento, Via Arnesano 73100 Lecce, Italy.;2 ‘Vito Fazzi’ Hospital, ItalyCorrespondence[email protected]
View further author information
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Pages 419-431 | Published online: 16 Apr 2010

Bibliography

  • Allen TM , CullisPR: Drug delivery systems: entering the mainstream.Science303, 1818–1822 (2004).
  • Hughes GA : Nanostructure-mediated drug delivery.Nanomedicine (Lond.)1(1), 22–30 (2005).
  • Langer R , TirrellDA: Designing materials for biology and medicine.Nature428(6982), 487–492 (2004).
  • Pridgen EM , LangerR, FarokhzadOC: Biodegradable polymeric nanoparticle delivery systems for cancer therapy.Nanomedicine (Lond.)2(5), 669–680 (2007).
  • Caruso F , CarusoRA, MöhwaldH: Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating.Science282, 1111–1114 (1998).
  • Donath E , SukhorukovGB, CarusoF, DavisS, MöhwaldH: Novel hollow polymer shells by colloid-templated assembly of polyelectrolytes.Angew. Chem. Int. Ed. Engl.37, 2201–2205 (1998).
  • Peyratout CS , DahneL: Tailor-made polyelectrolyte microcapsules: from multilayers to smart containers.Angew. Chem. Int. Ed. Engl.43, 3762–3783 (2004).
  • Volodkin DV , PetrovAI, PrevotM, SukhorukovGB. Matrix polyelectrolyte microcapsules: new system for macromolecule encapsulation. Langmuir20(8), 3398–3406 (2004).
  • Zebli B , SushaAS, SukhorukovGB, RogachAL, ParakWJ: Magnetic targeting and cellular uptake of polymer microcapsules simultaneously functionalized with magnetic and luminescent nanocrystals.Langmuir21(10), 4262–4265 (2005).
  • Sukhorukov GB , MöhwaldH: Multifunctional cargo systems for biotechnology.Trends Biotechnol.25(3), 93–98 (2007).
  • De Koker S , SukhorukovGB: Polyelectrolyte microcapsules for biomedical applications.Soft Matter5, 282–291 (2009).
  • Ibarz G , DahneL, DonathE, MöhwaldH: Smart micro and nanocontainers for storage, transport, and release.Adv. Mater.13, 1324–1327 (2001).
  • Volodkin DV , LarionovaNI, SukhorukovGB: Protein encapsulation via porous CaCO3 microparticles templating.Biomacromolecules5, 1962–1972 (2004).
  • Sukhorukov GB , FeryA, BrumenM, MöhwaldH: Physical chemistry of encapsulation and release.Phys. Chem. Chem. Phys.6, 4078–4089 (2004).
  • De Geest BG , SandersNN, SukhorukovGB, DemeesterJ, De Smedt SC: Release mechanisms for polyelectrolyte capsules. Chem. Soc. Rev.36(4), 636–649 (2007).
  • De Geest BG , VandenbrouckeRE, GuentherAMet al.: Intracellularly degradable polyelectrolyte microcapsules.Adv. Mater.18(8), 1005–1009 (2006).
  • Muñoz Javier A , KreftO, Piera Alberola A et al.: Combined atomic force microscopy and optical microscopy measurements as a method to investigate particle uptake by cells. Small2(3), 394–400 (2006).
  • De Koker S , De Geest BG, Cuvelier C et al.: In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsule. Adv. Funct. Mater.17, 3754–3763 (2007).
  • De Koker S , De Geest BG, Singh SK et al.: Polyelectrolyte microcapsules as antigen delivery vehicles to dendritic cells: uptake, processing, and cross-presentation of encapsulated antigens. Angew. Chem. Int. Ed. Engl.48(45), 8485–8489 (2009).
  • Rivera-Gil P , De Koker S, De Geest BG, Parak WJ: Intracellular processing of proteins mediated by biodegradable polyelectrolyte capsules. Nano Lett.9(12), 4398–4402 (2009).
  • Kirchner C , JavierAM, SushaASet al.: Cytotoxicity of nanoparticle-loaded polymer capsules.Talanta67(3), 486–491 (2005).
  • Ai H , PinkJJ, ShuaiX, BoothmanDA, GaoJ: Interactions between self-assembled polyelectrolyte shells and tumor cells.J. Biomed. Mater. Res. A73(3), 303–312 (2005).
  • Liu XY , GaoCY, ShenJC, MöhwaldH: Multilayer microcapsules as anti-cancer drug delivery vehicle deposition, sustained release, and in vitro bioactivity.Macromol. Biosci.5, 1209–1219 (2005).
  • Song W , HeQ, MöhwaldH, YangY, LiJ: Smart polyelectrolyte microcapsules as carriers for water-soluble small molecular drug.J. Control Release139(2), 160–166 (2009).
  • Agarwal A , LvovY, SawantR, TorchilinV: Stable nanocolloids of poorly soluble drugs with high drug content prepared using the combination of sonication and layer-by-layer technology.J. Control. Release128(3), 255–260 (2008).
  • Wang C , HeC, TongZ, LiuX, RenB, ZengF: Combination of adsorption by porous CaCO3 microparticles and encapsulation by polyelectrolyte multilayer films for sustained drug delivery.Int. J. Pharm.308, 160–167 (2006).
  • Schatzlein AG : Delivering cancer stem cell therapies – a role for nanomedicines?Eur. J. Cancer42, 1309–1315 (2006).
  • Dean M , FojoT, BatesS: Tumour stem cells and drug resistance.Nat. Rev. Cancer5(4), 275–284 (2005).
  • Ravandi F , EstrovZ: Eradication of leukemia stem cells as a new goal of therapy in leukemia.Clin. Cancer Res.12(2), 340–344 (2006).
  • Savona M , TalpazM: Getting to the stem of chronic myeloid leukaemia.Nat. Rev. Cancer8(5), 341–350 (2008).
  • Deininger M , BuchdungerE, DrukerBJ: The development of imatinib as a therapeutic agent for chronic myeloid leukemia.Blood105, 2640–2653 (2005).
  • Barnes DJ , MeloJV: Primitive, quiescent and difficult to kill: the role of non-proliferating stem cells in chronic myeloid leukemia.Cell Cycle5(24), 2862–2866 (2006).
  • Goldman GJ : Why do chronic myelogenous leukemia stem cells survive allogeneic stem cell transplantation or imatinib: does it really matter?Leuk. Lymphoma47, 1–7 (2006).
  • le Coutre P , MologniL, ClerisLet al.: In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor.J. Natl Cancer Inst.91(2), 163–168 (1999).
  • Irigoyen J , MoyaSE, IturriJJ, LlarenaI, AzzaroniO, DonathE: Specific ζ-potential response of layer-by-layer coated colloidal particles triggered by polyelectrolyte ion interactions.Langmuir25(6), 3374–3380 (2009).
  • Zhao Q , ZhangS, TongW, GaoC, ShenJ: Polyelectrolyte microcapsules templated on poly(styrene sulfonate)-doped CaCO3 particles for loading and sustained release of daunorubicin and doxorubicin.Eur. Polymer J.42, 3341–3351 (2006).
  • Palamà IE , ColucciaAML, della Torre A et al.: Multilayered polyelectrolyte capsules and coated colloids: cytotoxicity and uptake by cancer cells. Sci. Adv. Mater.2(2), 1947–2935 (2010).
  • Garon EB , MarcuL, LuongQ, TcherniantchoukO, CrooksGM, KoefflerHP: Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells.Leuk. Res.31(5), 643–651 (2007).
  • De Geest BG , SukhorukovGB, MöhwaldH: The pros and cons of polyelectrolyte capsules in drug delivery.Expert Opin. Drug Deliv.6(6), 613–624 (2009).
  • Klejman A , RushenL, MorrioneA, SlupianekA, SkorskiT: Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.Oncogene21, 5868–5876 (2002).
  • Hoover RR , MahonFX, MeloJV, DaleyGQ: Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336.Blood100, 1068–1071 (2002).
  • Gatto S , ScappiniB, PhamLet al.: The proteasome inhibitor PS-341 inhibits growth and induces apoptosis in BCR/ABL-positive cell lines sensitive and resistant to imatinib mesylate.Haematologica88, 853–863 (2003).
  • Reibetanz U , ClausC, TypltE, HoffmanJ, DonathE: Defoliation and plasmid delivery with layer-by-layer coated colloids.Macrom. Biosci.6, 153–160 (2006).
  • Johnston AP , LeeL, WangY, CarusoF: Controlled degradation of DNA capsules with engineered restriction-enzyme cut sites.Small5(12), 1418–1421 (2009).

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