Advanced search
Publication Cover
Nanomedicine Volume 5, 2010 - Issue 7
Submit an article Journal homepage
694
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Internalization and Biodistribution of Polymersomes Into Oral Squamous Cell Carcinoma Cells In Vitro and In Vivo

Craig Murdoch1 School of Clinical Dentistry, Unit of Oral & Maxillofacial Medicine & Surgery, University of Sheffield, Sheffield, UKView further author information
,
Kim J Reeves2 Department of Surgical Oncology, University of Sheffield, Sheffield, UKView further author information
,
Vanessa Hearnden1 School of Clinical Dentistry, Unit of Oral & Maxillofacial Medicine & Surgery, University of Sheffield, Sheffield, UK;3 Department of Biomedical Science, University of Sheffield, Sheffield, UK;4 Department of Engineering Materials, University of Sheffield, Sheffield, UKView further author information
,
Helen Colley1 School of Clinical Dentistry, Unit of Oral & Maxillofacial Medicine & Surgery, University of Sheffield, Sheffield, UK;3 Department of Biomedical Science, University of Sheffield, Sheffield, UKView further author information
,
Marzia Massignani3 Department of Biomedical Science, University of Sheffield, Sheffield, UK;4 Department of Engineering Materials, University of Sheffield, Sheffield, UKView further author information
,
Irene Canton3 Department of Biomedical Science, University of Sheffield, Sheffield, UKView further author information
,
Jeppe Madsen3 Department of Biomedical Science, University of Sheffield, Sheffield, UK;5 Department of Chemistry, University of Sheffield, Sheffield, UKView further author information
,
Adam Blanazs5 Department of Chemistry, University of Sheffield, Sheffield, UKView further author information
,
Steve P Armes5 Department of Chemistry, University of Sheffield, Sheffield, UKView further author information
,
Andrew L Lewis6 Biocompatibles UK Ltd, Farnham, Surrey, UKView further author information
,
Sheila MacNeil4 Department of Engineering Materials, University of Sheffield, Sheffield, UKView further author information
,
Nicola J Brown2 Department of Surgical Oncology, University of Sheffield, Sheffield, UKView further author information
,
Martin H Thornhill1 School of Clinical Dentistry, Unit of Oral & Maxillofacial Medicine & Surgery, University of Sheffield, Sheffield, UKView further author information
&
Giuseppe Battaglia3 Department of Biomedical Science, University of Sheffield, Sheffield, UK;7 Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK.Correspondence[email protected]
View further author information
 show all
Pages 1025-1036 | Published online: 27 Sep 2010

Bibliography

  • Kimmelman J : Recent developments in gene transfer: risk and ethics.BMJ330, 79–82 (2005).
  • Raper SE , ChirmuleN, LeeFSet al.: Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer.Mol. Genet. Metab.80, 148–158 (2003).
  • Photos PJ , BacakovaL, DischerB, BatesFS, DischerDE: Polymer vesicles in vivo: correlations with PEG molecular weight.J. Control. Release90, 323–334 (2003).
  • Meng F , HiemstraC, EngbersGHM, FeijenJ: Biodegradable polymersomes.Macromolecules36, 3004–3006 (2003).
  • Discher BM , WonYY, EgeDSet al.: Polymersomes: tough vesicles made from diblock copolymers.Science284, 1143–1146 (1999).
  • Discher DE , EisenbergA: Polymer vesicles.Science297, 967–973 (2002).
  • Battaglia G , RyanAJ: Bilayers and interdigitation in block copolymer vesicles.J. Am. Chem. Soc.127, 8757–8764 (2005).
  • Lopresti C , LomasH, MassignaniM, SmartT, BattagliaG: Polymersomes: nature inspired nanometer sized compartments.J. Mater. Chem.19, 3576–3590 (2009).
  • Meng F , ZhongZ, FeijenJ: Stimuli-responsive polymersomes for programmed drug delivery.Biomacromolecules10, 197–209 (2009).
  • Ahmed F , PakunluRI, SrinivasGet al.: Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation.Mol. Pharm.3, 340–350 (2006).
  • Ahmed F , PakunluRI, BrannanA, BatesF, MinkoT, DischerDE: Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug.J. Control. Release116, 150–158 (2006).
  • Lam JK , MaY, ArmesSP, LewisAL, BaldwinT, StolnikS: Phosphorylcholine-polycation diblock copolymers as synthetic vectors for gene delivery.J. Control. Release 100, 293–312 (2004).
  • Lomas H , CantonI, MacneilS, DuJet al.: Biomimetic pH sensitive polymersomes for efficient DNA encapsulation and delivery.Adv. Mater.19, 4238–4243 (2007).
  • Zhao J , LiuCS, YuanY, TaoXY, ShanXQ, ShengY, WuF: Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers.Biomaterials28, 1414–1422 (2007).
  • Kim Y , TewariM, PajerowskiJDet al.: Polymersome delivery of siRNA and antisense oligonucleotides.J. Control. Release134, 132–140 (2009).
  • Massignani M , LoprestiC, BlanazsAet al.: Controlling cellular uptake by surface chemistry, size, and surface topology at the nanoscale.Small5, 2424–2432 (2009).
  • Hearnden V , LomasH, MacneilSet al.: Diffusion studies of nanometer polymersomes across tissue engineered human oral mucosa.Pharm. Res.26, 1718–1728 (2009).
  • Ghoroghchian PP , FrailPR, SusumuKet al.: Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging.Proc. Natl Acad. Sci. USA102, 2922–2927 (2005).
  • Levine DH , GhoroghchianPP, FreudenbergJet al.: Polymersomes: a new multi-functional tool for cancer diagnosis and therapy.Methods46, 25–32 (2008).
  • Discher DE , AhmedF: Polymersomes.Annu. Rev. Biomed. Eng.8, 323–341 (2006).
  • Ahmed F , DischerDE: Self-porating polymersomes of PEG–PLA and PEG–PCL: hydrolysis-triggered controlled release vesicles.J. Control. Release96, 37–53 (2004).
  • Du J , TangY, LewisAL, ArmesSP: pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer.J. Am. Chem. Soc.127, 17982–17983 (2005).
  • Shen L , DuJ, ArmesSP, LiuS: Kinetics of pH-Induced formation and dissociation of polymeric vesicles assembled from a water-soluble zwitterionic diblock copolymer.Langmuir24, 10019–10025 (2008).
  • Giacomelli C , LeML, BorsaliRet al.: Phosphorylcholine-based pH-responsive diblock copolymer micelles as drug delivery vehicles: light scattering, electron microscopy, and fluorescence experiments.Biomacromolecules7, 817–828 (2006).
  • Deshpande MC , DaviesMC, GarnettMCet al.: The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes.J. Control. Release97, 143–156 (2004).
  • Lomas H , MassignaniM, AbdullahKAet al.: Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery.Faraday Discuss.139, 143–159 (2008).
  • Robinson KL , WeaverJV, ArmesSP, MartiED, MeldrumFC: Synthesis of controlled-structure sulfate-based copolymers via atom transfer radical polymerisation and thier use as crystal habit modifiers for BaSO4.J. Mater. Chem.12, 890–896 (2002).
  • Ma IY , LobbEJ, BillinghamNCet al.: Synthesis of biocompatible polymers. 1. Homopolymerisation of 2-methacryloyloxyethyl phosphorylcholine via ATRP in protic solvents: an optimization study.Macromolecules35(25), 9306–9314 (2002).
  • Rheinwald JG , BeckettMA: Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultures from human squamous cell carcinomas.Cancer Res.41, 1657–1663 (1981).
  • Marcus B , ArenbergD, LeeJet al.: Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma.Cancer101, 2779–2787 (2004).
  • Parkin DM , BrayF, FerlayJ, PisaniP: Global cancer statistics, 2002.CA Cancer J. Clin.55, 74–108 (2005).
  • Shah J , JohnsonNW, BatsakisJG: Oral Cancer. Martin Dunitz, London, UK (2003).
  • Chen W , MengF, ChengR, ZhongZ: pH-sensitive degradable polymersomes for triggered release of anticancer drugs: a comparative study with micelles.J. Control. Release142(1), 40–46 (2009).
  • Li S , ByrneB, WelshJ, PalmerAF: Self-assembled poly(butadiene)-β-poly(ethylene oxide) polymersomes as paclitaxel carriers.Biotechnol. Prog.23, 278–285 (2007).
  • Lee JC , BermudezH, DischerBMet al.: Preparation, stability, and in vitro performance of vesicles made with diblock copolymers.Biotechnol. Bioeng.73, 135–145 (2001).
  • Alexis F , PridgenE, MolnarLK, FarokhzadOC: Factors affecting the clearance and biodistribution of polymeric nanoparticles.Mol. Pharm.5, 505–515 (2008).
  • Nagayama S , OgawaraK, FukuokaY, HigakiK, KimuraT: Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics.Int. J. Pharm.342, 215–221 (2007).
  • Fang C , ShiB, PeiYY, HongMH, WuJ, ChenHZ: In vivo tumor targeting of tumor necrosis factor-α-loaded stealth nanoparticles: effect of MePEG molecular weight and particle size.Eur. J. Pharm. Sci.27, 27–36 (2006).
  • Howse JR , JonesRA, BattagliaG, DuckerRE, LeggettGJ, RyanAJ: Templated formation of giant polymer vesicles with controlled size distributions.Nat. Mater.8, 507–511 (2009).
  • Bermudez H , BrannanA, HammerDA, BatesFS, DischerDE: Molecular weight dependence of polymersome membrane structure, elasticity and stability.Macromolecules35, 8203–8208 (2002).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.