Advanced search
Publication Cover
Nanomedicine Volume 6, 2011 - Issue 2
Submit an article Journal homepage
93
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Novel Ferrocenyl Nitroxide Nanoparticles as Electron Paramagnetic Resonance Oximetry Probes In Vitro and In Vivo

Xiao Qiu1 Shanghai Key Laboratory of Functional Materials Chemistry, and Research Centre of Analysis & Test, East China University of Science & Technology, Shanghai200237, PR China.View further author information
,
Hongli Zhao1 Shanghai Key Laboratory of Functional Materials Chemistry, and Research Centre of Analysis & Test, East China University of Science & Technology, Shanghai200237, PR China.;2 The Institute of Applied Chemistry, East China University of Science & Technology, Shanghai, PR ChinaView further author information
,
Ronghua Yu1 Shanghai Key Laboratory of Functional Materials Chemistry, and Research Centre of Analysis & Test, East China University of Science & Technology, Shanghai200237, PR China.View further author information
,
Jiufeng Zhang1 Shanghai Key Laboratory of Functional Materials Chemistry, and Research Centre of Analysis & Test, East China University of Science & Technology, Shanghai200237, PR China.View further author information
&
Minbo Lan1 Shanghai Key Laboratory of Functional Materials Chemistry, and Research Centre of Analysis & Test, East China University of Science & Technology, Shanghai200237, PR China.Correspondence[email protected]
View further author information
Pages 225-231 | Published online: 21 Jun 2011

Bibliography

  • Krishna MC , EnglishS, YamadaKet al.: Overhauser enhanced magnetic resonance imaging for tumor oximetry: coregistration of tumor anatomy and tissue oxygen concentration.Pans99, 2216–2221 (2002).
  • Nordsmark M , AlsnerJ, KellerJet al.: Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations.Br. J. Cancer84(8), 1070–1075 (2001).
  • Edwards HS , BremnerJC, StratfordIJ: Induction of hypoxia in the KHT sarcoma by tumour necrosis factor and flavone acetic acid.Int. J. Rad. Biol.59(2), 419–432 (1991).
  • Kuppusamy P , LiH, IlangovanGet al.: Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels.Cancer Res.62(1), 307–312 (2002).
  • Vaupel P , KallinowskiF, OkunieffP: Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.Cancer Res.49(23), 6449–6465 (1989).
  • Griffiths JR , RobinsonSP: The OxyLite: a fibre-optic oxygen sensor.Br. J. Rad.72(859), 627–630 (1999).
  • Shen J , LiuS, MiyakeMet al.: Use of 3-acetoxymethoxycarbonyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl as an EPR oximetry probe: potential for in vivo measurement of tissue oxygenation in mouse brain.Magn. Reson. Med.55(6), 1433–1440 (2006).
  • Ilangovan G , LiH, ZweierJLet al.: In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: effect of carbogen-breathing.Magn. Reson. Med.48(4), 723–730 (2002).
  • Fuchs J , GrothN, HerrlingTet al.: Electron paramagnetic resonance studies on nitroxide radical 2, 2, 5, 5-tetramethyl-4-piperidin-1-oxyl (TEMPO) redox reactions in human skin.Free Radical Biol. Med.22(6), 967–976 (1997).
  • Shiga M , MiyazonoY, IshiyamaMet al.: 4-hydroxy-2, 2, 6, 6-tetramethyl-1-piperidinyloxy free radical as a novel ascorbic acid quencher.Anal. Commun.34(4), 115–118 (1997).
  • Wu Y , TangW, LiCLet al.: Cytotoxicity of a newly synthesized nitroxide derivative of 4-ferrocenecarboxyl-2,2,6,6-tetramethylpiperidine-1-oxyl in high metastatic lung tumor cells.Pharmazie61(12), 1028–1033 (2006).
  • Lukyanov AN , GaoZ, TorchilinVP: Micelles from polyethylene glycol/phosphatidylethanolamine conjugates for tumor drug delivery.J. Control. Release91(1–2), 97–102 (2003).
  • Glockner JF , NorbySW, SwartzHM: Simultaneous measurement of intracellular and extracellular oxygen concentrations using a nitroxide–liposome system.Magn. Reson. Med.29(1), 12–18 (1993).
  • Sostaric JZ , PandianRP, BrataszAet al.: Encapsulation of a highly sensitive EPR active oxygen probe into sonochemically prepared microspheres.J. Phys. Chem. B.111(12), 3298–3303 (2007).
  • Wu Y , MiaoLD, YuanHHet al.: A novel poly(DL-lactic acid) nanoparticle of nitroxide derivative, 4-ferrocenecarboxyl-2,2,6,6-tetramethyl piperidine-1-oxyl.Chem. Lett.35(7), 794–795 (2006).
  • Rapoport N : Stabilization and activation of Pluronic micelles for tumor-targeted drug delivery.Colloids Surf.B 16(1–4), 93–111 (1999).
  • Li L , TanYB: Preparation and properties of mixed micelles made of Pluronic polymer and PEG–PE.J. Colloid Interface Sci.317(1), 326–331 (2008).
  • Broadhead GD , OsgerbyJM: Ferrocene derivatives. Part V. Ferrocenealdehyde.J. Am. Chem. Soc.2, 650–656 (1958).
  • Stephan SH : Insertion von Carbenoiden in Cp-H-Bindungen von Ferrocenen: ein enantioselektiv-katalytischer Zugang zu planar-chiralen Ferrocenen.Angew. Chem.109(22), 2569–2572 (1997).
  • Kenneth L , Rinehart Jr, Ronald J et al.: Organic chemistry of ferrocene. II. The preparation of ferrocenyl aliphatic. J. Am. Chem. Soc.79(13), 3420–3424 (1957).
  • Rosenblum M , BanerjeeAK, DanieliNet al.: The structure and chemistry of ferrocene. VII. Bridged ferrocenes.J. Am. Chem. Soc.85(3), 316–324 (1963).
  • Wang J , TangFL: A convenient method for the synthesis of distamycin analogue.Chin. Chem. Lett.13, 1055–1056 (2002).
  • Lan M , BegheinN, CharlierNet al.: Carbon blacks as EPR sensors for localized measurements of tissue oxygenation.Magn. Reson. Med.51(6), 1272–1278 (2004).
  • Weissfloch L , WagnerM, ProbstTet al.: A new class of drugs for BNCT? Borylated derivatives of ferrocenium compounds in animal experiments.Biometals14(1), 43–49 (2001).
  • Liu KJ , GrinstaffMW, JiangJet al.: In vivo measurement of oxygen concentration using sonochemically synthesized microspheres.Biophysical J.67(2), 896–901 (1994).
  • Kirilyuk IA , BobkoAA, GrigorIAet al.: Synthesis of the tetraethyl substituted pH-sensitive nitroxides of imidazole series with enhanced stability towards reduction.Org. Biomol. Chem.2(7), 1025–1030 (2004).
  • Lan M , JiangY, GallezB: Sensitivity between oxygen and EPR signal dealing with carbon black used as biosensor.Synthetic Met.137(1–3), 1535–1536 (2003).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.