231
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Lipoplexes Carrying mRNA Encoding Gag Protein Modulate Dendritic Cells to Stimulate HIV-Specific Immune Responses

, , , , , , , , , & show all
Pages 77-87 | Received 26 Jan 2012, Accepted 17 Apr 2012, Published online: 20 Dec 2012

References

  • Lu D , BenjaminR, KimM, ConryRM, CurielDT. Optimization of methods to achieve mRNA-mediated transfection of tumor cells in vitro and in vivo employing cationic liposome vectors. Cancer Gene Ther.1(4), 245–252 (1994).
  • Read ML , SinghS, AhmedZet al. A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids. Nucleic Acids Res. 33(9), e86 (2005).
  • Yamamoto A , KormannM, RoseneckerJ, RudolphC. Current prospects for mRNA gene delivery. Eur. J. Pharm. Biopharm.71(3), 484–489 (2009).
  • Elamanchili P , DiwanM, CaoM, SamuelJ. Characterization of poly(D,L-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells. Vaccine22(19), 2406–2412 (2004).
  • Aline F , BrandD, PierreJet al. Dendritic cells loaded with HIV-1 p24 proteins adsorbed on surfactant-free anionic PLA nanoparticles induce enhanced cellular immune responses against HIV-1 after vaccination. Vaccine 9(4), 536–543 (2009).
  • De Haes W , De Koker S, Pollard C et al. Polyelectrolyte capsules-containing HIV-1 p24 and poly I:C modulate dendritic cells to stimulate HIV-1-specific immune responses. Mol. Ther.18(7), 1408–1416 (2010).
  • De Rose R , ZelikinAN, JohnstonAPRet al. Binding, internalization, and antigen presentation of vaccine-loaded nanoengineered capsules in blood. Adv. Mater. 20 (1–6), 4698–4703 (2008).
  • Espuelas S , RothA, ThumannC, FrischB, SchuberF. Effect of synthetic lipopeptides formulated in liposomes on the maturation of human dendritic cells. Mol. Immunol.42, 721–729 (2005).
  • Lisziewicz J , GabrilovichDI, VargaGet al. Induction of potent human immunodeficiency virus type 1-specific T-cell-restricted immunity by genetically modified dendritic cells. J. Virol. 75(16), 7621–7628 (2001).
  • Martinon F , KrishnanS, LenzenGet al. Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA. Eur. J. Immunol. 23(7), 1719–1722 (1993).
  • O‘Hagan DT , SinghM, UlmerJB. Microparticles for the delivery of DNA vaccines. Immunol. Rev.199, 191–200 (2004).
  • Pascolo S . Vaccination with messenger RNA (mRNA). Handb. Exp. Pharmacol. (183), 221–235 (2008).
  • Hawkins T . Understanding and managing the adverse effects of antiretroviral therapy. Antiviral Res.85(1), 201–209 (2010).
  • Routy J-P , Boulassel M-R, Yassine-Diab B et al. Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy. Clin. Immunol.134(2), 140–147 (2010).
  • Allard SD , De Keersmaecker B, de Goede AL et al. A Phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption. Clin. Immunol.142(3), 252–256 (2012).
  • Van Gulck E , VliegheE, VekemansMet al. mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients. AIDS 26(4), F1–F12 (2011).
  • Rejman J , TavernierG, BavarsadN, DemeesterJ, De Smedt SC. mRNA transfection of cervical carcinoma and mesenchymal stem cells mediated by cationic carriers. J. Control. Release147(3), 385–391 (2010).
  • Bojak A , WildJ, DemlL, WagnerR. Impact of codon usage modification on T cell immunogenicity and longevity of HIV-1 gag-specific DNA vaccines. Intervirology45(4–6), 275–286 (2002).
  • Ponsaerts P , Van Tendeloo VF, Cools N et al. mRNA-electroporated mature dendritic cells retain transgene expression, phenotypical properties and stimulatory capacity after cryopreservation. Leukemia16(7), 1324–1330 (2002).
  • Romani N , GrunerS, BrangDet al. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180(1), 83–93 (1994).
  • Jonuleit H , KuhnU, MullerGet al. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur. J. Immunol. 27(12), 3135–3142 (1997).
  • Banchereau J , SteinmanRM. Dendritic cells and the control of immunity. Nature392(6673), 245–252 (1998).
  • Van Gulck ER , VanhamG, HeyndrickxLet al. Efficient in vitro expansion of human immunodeficiency virus (HIV)-specific T-cell responses by gag mRNA-electroporated dendritic cells from treated and untreated HIV type 1-infected individuals. J. Virol. 82(7), 3561–3573 (2008).
  • Conry RM , LoBuglioAF, WrightMet al. Characterization of a messenger RNA polynucleotide vaccine vector. Cancer Res. 55(7), 1397–1400 (1995).
  • Van Nuffel AM , CorthalsJ, NeynsBet al. Immunotherapy of cancer with dendritic cells loaded with tumor antigens and activated through mRNA electroporation. Methods Mol. Biol. 629, 405–452 (2010).
  • Van Tendeloo VF , PonsaertsP, LardonFet al. Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells. Blood 98(1), 49–56 (2001).
  • Van Tendeloo VF , Van de Velde A, Van Driessche A et al. Induction of complete and molecular remissions in acute myeloid leukemia by Wilms’ tumor 1 antigen-targeted dendritic cell vaccination. Proc. Natl Acad. Sci. USA107(31), 13824–13829 (2010).
  • Yu H , BabiukLA, van Drunen Littel-van den Hurk S. Immunity and protection by adoptive transfer of dendritic cells transfected with hepatitis C NS3/4A mRNA. Vaccine25(10), 1701–1711 (2007).
  • Lorenzi JC , TromboneAP, RochaCDet al. Intranasal vaccination with messenger RNA as a new approach in gene therapy: use against tuberculosis. BMC Biotechnol. 10, 77 (2010).
  • Allard SD , PletinckxK, BreckpotKet al. Functional T-cell responses generated by dendritic cells expressing the early HIV-1 proteins Tat, Rev and Nef. Vaccine 26 (29–30), 3735–3741 (2008).
  • Chassin D , AndrieuM, CohenWet al. Dendritic cells transfected with the nef genes of HIV-1 primary isolates specifically activate cytotoxic T lymphocytes from seropositive subjects. Eur. J. Immunol. 29(1), 196–202 (1999).
  • Kavanagh DG , KaufmannDE, SunderjiSet al. Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef. Blood 107(5), 1963–1969 (2006).
  • Van Gulck ER , PonsaertsP, HeyndrickxLet al. Efficient stimulation of HIV-1-specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins. Blood 107(5), 1818–1827 (2006).
  • Remaut K , SandersNN, De Geest BG et al. Nucleic acid delivery: where material sciences and bio-sciences meet. Mat. Sci. Eng. R.58, 117–161 (2007).
  • Singh M , BrionesM, OttG, O‘HaganD. Cationic microparticles: a potent delivery system for DNA vaccines. Proc. Natl Acad. Sci. USA97(2), 811–816 (2000).
  • Lisziewicz J , TrocioJ, XuJet al. Control of viral rebound through therapeutic immunization with DermaVir. AIDS 19(1), 35–43 (2005).
  • Pantaleo G , KoupRA. Correlates of immune protection in HIV-1 infection: what we know, what we don’t know, what we should know. Nat. Med.10(8), 806–810 (2004).
  • Deeks SG , WalkerBD. Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity27(3), 406–416 (2007).
  • Deretic V . Multiple regulatory and effector roles of autophagy in immunity. Curr. Opin. Immunol.21(1), 53–62 (2009).
  • Rinaldo CR . Dendritic cell-based human immunodeficiency virus vaccine. J. Intern. Med.265(1), 138–158 (2009).
  • Yoshikawa T , NiwaT, MizuguchiH, OkadaN, NakagawaS. Engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer to enhance cancer vaccine potency. Gene Ther.15(19), 1321–1329 (2008).
  • Fotin-Mleczek M , DuchardtKM, LorenzCet al. Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity. J. Immunother. 34(1), 1–15 (2011).
  • De Keersmaecker B , HeirmanC, CorthalsJet al. The combination of 4-1BBL and CD40L strongly enhances the capacity of dendritic cells to stimulate HIV-specific T cell responses. J. Leukoc. Biol. 89(6), 989–999 (2011).
  • Roesler E , WeissR, WeinbergerEEet al. Immunize and disappear-safety-optimized mRNA vaccination with a panel of 29 allergens. J. Allergy Clin. Immunol. 124(5), 1070–1077 (2009).
  • Scheel B , AulwurmS, ProbstJet al. Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA. Eur. J. Immunol. 36(10), 2807–2816 (2006).
  • Kreiter S , SelmiA, DikenMet al. Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity. Cancer Res. 70(22), 9031–9040 (2010).
  • Kreiter S , DikenM, SelmiAet al. FLT3 ligand enhances the cancer therapeutic potency of naked RNA vaccines. Cancer Res. 71(19), 6132–6142 (2011).
  • Van Lint S , GoyvaertsC, MaenhoutSet al. Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy. Cancer Res. 72(7), 1661–1671 (2012).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.