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Nanomedicine Volume 8, 2013 - Issue 1
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Research Article

The Effect of Cell Cluster Size on Intracellular Nanoparticle-Mediated Hyperthermia: Is It Possible to Treat Microscopic Tumors?

Mohammad Hedayati1 Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD21231, USAView further author information
,
Owen Thomas1 Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD21231, USAView further author information
,
Budri Abubaker-Sharif1 Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD21231, USAView further author information
,
Haoming Zhou1 Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD21231, USAView further author information
,
Christine Cornejo1 Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD21231, USAView further author information
,
Yonggang Zhang1 Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD21231, USAView further author information
,
Michele Wabler1 Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD21231, USAView further author information
,
Jana Mihalic2 Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD21205, USAView further author information
,
Cordula Gruettner3 Micromod Partikeltechnologie GmbH, Rostock, GermanyView further author information
,
Fritz Westphal3 Micromod Partikeltechnologie GmbH, Rostock, GermanyView further author information
,
Alison Geyh2 Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD21205, USAView further author information
,
Theodore l Deweese1 Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD21231, USAView further author information
&
Robert Ivkov1 Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD21231, USACorrespondence[email protected]
View further author information
 show all
Pages 29-41 | Received 31 Oct 2011, Accepted 29 Feb 2012, Published online: 20 Dec 2012

References

  • Gordon RT , HinesJR, GordonD. Intracellular hyperthermia. A biophysical approach to cancer treatment via intracellular temperature and biophysical alterations. Med. Hypotheses5(1), 83–102 (1979).
  • Jordan A , WustP, ScholzRet al.: Magnetic fluid hyperthermia (MFH). Scientific and Clinical Applications of Magnetic Carriers. 569–595 (1997).
  • Jordan A , SchulzR, WustPet al. Endocytosis of dextran and silan-coated magnetite nanoparticles and the effect of intracellular hyperthermia on human mammary carcinoma cells in vitro. J. Magn. Magn. Mater. 194 (1–3), 185–196 (1999).
  • Kita E , OdaT, KayanoTet al. Ferromagnetic nanoparticles for magnetic hyperthermia and thermoablation therapy. J. Phys. D. Appl. Phys. 43(47), 474011 (2010).
  • Gilchrist RK , ShoreyWD, HanselmaRCet al. Effects of electromagnetic heating on internal viscera: a preliminary to the treatment of human tumors. Ann. Surg. 161, 890–896 (1965).
  • Jordan A , WustP, FaehlingHet al. Inductive heating of ferrimagnetic particles and magnetic fluids: physical evaluation of their potential for hyperthermia. Int. J. Hyperthermia 25(7), 499–511 (2009).
  • DeNardo SJ , DenardoGL, NatarajanAet al. Thermal dosimetry predictive of efficacy of 111In-ChL6 nanoparticle AMF-induced thermoablative therapy for human breast cancer in mice. J. Nucl. Med. 48(3), 437–444 (2007).
  • Rabin Y . Is intracellular hyperthermia superior to extracellular hyperthermia in the thermal sense? Int. J. Hyperthermia18(3), 194–202 (2002).
  • Kalambur VS , LongmireEK, BischofJC. Cellular level loading and heating of superparamagnetic iron oxide nanoparticles. Langmuir23(24), 12329–12336 (2007).
  • Hergt R , DutzS. Magnetic particle hyperthermia-biophysical limitations of a visionary tumour therapy. J. Magn. Magn. Mater.311(1), 187–192 (2007).
  • Keblinski P , CahillDG, BodapatiAet al. Limits of localized heating by electromagnetically excited nanoparticles. J. Appl.Phys. 100(5), 054305 (2006).
  • Yamada K , OdaT, HashimotoSet al. Minimally required heat doses for various tumour sizes in induction heating cancer therapy determined by computer simulation using experimental data. Int. J. Hyperthermia 26(5), 465–474 (2010).
  • Hergt R , d‘AmblyCG, AndraWet al. Physical limits of hyperthermia using magnetite fine particles. IEEE Trans. Magn. 34(5), 3745–3754 (1998).
  • Gruettner C , MuellerK, TellerJet al. Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy. J. Magn. Magn. Mater. 311(1), 181–186 (2007).
  • Dennis CL , JacksonAJ, BorchersJAet al. Nearly complete regression of tumors via collective behavior of magnetic nanoparticles in hyperthermia. Nanotechnology 20(39), 395103 (2009).
  • Bordelon D , CornejoC, GruettnerC, DeWeeseTL, IvkovR. Magnetic nanoparticle heating efficiency reveals magneto-structural differences when characterized with a wide ranging and high amplitude alternating magnetic field. J. Appl. Phys.109, 124904 (2011).
  • Ivkov R , MallipudiR, KumarA, DeweeseT. AMF shielding reduces non-specific tissue heating for magnetic nanoparticle therapy. Int. J. Rad. Onc. Biol. Phys.78(3 Suppl.), S658 (2010).
  • Bordelon D , GoldsteinR, NemkovVet al. Modified solenoid coil that efficiently produces high amplitude AC magnetic fields with enhanced uniformity for biomedical applications. IEEE Trans. Magn. 48(1) 47–52 (2012).
  • Balasubrumanian T , BowmanHF. Temperature field due to a time-dependent heat source of spherical geometry in an infinite medium. J. Heat Trans-T ASME96(3), 296–299 (1974).
  • Andra W , d‘AmblyCG, HergtRet al. Temperature distribution as function of time around a small spherical heat source of local magnetic hyperthermia. J. Magn. Magn. Mater. 194 (1–3), 197–203 (1999).
  • Wilhelm C , Fortin J-P, Gazeau F. Tumor cell toxicity of intracellular hyperthermia mediated by magnetic nanoparticles. J. Nanosci. Nanotechnol.7, 2933–2937 (2007).
  • Dewey WC . Arrhenius relationships from the molecule and cell to the clinic. Int. J. Hyperthermia25(1), 3–20 (2009).
  • Creixell M , BohórquezAC, Torres-LugoM, RinaldiC. EGFR-targeted magnetic nanoparticle heaters kill cancer cells without a perceptible temperature rise. ACS Nano5, 7124–7129 (2011).

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