Targeted Delivery of Silver Nanoparticles and Alisertib: In Vitro and In Vivo Synergistic Effect Against Glioblastoma

• Furnari FB , FentonT, BachooRMet al. Malignant astrocyticglioma: genetics, biology, and paths to treatment. Genes Dev. 21, 2683–2710 (2007).
   PubMed Web of Science ®Google Scholar
• Siegel R , NaishadhamD, JemalA. Cancer statistic. CA Cancer. J. Clin.62, 10–29 (2012).
   PubMed Web of Science ®Google Scholar
• Weingart J , GrossmanSA, CarsonKAet al. Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS Consortium Trial. J. Clin. Oncol. 25(4), 399–404 (2007).
   PubMed Web of Science ®Google Scholar
• Stupp R , MasonWP, van den Bent MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med.352, 987–996 (2005).
   PubMed Web of Science ®Google Scholar
• de Groot JF , FullerG, KumarAJ, PiaoY, EterovicKJY, ConradCA. Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice. Neuro-Oncology12(3), 233–242 (2010).
   PubMed Web of Science ®Google Scholar
• Addeo R , CaragliaM, De Santi S et al. A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma. J. Neurooncol.102, 417–424 (2011).
   PubMed Web of Science ®Google Scholar
• Kohler BA , WardE, McCarthyBKet al. Annual report to the nation on the status of cancer, 1975–2007, featuring tumors of the brain and other nervous system. J. Natl Cancer Inst. 103, 714–736 (2011).
   PubMed Web of Science ®Google Scholar
• Wagner V , DullaartA, BockAK, ZweckA. The emerging nanomedicine landscape. Nat. Biotech.24, 1211–1217 (2006).
   PubMed Web of Science ®Google Scholar
• Kawasaki ES , PlayerA. Nanotechnology, nanomedicine, and the development of new, effective therapies for cancer. Nanomedicine1, 101–109 (2005).
   PubMed Web of Science ®Google Scholar
• Koo OM , RubinsteinI, OnyukselH. Role of nanotechnology in targeted drug delivery and imaging: a concise review. Nanomedicine1, 193–212 (2005).
   PubMed Web of Science ®Google Scholar
• Freitas RA . What is nanomedicine? Nanomedicine1, 2 (2005).
   PubMed Web of Science ®Google Scholar
• Kreuter J . Nanoparticles as drug delivery systems. In: Encycolpedia of Nanoscience and Nanotechnology (Volume 7). Nalwa HS (Ed.). American Scientific Publishers, CA, USA, 161–180 (2004).
   Google Scholar
• Lamprecht A , UbrichN, YamamotoHet al. Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease. J. Pharmacol. Exp. Ther. 299, 775–781 (2001).
   PubMed Web of Science ®Google Scholar
• Gregoriadis G . Drug entrapment in liposomes. FEBS Lett.36, 292–296 (1973).
   PubMed Web of Science ®Google Scholar
• Hrkach J , Von Hoff D, Ali MM et al. Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile. Sci. Transl. Med.4, 128 (2012).
   Web of Science ®Google Scholar
• Gu F , ZhangL, TeplyBAet al. Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers. Proc. Natl Acad. Sci. USA 105, 2586–2591 (2008).
   PubMed Web of Science ®Google Scholar
• Locatelli E , Comes Franchini M. Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties and nanomedical applications as drug delivery system. J. Nanop. Res.14, 1316 (2012).
   Google Scholar
• Locatelli E , BroggiF, PontiJ, MarmoratoP, LenaS, Comes Franchini M. Lipophilic silver nanoparticles and their polymeric entrapment into targeted-PEG-based micelles for the treatment of glioblastoma. Adv. Healthcare Mat.1, 342–347 (2012).
   PubMed Web of Science ®Google Scholar
• Deshane J , GarnerCG, SontheimerH. Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2. J. Biol. Chem.278, 4135–4144 (2003).
   PubMed Web of Science ®Google Scholar
• Veiseh O , SunC, GunnJet al. Optical and MRI multifunctional nanoprobe for targeting gliomas. Nano Lett. 5, 1003–1008 (2005).
   PubMed Web of Science ®Google Scholar
• Psimadas D , BaldiG, RavagliCet al. Preliminary evaluation of a 99mTc labeled hybrid nanoparticle bearing a cobalt ferrite core. J. Biomed. Nanotechnol. 8(4), 575–585 (2012).
   PubMed Web of Science ®Google Scholar
• Psimadas D , BouziotisP, GeorgouliasP, ValotassiouV, TsotakosT, LoudosG. Radiolabeling approaches of nanoparticles with 99mTc. Contrast Media Mol. Imaging8(4), 333–339 (2013).
   PubMed Web of Science ®Google Scholar
• Loudos G , MajewskiS, WojcikRet al. Performance evaluation of a dedicated camera suitable for dynamic radiopharmaceuticals evaluation in small animals. IEEE Trans. Nucl. Sci. 54(3), 454–460 (2007).
   Web of Science ®Google Scholar
• Gentili D , OriG, Comes Franchini M. Double phase transfer of gold nanorods for surface functionalization and entrapment into PEG-based nanocarriers. Chem. Comm.39, 5874 (2009).
   Google Scholar
• Ponti J , LemorR, FournelleM, BroggiF, LocatelliE, Comes Franchini M. Polymeric entrapped thiol-coated gold nanorods: cytotoxicity and suitability as molecular optoacoustic contrast agent. J. Mat. Chem.20, 10908–10914 (2010).
   Google Scholar
• Bonini BF , CamaggiCM, Comes Franchini M et al. Design and synthesis of novel 3, 4-disubstituted pyrazoles for nanomedicine applications against malignant gliomas. Eng. J. Med. Chem.45, 2024–2033 (2010).
   Google Scholar
• Liu J , SonshineD, ShervaniS, HurtRH. Controlled release of biologically active silver from nanosilver surfaces. ACS Nano4, 6903–6913 (2010).
   PubMed Web of Science ®Google Scholar
• Albanese A , TangPS, ChanWC. The effect of nanoparticle size, shape, and surface chemistry on biological systems. Ann. Rev. Biomed. Eng.14, 1–16 (2012).
   PubMed Web of Science ®Google Scholar
• Nemmar A , HoylaertsMF, HoetPHet al. Ultrafine particles affect experimental thrombosis in an In vivo hamster model. Am. J. Respir. Crit. Care Med. 166, 998–1004 (2002).
   PubMed Web of Science ®Google Scholar
• Kedmi R , Ben-ArieN, PeerD. The systemic toxicity of positively charged lipid-nanoparticles and the role of Toll-like receptor 4 in immune activation. Biomaterials31, 6867–6875 (2010).
   PubMed Web of Science ®Google Scholar
• Matulonis UA , SharmaS, GhamandeSet al. Phase II study of MLN8237 (alisertib), an investigational aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. Gynecol. Oncol. 127(1), 63 (2012).
   PubMed Web of Science ®Google Scholar
• Cervantes A , ElezE, RodaDet al. Phase I pharmacokinetic/pharmacodynamic study of MLN8237, an investigational, oral, selective aurora A kinase inhibitor, in patients with advanced solid tumors. Clin. Cancer Res. 18(17), 4764–4774 (2012).
   PubMed Web of Science ®Google Scholar
• Dees EC , CohenRB, von Mehren M et al. Phase I study of aurora a kinase inhibitor MLN8237 in advanced solid tumors: safety, pharmacokinetics, pharmacodynamics, and bioavailability of two oral formulations. Clin. Cancer Res.18(17), 4775–4784 (2012).
   PubMed Web of Science ®Google Scholar
• Jeyaraj M , SathishkumarG, SivanandhanGet al. Biogenic silver nanoparticles for cancer treatment: an experimental report. Colloids Surf. B Biointerfaces 106, 86–92 (2013).
   PubMed Web of Science ®Google Scholar
• Guo D , ZhuL, HuangZet al. Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions. Biomaterials 34(32), 7884–7894 (2013).
   PubMed Web of Science ®Google Scholar
• Wu Q , CaoH, LuanQet al. Biomolecule-assisted synthesis of water-soluble silver nanoparticles and their biomedical applications. Inorg. Chem. 47, 5882–5888 (2008).
   PubMed Web of Science ®Google Scholar
• Asharani PV , WuYL, GongZ, ValiyaveettilS. Toxicity of silver nanoparticles in zebrafish models. Nanotechnology19, 255102–255110 (2008).
   PubMed Web of Science ®Google Scholar
• Eckelman WC , RichardsP, MeinkenG. The chemical state of 99mTc in biomedical products. II. The chelation of reduced technetium with DTPA. J. Nucl. Med.13, 577–581 (1972).
   PubMed Web of Science ®Google Scholar
• Rattat D , TerwingheC, VerbruggenA. Comparison of ‘classic’ 99mTc-DTPA, 99mTc (CO) 3-DTPA and 99mTc (CO) 2 (NO)-DTPA. Tetrahedron61(40), 9563–9566 (2005).
   Web of Science ®Google Scholar
• Psimadas D , OliveiraH, ThevenotJet al. Polymeric micelles and vesicles: biological behavior evaluation using radiolabeling techniques. Pharm. Dev. Technol. 19(2), 189–193 (2014).
   PubMed Web of Science ®Google Scholar
• Caraglia M , LongoL, SalzanoGet al. Stealth liposomes encapsulating zoledronic acid: a new opportunity to treat neuropathic pain. Mol. Pharmaceutics 10, 1111–1118 (2013).
   PubMed Web of Science ®Google Scholar
• Pratsinis A , HervellaP, LerouxJC, PratsinisSE, SotiriouGA. Toxicity of silver nanoparticles in macrophages. Small9(15), 2576–2584 (2013).
   PubMed Web of Science ®Google Scholar
• Kittler S , GreulichC, DiendorfJ, KoellerM, EppleM. Toxicity of silver nanoparticles increases during storage because of slow dissolution under release of silver ions. Chem. Mater.22, 4548–4554 (2010).
   Web of Science ®Google Scholar
• Xiu ZM , ZhangQB, PuppalaHL, ColvinVL, AlvarezPJJ. Negligible particle-specific antibacterial activity of silver nanoparticles. Nano Lett.12, 4271–4275 (2012).
   PubMed Web of Science ®Google Scholar

Website

• ClinicalTrials.gov www.clinicaltrials.gov
   Google Scholar