Pharmacogenetic Research Activity in Central America and the Caribbean: A Systematic Review

References

• Committee for proprietary medicinal products . Position paper on terminology in pharmacogenetics . www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003889.pdf
   Google Scholar
• Center for drug evaluation and research . Genomics – table of pharmacogenomic biomarkers in drug labeling . www.fda.gov/Drugs/ScienceResearch/ResearchAreas/Pharmacogenetics/ucm083378.htm
   Google Scholar
• Agency EM . European public assessment reports . www.ema.europa.eu/ema/index.jsp?curl=/pages/medicines/landing/epar_search.jsp&mid=WC0b01ac058001d124
   Google Scholar
• Céspedes-Garro C , NaranjoM-EG , RamírezRet al. Pharmacogenetics in Central American healthy volunteers: interethnic variability . Drug Metab. Pers. Ther.30 ( 1 ), 19 – 31 ( 2015 ).
   PubMedGoogle Scholar
• IndexMundi ( 2016 ). www.indexmundi.com
   Google Scholar
• Moreno-Estrada A , GravelS , ZakhariaFet al. Reconstructing the population genetic history of the Caribbean . PLoS Genet.9 ( 11 ), e1003925 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Moher D , LiberatiA , TetzlaffJ , AltmanDG . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement . PLoS Med.6 ( 7 ), e1000097 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• The Pharmacogenomics Knowledgebase . Table of CPIC gene/drugs . ( 2015 ). www.pharmgkb.org/cpic/pairs
   Google Scholar
• CenterWatch . FDA approved drugs for oncology . CenterWatch . ( 2014 ). www.centerwatch.com/drug-information/fda-approved-drugs/therapeutic-area/12/oncology/n
   Google Scholar
• Holmes MV , ShahT , VickeryCet al. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies . PLoS ONE4 ( 12 ), e7960 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Cornelis MC , El-SohemyA , CamposH . Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction . J. Med. Genet.41 ( 10 ), 758 – 762 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• González A , RamírezV , CuencaPet al. Polymorphisms in detoxification genes CYP1A1, CYP2E1, GSTT1 and GSTM1 in gastric cancer susceptibility . Rev. Biol. Trop.52 ( 3 ), 591 – 600 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Xie H , HouL , ShieldsPGet al. Metabolic polymorphisms, smoking, and oral cancer in Puerto Rico . Oncol. Res.14 ( 6 ), 315 – 320 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Iyer S , PereraF , ZhangBet al. Significant interactions between maternal PAH exposure and haplotypes in candidate genes on B(a)P-DNA adducts in a NYC cohort of non-smoking African-American and Dominican mothers and newborns . Carcinogenesis35 ( 1 ), 69 – 75 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Cornelis MC , El-SohemyA , KabagambeEKet al. Coffee, CYP1A2 genotype, and risk of myocardial infarction . JAMA295 ( 10 ), 1135 – 1141 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Cornelis MC , El-SohemyA , CamposH . Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption . Am. J. Clin. Nutr.86 ( 1 ), 240 – 244 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• González Argüello R . El citocromo 1A2 (CYP1A2) en una población universitaria de Costa Rica . Rev. Costarric. Cienc. Med.23 ( 1–2 ), 25 – 31 ( 2002 ). [Spanish]
   Google Scholar
• Leger P , DillinghamR , BeauharnaisCAet al. CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti . J. Infect. Dis.200 ( 6 ), 955 – 964 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Arenaz I , VicenteJ , FanloAet al. Haplotype structure and allele frequencies of CYP2B6 in Spaniards and Central Americans . Fundam. Clin. Pharmacol.24 ( 2 ), 247 – 253 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Inaba T , JorgeLF , AriasTD . Mephenytoin hydroxylation in the Cuna Amerindians of Panama . Br. J. Clin. Pharmacol.25 ( 1 ), 75 – 79 ( 1988 ).
   PubMed Web of Science ®Google Scholar
• Arias TD , JorgeLF . Population pharmacology and ethnopharmacokinetics in 3 Amerindian groups from Panama: Cuna, Ngawbe Guaymi and Teribe . Rev. Med. Panama.15 ( 1 ), 20 – 26 ( 1990 ).
   PubMedGoogle Scholar
• Duconge J , CadillaCL , RentaJYet al. Prevalence of CYP2C19 gene polymorphisms in the Puerto Rican population: a preliminary report . P. R. Health. Sci. J.27 ( 4 ), 357 – 358 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Orengo-Mercado C , NievesB , LópezLet al. Frequencies of functional polymorphisms in three pharmacokinetic genes of clinical interest within the admixed Puerto Rican population . J. Pharmacogenomics Pharmacoproteomics4 ( 113 ), pii: 1000113 ( 2013 ).
   PubMedGoogle Scholar
• Duconge J , EscaleraO , KorchelaM , RuañoG . Clinical implications of genetic admixture in Hispanic Puerto Ricans: impact on the pharmacogenetics of CYP2C19 and PON1 . In : Clinical Applications of Pharmacogenetics . SanoudouD ( Ed. ). Intech151 – 163 ( 2012 ). www.intechopen.com/books/clinical-applications-of-pharmacogenetics/clinical-implications-of-genetic-admixture-in-hispanic-puerto-ricans-impact-on-the-pharmacogenetics
   Google Scholar
• Ramos AS , SeipRL , Rivera-MirandaGet al. Development of a pharmacogenetic-guided warfarin dosing algorithm for Puerto Rican patients . Pharmacogenomics13 ( 16 ), 1937 – 1950 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Valentin II , VazquezJ , Rivera-MirandaGet al. Prediction of warfarin dose reductions in Puerto Rican patients, based on combinatorial CYP2C9 and VKORC1 genotypes . Ann. Pharmacother.46 ( 2 ), 208 – 218 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Valentin II , RiveraG , Nieves-PlazaMet al. Pharmacogenetic association study of warfarin safety endpoints in Caribbean Hispanics . P. R. Health Sci. J. ( 3 ), 97 – 104 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Llerena A , AlvarezM , DoradoPet al. Interethnic differences in the relevance of CYP2C9 genotype and environmental factors for diclofenac metabolism in Hispanics from Cuba and Spain . Pharmacogenomics J.14 ( 3 ), 229 – 234 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Villagra D , DucongeJ , WindemuthAet al. CYP2C9 and VKORC1 genotypes in Puerto Ricans: a case for admixture-matching in clinical pharmacogenetic studies . Clin. Chim. Acta411 ( 17–18 ), 1306 – 1311 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Duconge J , CadillaCL , WindemuthAet al. Prevalence of combinatorial CYP2C9 and VKORC1 genotypes in Puerto Ricans: implications for warfarin management in Hispanics . Ethn. Dis.19 ( 4 ), 390 – 395 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Arias TD , JorgeL , LeeDet al. Biotransformation of sparteine in the Cuna American Indians of Panama . Rev. Med. Panama11 ( 3 ), 199 – 209 ( 1986 ).
   PubMedGoogle Scholar
• Arias TD , InabaT , CookeRGet al. A preliminary note on the transient polymorphic oxidation of sparteine in the Ngawbé Guaymí Amerindians: a case of genetic divergence with tentative phylogenetic time frame for the pathway . Clin. Pharmacol. Ther.44 ( 3 ), 343 – 352 ( 1988 ).
   PubMed Web of Science ®Google Scholar
• Arias TD , JorgeLF . An observation on the ethnic uniqueness of the debrisoquine and sparteine antimodes: a study in the Ngawbé Guaymí Amerindians of Panamá . Br. J. Clin. Pharmacol.28 ( 4 ), 493 – 494 ( 1989 ).
   PubMed Web of Science ®Google Scholar
• Arias TD , JorgeLF , LeeDet al. The oxidative metabolism of sparteine in the Cuna Amerindians of Panama: absence of evidence for deficient metabolizers . Clin. Pharmacol. Ther.43 ( 4 ), 456 – 465 ( 1988 ).
   PubMed Web of Science ®Google Scholar
• González-Tejera G , GaedigkA , CoreyS . Genetic variants of the drug-metabolizing enzyme CYP2D6 in Puerto Rican psychiatry patients: a preliminary report and potential implications for breast cancer patients . P. R. Health Sci. J.29 ( 3 ), 299 – 304 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Gaedigk A , Isidoro-GarcíaM , PearceREet al. Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations . Eur. J. Clin. Pharmacol.66 ( 9 ), 859 – 864 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Céspedes-Garro C , Jiménez-ArceG , NaranjoM-EGet al. Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans . Rev. Biol. Trop.62 ( 4 ), 1659 – 1671 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• LLerena A , DoradoP , RamírezRet al. CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans . Pharmacogenomics J.12 ( 2 ), 176 – 183 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Llerena A , DoradoP , RamírezRet al. CYP2D6 -1584C>G promoter polymorphism and debrisoquine ultrarapid hydroxylation in healthy volunteers . Pharmacogenomics14 ( 16 ), 1973 – 1977 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• González I , Peñas-LledóEM , PérezBet al. Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers . Pharmacogenomics9 ( 7 ), 833 – 840 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Peñas-Lledó EM , GonzálezI , DoradoPet al. Eating disorder symptoms and CYP2D6 variation in Cuban healthy females: a report from the Ibero-American Network of Pharmacogenetics . Curr. Pharmacogenomics Person. Med.10 ( 4 ), 10 – 14 ( 2012 ).
   Google Scholar
• Jorge LF , EichelbaumM , GrieseEUet al. Comparative evolutionary pharmacogenetics of CYP2D6 in Ngawbe and Embera Amerindians of Panama and Colombia: role of selection versus drift in world populations . Pharmacogenetics9 ( 2 ), 217 – 228 ( 1999 ).
   PubMedGoogle Scholar
• Jorge LF , AriasTD , InabaTet al. Unimodal distribution of the metabolic ratio for debrisoquine in Cuna Amerindians of Panama . Br. J. Clin. Pharmacol.30 ( 2 ), 281 – 285 ( 1990 ).
   PubMed Web of Science ®Google Scholar
• Montané Jaime LK , LallaA , SteimerWet al. Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants . Pharmacogenomics14 ( 3 ), 261 – 276 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Álvarez Corredera M , Pérez HernándezB , LlerenaAet al. Estudio del polimorfismo de debrisoquina en una muestra de la población cubana . Rev. Cuba Farm.39 ( 1 ), 1 – 6 ( 2005 ). [Spanish]
   Google Scholar
• Céspedes-Garro C , Rodrigues-SoaresF , Jiménez-ArceGet al. Relevance of the ancestry for the variability of the drug-metabolizing enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population . Rev. Biol. Trop.64 ( 3 ), doi:10.15517/rbt.v64i3.20901 ( 2016 ) ( Epub ahead of print ).
   PubMed Web of Science ®Google Scholar
• Martínez C , AgúndezJAG , OliveraMet al. Influence of genetic admixture on polymorphisms of drug-metabolizing enzymes: analyses of mutations on NAT2 and CYP2E1 genes in a mixed Hispanic population . Clin. Pharmacol. Ther.63 ( 6 ), 623 – 628 ( 1998 ).
   PubMed Web of Science ®Google Scholar
• Sinues B , VicenteJ , FanloAet al. CYP3A5*3 and CYP3A4*1B allele distribution and genotype combinations: differences between Spaniards and Central Americans . Ther. Drug Monit.29 ( 4 ), 412 – 416 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Taioli E , SearsV , WatsonAet al. Polymorphisms in CYP17 and CYP3A4 and prostate cancer in men of African descent . Prostate.73 ( 6 ), 668 – 676 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Cornelis MC , El-SohemyA , CamposH . Microsomal epoxide hydrolase genotype and risk of myocardial infarction . Arch. Toxicol.81 ( 9 ), 641 – 645 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Garcia M , EstradaM , GutierrezAet al. Glyoxalase I polymorphism and racial admixture in the Cuban population . Hum. Genet.61 ( 1 ), 50 – 51 ( 1982 ).
   PubMed Web of Science ®Google Scholar
• Azofeifa J , BarrantesR . Genetic variation in the Bribri and Cabecar Amerindians from Talamanca, Costa Rica . Rev. Biol. Trop.39 ( 2 ), 249 – 253 ( 1991 ).
   PubMed Web of Science ®Google Scholar
• Carter TE , MaloyH , von FrickenMet al. Glucose-6-phosphate dehydrogenase deficiency A variant in febrile patients in Haiti . Am. J. Trop. Med. Hyg.91 ( 2 ), 412 – 414 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Xu JZ , FrancisRO , Lerebours NadalLEet al. G6PD deficiency in an HIV clinic setting in the Dominican Republic . Am. J. Trop. Med. Hyg.93 ( 4 ), 722 – 729 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Zúñiga MÁ , MejíaRE , SánchezALet al. Glucose-6-phosphate dehydrogenase deficiency among malaria patients of Honduras: a descriptive study of archival blood samples . Malar. J.14 , 308 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Rahbar MH , Samms-VaughanM , MaJet al. Role of metabolic genes in blood arsenic concentrations of Jamaican children with and without autism spectrum disorder . Int. J. Environ. Res. Public Health11 ( 8 ), 7874 – 7895 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Emeville E , BroquèreC , BrureauLet al. Copy number variation of GSTT1 and GSTM1 and the risk of prostate cancer in a Caribbean population of African descent . PLoS ONE9 ( 9 ), e107275 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Mallick S , RomanaM , BlanchetPet al. GSTM1 and GSTT1 polymorphisms and the risk of prostate cancer in a Caribbean population of African descent . Urology69 ( 6 ), 1165 – 1169 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Rahbar MH , Samms-VaughanM , MaJet al. Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders . Res. Autism Spectr. Disord.12 , 1 – 9 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Cornelis MC , El-SohemyA , CamposH . GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction . Am. J. Clin. Nutr.86 ( 3 ), 752 – 758 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Cumming AM , OlujohungbeA , KeeneySet al. The methylenetetrahydrofolate reductase gene C677T polymorphism in patients with homozygous sickle cell disease and stroke . Br. J. Haematol.107 ( 3 ), 569 – 571 ( 1999 ).
   PubMed Web of Science ®Google Scholar
• Morales-Borges RH . Prevalence of MTHFR C677T and A1298C mutations and thrombophilia in Puerto Rico . J. Blood Disord. Transfus.05 ( 05 ), 213 ( 2014 ).
   Google Scholar
• García-Fragoso L , García-GarcíaI , LeavittGet al. MTHFR polymorphisms in Puerto Rican children with isolated congenital heart disease and their mothers . Int. J. Genet. Mol. Biol.2 ( 3 ), 43 – 47 ( 2010 ).
   PubMedGoogle Scholar
• Lai C-Q , ParnellLD , TroenAMet al. MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate . Am. J. Clin. Nutr.91 ( 5 ), 1377 – 1386 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Salazar-Sánchez L , ChavesL , CartinMet al. Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica . Rev. Biol. Trop.54 ( 1 ), 1 – 11 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Ye X , LaiC-Q , CrottJWet al. The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults . Psychosom. Med.73 ( 5 ), 385 – 392 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Jackson MD , Tulloch-ReidMK , McFarlane-AndersonNet al. Complex interaction between serum folate levels and genetic polymorphisms in folate pathway genes: biomarkers of prostate cancer aggressiveness . Genes Nutr.8 ( 2 ), 199 – 207 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Marshall KG , HowellS , BadalooAVet al. Polymorphisms in genes involved in folate metabolism as risk factors for oedematous severe childhood malnutrition: a hypothesis-generating study . Ann. Trop. Paediatr.26 ( 2 ), 107 – 114 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Weinstein SJ , GridleyG , HartyLCet al. Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype are not associated with oral cancer risk in Puerto Rico . J. Nutr.132 ( 4 ), 762 – 767 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Herrmann FH , Salazar-SánchezL , SchusterGet al. Molecular markers in the genes for FV (FVL, FV HR2, FVIVS 16), MTHFR, prothrombin and ACE in Amerindians and Africans from Costa Rica . In : Gene Diagnosis of Inherited Bleeding Disorders , Pabst Science Publishers , Lengerich, Germany , 203 – 220 ( 2002 ).
   Google Scholar
• Holst-Schumacher I , Monge-RojasR , Cambronero-GutiérrezPet al. Genetic, dietary, and other lifestyle determinants of serum homocysteine levels in young adults in Costa Rica . Rev. Panam. Salud Publica17 ( 4 ), 263 – 270 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Arias TD , JorgeLF , NúñezGet al. Preliminary study of the phenotype for acetylation in Teribe Amerindians . Rev. Med. Panama12 ( 1 ), 30 – 36 ( 1987 ).
   PubMedGoogle Scholar
• Inaba T , AriasTD . On phenotyping with isoniazid: the use of urinary acetylation ratio and the uniqueness of antimodes. Study of two Amerindian populations . Clin. Pharmacol. Ther.42 ( 5 ), 493 – 497 ( 1987 ).
   PubMed Web of Science ®Google Scholar
• Arias TD , JorgeLF , GrieseEUet al. Polymorphic N-acetyltransferase (NAT2) in Amerindian populations of Panama and Colombia: high frequencies of point mutation 857A, as found in allele S3/M3 . Pharmacogenetics3 ( 6 ), 328 – 331 ( 1993 ).
   PubMedGoogle Scholar
• Jorge-Nebert LF , EichelbaumM , GrieseE-Uet al. Analysis of six SNPs of NAT2 in Ngawbe and Embera Amerindians of Panama and determination of the Embera acetylation phenotype using caffeine . Pharmacogenetics12 ( 1 ), 39 – 48 ( 2002 ).
   PubMedGoogle Scholar
• Garrido C , SantizoVG , MüllersPet al. Frequency of thiopurine S-methyltransferase mutant alleles in indigenous and admixed Guatemalan patients with acute lymphoblastic leukemia . Med. Oncol.30 ( 1 ), 474 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Haverfield EV , McKenzieCA , ForresterTet al. UGT1A1 variation and gallstone formation in sickle cell disease . Blood105 ( 3 ), 968 – 972 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Brureau L , MoningoD , EmevilleEet al. Polymorphisms of estrogen metabolism-related genes and prostate cancer risk in two populations of African ancestry . PLoS ONE11 ( 4 ), e0153609 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Choudhry S , UngN , AvilaPCet al. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma . Am. J. Respir. Crit. Care Med.171 ( 6 ), 563 – 570 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Beason TS , BunkerCH , ZmudaJMet al. ADRB2 gene variants, dual-energy x-ray absorptiometry body composition, and hypertension in Tobago men of African descent . Metabolism60 ( 5 ), 698 – 705 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Brehm JM , RamratnamSK , TseSMet al. Stress and bronchodilator response in children with asthma . Am. J. Respir. Crit. Care Med.192 ( 1 ), 47 – 56 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Camacho H , NazábalM . Análisis de asociación de polimorfismos del gen COMT y la esquizofrenia en una muestra familiar cubana . Biotecnol. Apl.28 ( 2 ), 91 – 95 ( 2011 ). [Spanish]
   Google Scholar
• Hisada M , LalRB , MasciotraSet al. Chemokine receptor gene polymorphisms and risk of human T lymphotropic virus type I infection in Jamaica . J. Infect. Dis.185 ( 9 ), 1351 – 1354 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Kidd LR , JonesDZ , RogersENet al. Chemokine ligand 5 (CCL5) and chemokine receptor (CCR5) genetic variants and prostate cancer risk among men of African descent: a case–control study . Hered. Cancer Clin. Pract.10 ( 1 ), 16 ( 2012 ).
   PubMedGoogle Scholar
• Al Hadithy AF , WilffertB , StewartREet al. Pharmacogenetics of Parkinsonism, rigidity, rest tremor, and bradykinesia in African–Caribbean inpatients: differences in association with dopamine and serotonin receptors . Am. J. Med. Genet. B Neuropsychiatr. Genet.147 ( 6 ), 890 – 897 ( 2008 ).
   Google Scholar
• Al Hadithy AF , WilffertB , BruggemanRet al. Lack of association between antipsychotic-induced Parkinsonism or its subsymptoms and rs4606 SNP of RGS2 gene in African–Caribbeans and the possible role of the medication: the Curacao Extrapyramidal Syndromes Study X . Hum. Psychopharmacol.24 ( 2 ), 123 – 128 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Ballon N , LeroyS , RoyCet al. Polymorphisms TaqI a of the DRD2, ball of the DRD3, exon III repeat of the DRD4, and 3′ UTR VNTR of the DAT: Association with childhood ADHD in male African–Caribbean cocaine dependents? Am. J. Med. Genet. Part B Neuropsychiatr. Genet. 144 ( 8 ), 1034 – 1041 ( 2007 ).
   Google Scholar
• Madrid GA , MacMurrayJ , LeeJWet al. Stress as a mediating factor in the association between the DRD2 TaqI polymorphism and alcoholism . Alcohol.23 ( 2 ), 117 – 122 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Cangiano J , CentenoBA , GarrettCRet al. Signal transduction proteins in tumors from Puerto Rican and Caucasian gastric adenocarcinoma patients: expression differences with potential for specific targeted therapies . Dig. Dis. Sci.53 ( 8 ), 2090 – 2100 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Kang D , GridleyG , HuangW-Yet al. Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-alpha (TGFA) gene and risk of oral cancer in Puerto Rico . Pharmacogenet. Genomics15 ( 5 ), 343 – 347 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Leduc N , AhomadegbeC , AgossouMet al. Incidence of lung adenocarcinoma biomarker in a caribbean and African Caribbean population . J. Thorac. Oncol.11 ( 5 ), 769 – 773 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Arrieta O , CardonaAF , MartínCet al. Updated frequency of EGFR and KRAS mutations in nonsmall-cell lung cancer in Latin America: the Latin-American Consortium for the Investigation of Lung Cancer (CLICaP) . J. Thorac. Oncol.10 ( 5 ), 838 – 843 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Alarcón GS , McGwinG , PetriMet al. Time to renal disease and end-stage renal disease in PROFILE: a multiethnic lupus cohort . PLoS Med.3 ( 10 ), 1949 – 1956 ( 2006 ).
   Web of Science ®Google Scholar
• Cuero CJ , Vernaza-KwiersA , de GómezIet al. Immunologic profile of patients with renal transplantation in Panama . Rev. Med. Panama24 ( 1 ), 10 – 12 ( 1999 ).
   PubMedGoogle Scholar
• Miranda MT , SuárezE , AbbasMet al. HLA class I & II alleles in multiple sclerosis patients from Puerto Rico . Bol. Asoc. Med. P. R.105 ( 1 ), 18 – 23 ( 2013 ).
   PubMedGoogle Scholar
• Gómez-Casado E , Martínez-LasoJ , MoscosoJet al. Origin of Mayans according to HLA genes and the uniqueness of Amerindians . Tissue Antigens61 ( 6 ), 425 – 436 ( 2003 ).
   PubMedGoogle Scholar
• Carreon JD , MartinMP , HildesheimAet al. Human leukocyte antigen class I and II haplotypes and risk of cervical cancer . Tissue Antigens66 ( 4 ), 321 – 324 ( 2005 ).
   PubMedGoogle Scholar
• Arrieta-Bolaños E , Maldonado-TorresH , DimitriuOet al. HLA-A, -B, -C, -DQB1, and -DRB1, 3, 4, 5 allele and haplotype frequencies in the Costa Rica central valley population and its relationship to worldwide populations . Hum. Immunol.72 ( 1 ), 80 – 86 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Vernaza-Kwiers AA , de GómezIJ , Díaz-IsaacsMet al. Gene frequency and haplotypes of the HLA system in the Panamanian population . Rev. Med. Panama20 ( 3 ), 116 – 123 ( 1995 ).
   PubMedGoogle Scholar
• Paradoa ML , MiddletonD , AcostaAet al. Genes HLA en una muestra de la población cubana . Vaccimonitor9 ( 3 ), 3 – 7 ( 2000 ) [Spanish] .
   Google Scholar
• Goedert JJ , LiHC , GaoXJet al. Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types . Int. J. Cancer121 ( 5 ), 1092 – 1097 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Brown MG , SalasRA , VickersIEet al. Dengue HLA associations in Jamaicans . West Indian Med. J.60 ( 2 ), 126 – 131 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Sierra B , AlegreR , PérezABet al. HLA-A, -B, -C, and -DRB1 allele frequencies in Cuban individuals with antecedents of dengue 2 disease: advantages of the Cuban population for HLA studies of dengue virus infection . Hum. Immunol.68 ( 6 ), 531 – 540 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Santiago-Delpín EA , de EchegarayS , Rivera-CruzFet al. The histocompatibility profile of the Puerto Rican population . Transplant. Proc.34 ( 8 ), 3075 – 3078 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Morera Barrios LM , Verdura GonzálezT , Ricardo LorenzoRet al. Estudio preliminar de la frecuencia fenotípica y génica de los antígenos HLA en la enfermedad de Voght-Koyanagi-Harada . Revista Cubana de Hematología, Inmunología y Hemoterapia17 ( 2 ), 128 – 131 ( 2001 ). [Spanish]
   Google Scholar
• Chang Monteagudo A , García OliveraT , Morera BarriosLMet al. Ausencia de asociación HLA-A*68-enfermedad renal crónica, en pacientes del occidente y centro de Cuba . Revista Cubana de Hematología, Inmunología y Hemoterapia31 ( 3 ), 318 – 323 ( 2015 ). [Spanish]
   Google Scholar
• Pino-Yanes M , GignouxCR , GalanterJMet al. Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos . J. Allergy Clin. Immunol.135 ( 6 ), 1502 – 1510 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Wang SS , WheelerCM , HildesheimAet al. Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica . J. Infect. Dis.184 ( 10 ), 1310 – 1314 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Iwanaga KK , EberleM , KolmanCJet al. Further diversification of the HLA-B locus in Central American Amerindians: new B*39 and B*51 alleles in the Kuna of Panama . Tissue Antigens.50 ( 3 ), 251 – 257 ( 1997 ).
   PubMedGoogle Scholar
• Wilffert B , Al HadithyAFY , SingVJet al. The role of dopamine D3, 5-HT2A and 5-HT2C receptor variants as pharmacogenetic determinants in tardive dyskinesia in African–Caribbean patients under chronic antipsychotic treatment: Curacao extrapyramidal syndromes study IX . J. Psychopharmacol.23 ( 6 ), 652 – 659 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Safaeian M , HildesheimA , GonzalezPet al. Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer . PLoS ONE7 ( 4 ), e33619 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Pereira E , FerreiraR , HermelinBet al. Recurrent and novel LDL receptor gene mutations causing heterozygous familial hypercholesterolemia in La Habana . Hum. Genet.96 ( 3 ), 319 – 322 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Thiart R , LoubserO , de VilliersJNet al. Novel stop mutation causing familial hypercholesterolemia in a Costa Rican family . Mol. Cell. Probes11 ( 6 ), 457 – 458 ( 1997 ).
   PubMed Web of Science ®Google Scholar
• Morera B , Sánchez-RiveraG , Jiménez-ArceGet al. Nicaraguan population data on LDLR, GYPA, D7S8, HBGG, GC and HLA-DQA1 loci . Rev. Biol. Trop.49 ( 3 ), 1253 – 1260 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Morales AI , MoreraB , Jiménez-ArceGet al. Allele frequencies of markers LDLR, GYPA, D7S8, HBGG, GC, HLA-DQA1 and D1S80 in the general and minority populations of Costa Rica . Forensic Sci. Int.124 ( 1 ), 1 – 4 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Vicente J , SinuesB , FanloAet al. Polymorphism C3435T of the MDR1 gene in Central Americans and Spaniards . Mol. Biol. Rep.35 ( 3 ), 473 – 478 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Contreras J , HareL , CamarenaBet al. The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders . Acta Psychiatr. Scand.119 ( 2 ), 117 – 127 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Contreras J , HernándezS , QuezadaPet al. Association of serotonin transporter promoter gene polymorphism (5-HTTLPR) with depression in Costa Rican schizophrenic patients . J. Neurogenet.24 ( 2 ), 83 – 89 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Carranza C , GranadosL , MoralesOet al. Frequency of the ETV6–RUNX1, BCR–ABL1, TCF3–PBX1, and MLL–AFF1 fusion genes in Guatemalan pediatric acute lymphoblastic leukemia patients and their ethnic associations . Cancer Genet.206 ( 6 ), 227 – 232 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Santamaría-Quesada C , VargasM , VenegasPet al. Molecular and epidemiologic findings of childhood acute leukemia in Costa Rica . J. Pediatr. Hematol.31 ( 2 ), 131 – 135 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Ceppi F , BrownA , BettsDRet al. Cytogenetic characterization of childhood acute lymphoblastic leukemia in Nicaragua . Pediatr. Blood Cancer53 ( 7 ), 1238 – 1241 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Jiménez-Arce G , CarrilloJ , ChavesMet al. Molecular detection of the BCR–ABL gene by RT-PCR in Costa Rican children with leukemia . Rev. Biol. Trop.56 ( 4 ), 1613 – 1618 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Casanueva-Calero K , Pantaleón-FloridoG , Ruiz-NoaYet al. Estudio del reordenamiento molecular BCR–ABL en pacientes cubanos con diagnóstico presuntivo de leucemia mieloide crónica . Rev. Hematol. Mex.12 ( 4 ), 243 – 248 ( 2011 ) [Spanish] .
   Google Scholar
• Amor-Vigil AM , González-MedinaY , Cayado-GutiérrezNet al. Frecuencia de los transcriptos BCR–ABL en pacientes cubanos con leucemia mieloide crónica . Revista Cubana de Hematología, Inmunología y Hemoterapia28 ( 4 ), 428 – 434 ( 2012 ) [Spanish] .
   Google Scholar
• Morán VP , BauteRG , FacundoJCJet al. Introduction of imatinib as first-line therapy for chronic myeloid leukemia in Cuba . MEDICC Rev.13 ( 1 ), 35 – 40 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• De Jesus-Monge WE , Gonzalez-KeelanC , ZhaoRet al. Mismatch repair protein expression and colorectal cancer in Hispanics from Puerto Rico . Fam. Cancer9 ( 2 ), 155 – 166 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Mendoza Y , SinghC , Castillo MewaJ , FonsecaEet al. Beginning of personalized medicine in Panama: molecular and pathological characteristics of gastrointestinal stromal tumors from archival paraffin-embedded tissue . Oncol. Lett.2 ( 5 ), 941 – 947 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Venegas PB , NovakJM , OscarCAet al. Cystic fibrosis mutations in Costa Rica . Hum. Biol. An. Int. Rec. Res.75 ( 2 ), 179 – 188 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Mesa TC , IbarraHG , MartínezAMBet al. Frecuencia de las mutaciones G542X R1162X y N1303K en familias fibroquísticas cubanas . Biotecnol. Apl.20 ( 4 ), 220 – 221 ( 2003 ) [Spanish] .
   Google Scholar
• González L , CollazoT , ClarkYet al. Caracterización del marcador microsatélite IVS17bTA y seis mutaciones del gen CFTR en 21 familias cubanas con fibrosis quística . Biotecnol. Apl.30 ( 4 ), 262 – 266 ( 2013 ) [Spanish] .
   Google Scholar
• Collazo T , BofillAM , ClarkYet al. Common mutations in Cuban cystic fibrosis patients . J. Cyst. Fibros.8 ( 1 ), 47 – 49 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Brehm JM , Man TseS , Croteau-ChonkaDCet al. A genome-wide association study of post-bronchodilator lung function in children with asthma . Am. J. Respir. Crit. Care Med.192 ( 5 ), 634 – 637 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Duan QL , Lasky-SuJ , HimesBEet al. A genome-wide association study of bronchodilator response in asthmatics . Pharmacogenomics J.14 , 1 – 7 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Morales-Vásquez L , Miranda-AvaloEI , Rodríguez-MedinaJRet al. Demographics, clinical characteristics, IFNL3- and IFNL4-polymorphisms in a cohort of hepatitis C patients from Puerto Rico . P. R. Health Sci. J.33 ( 4 ), 177 – 183 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Ruiz-Candelaria Y , Miranda-DiazC , Hunter-MelladoRF . K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011 . Int. J. Biol. Markers28 ( 4 ), e393 – e397 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Quesada Dorta M , Pantaleón FloridoG , Bello ÁlvarezDet al. Resultados citogéneticos en pacientes con leucemia mieloide crónica . Rev. Cubana Med.50 ( 4 ), 341 – 347 ( 2011 ) [Spanish] .
   Google Scholar
• Martínez EE , EstradaEEE , MoránVPet al. Tratamiento de la leucemia mieloide crónica con mesilato de imatinib en pacientes resistentes o intolerantes al interferón a recombinante . Rev. Cuba. Hematol. Inmunol y. Hemoter.26 ( 1 ), 12 – 26 ( 2010 ) [Spanish] .
   Google Scholar
• Wang SS , BrattiMC , RodríguezACet al. Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer . J. Infect. Dis.199 ( 1 ), 20 – 30 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Azofeifa J , HahnM , RuizEet al. The STR polymorphism (AAAAT)n within the intron 1 of the tumor protein 53 (TP53) locus in 17 populations of different ethnic groups of Africa, America, Asia and Europe . Rev. Biol. Trop.52 ( 3 ), 645 – 657 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Koshiol J , HildesheimA , GonzalezPet al. Common genetic variation in TP53 and risk of human papillomavirus persistence and progression to CIN3/cancer revisited . Cancer Epidemiol. Biomarkers Prev.18 ( 5 ), 1631 – 1637 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Huang W-YY , OlshanAF , SchwartzSMet al. Selected genetic polymorphisms in MGMT,XRCC1,XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis . Cancer Epidemiol. Biomarkers Prev.14 ( 7 ), 1747 – 1753 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• LLerena A , NaranjoMEG , Rodrigues-SoaresFet al. Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations . Expert Opin. Drug Metab. Toxicol.10 ( 11 ), 1569 – 1583 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Duda SN , FarrAM , LindegrenM Louet al. Characteristics and comprehensiveness of adult HIV care and treatment programmes in Asia–Pacific, sub-Saharan Africa and the Americas: results of a site assessment conducted by the International epidemiologic Databases to Evaluate AIDS . J. Int. AIDS Soc.17 ( 1 ), 19045 ( 2014 ).
   PubMedGoogle Scholar
• Vasconcelos SMR , SorensonMM , LetaJ , Sant’anaMet al. Researchers’ writing competence: a bottleneck in the publication of Latin-American science? EMBO Rep. 9 ( 8 ), 700 – 702 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• RiBEF . www.ribef.com
   Google Scholar
• Peñas-LLedó EM , DoradoP , PachecoRet al. Relation between CYP2D6 genotype, personality, neurocognition and overall psychopathology in healthy volunteers . Pharmacogenomics10 ( 7 ), 1111 – 1120 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Peñas-Lledó EM , DoradoP , AgüeraZet al. CYP2D6 polymorphism in patients with eating disorders . Pharmacogenomics J.12 ( 2 ), 173 – 175 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Peñas-Lledó EM , Blasco-FontecillaH , DoradoPet al. CYP2D6 and the severity of suicide attempts . Pharmacogenomics13 ( 2 ), 179 – 184 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Peñas-Lledó EM , DoradoP , AgüeraZet al. High risk of lifetime history of suicide attempts among CYP2D6 ultrarapid metabolizers with eating disorders . Mol. Psychiatry16 ( 7 ), 691 – 692 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Blasco-Fontecilla H , Peñas-LledóE , Vaquero-LorenzoCet al. CYP2D6 polymorphism and mental and personality disorders in suicide attempters . J. Pers. Disord.28 ( 6 ), 873 – 883 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Peñas-Lledó EM , TrejoHD , DoradoPet al. CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitriptyline monotherapy treatment in major depressive patients . Mol. Psychiatry18 ( 1 ), 8 – 9 ( 2013 ).
   PubMed Web of Science ®Google Scholar