Advanced search
Publication Cover
Pharmacogenomics Volume 22, 2021 - Issue 2
Submit an article Journal homepage
215
Views
0
CrossRef citations to date
0
Altmetric
Case Report

Case Report: Severe Toxicity in an African–American Patient Receiving FOLFOX Carrying Uncommon Allelic Variants in DPYD

Tristan M Sissung1 Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD20892, USAORCID Iconhttps://orcid.org/0000-0002-3684-5377View further author information
ORCID Icon,
Lisa Cordes2 Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD20892, USAORCID Iconhttps://orcid.org/0000-0003-3833-4084View further author information
ORCID Icon,
Cody J Peer1 Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD20892, USAORCID Iconhttps://orcid.org/0000-0001-9395-3473View further author information
ORCID Icon,
Shruti Gandhy2 Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD20892, USAView further author information
,
Jason Redman2 Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD20892, USAORCID Iconhttps://orcid.org/0000-0001-8200-0167View further author information
ORCID Icon,
Julius Strauss3 Laboratory of Tumor Immunology & Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD20892, USAORCID Iconhttps://orcid.org/0000-0002-7550-4938View further author information
ORCID Icon &
William D Figg1 Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD20892, USA;2 Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD20892, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2428-5613View further author information
ORCID Icon show all
Pages 81-85 | Received 25 Aug 2020, Accepted 26 Oct 2020, Published online: 11 Dec 2020

References

  • Wagner AD , SynNL , MoehlerMet al. Chemotherapy for advanced gastric cancer. Cochrane Database Syst. Rev.8, CD004064 (2017).
  • Lunenburg C , HenricksLM , GuchelaarHJet al. Prospective DPYD genotyping to reduce the risk of fluoropyrimidine-induced severe toxicity: ready for prime time. Eur. J. Cancer54, 40–48 (2016).
  • Amstutz U , HenricksLM , OfferSMet al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing: 2017 update. Clin. Pharmacol. Ther.103(2), 210–216 (2018).
  • Burmester JK , SedovaM , ShaperoMH , MansfieldE. DMET microarray technology for pharmacogenomics-based personalized medicine. Methods Mol. Biol.632, 99–124 (2010).
  • Campbell JM , BatemanE , PetersM , BowenJM , KeefeDM , StephensonMD. Fluoropyrimidine and platinum toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses. Pharmacogenomics17(4), 435–451 (2016).
  • Lam SW , GuchelaarHJ , BovenE. The role of pharmacogenetics in capecitabine efficacy and toxicity. Cancer Treat. Rev.50, 9–22 (2016).
  • National Center for Biotechnology Information (US) . DeanL. Fluorouracil therapy and DPYD genotype. In: Medical Genetics SummariesPrattVM, McLeodHL, RubinsteinWS ( Eds). National Center for Biotechnology Information, MD, USA (2012).
  • Varma KA , JayanthiM , DubashiB , ShewadeDG. Influence of DPYD*9A, DPYD*6 and GSTP1 ile105val genetic polymorphisms on capecitabine and oxaliplatin (CAPOX) associated toxicities in colorectal cancer (CRC) patients. Asian Pac. J. Cancer Prev.20(10), 3093–3100 (2019).
  • Peng Z , WangQ , GaoJet al. Association between GSTP1 Ile105Val polymorphism and oxaliplatin-induced neuropathy: a systematic review and meta-analysis. Cancer Chemother. Pharmacol.72(2), 305–314 (2013).
  • Rosmarin D , PallesC , PagnamentaAet al. A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS. Gut64(1), 111–120 (2015).
  • Kosovec JE , EgorinMJ , GjurichS , BeumerJH. Quantitation of 5-fluorouracil (5-FU) in human plasma by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom.22(2), 224–230 (2008).
  • Morawska K , GoirandF , MarceauLet al. 5-FU therapeutic drug monitoring as a valuable option to reduce toxicity in patients with gastrointestinal cancer. Oncotarget9(14), 11559–11571 (2018).
  • Genomes Project C , AutonA , BrooksLDet al. A global reference for human genetic variation. Nature526(7571), 68–74 (2015).
  • Offer SM , LeeAM , MattisonLK , FossumC , WegnerNJ , DiasioRB. A DPYD variant (Y186C) in individuals of african ancestry is associated with reduced DPD enzyme activity. Clin. Pharmacol. Ther.94(1), 158–166 (2013).
  • Saif MW , LeeAM , OfferSM , McconnellK , ReliasV , DiasioRB. A DPYD variant (Y186C) specific to individuals of African descent in a patient with life-threatening 5-FU toxic effects: potential for an individualized medicine approach. Mayo Clin. Proc.89(1), 131–136 (2014).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.