158
Views
0
CrossRef citations to date
0
Altmetric
Case Series

Contrasting ABCB1 Pharmacogenetics and Psychotropic Responses in Child and Adolescent Psychiatry: A case comparison

, , , ORCID Icon &
Pages 131-139 | Received 01 Sep 2022, Accepted 21 Dec 2022, Published online: 02 Feb 2023

References

  • Oslin DW , LynchKG , ShihMet al. Effect of pharmacogenomic testing for drug–gene interactions on medication selection and remission of symptoms in major depressive disorder: the PRIME Care Randomized Clinical Trial. JAMA328(2), 151–161 (2022).
  • Ruaño G , HolfordT , SeipRL , GoetheJW , MehendruR. Pharmacogenetic clinical decision support for psychiatric hospitalization: design of the CYP-GUIDES randomized controlled trial. Contemp. Clin. Trials83, 27–36 (2019).
  • Namerow LB , WalkerSA , LoftusM , BishopJR , RuañoG , MalikS. Pharmacogenomics: an update for child and adolescent psychiatry. Curr. Psy. Rep.22(5), 26 (2020).
  • Liko I , LeeYM , StutzmanDLet al. Providers’ perspectives on the clinical utility of pharmacogenomic testing in pediatric patients. Pharmacogenomics22(5), 263–274 (2021).
  • Vande Voort JL , OrthSS , ShekunovJet al. A randomized controlled trial of combinatorial pharmacogenetics testing in adolescent depression. J. Am. Acad. Child Adolesc. Psychiatry61(1), 46–55 (2022).
  • Villagra D , GoetheJ , SchwartzHIet al. Novel drug metabolism indices for pharmacogenetic functional status based on combinatory genotyping of CYP2C9, CYP2C19 and CYP2D6 genes. Biomark. Med.5(4), 427–438 (2011).
  • Poweleit EA , AldrichSL , MartinLJ , HahnD , StrawnJR , RamseyLB. Pharmacogenetics of sertraline tolerability and response in pediatric anxiety and depressive disorders. J. Child Adolesc. Psychopharmacol.29(5), 348–361 (2019).
  • Aldrich SL , PoweleitEA , ProwsCA , MartinLJ , StrawnJR , RamseyLB. Influence of CYP2C19 metabolizer status on escitalopram/citalopram tolerability and response in youth with anxiety and depressive disorders. Front. Pharmacol.10, 99 (2019).
  • Hodges LM , MarkovaSM , ChinnLWet al. Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein). Pharmacogenet. Genomics21(3), 152–161 (2011).
  • Fromm MF . Importance of P-glycoprotein at blood–tissue barriers. Trends Pharmacol. Sci.25(8), 423–429 (2004).
  • Kealy J , GreeneC , CampbellM. Blood–brain regulation in psychiatric disorders. Neurosci. Lett.726, 133664 (2020).
  • Al Maruf A , GreensladeA , ArnoldPD , BousmanC. Antidepressant pharmacogenetics in children and young adults: a systematic review. J. Affect. Disord.254, 98–108 (2019).
  • Ivashchenko DV , KhoangSZ , TazagulovaMKet al. The polymorphic variants DRD2 rs1800497 and ABCB1 3435C>T are associated with antipsychotic safety parameters in adolescents with an acute psychotic episode: the results of a pilot study. Neurology, Neuropsychiatry, Psychosomatics12(5), 24–31 (2020).
  • Uhr M , TontschA , NamendorfCet al. Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron57(2), 203–209 (2008).
  • Brückl TM , UhrM. ABCB1 genotyping in the treatment of depression. Pharmacogenomics17(18), 2039–2069 (2016).
  • Whirl-Carrillo M , HuddartR , GongLet al. An evidence-based framework for evaluating pharmacogenomics knowledge for personalized medicine. Clin. Pharmacol. Ther.110(3), 563–572 (2021).
  • Whirl-Carrillo M , McDonaghEM , HebertJMet al. Pharmacogenomics knowledge for personalized medicine. Clin. Pharmacol. Ther.92(4), 414–417 (2012).
  • Van Booven D , MarshS , McLeodHet al. Cytochrome P450 2C9 – CYP2C9. Pharmacogenet. Genomics20(4), 277–281 (2010).
  • National Institutes of Health . DBH gene. Medline Plushttps://medlineplus.gov/genetics/gene/dbh/ (2020) ( Online).
  • Yamamoto K , CubellsJF , GelernterJet al. Dopamine beta hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study. Am. J. Med. Genet.117B, 33–38 (2003).
  • Stelzer G , RosenR , PlaschkesIet al. The GeneCards Suite: from gene data mining to disease genome sequence analysis. Curr. Protoc. Bioinformatics54, 1.30.1–1.30.33 (2016).
  • Ramsay H , BarnettJH , MiettunenJet al. Association between dopamine receptor D2 (DRD2) variations rs6277 and rs1800497 and cognitive performance according to risk type for psychosis: a nested case control study in a Finnish population sample. PLOS ONE10(6), e0127602 (2015).
  • Zhao L , WangY , WeiJet al. Association of gender, age, education, and polymorphism of DRD4 gene with cognitive functions in adults. Zhonghua Yi Xue Yi Chuan Xue Za Zhi32(3), 391–394 (2015).
  • Davis C , LevitanR , KaplanAet al. Dopamine transporter gene (DAT1) associated with appetite suppression to methylphenidate in a case–control study of binge eating disorder. Neuropsychopharmacology32, 2199–2206 (2007).
  • Stephens DN , KingSL , LambertJJ , BelelliD , DukaT. GABAA receptor subtype involvement in addictive behaviour. Genes Brain Behav.16(1), 149–184 (2017).
  • Unschuld PG , IsingM , RoeskeDet al. Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response. Neuropsychopharmacology35(7), 1583–1592 (2010).
  • Odgerel Z , TalatiA , HamiltonSP , LevinsonDF , WeissmanMM. Genotyping serotonin transporter polymorphisms 5-HTTLPR and rs25531 in European–and African–American subjects from the National Institute of Mental Health’s Collaborative Center for Genomic Studies. Transl. Psychiatry3(9), e307 (2013).
  • Saiz-Rodríguez M , BelmonteC , RománMet al. Effect of ABCB1 C3435T polymorphism on pharmacokinetics of antipsychotics and antidepressants. Basic Clin. Pharmacol. Toxicol.123(4), 474–485 (2018).
  • Saiz-Rodríguez M , BelmonteC , RománMet al. Effect of polymorphisms on the pharmacokinetics, pharmacodynamics and safety of sertraline in healthy volunteers. Basic Clin. Pharmacol. Toxicol.122(5), 501–511 (2018).
  • Vendelbo J , OlesenRH , LauridsenJKet al. Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African Americans than Caucasians. Pharmacogenomics J.18(1), 121–126 (2018).
  • Caudle KE , SangkuhlK , Whirl-CarilloMet al. Standardizing CYP2D6 genotype to phenotype translation: consensus recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group. Clin. Transl. Sci.13(1), 116–124 (2019).
  • Oshikoya KA , NeelyKM , CarrollRJet al. CYP2D6 genotype and adverse events to risperidone in children and adolescents. Pediatr. Res.85(5), 602–606 (2019).
  • Linnet K , EjsingTB. A review on the impact of P-glycoprotein on the penetration of drugs into the brain. Focus on psychotropic drugs. Eur. Neuropsychopharmacol.18(3), 157–169 (2008).
  • Singh AB , BousmanCA , NgCH , ByronK , BerkM. ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression. Transl. Psychiatry2(11), e198 (2012).
  • Jensen BP , RobertsRL , VyasR , BonkeG , JardineDL , BeggEJ. Influence of ABCB1 (P-glycoprotein) haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers. Br. J. Clin. Pharmacol.73(4), 619–628 (2012).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.