Human Lymphoblastoid Cell Line Panels: Novel Tools for Assessing Shared Drug Pathways

• Lamb J , CrawfordED, PeckD et al.: The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.Science313 , 1929–1935 (2006).
   PubMed Web of Science ®Google Scholar
• Michnick SW : The Connectivity Map.Nat. Chem. Biol.2(12) , 663–664 (2006).
   PubMed Web of Science ®Google Scholar
• Lamb J : The Connectivity Map: a new tool for biomedical research.Nat. Rev. Cancer7(1) , 54–60 (2007).
   PubMed Web of Science ®Google Scholar
• Hernandez-Boussard T , Whirl-CarrilloM, HebertJM et al.: The pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledge.Nucleic Acids Res.36 , D913–D918 (2008).
   PubMed Web of Science ®Google Scholar
• Sangkuhl K , BerlinDS, AltmanRB, KleinTE: PharmGKB: understanding the effects of individual genetic variants.Drug Metab. Rev.40(4) , 539–551 (2008).
   PubMed Web of Science ®Google Scholar
• Keiser MJ , SetolaV, IrwinJJ et al.: Predicting new molecular targets for known drugs.Nature462 , 175–181 (2009).
   PubMed Web of Science ®Google Scholar
• Miller G : Human lymphoblastoid cell lines and Epstein-Barr virus: a review of their interrelationships and their relevance to the etiology of leukoproliferative states in man.Yale J. Biol. Med.43(6) , 358–384 (1971).
   PubMed Web of Science ®Google Scholar
• Sie L , LoongS, TanEK: Utility of lymphoblastoid cell lines.J. Neurosci. Res.87(9) , 1953–1959 (2009).
   PubMed Web of Science ®Google Scholar
• Shukla SJ , DuanS, BadnerJA, WuX, DolanME: Susceptibility loci involved in cisplatin-induced cytotoxicity and apoptosis.Pharmacogenet. Genomics18(3) , 253–262 (2008).
   PubMed Web of Science ®Google Scholar
• Bleibel WK , DuanS, HuangRS et al.: Identification of genomic regions contributing to etoposide-induced cytotoxicity.Hum. Genet.125(2) , 173–180 (2009).
   PubMed Web of Science ®Google Scholar
• Hartford CM , DuanS, DelaneySM et al.: Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity.Blood113(10) , 2145–2153 (2009).
   PubMed Web of Science ®Google Scholar
• Fry RC , SvenssonJP, ValiathanC et al.: Genomic predictors of interindividual differences in response to DNA damaging agents.Genes Dev.22 , 2621–2626 (2008).
   PubMed Web of Science ®Google Scholar
• Li L , FridleyB, KalariK et al.: Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression.Cancer Res.68(17) , 7050–7058 (2008).
   PubMed Web of Science ®Google Scholar
• Choy E , YelenskyR, BonakdarS et al.: Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.PLoS Genet.4(11) , E1000287 (2008).
   PubMed Web of Science ®Google Scholar
• Zhang W , HuangRS, DuanS, DolanME: Gene set enrichment analyses revealed differences in gene expression patterns between males and females.In Silico Biol.9(3) , 55–63 (2009).
   PubMedGoogle Scholar
• Abdul M , LogothetisCJ, HooseinNM: Growth-inhibitory effects of serotonin uptake inhibitors on human prostate carcinoma cell lines.J. Urol.154(1) , 247–250 (1995).
   PubMed Web of Science ®Google Scholar
• Volpe DA , EllisonCD, ParchmentRE, GrieshaberCK, FaustinoPJ: Effects of amitriptyline and fluoxetine upon the in vitro proliferation of tumor cell lines.J. Exp. Ther. Oncol.3(4) , 169–184 (2003).
   PubMedGoogle Scholar
• Rosetti M , FrasnelliM, TeseiA, ZoliW, ContiM: Cytotoxicity of different selective serotonin reuptake inhibitors (SSRIs) against cancer cells.J. Exp. Ther. Oncol.6(1) , 23–29 (2006).
   PubMedGoogle Scholar
• Serafeim A , HolderMJ, GraftonG et al.: Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells.Blood101(8) , 3212–3219 (2003).
   PubMed Web of Science ®Google Scholar
• Schuster C , FernbachN, RixU et al.: Selective serotonin reuptake inhibitors – a new modality for the treatment of lymphoma/leukaemia?Biochem. Pharmacol.74(9) , 1424–1235 (2007).
   PubMed Web of Science ®Google Scholar
• Gurwitz D , KimchiO, Bonne-TamirB: The Israeli DNA and Cell Line Collection: A Human Diversity Repository. In: Populations and Genetics. Legal and Socio-Ethical Perspectives. Knoppers BM (Ed.). Martinus Nijhoff, Leiden, The Netherlands 95–113 (2003).
   Google Scholar
• Gillman PK : Tricyclic antidepressant pharmacology and therapeutic drug interactions updated.Br. J. Pharmacol.151(6) , 737–748 (2007).
   PubMed Web of Science ®Google Scholar
• Barkan T , GurwitzD, LevyG, WeizmanA, RehaviM: Biochemical and pharmacological characterization of the serotonin transporter in human peripheral blood lymphocytes.Eur. Neuropsychopharmacol.14(3) , 237–243 (2004).
   PubMed Web of Science ®Google Scholar
• Lee MH , ChoiBY, KunduJK et al.: Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target.Cancer Res.69(18) , 7449–7458 (2009).
   PubMed Web of Science ®Google Scholar
• Sahasranaman S , HowardD, RoyS: Clinical pharmacology and pharmacogenetics of thiopurines.Eur. J. Clin. Pharmacol.64(8) , 753–767 (2008).
   PubMed Web of Science ®Google Scholar
• Hellbom E : Chlorpheniramine, selective serotonin-reuptake inhibitors (SSRIs) and over-the-counter (OTC) treatment.Med. Hypotheses66(4) , 689–690 (2006).
   PubMed Web of Science ®Google Scholar
• Carlsson A , LinqvistM: Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines.J. Pharm. Pharmacol.21 , 460–464 (1969).
   PubMed Web of Science ®Google Scholar
• Alisky JM : Can chlorpheniramine cause serotonin syndrome?Singapore Med. J.47(11) , 1014 (2006).
   PubMedGoogle Scholar
• Rangrej J , BeyeneJ, HuP, PatersonAD: Sex, age and generation effects on genome-wide linkage analysis of gene expression in transformed lymphoblasts.BMC Proc.1(Suppl. 1) , S92 (2007)
   PubMedGoogle Scholar
• Duan S , HuangRS, ZhangW et al.: Expression and alternative splicing of folate pathway genes in HapMap lymphoblastoid cell lines.Pharmacogenomics10(4) , 549–563 (2009).
   PubMed Web of Science ®Google Scholar
• Brennan EP , EhrichM, BrazilDP et al.: Comparative analysis of DNA methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines.Epigenetics4(3) , 159–164 (2009).
   PubMed Web of Science ®Google Scholar
• Gurwitz D , WeizmanA: Personalized psychiatry: a realistic goal.Pharmacogenomics5(2) , 213–217 (2004).
   PubMed Web of Science ®Google Scholar
• Kirchheiner J , SeeringerA, VivianiR: Pharmacogenetics in psychiatry – a useful clinical tool or wishful thinking for the future?Curr. Pharm. Des. (2009) (Epub ahead of print).
   Web of Science ®Google Scholar

▪ Websites

• The Connectivity Map. www.broadinstitute.org/cmap
   Google Scholar
• Pharmacogenomics Knowledge Base. www.pharmgkb.org
   Google Scholar
• Coriell Cell Repositories. http://ccr.coriell.org
   Google Scholar
• European Collection of Cell Cultures at the Health Protection Agency Culture Collections. www.hpacultures.org.uk/collections/ecacc.jsp
   Google Scholar
• National Laboratory for the Genetics of Israeli Populations at Tel Aviv University. http://nlgip.tau.ac.il
   Google Scholar
• HapMap Project. www.hapmap.org
   Google Scholar
• HGDP-CEPH Human Genome Diversity Cell Line Panel. www.cephb.fr/en/hgdp/diversity.php/
   Google Scholar