CD40-1C>T Polymorphism (rs1883832) is Associated with Brain Vessel Reocclusion after Fibrinolysis in Ischemic Stroke

• The National Institutes of Neurological Disorders and Stroke rt-PA Stroke Study Group: Tissue plasminogen activator for acute ischemic stroke. N. Engl. J. Med.333 , 1581–1587 (1995).
   PubMed Web of Science ®Google Scholar
• Rubiera M , Alvarez-SabinJ, RiboM et al.: Predictors of early arterial reocclusion after tissue plasminogen activator-induced recanalization in acute ischemic stroke.Stroke36 , 1452–1456 (2005).
   PubMed Web of Science ®Google Scholar
• Janjua N , AlkawiA, SuriMF, QureshiAI: Impact of arterial reocclusion and distal fragmentation during thrombolysis among patients with acute ischemic stroke.AJNR Am. J. Neuroradiol.29(2) , 253–258 (2008).
   PubMed Web of Science ®Google Scholar
• Qureshi AI , HusseinHM, AbdelmoulaM, GeorgiadisAL, JanjuaN: Subacute recanalization and reocclusion in patients with acute ischemic stroke following endovascular treatment.Neurocrit. Care10(2) , 195–203 (2009).
   PubMed Web of Science ®Google Scholar
• Hacke W , KasteM, BluhmkiE et al.; ECASS Investigators: Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N. Engl. J. Med.359(13) , 1317–1329 (2008).
   PubMed Web of Science ®Google Scholar
• Fernandez-Cadenas I , MolinaCA, Alvarez-SabinJ et al.: ACE gene polymorphisms influence t-PA-induced brain vessel reopening following ischemic stroke.Neurosci. Lett.398 , 167–171 (2006).
   PubMed Web of Science ®Google Scholar
• Gonzalez-Conejero R , Fernandez-CadenasI, IniestaJA et al.; Proyecto Ictus Research Group: Role of fibrinogen levels and factor XIII V34L polymorphism in thrombolytic therapy in stroke patients. Stroke37 , 2288–2293 (2006).
   PubMed Web of Science ®Google Scholar
• Fernandez-Cadenas I , Alvarez-SabinJ, RiboM et al.: Influence of thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 gene polymorphisms on tissue-type plasminogen activator-induced recanalization in ischemic stroke patients.J. Thromb. Haemost.5 , 1862–1868 (2007).
   PubMed Web of Science ®Google Scholar
• Ohman EM , CaliffRM, TopolEJ et al.; TAMI Study Group: Consequences of reocclusion after successful reperfusion therapy in acute myocardial infarction. Circulation82 , 781–791 (1990).
   PubMed Web of Science ®Google Scholar
• Adams HP Jr, Bendixen BH, Kappelle LJ et al.: Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org doi:10.1161/01.str.24.1.35 in Acute Stroke Treatment. Stroke24(1) , 35–41 (1993).
   PubMed Web of Science ®Google Scholar
• Brott TG , HaleyEC, LevyDE et al.: Urgent therapy for stroke, part I: pilot study of tissue plasminogen activator administered within 90 minutes.Stroke23 , 632–640 (1992).
   PubMed Web of Science ®Google Scholar
• Wolfe CD , TaubNA, WoodrowEJ, BurneyPG: Assessment of scales of disability and handicap for stroke patients.Stroke22(10) , 1242–1244 (1991).
   PubMed Web of Science ®Google Scholar
• Demchuk AM , BurginWS, ChristouI et al.: Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator.Stroke32(1) , 89–93 (2001).
   PubMed Web of Science ®Google Scholar
• Domingues-Montanari S , Fernández-CadenasI, Del Río-Espinola A et al.: KCNK17 genetic variants in ischemic stroke. Atherosclerosis208(1) , 203–209 (2010).
   PubMed Web of Science ®Google Scholar
• Rodriguez S , GauntTR, DayI: Hardy–Weinberg equilibrium testing of biological ascertainment for mendelian randomization studies.Am. J. Epidemiol.169(4) , 505–514 (2009).
   PubMed Web of Science ®Google Scholar
• Olejnik S , LiJ, SupattathumS, HubertyCJ: Multiple testing and statistical power with modified bonferroni procedures.J. Educ. Behav. Stat.22(4) , 389–406 (1997).
   Web of Science ®Google Scholar
• Molina CA , AlexandrovAV, DemchukAM, SaqqurM, UchinoK, Alvarez-SabínJ: Improving the predictive accuracy of recanalization on stroke outcome in patients treated with tissue plasminogen activator.Stroke35 , 151–156 (2004).
   PubMed Web of Science ®Google Scholar
• Baird AE , DambrosiaJ, Janket S-J et al.: A three-item scale for the early prediction of stroke recovery. Lancet357 , 2095–2099 (2001).
   PubMed Web of Science ®Google Scholar
• Little J , HigginsJP, IoannidisJP et al.: STrengthening the REporting of Genetic Association studies (STREGA), an extension of the STROBE Statement.Ann. Intern. Med.150(3) , 206–215 (2009).
   PubMed Web of Science ®Google Scholar
• Farzaneh-Far A , DaviesJD, BraamLA et al.: A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels.J. Biol. Chem.276(35) , 32466–32473 (2001).
   PubMed Web of Science ®Google Scholar
• Farzaneh-Far A , WeissbergPL, ProudfootD, ShanahanCM: Transcriptional regulation of matrix Gla protein.Z. Kardiol.90(Suppl. 3) , 38–42 (2001).
   PubMedGoogle Scholar
• Herrmann SM , WhatlingC, BrandE et al.: Polymorphisms of the human matrix Gla protein (MGP) gene, vascular calcification, and myocardial infarction.Arterioscler. Thromb. Vasc. Biol.20(11) , 2386–2393 (2000).
   PubMed Web of Science ®Google Scholar
• Hendig D , ZarbockR, SzliskaC, KleesiekK, GöttingC: The local calcification inhibitor matrix Gla protein in pseudoxanthoma elasticum.Clin. Biochem.41(6) , 407–412 (2008).
   PubMed Web of Science ®Google Scholar
• Brancaccio D , BiondiML, GallieniM et al.: Matrix GLA protein gene polymorphisms: clinical correlates and cardiovascular mortality in chronic kidney disease patients.Am. J. Nephrol.25(6) , 548–552 (2005).
   PubMed Web of Science ®Google Scholar
• Munroe PB , OlgunturkRO, FrynsJP et al.: Mutations in the gene encoding the human matrix GLA protein cause Keutel syndrome.Nat. Genet.21(1) , 142–144 (1999).
   PubMed Web of Science ®Google Scholar
• Luo G , DucyP, McKeeMD et al.: Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein.Nature386(6620) , 78–81 (1997).
   PubMed Web of Science ®Google Scholar
• Cranenburg EC , VermeerC, KoosR et al.: The circulating inactive form of matrix Gla protein (ucMGP) as a biomarker for cardiovascular calcification.J. Vasc. Res.45(5) , 427–436 (2008).
   PubMed Web of Science ®Google Scholar
• Danziger J : Vitamin K-dependent proteins, warfarin, and vascular calcification.Clin. J. Am. Soc. Nephrol.3(5) , 1504–1510 (2008)
   PubMed Web of Science ®Google Scholar
• Jacobson EM , ConcepcionE, OashiT, TomerY: A Graves‘ disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: a case for translational pathophysiology.Endocrinology146(6) , 2684–2691 (2005).
   PubMed Web of Science ®Google Scholar
• Kozak M : An analysis of vertebrate mRNA sequences: intimations of translational control.J. Cell. Biol.115(4) , 887–903 (1991).
   PubMed Web of Science ®Google Scholar
• Park JH , ChangHS, ParkCS et al.: Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE.Am. J. Respir. Crit. Care. Med.175(8) , 775–782 (2007).
   PubMed Web of Science ®Google Scholar
• Skibola CF , NietersA, BracciPM et al.: A functional TNFRSF5 gene variant is associated with risk of lymphoma.Blood111(8) , 4348–4354 (2008).
   PubMed Web of Science ®Google Scholar
• Grewal IS , FlavellRA: CD40 and CD154 in cell-mediated immunity.Annu. Rev. Immunol.16 , 111–135 (1998).
   PubMed Web of Science ®Google Scholar
• Jacobson EM , HuberAK, AkenoN et al.: A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression.Genes Immun.8(3) , 205–214 (2007).
   PubMed Web of Science ®Google Scholar
• Chabot S , CharletD, WilsonTL, YongVW: Cytokine production consequent to T cell–microglia interaction: the PMA/IFN g-treated U937 cells display similarities to human microglia.J. Neurosci. Methods105(2) , 111–120 (2001).
   PubMed Web of Science ®Google Scholar
• Garber E , SuL, EhrenfelsB, KarpusasM, HsuYM: CD154 variants associated with hyper-IgM syndrome can form oligomers and trigger CD40-mediated signals.J. Biol. Chem.274(47) , 33545–33550 (1999).
   PubMed Web of Science ®Google Scholar
• Grau AJ , LichyC: Editorial comment: stroke and the CD40-CD40 ligand system: at the hinge between inflammation and thrombosis.Stroke34(6) , 1417–1418 (2003).
   PubMed Web of Science ®Google Scholar
• Kassner SS , KollmarR, BonaterraGA, HildebrandtW, SchwabS, KinscherfR: The early immunological response to acute ischemic stroke: differential gene expression in subpopulations of mononuclear cells.Neuroscience160(2) , 394–401 (2009).
   PubMed Web of Science ®Google Scholar
• Garlichs CD , KozinaS, Fateh-MoghadamS et al.: Upregulation of CD40–CD40 ligand (CD154) in patients with acute cerebral ischemia.Stroke34(6) , 1412–1418 (2003).
   PubMed Web of Science ®Google Scholar
• Cha JK , JeongMH, KimEK et al.: Surface expression of P-selectin on platelets is related with clinical worsening in acute ischemic stroke.J. Korean Med. Sci.17(6) , 811–816 (2002).
   PubMed Web of Science ®Google Scholar
• Schumacher H , KaiserE, SchnabelPA, SykoraJ, EcksteinHH, AllenbergJR: Immunophenotypic characterisation of carotid plaque: increased amount of inflammatory cells as an independent predictor for ischaemic symptoms.Eur. J. Vasc. Endovasc. Surg.21(6) , 494–501 (2001).
   PubMed Web of Science ®Google Scholar
• Ishikawa M , VowinkelT, StokesKY et al.: CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion.Circulation111(13) , 1690–1696 (2005).
   PubMed Web of Science ®Google Scholar
• Luomala M , PäiväH, LaaksonenR et al.: Plasma-soluble CD40 is related to cholesterol metabolism in patients with moderate hypercholesterolemia.Scand. Cardiovasc. J.40(5) , 280–284 (2006).
   PubMed Web of Science ®Google Scholar
• Lobbes MB , LutgensE, HeenemanS et al.: Is there more than C-reactive protein and fibrinogen? The prognostic value of soluble CD40 ligand, interleukin-6 and oxidized low-density lipoprotein with respect to coronary and cerebral vascular disease.Atherosclerosis187(1) , 18–25 (2006).
   PubMed Web of Science ®Google Scholar
• Plaikner M , PeerA, FalkensammerG et al.: Lack of association of soluble CD40 ligand with the presence of acute myocardial infarction or ischemic stroke in the emergency department.Clin. Chem.55(1) , 175–178 (2009).
   PubMed Web of Science ®Google Scholar
• Yilmaz G , ArumugamTV, StokesKY, GrangerDN: Role of T lymphocytes and interferon-g in ischemic Stroke.Circulation113 , 2105–2112 (2006).
   PubMed Web of Science ®Google Scholar
• Burdon KP , LangefeldCD, BeckSR et al.: Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS).Am. Heart. J.151(3) , 706–711 (2006).
   PubMed Web of Science ®Google Scholar
• Derdeyn CP : Acute ischemic stroke – are hemodynamic variables predictive of outcome after systemic thrombolysis?Nat. Clin. Pract. Neurol.3(2) , 72–73 (2007).
   PubMedGoogle Scholar
• Bertram U , MoserM, PeterK et al.: Effects of different thrombolytic treatment regimen with abciximab and tirofiban on platelet aggregation and platelet-leukocyte interactions: a subgroup analysis from the GUSTO V and FASTER trials.J. Thromb. Thrombolysis.14(3) , 197–203 (2002).
   PubMed Web of Science ®Google Scholar
• Szabo S , EtzelD, EhlersR et al.: Combined thrombolysis with abciximab favourably influences platelet-leukocyte interactions and platelet activation in acute myocardial infarction.J. Thromb. Thrombolysis.20(3) , 155–161 (2005).
   PubMed Web of Science ®Google Scholar
• Kiefer TL , BeckerRC: Inhibitors of platelet adhesion.Circulation120(24) , 2488–2495 (2009).
   PubMed Web of Science ®Google Scholar

▪ Website

• Stroke Trials Registry www:strokecenter.org/trials
   Google Scholar