CYP2W1 Variant Alleles in Caucasians and Association of the CYP2W1 G541A (Ala181Thr) Polymorphism with Increased Colorectal Cancer Risk

• Parkin DM , BrayF, FerlayJ, PisaniP: Global cancer statistics, 2002.CA Cancer J. Clin.55(2) , 74–108 (2005).
   PubMed Web of Science ®Google Scholar
• Pittman AM , WebbE, Carvajal-CarmonaL et al.: Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer.Hum. Mol. Genet.17(23) , 3720–3727 (2008).
   PubMed Web of Science ®Google Scholar
• Tomlinson IP , WebbE, Carvajal-CarmonaL et al.: A Genome-Wide Association Study Identifies Colorectal Cancer Susceptibility Loci on Chromosomes 10.14 and 8q23.3.Nat. Genet.40(5) , 623–630 (2008).
   PubMed Web of Science ®Google Scholar
• Martinez C , Garcia-MartinEs , PizarroRM, Garcia-GamitoFJ, AgundezJA: Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy.Br. J. Cancer87(6) , 681–686 (2002).
   PubMed Web of Science ®Google Scholar
• Sinha R , PetersU, CrossAJ et al.: Meat, meat cooking methods and preservation, and risk for colorectal adenoma.Cancer Res.65(17) , 8034–8041 (2005).
   PubMed Web of Science ®Google Scholar
• Sachse C , SmithG, WilkieMJ et al.: A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.Carcinogenesis23(11) , 1839–1849 (2002).
   PubMed Web of Science ®Google Scholar
• Martinez C , Garcia-MartinE, LaderoJM et al.: Association of CYP2C9 genotypes leading to high enzyme activity and colorectal cancer risk.Carcinogenesis22(8) , 1323–1326 (2001).
   PubMed Web of Science ®Google Scholar
• Agundez JA : Cytochrome P450 gene polymorphism and cancer.Curr. Drug Metab.5(3) , 211–224 (2004).
   PubMed Web of Science ®Google Scholar
• Agundez JA : Polymorphisms of human N-acetyltransferases and cancer risk.Curr. Drug Metab.9(6) , 520–531 (2008).
   PubMed Web of Science ®Google Scholar
• Girault I , RougierN, ChesneC et al.: Simultaneous measurement of 23 isoforms from the human cytochrome P450 families 1 to 3 by quantitative reverse transcriptase-polymerase chain reaction.Drug Metab. Dispos.33(12) , 1803–1810 (2005).
   PubMed Web of Science ®Google Scholar
• Aung PP , OueN, MitaniY et al.: Systematic search for gastric cancer-specific genes based on sage data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer.Oncogene25(17) , 2546–2557 (2006).
   PubMed Web of Science ®Google Scholar
• Choudhary D , JanssonI, StoilovI, SarfaraziM, SchenkmanJB: Expression patterns of mouse and human CYP orthologs (families 1–4) during development and in different adult tissues.Arch. Biochem. Biophys.436(1) , 50–61 (2005).
   PubMed Web of Science ®Google Scholar
• Karlgren M , GomezA, StarkK et al.: Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1.Biochem. Biophys. Res. Commun.341(2) , 451–458 (2006).
   PubMed Web of Science ®Google Scholar
• Gomez A , KarlgrenM, EdlerD, BernalML, MkrtchianS, Ingelman-SundbergM: Expression of CYP2W1 in colon tumors: regulation by gene methylation.Pharmacogenomics8(10) , 1315–1325 (2007).
   PubMed Web of Science ®Google Scholar
• Edler D , StenstedtK, OhrlingK et al.: The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer – a pilot study.Eur. J. Cancer45(4) , 705–712 (2009).
   PubMed Web of Science ®Google Scholar
• Wu Z l, Sohl CD, Shimada T, Guengerich FP: Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Mol. Pharmacol.69(6) , 2007–2014 (2006).
   PubMed Web of Science ®Google Scholar
• Yoshioka H , KasaiN, IkushiroS et al.: Enzymatic properties of human CYP2W1 expressed in Escherichia coli.Biochem. Biophys. Res. Commun.345(1) , 169–174 (2006).
   PubMed Web of Science ®Google Scholar
• Hanzawa Y , SasakiT, MizugakiM, IshikawaM, HiratsukaM: Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population.Drug Metab. Dispos.36(2) , 349–352 (2008).
   PubMed Web of Science ®Google Scholar
• Agundez JAG , LozanoL, LaderoJM et al.: N-acetyltransferase 2 (NAT2) genotype and colorectal carcinoma: risk variability according to tumour site?Scand. J. Gastroenterol.35(10) , 1087–1091 (2000).
   PubMed Web of Science ®Google Scholar
• Gervasini G , VizcainoS, GasibaC, CarrilloJA, BenitezJ: Differences in CYP3A5*3 genotype distribution and combinations with other polymorphisms between Spaniards and other Caucasian populations.Ther. Drug Monit.27(6) , 819–821 (2005).
   PubMed Web of Science ®Google Scholar
• Martinez C , MartinF, FernandezJM et al.: Glutathione S-transferases µ1, θ1, π1, α1 and µ3 genetic polymorphisms and the risk of colorectal and gastric cancers in humans.Pharmacogenomics7(5) , 711–718 (2006).
   PubMed Web of Science ®Google Scholar
• Agundez JA , GolkaK, MartinezC, SelinskiS, BlaszkewiczM, Garcia-MartinE: Unraveling ambiguous NAT2 genotyping data.Clin. Chem.54(8) , 1390–1394 (2008).
   PubMed Web of Science ®Google Scholar
• Stephens M , DonnellyP: A comparison of Bayesian methods for haplotype reconstruction from population genotype data.Am. J. Hum. Genet.73(5) , 1162–1169 (2003).
   PubMed Web of Science ®Google Scholar
• Brennan P : Gene–environment interaction and aetiology of cancer: what does it mean and how can we measure it?Carcinogenesis23(3) , 381–387 (2002).
   PubMed Web of Science ®Google Scholar
• Agundez JA , MartinezC, LedesmaMC, LadonaMG, LaderoJM, BenitezJ: Genetic basis for differences in debrisoquin polymorphism between a Spanish and other white populations.Clin. Pharmacol. Ther.55(4) , 412–417 (1994).
   PubMed Web of Science ®Google Scholar
• Adams SM , BoschE, BalaresquePL et al.: The genetic legacy of religious diversity and intolerance: paternal lineages of Christians, Jews, and Muslims in the Iberian peninsula.Am. J. Hum. Genet.83(6) , 725–736 (2008).
   PubMed Web of Science ®Google Scholar
• Lucotte G , GerardN, MercierG: North African genes in Iberia studied by y-chromosome DNA haplotype 5.Hum. Biol.73(5) , 763–769 (2001).
   PubMed Web of Science ®Google Scholar
• Li W , TangY, HoshinoT, NeyaS: Molecular modeling of human cytochrome P450 2W1 and its interactions with substrates.J. Mol. Graph. Model.28(2) , 170–176 (2009).
   PubMed Web of Science ®Google Scholar
• Ramensky V , BorkP, SunyaevS: Human non-synonymous SNPs: server and survey.Nucleic Acids Res.30(17) , 3894–3900 (2002).
   PubMed Web of Science ®Google Scholar
• Martinez C , GalvanS, Garcia-MartinE, RamosMI, Gutierrez-MartinY, AgundezJA: Variability in ethanol biodisposition in whites is modulated by polymorphisms in the ADH1B and ADH1C genes.Hepatology51(2) , 491–500 (2010).
   PubMed Web of Science ®Google Scholar
• Ingelman-Sundberg M : Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future.Trends Pharmacol. Sci.25(4) , 193–200 (2004).
   PubMed Web of Science ®Google Scholar
• Karlgren M , Ingelman-SundbergM: Tumour-specific expression of CYP2W1: its potential as a drug target in cancer therapy.Expert Opin. Ther. Targets11(1) , 61–67 (2007).
   PubMed Web of Science ®Google Scholar

▪ Website

• International HapMap Project www.hapmap.org
   Google Scholar