Lymphoblastoid Cell Lines in Pharmacogenomic Discovery and Clinical Translation

• Welsh M , MangraviteL, MedinaMW et al. Pharmacogenomic discovery using cell-based models. Pharmacol. Rev. 61(4) , 413–429 (2009).
   PubMed Web of Science ®Google Scholar
• Gamazon ER , ZhangW, KonkashbaevA et al. SCAN: SNP and copy number annotation. Bioinformatics 26(2) , 259–262 (2010).
   PubMed Web of Science ®Google Scholar
• Zhou SF , LiuJP, ChowbayB. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab. Rev.41(2) , 89–295 (2009).
   PubMed Web of Science ®Google Scholar
• van Baarsen LG , VosslamberS, TijssenM et al. Pharmacogenomics of interferon-beta therapy in multiple sclerosis: baseline IFN signature determines pharmacological differences between patients. PLoS ONE 3(4) , e1927 (2008).
   PubMed Web of Science ®Google Scholar
• Wertz IE , KusamS, LamC et al. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 471(7336) , 110–114 (2011).
   PubMed Web of Science ®Google Scholar
• Choy E , YelenskyR, BonakdarS et al. Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines. PLoS Genet. 4(11) , e1000287 (2008).
   PubMed Web of Science ®Google Scholar
• Stark AL , ZhangW, MiS et al. Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines. Pharmacogenomics J. 10(6) , 505–512 (2010).
   PubMed Web of Science ®Google Scholar
• Liu MT , ChenYR, ChenSC et al. Jpgtein–Barr virus latent membrane protein 1 induces micronucleus formation, represses DNA repair and enhances sensitivity to DNA-damaging agents in human epithelial cells. Oncogene 23(14) , 2531–2539 (2004).
   PubMed Web of Science ®Google Scholar
• Caliskan M , CusanovichDA, OberC, GiladY. The effects of EBV transformation on gene expression levels and methylation profiles. Hum. Mol. Genet.20(8) , 1643–1652 (2011).
   PubMed Web of Science ®Google Scholar
• Bullaughey K , ChavarriaCI, CoopG, GiladY. Expression quantitative trait loci detected in cell lines are often present in primary tissues. Hum. Mol. Genet.18(22) , 4296–4303 (2009).
   PubMed Web of Science ®Google Scholar
• Ding J , GudjonssonJE, LiangL et al. Gene expression in skin and lymphoblastoid cells: refined statistical method reveals extensive overlap in cis-eQTL signals. Am. J. Hum. Genet. 87(6) , 779–789 (2010).
   PubMed Web of Science ®Google Scholar
• Schadt EE , MolonyC, ChudinE et al. Mapping the genetic architecture of gene expression in human liver. PLoS Biol. 6(5) , e107 (2008).
   PubMed Web of Science ®Google Scholar
• Dausset J , CannH, CohenD, LathropM, LalouelJM, WhiteR. Centre d‘Etude du Polymorphisme Humain (CEPH): collaborative genetic mapping of the human genome. Genomics6(3) , 575–577 (1990).
   PubMed Web of Science ®Google Scholar
• Thorisson GA , SteinLD. The SNP Consortium website: past, present and future. Nucleic Acids Res.31(1) , 124–127 (2003).
   PubMed Web of Science ®Google Scholar
• Morley M , MolonyCM, WeberTM et al. Genetic analysis of genome-wide variation in human gene expression. Nature 430(7001) , 743–747 (2004).
   PubMed Web of Science ®Google Scholar
• Burdick JT , ChenWM, AbecasisGR, CheungVG. In silico method for inferring genotypes in pedigrees. Nat. Genet.38(9) , 1002–1004 (2006).
   PubMed Web of Science ®Google Scholar
• Dolan ME , NewboldKG, NagasubramanianR et al. Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity. Cancer Res. 64(12) , 4353–4356 (2004).
   PubMed Web of Science ®Google Scholar
• Watters JW , KrajaA, MeucciMA, ProvinceMA, McLeodHL. Genome-wide discovery of loci influencing chemotherapy cytotoxicity. Proc. Natl Acad. Sci. USA101(32) , 11809–11814 (2004).
   PubMed Web of Science ®Google Scholar
• Altshuler D , BrooksLD, ChakravartiA, CollinsFS, DalyMJ, DonnellyP. A haplotype map of the human genome. Nature437(7063) , 1299–1320 (2005).
   PubMed Web of Science ®Google Scholar
• Altshuler DM , GibbsRA, PeltonenL et al. Integrating common and rare genetic variation in diverse human populations. Nature 467(7311) , 52–58 (2010).
   PubMed Web of Science ®Google Scholar
• Frazer KA , BallingerDG, CoxDR et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 449(7164) , 851–861 (2007).
   PubMed Web of Science ®Google Scholar
• Thorisson GA , SmithAV, KrishnanL, SteinLD. The International HapMap Project Web site. Genome Res.15(11) , 1592–1593 (2005).
   PubMed Web of Science ®Google Scholar
• The 1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature467(7319) , 1061–1073 (2010).
   PubMed Web of Science ®Google Scholar
• O‘Donnell PH , DolanME. Cancer pharmacoethnicity: ethnic differences in susceptibility to the effects of chemotherapy. Clin. Cancer Res.15(15) , 4806–4814 (2009).
   PubMed Web of Science ®Google Scholar
• Calvo E , BaselgaJ. Ethnic differences in response to epidermal growth factor receptor tyrosine kinase inhibitors. J. Clin. Oncol.24(14) , 2158–2163 (2006).
   PubMed Web of Science ®Google Scholar
• Rotimi CN , JordeLB. Ancestry and disease in the age of genomic medicine. N. Engl. J. Med.363(16) , 1551–1558 (2010).
   PubMed Web of Science ®Google Scholar
• Need AC , GoldsteinDB. Next generation disparities in human genomics: concerns and remedies. Trends Genet.25(11) , 489–494 (2009).
   PubMed Web of Science ®Google Scholar
• Wheeler HE , GorsicLK, WelshM et al. Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African–Americans. PLoS ONE 6(7) , e21920 (2011).
   PubMed Web of Science ®Google Scholar
• Dumitrescu L , CartyCL, TaylorK et al. Genetic determinants of lipid traits in diverse populations from the Population Architecture using Genomics and Epidemiology (PAGE) study. PLoS Genet. 7(6) , e1002138 (2011).
   PubMed Web of Science ®Google Scholar
• Peters EJ , KrajaAT, LinSJ et al. Association of thymidylate synthase variants with 5-fluorouracil cytotoxicity. Pharmacogenet. Genomics 19(5) , 399–401 (2009).
   PubMed Web of Science ®Google Scholar
• Pinedo HM , PetersGF. Fluorouracil: biochemistry and pharmacology. J. Clin. Oncol.6(10) , 1653–1664 (1988).
   PubMed Web of Science ®Google Scholar
• Gamazon ER , HuangRS, CoxNJ, DolanME. Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci. Proc. Natl Acad. Sci. USA107(20) , 9287–9292 (2010).
   PubMed Web of Science ®Google Scholar
• Matsson P , YeeSW, MarkovaS et al. Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping. Pharmacogenomics J. doi:10.1038/tpj.2011.8 (2011) (Epub ahead of print).
   PubMed Web of Science ®Google Scholar
• Huang RS , DuanS, BleibelWK et al. A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity. Proc. Natl Acad. Sci. USA 104(23) , 9758–9763 (2007).
   PubMed Web of Science ®Google Scholar
• Hartford CM , DuanS, DelaneySM et al. Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity. Blood 113(10) , 2145–2153 (2009).
   PubMed Web of Science ®Google Scholar
• Yin G , ZhengQ, YanC, BerkBC. GIT1 is a scaffold for ERK1/2 activation in focal adhesions. J. Biol. Chem.280(30) , 27705–27712 (2005).
   PubMed Web of Science ®Google Scholar
• Lu Z , XuS. ERK1/2 MAP kinases in cell survival and apoptosis. IUBMB Life58(11) , 621–631 (2006).
   PubMed Web of Science ®Google Scholar
• Shaw GC , CopeJJ, LiL et al. Mitoferrin is essential for erythroid iron assimilation. Nature 440(7080) , 96–100 (2006).
   PubMed Web of Science ®Google Scholar
• Leardi A , CaragliaM, SelleriC et al. Desferioxamine increases iron depletion and apoptosis induced by ara-C of human myeloid leukaemic cells. Br. J. Haematol. 102(3) , 746–752 (1998).
   PubMed Web of Science ®Google Scholar
• Lamba JK , CrewsK, PoundsS et al. Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants. J. Pharmacol. Exp. Ther. 323(3) , 935–945 (2007).
   PubMed Web of Science ®Google Scholar
• Gamazon ER , DuanS, ZhangW et al. PACdb: a database for cell-based pharmacogenomics. Pharmacogenet. Genomics 20(4) , 269–273 (2010).
   PubMed Web of Science ®Google Scholar
• Li L , FridleyBL, KalariK et al. Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers. PLoS ONE 4(11) , e7765 (2009).
   PubMed Web of Science ®Google Scholar
• Shin BK , WangH, YimAM et al. Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J. Biol. Chem. 278(9) , 7607–7616 (2003).
   PubMed Web of Science ®Google Scholar
• Trenkle T , McClellandM, AdlkoferK, WelshJ. Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors. Gene245(1) , 139–149 (2000).
   PubMed Web of Science ®Google Scholar
• Kalari KR , HebbringSJ, ChaiHS et al. Copy number variation and cytidine analogue cytotoxicity: a genome-wide association approach. BMC Genomics 11 , 357 (2010).
   PubMed Web of Science ®Google Scholar
• O‘Donnell PH , GamazonE, ZhangW et al. Population differences in platinum toxicity as a means to identify novel genetic susceptibility variants. Pharmacogenet. Genomics 20(5) , 327–337 (2010).
   PubMed Web of Science ®Google Scholar
• Millward MJ , BoyerMJ, LehnertM et al. Docetaxel and carboplatin is an active regimen in advanced non-small-cell lung cancer: a Phase II study in Caucasian and Asian patients. Ann. Oncol. 14(3) , 449–454 (2003).
   PubMed Web of Science ®Google Scholar
• Wu B , DrogeP, DaveyCA. Site selectivity of platinum anticancer therapeutics. Nat. Chem. Biol.4(2) , 110–112 (2008).
   PubMed Web of Science ®Google Scholar
• Wang D , LippardSJ. Cisplatin-induced post-translational modification of histones H3 and H4. J. Biol. Chem.279(20) , 20622–20625 (2004).
   PubMed Web of Science ®Google Scholar
• Wheeler HE , GamazonER, StarkAL et al. Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations. Pharmacogenomics J. doi: https://doi.org/10.1038/tpj.2011.38. (2011) (Epub ahead of print).
   PubMed Web of Science ®Google Scholar
• Eliopoulos AG , KerrDJ, Herod J et al. The control of apoptosis and drug resistance in ovarian cancer: influence of p53 and Bcl-2. Oncogene11(7) , 1217–1228 (1995).
   PubMed Web of Science ®Google Scholar
• Marsh S , McLeodH, DolanE et al. Platinum pathway. Pharmacogenet. Genomics 19(7) , 563–564 (2009).
   PubMed Web of Science ®Google Scholar
• Rabik CA , DolanME. Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat. Rev.33(1) , 9–23 (2007).
   PubMed Web of Science ®Google Scholar
• Shukla SJ , DuanS, BadnerJA, WuX, DolanME. Susceptibility loci involved in cisplatin-induced cytotoxicity and apoptosis. Pharmacogenet. Genomics18(3) , 253–262 (2008).
   PubMed Web of Science ®Google Scholar
• Wen Y , GorsicLK, WheelerHE, ZiliakDM, HuangSR, DolanEM. Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies. Pharmacogenet. Genomics21(8) , 476–488 (2011).
   PubMed Web of Science ®Google Scholar
• French D , YangW, ChengC et al. Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia. Blood 113(19) , 4512–4520 (2009).
   PubMed Web of Science ®Google Scholar
• West CM , ElliottRM, BurnetNG. The genomics revolution and radiotherapy. Clin. Oncol. (R. Coll. Radiol.)19(6) , 470–480 (2007).
   PubMed Web of Science ®Google Scholar
• Smirnov DA , MorleyM, ShinE, SpielmanRS, CheungVG. Genetic analysis of radiation-induced changes in human gene expression. Nature459(7246) , 587–591 (2009).
   PubMed Web of Science ®Google Scholar
• Wyrobek AJ , ManoharCF, KrishnanVV et al. Low dose radiation response curves, networks and pathways in human lymphoblastoid cells exposed from 1 to 10cGy of acute gamma radiation. Mutat. Res. 722(2) , 119–130 (2011).
   PubMed Web of Science ®Google Scholar
• Niu N , QinY, FridleyBL et al. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Genome Res. 20(11) , 1482–1492 (2010).
   PubMed Web of Science ®Google Scholar
• LaRosa JC , HeJ, VupputuriS. Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials. JAMA282(24) , 2340–2346 (1999).
   PubMed Web of Science ®Google Scholar
• Simon JA , LinF, HulleySB et al. Phenotypic predictors of response to simvastatin therapy among African–Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study. Am. J. Cardiol. 97(6) , 843–850 (2006).
   PubMed Web of Science ®Google Scholar
• Krauss RM , MangraviteLM, SmithJD et al. Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment. Circulation 117(12) , 1537–1544 (2008).
   PubMed Web of Science ®Google Scholar
• Medina MW , GaoF, RuanW, RotterJI, KraussRM. Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin. Circulation118(4) , 355–362 (2008).
   PubMed Web of Science ®Google Scholar
• Mangravite LM , MedinaMW, CuiJ et al. Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin. Arterioscler. Thromb. Vasc. Biol. 30(7) , 1485–1492 (2010).
   PubMed Web of Science ®Google Scholar
• Souery D , OswaldP, MassatI et al. Clinical factors associated with treatment resistance in major depressive disorder: results from a European multicenter study. J. Clin. Psychiatry 68(7) , 1062–1070 (2007).
   PubMed Web of Science ®Google Scholar
• Kirchheiner J , NickchenK, BauerM et al. Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. Mol. Psychiatry 9(5) , 442–473 (2004).
   PubMed Web of Science ®Google Scholar
• Morag A , Pasmanik-ChorM, Oron-KarniV, RehaviM, StinglJC, GurwitzD. Genome-wide expression profiling of human lymphoblastoid cell lines identifies CHL1 as a putative SSRI antidepressant response biomarker. Pharmacogenomics12(2) , 171–184 (2011).
   PubMed Web of Science ®Google Scholar
• Montag-Sallaz M , BaarkeA, MontagD. Aberrant neuronal connectivity in CHL1-deficient mice is associated with altered information processing-related immediate early gene expression. J. Neurobiol.57(1) , 67–80 (2003).
   PubMedGoogle Scholar
• Chen QY , ChenQ, FengGY et al. Case–control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population. Schizophr. Res. 73(2–3) , 269–274 (2005).
   PubMed Web of Science ®Google Scholar
• Sakurai K , MigitaO, ToruM, ArinamiT. An association between a missense polymorphism in the close homologue of L1 (CHL1, CALL) gene and schizophrenia. Mol. Psychiatry7(4) , 412–415 (2002).
   PubMed Web of Science ®Google Scholar
• Wu TY , FridleyBL, JenkinsGD, BatzlerA, WangL, WeinshilboumRM. Mycophenolic acid response biomarkers: a cell line model system-based genome-wide screen. Int. Immunopharmacol.11(8) , 1057–1064 (2011).
   PubMed Web of Science ®Google Scholar
• Niu N , ManickamV, KalariKR et al. Human glucocorticoid receptor alpha gene (NR3C1) pharmacogenomics: gene resequencing and functional genomics. J. Clin. Endocrinol. Metab. 94(8) , 3072–3084 (2009).
   PubMed Web of Science ®Google Scholar
• Moyer AM , FridleyBL, JenkinsGD et al. Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. Toxicol. Sci. 120(1) , 33–41 (2011).
   PubMed Web of Science ®Google Scholar
• Penela P , MurgaC, RibasC, TutorAS, PeregrinS, MayorF Jr. Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease. Cardiovasc. Res.69(1) , 46–56 (2006).
   PubMed Web of Science ®Google Scholar
• Lobmeyer MT , WangL, ZinehI et al. Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patients. Pharmacogenet. Genomics 21(1) , 42–49 (2011).
   PubMed Web of Science ®Google Scholar
• Li L , FridleyB, KalariK et al. Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression. Cancer Res. 68(17) , 7050–7058 (2008).
   PubMed Web of Science ®Google Scholar
• Pei H , LiL, FridleyBL et al. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell16(3) , 259–266 (2009).
   PubMed Web of Science ®Google Scholar
• Mitra AK , CrewsK, PoundsS et al. Impact of genetic variation in FKBP5 on clinical response in pediatric acute myeloid leukemia patients: a pilot study. Leukemia 25(8) , 1354–1356 (2011).
   PubMed Web of Science ®Google Scholar
• Chen SH , YangW, FanY et al. A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity. Leukemia 25(1) , 66–74 (2011).
   PubMed Web of Science ®Google Scholar
• Ziliak D , O‘DonnellP H, Im HK et al. Germline polymorphisms discovered via a cell-based, genome-wide approach predict platinum response in head and neck cancers. Transl. Res.157(5) , 265–272 (2011).
   PubMed Web of Science ®Google Scholar
• Huang RS , JohnattySE, GamazonER et al. Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients. Clin. Cancer Res. 17(16) , 1–11 (2011).
   Web of Science ®Google Scholar
• Tan XL , MoyerAM, FridleyBL et al. Genetic variation predicting cisplatin cytotoxicity associated with overall survival in lung cancer patients receiving platinum-based chemotherapy. Clin. Cancer Res. 17(17) , 5801–5811 (2011).
   PubMed Web of Science ®Google Scholar
• Ingle JN , SchaidDJ, GossPE et al. Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors. J. Clin. Oncol. 28(31) , 4674–4682 (2010).
   PubMed Web of Science ®Google Scholar
• Matys V , FrickeE, GeffersR et al. TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res. 31(1) , 374–378 (2003).
   PubMed Web of Science ®Google Scholar
• Kaiser J . DNA sequencing. A plan to capture human diversity in 1000 genomes. Science319(5862) , 395 (2008).
   PubMed Web of Science ®Google Scholar
• Li B , LealSM. Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am. J. Hum. Genet.83(3) , 311–321 (2008).
   PubMed Web of Science ®Google Scholar
• Liu JZ , McRaeAF, NyholtDR et al. A versatile gene-based test for genome-wide association studies. Am. J. Hum. Genet. 87(1) , 139–145 (2010).
   PubMed Web of Science ®Google Scholar
• Tatonetti NP , DudleyJT, SagreiyaH, ButteAJ, AltmanRB. An integrative method for scoring candidate genes from association studies: application to warfarin dosing. BMC Bioinformatics11(Suppl. 9) , S9 (2010).
   PubMedGoogle Scholar
• Zhu X , FengT, LiY, LuQ, ElstonRC. Detecting rare variants for complex traits using family and unrelated data. Genet. Epidemiol.34(2) , 171–187 (2010).
   PubMed Web of Science ®Google Scholar
• Gamazon ER , ImHK, DuanS et al. Exprtarget: an integrative approach to predicting human microRNA targets. PLoS ONE 5(10) , e13534 (2010).
   PubMed Web of Science ®Google Scholar
• Wang L , ObergAL, AsmannYW et al. Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines. PLoS ONE 4(6) , e5878 (2009).
   PubMed Web of Science ®Google Scholar
• Bell JT , PaiAA, PickrellJK et al. DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol. 12(1) , R10 (2011).
   PubMed Web of Science ®Google Scholar
• Sugawara H , IwamotoK, BundoM, UedaJ, IshigookaJ, KatoT. Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell lines. Epigenetics6(4) , 508–515 (2011).
   PubMed Web of Science ®Google Scholar
• Baer-Dubowska W , Majchrzak-CelinskaA, CichockiM. Pharmocoepigenetics: a new approach to predicting individual drug responses and targeting new drugs. Pharmacol. Rep.63(2) , 293–304 (2011).
   PubMed Web of Science ®Google Scholar
• Mishra PJ , BanerjeeD, BertinoJR. MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: introducing microRNA pharmacogenomics. Cell Cycle7(7) , 853–858 (2008).
   PubMed Web of Science ®Google Scholar
• Zhang W , HuangRS, DolanME. Integrating epigenomics into pharmacogenomic studies. Pharmgenomics Pers. Med.2008(1) , 7–14 (2008).
   PubMedGoogle Scholar
• Ciaccio MF , WagnerJP, ChuuCP, LauffenburgerDA, JonesRB. Systems analysis of EGF receptor signaling dynamics with microwestern arrays. Nat. Methods7(2) , 148–155 (2010).
   PubMed Web of Science ®Google Scholar
• Nica AC , MontgomerySB, DimasAS et al. Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations. PLoS Genet. 6(4) , e1000895 (2010).
   PubMed Web of Science ®Google Scholar
• Nicolae DL , GamazonE, ZhangW, DuanS, DolanME, CoxNJ. Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet.6(4) , e1000888 (2010).
   PubMed Web of Science ®Google Scholar
• Relling MV , GardnerEE, SandbornWJ et al. Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clin. Pharmacol. Ther. 89(3) , 387–391 (2011).
   PubMed Web of Science ®Google Scholar

▪ Websites

• The SNP Consortium Database. http://snpdata.cshl.edu
   Google Scholar
• International HapMap Project. www.hapmap.org
   Google Scholar
• The 1000 Genomes Project. www.1000genomes.org
   Google Scholar
• Human Variation Panel dbGaP Access. www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000211.v1.p1
   Google Scholar
• SCAN Database. www.scandb.org
   Google Scholar
• Gene Expression Omnibus (CEPH pedigrees GEO accession: GSE1485). www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE1485
   Google Scholar
• Gene Expression Omnibus (Human Variation Panel GEO accession: GSE24277). www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE24277
   Google Scholar
• eQTL resources at the Pritchard Lab. http://eqtl.uchicago.edu/Home.html
   Google Scholar
• CEU RNA-Seq Data. http://jungle.unige.ch/rnaseq_CEU60
   Google Scholar
• Coriell Cell Repositories. http://ccr.coriell.org
   Google Scholar
• PACdb. www.pacdb.org
   Google Scholar
• TRANSFAC Database. www.gene-regulation.com
   Google Scholar
• Pharmacogenomics Research Network. http://pgrn.org
   Google Scholar