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Research Highlights: Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity

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Pages 1567-1569 | Published online: 13 Nov 2012

References

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  • Chessman D , KostenkoL, LethborgT et al. Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity. Immunity 28(6) , 822–832 (2008).
  • Illing PT , VivianJP, DudekNL et al. Immune self-reactivity triggered by drug-modified HLA-peptide repertoire. Nature 486(7404) , 554–558 (2012).
  • Ostrov DA , GrantBJ, PompeuYA et al. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc. Natl Acad. Sci. USA 109(25) , 9959–9964 (2012).
  • Norcross MA , LuoS, LuL et al. Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity. AIDS 26(11) , F21–F29 (2012).
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