Role of Interactions in Pharmacogenetic Studies: Leukotrienes in Asthma

• Zuk O , HechterE, SunyaevSR, LanderES. The mystery of missing heritability: genetic interactions create phantom heritability. Proc. Natl Acad. Sci. USA109(4) , 1193–1198 (2012).
   PubMed Web of Science ®Google Scholar
• Manolio TA , CollinsFS, CoxNJ et al. Finding the missing heritability of complex diseases. Nature 461(7265) , 747–753 (2009).
   PubMed Web of Science ®Google Scholar
• Kidd JM , CooperGM, DonahueWF et al. Mapping and sequencing of structural variation from eight human genomes. Nature 453(7191) , 56–64 (2008).
   PubMed Web of Science ®Google Scholar
• McCarroll SA , HuettA, KuballaP et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn‘s disease. Nat. Genet. 40 , 1107–1112 (2008).
   PubMed Web of Science ®Google Scholar
• Willer CJ , SpeliotesEK, LoosRJ et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41 , 25–34 (2009).
   PubMed Web of Science ®Google Scholar
• Helbig I , MeffordHC, SharpAJ et al. 15q13.3 microdeletions increase risk of idiopathic generalized epilepsy. Nat. Genet. 41 , 160–162 (2009).
   PubMed Web of Science ®Google Scholar
• Sharp AJ , MeffordHC, LiK et al. A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures. Nat. Genet. 40 , 322–328 (2008).
   PubMed Web of Science ®Google Scholar
• Via M , GignouxC, BurchardEG. The 1000 Genomes Project: new opportunities for research and social challenges. Genome Med.2(1) , 3 (2010).
   PubMedGoogle Scholar
• The 1000 Genomes Project Consortium, Abecasis GR, Auton A, Brooks LD et al. An integrated map of genetic variation from 1,092 human genomes. Nature491(7422) , 56–65 (2012).
   PubMed Web of Science ®Google Scholar
• Spencer CC , SuZ, DonnellyP, MarchiniJ. Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet.5(5) , e1000477 (2009).
   PubMed Web of Science ®Google Scholar
• Horgan AM , YangB, AzadAK et al. Pharmacogenetic and germline prognostic markers of lung cancer. J. Thorac. Oncol. 6(2) , 296–304 (2011).
   PubMed Web of Science ®Google Scholar
• Fisher MC , CronsteinBN. Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity. J. Rheumatol.36(3) , 539–545 (2009).
   PubMed Web of Science ®Google Scholar
• Visscher PM , BrownMA, McCarthyMI, YangJ. Five years of GWAS discovery. Am. J. Hum. Genet.90(1) , 7–24 (2012).
   PubMed Web of Science ®Google Scholar
• Torgerson DG , AmplefordEJ, ChiuGY et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat. Genet. 43(9) , 887–892 (2011).
   PubMed Web of Science ®Google Scholar
• Burchard EG , ZivE, CoyleN et al. The importance of race and ethnic background in biomedical research and clinical practice. N. Engl. J. Med. 348(12) , 1170–1175 (2003).
   PubMed Web of Science ®Google Scholar
• Bustamante CD , BurchardEG, de la Vega FM. Genomics for the world. Nature475(7355) , 163–165 (2011).
   PubMed Web of Science ®Google Scholar
• Gifford AL , CunninghamWE, HeslinKC et al. Participation in research and access to experimental treatments by HIV-infected patients. N. Engl. J. Med. 346 , 1373–1382 (2002).
   PubMed Web of Science ®Google Scholar
• Visscher PM , HillWG, WrayNR. Heritability in the genomics era – concepts and misconceptions. Nat. Rev. Genet.9(4) , 255–266 (2008).
   PubMed Web of Science ®Google Scholar
• Kelly TN , HeJ. Genomic epidemiology of blood pressure salt sensitivity. J. Hypertens.30(5) , 861–873 (2012).
   PubMed Web of Science ®Google Scholar
• Rose AM , BellLC. Epistasis and immunity: the role of genetic interactions in autoimmune diseases. Immunology137(2) , 131–138 (2012).
   PubMed Web of Science ®Google Scholar
• Berlanga-Taylor AJ , DisantoG, EbersGC, RamagopalanSV. Vitamin D-gene interactions in multiple sclerosis. J. Neurol. Sci.311(1–2) , 32–36 (2011).
   PubMed Web of Science ®Google Scholar
• Peters-Golden M , HendersonWR Jr. Leukotrienes. N. Engl. J. Med.357 , 1841–1854 (2007).
   PubMed Web of Science ®Google Scholar
• Malmstrom K , Rodriguez-GomezG, GuerraJ et al. Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast/Beclomethasone Study Group. Ann. Intern. Med. 130 , 487–495 (1999).
   PubMed Web of Science ®Google Scholar
• Szefler SJ , PhillipsBR, MartinezFD et al. Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J. Allergy Clin. Immunol. 115 , 233–242 (2005).
   PubMed Web of Science ®Google Scholar
• Rovati GE , BaroffioM, CitroS et al. Cysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma. Respir. Res. 7 , 103 (2006).
   PubMed Web of Science ®Google Scholar
• Burchard EG , AvilaPC, NazarioS et al. Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am. J. Respir. Crit. Care Med. 169 , 386–392 (2004).
   PubMed Web of Science ®Google Scholar
• Choudhry S , UngN, AvilaPC et al. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am. J. Respir. Crit. Care Med. 171 , 563–570 (2005).
   PubMed Web of Science ®Google Scholar
• Tcheurekdjian H , ThyneSM, WilliamsLK et al. Augmentation of bronchodilator responsiveness by leukotriene modifiers in Puerto Rican and Mexican children. Ann. Allergy Asthma Immunol. 102(6) , 510–517 (2009).
   PubMed Web of Science ®Google Scholar
• Via M , De Giacomo A, Corvol H et al. The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. Clin. Exp. Allergy40(4) , 582–589 (2010).
   PubMed Web of Science ®Google Scholar
• Tcheurekdjian H , ViaM, de Giacomo A et al.ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos. J. Allergy Clin. Immunol.126(4) , 853–858 (2010).
   PubMed Web of Science ®Google Scholar
• Helgadottir A , ManolescuA, ThorleifssonG et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat. Genet. 36(3) , 233–239 (2004).
   PubMed Web of Science ®Google Scholar
• Mougey EB , ChenC, TantisiraKG et al. Pharmacogenetics of asthma controller treatment. Pharmacogenomics J. doi:10.1038/tpj.2012.5 (2012) (Epub ahead of print).
   PubMed Web of Science ®Google Scholar
• Harper AR , TopolEJ. Pharmacogenomics in clinical practice and drug development. Nat. Biotechnol.30(11) , 1117–1124 (2012).
   PubMed Web of Science ®Google Scholar
• Min JL , TaylorJM, RichardsJB et al. The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits. PLoS ONE 6(7) , e22070 (2011).
   PubMed Web of Science ®Google Scholar
• Maranville JC , LucaF, RichardsAL et al. Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes. PLoS Genet. 7(7) , e1002162 (2011).
   PubMed Web of Science ®Google Scholar
• Mishiro T , IshiharaK, HinoS et al. Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster. EMBO J. 28(9) , 1234–1245 (2009).
   PubMed Web of Science ®Google Scholar

▪ Websites

• A catalog of published genome-wide association studies. www.genome.gov/gwastudies (Accessed 17October2012).
   Google Scholar
• The 1000 Genomes Project. www.1000genomes.org
   Google Scholar
• Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention (2011). www.ginasthma.org (Accessed 3December2012).
   Google Scholar
• NCBI database of Genotypes and Phenotypes (dbGaP). www.ncbi.nlm.nih.gov/gap
   Google Scholar