CYP3A4*22 and CYP3A Combined Genotypes Both Correlate With Tacrolimus Disposition in Pediatric Heart Transplant Recipients

• Penninga L , M⊘llerCH, GustafssonF, SteinbrüchelDA, GluudC. Tacrolimus versus cyclosporine as primary immunosuppression after heart transplantation: systematic review with meta-analyses and trial sequential analyses of randomised trials. Eur. J. Clin. Pharmacol.66(12) , 1177–1187 (2010).
   PubMed Web of Science ®Google Scholar
• Robinson BV , BoyleGJ, MillerSA et al. Optimal dosing of intravenous tacrolimus following pediatric heart transplantation. J. Heart Lung Transplant. 18(8) , 786–791 (1999).
   PubMed Web of Science ®Google Scholar
• Aidong W , ZhenjieC, TongL et al. Therapeutic drug monitoring of tacrolimus in early stage after heart transplantation. Transplant. Proc. 36(8) , 2388–2389 (2004).
   PubMed Web of Science ®Google Scholar
• Staatz CE , GoodmanLK, TettSE. Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I. Clin. Pharmacokinet.49(3) , 141–175 (2010).
   PubMed Web of Science ®Google Scholar
• Kniepeiss D , RennerW, TrummerO et al. The role of CYP3A5 genotypes in dose requirements of tacrolimus and everolimus after heart transplantation. Clin. Transplant. 25(1) , 146–150 (2011).
   PubMed Web of Science ®Google Scholar
• Zheng H , WebberS, ZeeviA et al. Tacrolimus dosing in pediatric heart transplant patients is related to CYP3A5 and MDR1 gene polymorphisms. Am. J. Transplant. 3(4) , 477–483 (2003).
   PubMed Web of Science ®Google Scholar
• Gijsen V , MitalS, van Schaik RH et al. Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients. J. Heart Lung Transplant.30(12) , 1352–1359 (2011).
   PubMed Web of Science ®Google Scholar
• Danielson PB . The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr. Drug Metab.3(6) , 561–597 (2002).
   PubMed Web of Science ®Google Scholar
• Lamba JK , LinYS, SchuetzEG, ThummelKE. Genetic contribution to variable human CYP3A-mediated metabolism. Adv. Drug Deliv. Rev.54(10) , 1271–1294 (2002).
   PubMed Web of Science ®Google Scholar
• Shimada T , YamazakiH, MimuraM, InuiY, GuengerichFP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther.270(1) , 414–423 (1994).
   PubMed Web of Science ®Google Scholar
• Westlind A , LöfbergL, TindbergN, AnderssonTB, Ingelman-SundbergM. Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5´-upstream regulatory region. Biochem. Biophys. Res. Commun.259(1) , 201–205 (1999).
   PubMed Web of Science ®Google Scholar
• Westlind-Johnsson A , MalmeboS, JohanssonA et al. Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. Drug Metab. Dispos. 31(6) , 755–761 (2003).
   PubMed Web of Science ®Google Scholar
• Wang D , GuoY, WrightonSA, CookeGE, SadeeW. Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs. Pharmacogenomics J.11(4) , 274–286 (2011).
   PubMed Web of Science ®Google Scholar
• Elens L , van Schaik RH, Panin N et al. Effect of a new functional CYP3A4 polymorphism on calcineurin inhibitors‘ dose requirements and trough blood concentrations in stable renal transplant patients. Pharmacogenomics12(10) , 1383–1396 (2011).
   PubMed Web of Science ®Google Scholar
• Elens L , BouamarR, HesselinkDA et al. A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients. Clin. Chem. 57(11) , 1574–1583 (2011).
   PubMed Web of Science ®Google Scholar
• Stewart S , WintersGL, FishbeinMC et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J. Heart Lung Transplant. 24(11) , 1710–1720 (2005).
   PubMed Web of Science ®Google Scholar
• Schwartz GJ , BrionLP, SpitzerA. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr. Clin. North Am.34(3) , 571–590 (1987).
   PubMed Web of Science ®Google Scholar
• Volosov A , NapoliKL, SoldinSJ. Simultaneous simple and fast quantification of three major immunosuppressants by liquid chromatography–tandem mass-spectrometry. Clin. Biochem.34(4) , 285–290 (2001).
   PubMed Web of Science ®Google Scholar
• van Schaik RHN , van der Heiden IP, van den Anker JN, Lindemans J. CYP3A5 variant allele frequencies in Dutch Caucasians. Clin. Chem.48(10) , 1668–1671 (2002).
   PubMed Web of Science ®Google Scholar
• Hesselink DA , van Schaik RHN, van der Heiden IP et al. Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus. Clin. Pharmacol. Ther.74(3) , 245–254 (2003).
   PubMed Web of Science ®Google Scholar
• Rodriguez S , GauntTR, DayINM. Hardy–Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am. J. Epidemiol.169(4) , 505–514 (2009).
   PubMed Web of Science ®Google Scholar
• Leeder JS . Developmental and pediatric pharmacogenomics. Pharmacogenomics4(3) , 331–341 (2003).
   PubMed Web of Science ®Google Scholar
• Blake MJ , CastroL, LeederJS, KearnsGL. Ontogeny of drug metabolizing enzymes in the neonate. Semin. Fetal Neonatal Med.10(2) , 123–138 (2005).
   PubMed Web of Science ®Google Scholar
• Kearns GL , Abdel-RahmanSM, AlanderSW, BloweyDL, LeederJS, KauffmanRE. Developmental pharmacology – drug disposition, action, and therapy in infants and children. N. Engl. J. Med.349(12) , 1157–1167 (2003).
   PubMed Web of Science ®Google Scholar
• Malluche H , SawayaBP, HakimRM, SayeghMH. Clinical Nephrology, Dialysis and Transplantation. Dustri-Verlag, FL, USA (2004).
   Google Scholar
• Urbschat A , ObermüllerN, HaferkampA. Biomarkers of kidney injury. Biomarkers.16(Suppl. 1) , S22–30 (2011).
   PubMed Web of Science ®Google Scholar

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• Home Page of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee. www.cypalleles.ki.se
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