Advanced search
Publication Cover
Pharmacogenomics Volume 15, 2014 - Issue 5
Submit an article Journal homepage
846
Views
0
CrossRef citations to date
0
Altmetric
Research Article

How Common are Drug and Gene Interactions? Prevalence in a Sample of 1143 Patients with CYP2C9, CYP2C19 and CYP2D6 Genotyping

Paul Verbeurgt1 Genelex Corporation, 3101 Western Avenue #100, Seattle, WA98121, USACorrespondence[email protected]
View further author information
,
Tyler Mamiya1 Genelex Corporation, 3101 Western Avenue #100, Seattle, WA98121, USAView further author information
&
Jessica Oesterheld1 Genelex Corporation, 3101 Western Avenue #100, Seattle, WA98121, USAView further author information
Pages 655-665 | Published online: 05 May 2014

References

  • WHO. International drug monitoring: the role of national centres. Report of a WHO meeting. World Health Organ. Tech. Rep. Ser.498 , 1–25 (1972).
  • FDA. Safe use initiative: collaborating to reduce preventable harm from medications (2009). www.fda.gov/downloads/drugs/drugsafety/ucm188961.pdf
  • Centers for Disease Control and Prevention: Medication Safety Programme (2010). www.cdc.gov/medicationsafety/basics.html
  • Lazarou J , PomeranzBH, CoreyPN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA279(15) , 1200–1205 (1998).
  • Giacomini KM , KraussRM, RodenDM, EichelbaumM, HaydenMR, NakamuraY. When good drugs go bad. Nature446(7139) , 975–977 (2007).
  • Phillips KA , VeenstraDL, OrenE, LeeJK, SadeeW. Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review. JAMA286(18) , 2270–2279 (2001).
  • Ingelman-Sundberg M . Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future. Trends Pharmacol. Sci.25(4) , 193–200 (2004).
  • Hisaka A , OhnoY, YamamotoT, SuzukiH. Prediction of pharmacokinetic drug–drug interaction caused by changes in cytochrome P450 activity using in vivo information. Pharmacol. Ther.125(2) , 230–248 (2010).
  • Sanchez Munoz-Torrero JF , BarquillaP, VelascoR et al. Adverse drug reactions in internal medicine units and associated risk factors. Eur. J. Clin. Pharmacol. 66(12) , 1257–1264 (2010).
  • Tulner LR , FrankfortSV, GijsenGJ, Van Campen JP, Koks CH, Beijnen JH. Drug–drug interactions in a geriatric outpatient cohort: prevalence and relevance. Drugs Aging25(4) , 343–355 (2008).
  • Marzolini C , ElziL, GibbonsS et al. Prevalence of comedications and effect of potential drug–drug interactions in the Swiss HIV Cohort study. Antivir. Ther. 15(3) , 413–423 (2010).
  • Smithburger PL , Kane-GillSL, SeybertAL. Drug–drug interactions in cardiac and cardiothoracic intensive care units: an analysis of patients in an academic medical centre in the US. Drug Saf.33(10) , 879–888 (2010).
  • Mino-Leon D , Galvan-PlataME, DoubovaSV, Flores-HernandezS, Reyes-MoralesH. A pharmacoepidemiological study of potential drug interactions and their determinant factors in hospitalized patients. Rev. Invest. Clin.63(2) , 170–178 (2011).
  • Lamy PP . The elderly and drug interactions. J. Am. Geriatr. Soc.34(8) , 586–592 (1986).
  • Magro L , MorettiU, LeoneR. Epidemiology and characteristics of adverse drug reactions caused by drug–drug interactions. Expert Opin. Drug Saf.11(1) , 83–94 (2012).
  • Glintborg B , AndersenS, DalhoffK. Drug–drug interactions among recently hospitalised patients – frequent but mostly clinically insignificant. Eur. J. Clin. Pharmacol.61(9) , 675–681 (2005).
  • Obreli-Neto PR , NobiliA, De Oliveira Baldoni A et al. Adverse drug reactions caused by drug–drug interactions in elderly outpatients: a prospective cohort study. Eur. J. Clin. Pharmacol.68(12) , 1667–1676 (2012).
  • Kurfees JF , DotsonRL. Drug interactions in the elderly. J. Fam. Pract.25(5) , 477–488 (1987).
  • Tamai I , StromeL, MarshallC, MooradianA. Analysis of drug–drug interactions among nursing home residents. Am. J. Hosp. Pharm.46(8) , 1567–1569 (1989).
  • Kohler GI , Bode-BogerSM, BusseR, HoopmannM, WelteT, BogerRH. Drug–drug interactions in medical patients: effects of in-hospital treatment and relation to multiple drug use. Int. J. Clin. Pharmacol. Ther.38(11) , 504–513 (2000).
  • Karczewski KJ , DaneshjouR, AltmanRB. Chapter 7: Pharmacogenomics. In: PLoS Comput. Biol. Lewitter F, Kann M (Eds) (2012).
  • Conrado DJ , RogersHL, ZinehI, PacanowskiMA. Consistency of drug–drug and gene–drug interaction information in US FDA-approved drug labels. Pharmacogenomics14(2) , 215–223 (2013).
  • Peterson JF , BowtonE, FieldJR et al. Electronic health record design and implementation for pharmacogenomics: a local perspective. Genet. Med. Official J. Am. Coll. Med. Genet. 15(10) , 833–841 (2013).
  • Tod M , Nkoud-MongoC, GueyffierF. Impact of genetic polymorphism on drug–drug interactions mediated by cytochromes: a general approach. AAPS J.15(4) , 1242–1252 (2013).
  • Kubica A , KozinskiM, GrzeskG, FabiszakT, NavareseE, GochA. Genetic determinants of platelet response to clopidogrel. J. Thromb. Thrombolysis32(4) , 459–466 (2011).
  • Bjorkman IK , FastbomJ, SchmidtIK, BernstenCB. Pharmaceutical care of the elderly in europe research G: drug–drug interactions in the elderly. Ann. Pharmacother.36(11) , 1675–1681 (2002).
  • Kisor DF , MunroC, LoudermilkE. Pharmacogenomics and the most commonly prescribed drugs of 2011. Pharm. Times (2012). www.pharmacytimes.com/publications/issue/2012/December2012/Pharmacogenomics-and-the-Most-Commonly-Prescribed-Drugs-of-2011
  • Mikus G , SchowelV, DrzewinskaM et al. Potent cytochrome P450 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir. Clin. Pharmacol. Ther. 80(2) , 126–135 (2006).
  • Gschwind L , RollasonV, BoehlenF et al. Impact of CYP2C9 polymorphisms on the vulnerability to pharmacokinetic drug–drug interactions during acenocoumarol treatment. Pharmacogenomics 14(7) , 745–753 (2013).
  • Sim SC . The human cytochrome P450 (CYP) allele nomenclature database (2013). www.cypalleles.ki.se
  • Patterson R , OesterheldJO. Genetic data analysis and database tools. US Patent #US8311851 (2012). www.google.com/patents/US8311851
  • Patterson R , OesterheldJO. Genetic data analysis and database tools. US patent #US8099298 (2012). www.google.com/patents/US8311851
  • Villagra D , GoetheJ, SchwartzHI et al. Novel drug metabolism indices for pharmacogenetic functional status based on combinatory genotyping of CYP2C9, CYP2C19 and CYP2D6 genes. Biomarkers 5(4) , 427–438 (2011).
  • Zakrzewski-Jakubiak H , DoanJ, LamoureuxP, SinghD, TurgeonJ, TannenbaumC. Detection and prevention of drug–drug interactions in the hospitalized elderly: utility of new cytochrome P450–based software. Am. J. Geriatr. Pharmacother.9(6) , 461–470 (2011).
  • Hoffmann W , Van Den Berg N, Thyrian JR, Fiss T. Frequency and determinants of potential drug–drug interactions in an elderly population receiving regular home visits by GPs–results of the home medication review in the AGnES-studies. Pharmacoepidemiol. Drug Saf.20(12) , 1311–1318 (2011).
  • Lin CF , WangCY, BaiCH. Polypharmacy, aging and potential drug–drug interactions in outpatients in Taiwan: a retrospective computerized screening study. Drugs Aging28(3) , 219–225 (2011).
  • Heuberger R . Polypharmacy and food–drug interactions among older persons: a review. J. Nutr. Gerontol. Geriatr.31(4) , 325–403 (2012).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.