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Review

Role of β-Blocker Therapy in Pediatric Heart Failure

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Pages 45-58 | Published online: 25 Jan 2010

Bibliography

  • Towbin JA , LoweAM, ColanSD, SleeperLAet al.: Incidence, causes and outcomes of dilated cardiomyopathy in children: findings from the Pediatric Cardiomyopathy Registry.JAMA296(15), 1867–1876(2006).
  • Nugent AW , DaubeneyPE, ChondrosPet al.: The epidemiology of childhood cardiomyopathy in Australia.N. Engl. J. Med.(348), 1639–1646(2003).
  • Hoffman J , KaplanS: The incidence of congenital heart disease.J. Am. Coll. Cardiol.39(12), 1890–1900(2002).
  • Kay JD , ColanSD, GrahamTP: Congestive heart failure in pediatric patients.Am. Heart J.142(5), 923–928(2001).
  • Kirk R , EdwardsLB, AuroraPet al.: Registry of the Internation Society of of Heart and Lung Transplantation: Eleventh Official Pediatric Heart Transplantation Report – 2008.J. Heart Lung Transplant.27(9), 970–977(2008).
  • Harmon WG , SleeperLA, CunibertiLet al.: Treating children with idiopathic dilated cardiomyopathy (from the Pediatric Cardiomyopathy Registry).Am. J. Cardiol.104(2), 281–286(2009).
  • Rosenthal D , ChrisantM, EdenEet al.: International Society for Heart and Lung Transplantion: Practice guidelines for management of heart failure in children.J. Heart Lung Transplant.23(12), 1313–1333(2004)
  • Shaddy RE : Paediatric heart failure trials and tribulations.Cardiol. Young17, 354–355(2007).
  • Bristow MR : Mechanisms of action of β-blocking agents in heart failure.Am. J. Cardiol.80(11A), 26L–40L (1997).
  • Cohn JN , FerrariR, SharpeN: Cardiac remodeling-concepts and clinical implications: a concensus paper from an international forum on cardiac remodeling. behalf of an International Forum on Cardiac Remodeling.J. Am. Coll. Cardiol.35(3), 569–582(2000).
  • Colucci WS , SawyerDB, SinghK, CommunalC: Adrenergic overload and apoptosis in heart failure: implications for therapy.J. Card. Fail.6(2 Suppl. 1), 1–7(2000).
  • Port JD , BristowMR: Altered β-adrenergic receptor gene regulation and signaling in chronic heart failure.J. Mol. Cell. Cardiol.33(5), 887–905(2001).
  • Floras J : Sympathetic nervous system activiation in human heart failure: clinical implications of an updated model.J. Am. Coll. Cardiol.54(5), 375–385(2009).
  • Gilbert EM , AndersonJL, DeitchmanDet al.: Long-term β blocker vasodilator therapy improves cardiac function idiopathic dilated cardiomyopathy: a double-blinded randomized study of bucindolol vs. placebo.Am. J. Med.88(3), 223–228(1990).
  • Waagstein F , BristowMR, SwedbergKet al.: Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial.Lancet342(8885), 1441–1446(1993).
  • CIBIS Investigators: A randomized trial of β-blockers in heart failure. The Cardiac Insufficiency Bisoprolol Study. Circulation90, 1765–1773(1994).
  • Bristow MR , GilbertEM, AbrahamWT: Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators.Circulation94(11), 2807–2816(1996).
  • Colucci WS , PackerM, BristowMRet al.: Carvedilol inhibits clinical progression in patients with mild symptoms of heart failure. US Carvedilol Heart Failure Study Group.Circulation94(11), 2800–2806(1996).
  • Packer M , BristowMR, CohnJNet al.: The effect of carvedilol on morbidity and mortality in patients with chronic heart failure.N. Engl. J. Med.334(21), 1349–1355(1996).
  • Packer M , ColluciWS, Sankner-BernsteinJDet al.: Double-blind, placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure. The PRECISE Trial. Prospective randomized evaluation of carvedilol on symptoms and exercise.Circulation94(11), 2793–2799(1996).
  • Lechat P , EscolanoS, GolmardJLet al.: Prognostic value of bisoprolol-induced hemodynamic effects in heart failure during the Cardiac Insufficiency Bisoprolol study (CIBIS).Circulation96, 2197–2205(1997).
  • CIBIS II Investigators: The Cardiac Insufficiency Bisoprolol study (CIBIS-II). Lancet353, 9–13(1999).
  • Hjalmarson A , GoldsteinS, FagerbergBet al.: Effect of metoprolol CR/XL in chronic heart failure: metoprolol CR/XL randomized intervention trial in congestive heart failure.Lancet353, 2001–2007(1999).
  • Hialmarson A , GoldsteinS, FagerbergBet al.: Effect of controlled-release metoprolol on total mortality, hospitalization and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure MERIT-HF Study Group.JAMA283, 1295–1302(2000).
  • Fowler MB , Vera-LlnchM, OsterGet al.: Influence of carvedilol on hospitalizations in heart failure: incidence, resource utilization and costs. U.S. Carvedilol Heart Failure Study Group.J. Am. Coll. Cardiol.37, 1692–1699(2001).
  • Packer M , CoatsAJ, FowlerMBet al.: Effect of carvedilol on survival in severe chronic heart failure. Carvedilol Prospective Randomized Cumulative Survival study group.N. Engl. J. Med.344(22), 1651–1658(2001).
  • BEST Trial Investigators: A trial of the β-blocker bucindolol in patients with advanced chronic heart failure. N. Engl. J. Med.344(22), 1659–1667(2001).
  • Leizorovicz A , LechatP, CucheratMet al.: Bisoprolol for the treatment of chronic heart failure: a meta-analysis on individual data of two placebo-controlled studies – CIBIS and CIBIS II. Cardiac Insufficiency Bisoprolol Study.Am. Heart J.143, 301–307(2002).
  • Packer M , FowlerMB, RoeckerEBet al.: Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) study. Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) study group.Circulation106, 2194–2199(2002).
  • Poole-Wilson PA , SwedbergK, ClelandJGet al.: Comparison of carvedilol and metroprolol on clincial outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomized control trial.Lancet362, 7–13(2003).
  • Poole-Wilson PA : Commentary on the Carvedilol or Metoprolol European Trial (COMET).Am J Cardiology.93(9A), 40B–2B (2004).
  • Flather MD , ShibataMC, CoatsAJet al.: Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS).Eur. Heart J.26(3), 215–225(2005).
  • Mann DL , BristowMR: Mechanisms and models in heart failure: the biomechanical model and beyond.Circulation111, 2837–2849(2005).
  • Bristow MR , GinsburgR, UmansVet al.: β1- and β2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes in muscle contraction and selective β1-receptor down-regulation in heart failure.Circ. Res.59(3), 297–309(1986).
  • Patel PA , TilleyDG, RockmanHA: β-arrestin-mediated signaling in the heart.Circ. J.72, 1725–1729(2008).
  • Pleger ST , BoucherM, MostP, KochWJ: Targeting myocardial β-adrenergic receptor signaling and calcium cycling for heart failure gene therapy.J. Cardiac Fail.13, 401–414(2007).
  • Gauthier C , TavernierGC, LanginD, Le Marec H: Functional β3-adrenoceptor in the human heart. Clin. Invest.98, 556–562(1996).
  • Gauthier C , Seze-GoismierC, RozeeB: β-3 adrenoreceptors in the cardiovascular system.Clin. Hemrheol. Microcirc.37, 193–204(2007).
  • Liggett SB , FreedmanNJ, SchwinnDA, LefkowitzRJ: Structural basis for receptor subtype-specific regulation revealed by a chimeric β-3/β-2 adrenergic receptor.Proc. Natl Acad. Sci.90, 3665–3669(1993).
  • Hort W : Quantitative histologische untersuchungen an wachsenden herzen.Virchows Arch.323, 223–242(1953).
  • Zak R : Development and proliferative capacity of cardiac muscle cells.Circ. Res.35, 17–26(1974).
  • Mahony L : Development of myocardial structure and function. In: Moss and Adams’ Heart Disease in Infants, Children, and Adolescents (7th Edition, Volume 1). Allen HD, Driscoll DJ, Shaddy RE, Feltes TF (Eds). Lippincott Williams & Wilkins, PA, USA, 573–592(2008).
  • Wittnich C , BelangerMP, BandaliK: Are there ventricle-specific postnatal maturational differences in myocardial β-adrenoceptors?Can. J. Physiol. Pharmacol.84, 859–865(2006).
  • Teitel DF , SidiD, ChinT: Developmental changes in myocardial contractile reserve in the lamb.Pediatr. Res.19(9), 948–955(1985).
  • Kozlik R , KramerHH, WichtH, KrianA, OstermeyerJ, ReinhardtD: Myocardial β-adrenoreceptor density and the distribution of β1- and β2-adrenoreceptor subpopulations in children with congenital heart disease.Eur. J. Pediatr.150, 388–394(1991).
  • Kozlik R , KramerHH, WichtH, BircksW, ReinhardtD: β-adrenoreceptor density on mononuclear leukocytes and right atrial myocardium in infants and children with congenital heart disease.Klin. Wochenschr.69, 910–916(1991).
  • Kozlik-Feldman R , KramerHH, WichtH, FeldmannR, NetzH, ReinhardtD: Distribution of myocardial β-adrenoceptor subtypes and coupling to the adenylate cyclase in children with congenital heart disease and implications for treatment.J. Clin. Pharmacol.33(7), 588–595(1993).
  • Dzimiri N , GalalO, MoorjiAet al.: Regulation of sympathetic activity in children with various congenital heart diseases.Pediatr. Res.38(1), 55–60(1995).
  • Wu JR , ChangHR, HuangTY, ChiangCH, ChenSS: Reduction in lymphocyte β-adrenergic receptor density in infants and children with heart failure secondary to congenital heart disease.Am. J. Cardiol.77, 170–174(1996).
  • Reithmann C , ReberD, Kozlik-FeldmannRet al.: A post-receptor defect of adenylyl cyclase in severely failing myocardium from children with congenital heart disease.Eur. J. Pharmacol.330, 79–86(1997).
  • Ohuchi H , HasegawaS, YasudaKet al.: Severly impaired cardiac autonomic nervous activity after the Fontan operation.Circulation104, 1513–1518(2001).
  • Buchhorn R , Hulpke-WetteM, RuschewskiWet al.: β-receptor downregulation in congenital heart disease: a risk factor for complications after surgical repair?Ann. Thorac. Surg.73(2), 610–613(2002).
  • Davos CH , DavlourosPA, WenselRet al.: Global impairment of cardiac autonomic nervous activity late after repair of Tetralogy of Fallot.Circulation106(12 Suppl. 1), I69–75(2002).
  • Bolger AP , SharmaR, LiWet al.: Neurohormal activiation and the chronic heart failure syndrome in adults with congenital heart disease.Circulation106(1), 92–99(2002).
  • Davos CH , FrancisDP, LeenartsMFet al.: Global impairment of cardiac autonomic nervous activity later after the Fontan operation.Circulation108(Suppl. 1), II80–II85 (2003).
  • Kaufman BD , DesaiM, ReddySet al.: Genomic profiling of left and right ventricular hypertrophy in congenital heart disease.J. Cardiac Fail.14(9), 760–767(2008)
  • Kalay N , BasarE, OzdogruIet al.: Protective effects of carvedilol against anthracycline-induced cardiomyopathy.J. Am. Coll. Cardiol.48, 2258–2262(2006).
  • Stock JP : β adrenergic blocking drugs in the clinical management of cardiac arrhythmias.Am. J. Cardiol.18, 444–449(1966).
  • Hunt SA , AbrahamW, ChinMet al.: ACC/AHA 2005 Guideline update for the diagnosis and management of chronic heart failure in the adult.Circulation112, E154–E235 (2005).
  • Bruns LA , CanterCE: Should β-blockers be used for the treatment of pediatric patients with chronic heart failure?Pediatr. Drugs4(12), 771–778(2002).
  • Foerster SR , CanterCE: Pediatric heart failure therapy with β-adrenoceptor antagonists.Pediatr. Drugs10(2), 125–134(2008).
  • Zebrack JS , MungerM, MacGregorJ, LombardiWL, StoddardGP, GilbertEM: β-receptor Selectivity of Carvedilol and Metoprolol Succinate in Patients with Heart Failure (SELECT trial): a randomized dose-ranging trial.Pharmacotherapy29(8), 883–890(2009).
  • Keating G , JarvisB: Carvedilol: a review of its use in chronic heart failure.Drugs63(16), 1697–1741(2003).
  • Okafor CC , Perreault-MicaleC, HajjarRJet al.: Chronic treatment with carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failure.BMC Physiol.3(6), 1–9(2003).
  • Gielser G , LenihanDJ, DurandJBet al.: The update on the rationale, use and selection of β-blockers in heart failure.Curr. Opin. Cardiol.19, 250–253(2004).
  • Udelson JE : Ventricular remodeling in heart failure and the effect of β-blockade.Am. J. Cardiol.93(9 Suppl. 1), 43–48(2004).
  • Al-Hesayan A , AzevedoE, FlorasJet al.: Selective versus nonselective β-adrenergic receptor blockade in chronic heart failure: differential effects on myocardial energy substrate utilization.Eur. J. Heart Fail.7, 618–623(2005).
  • Andreka P , AiyarN, OlsonLCet al.: Bucindolol displays intrinsic sympathomimetic activity in human myocardium.Circulation105, 2429–2434(2002).
  • Gan RT , LiWM, XiuCH: Chronic blocking of β 3-adrenoreceptor ameliorates cardiac function in rat model of heartfailure.Chinese Med. J.120(24), 2250–2255(2007).
  • Moniette S , BalligandJL: Potential use of β(3)-adrenoreceptor antagonists in heart failure therapy.Cardiovasc. Drug Rev.20(1), 19–26(2002).
  • Greenway SC , BensonLN: The use of carvedilol in pediatric heart failure.Cardiovasc. Hematol. Disord. Drug Targets6, 35–42(2006).
  • Laer S , MirTS, BehnFet al.: Carvedilol therapy in pedatric pateints with congestive heart failure: a study investigating clincal and pharmocokinetic parameters.Am. Heart J.143(5), 916–922(2002).
  • Albers S , MeibohmB, MirT, LaerS: Population pharmacokinetics and dose simulation of carvedilol in paediatric patients with congestive heart failure.Br. J. Clin. Pharmacol.65(4), 511–522(2007).
  • Azuma J , NonenS: Chronic heart failure: β-blockers and pharmacogenetics.Eur. J. Clin. Pharmacol.63, 3–17(2009).
  • Taylor MR : Pharmacogenetics of the human β-adrenergic receptors.Pharmacogenetics J.7, 29–37(2007).
  • Dorn GW , LiggettSB: Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure.Mol. Pharm.76, 466–480(2009).
  • Wagoner LE , CraftLL, ZengelP: Polymorphisms of the β1-adrenergic receptor predict exercise capacity in heart failure.Am. Heart J.144, 840–846(2002).
  • Mialet Perez J , RathzDA, PetrashevskayaNN: β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.Nat. Med.9, 1300–1305(2003).
  • Molenaar P , ChenL, SemmlerABet al.: Human heart β-adrenoreceptors: β1-adrenoreceptor diversification through affinity states’ and polymorphism.Clin. Exp. Pharmacol. Physiol.34, 1020–1028(2007).
  • Liggett S , Mialet-PerezJ, Thaneemit-ChenS: A polymorphism within a conserved β1 adrenergic receptor motif alters cardiac function and β-blocker response in human heart failure.Proc. Natl Acad. Sci.103, 11288–11293(2006).
  • White HL , de Boer RA, Maqbool A: An evaluation of the β1-adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-st. Eur. J. Heart Fail.5, 463–468(2003).
  • de Groote P , LamblinN, HelbecqueNet al.: The impact of β-adrenoreceptor gene polymorphisms on survival in patients with congestive heart failure.Eur. J. Heart Fail.7(6), 966–973(2005).
  • Sehnert AJ , DanielsSE, ElashoffMet al.: Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol and metoprolol.J. Am. Coll. Cardiol.52, 644–651(2008).
  • Packer M , AntonopoulosGV, BerlinJA, ChittamsJ, KonstamMA, UnderlsonJE: Comparative effects of carvedilol and metoprolol on left ventricular ejection fraction in heart failure: results of a meta-analysis.Am. Heart J.141(6), 899–907(2001).
  • Buchorn R , BartmusD, SiekmeyerW, Hulpke-WetteM, SchulzR, BurschJ: β-blocker therapy of severe congestiveheart failure in infants with left to right shunts.Am. J. Cardiol.81(11), 366–368(1998).
  • Buchhorn R , Hulpke-WetteM, HilgersR, BartmusD, WesselA, BurschJ: Propranolol treatment of congestive heart failure in infants with congenital heart disease: the CHF-PRO-INFANT Trial. Congestive heart failure in infants treated with propranolol.Int. J. Cardiol.79, 167–173(2001).
  • Buchhorn R , Hulpke-WetteM, RuschewskiW: Effects of therapeutic β blockade on myocardial function and cardiac remodeling in congenital cardiac disease.Cardiol. Young.13(1), 36–43(2003).
  • Shaddy RE , OlsenSL, BristowMRet al.: Efficacy and safety of metoprolol in the treatment of doxorubicin-induced cardiomyopathy in pediatric patients.Am. Heart J.129(1), 197–199(1995).
  • Shaddy RE : β-blocker therapy in young children with congestive heart failure under consideration for heart transplantation.Am. Heart J.136(1), 19–21(1998).
  • Shaddy RE , TaniLY, GiddingSSet al.: β-blocker treatment of dilated cardiomyopathy with congestive heart failure in children: a multi-institutional experience.J. Heart Lung Transplant.18(3), 269–274(1999).
  • Metra M , GiubbiniR, NodariS, BoldiE, ModenaMG, Dei Cas L: Differential effects of β-blockers in patients with heart failure: a prospective, randomized, double-blinded comparision of the long-term effects of metoprolol versus carvedilol. Circulation102(5), 546–551(2000).
  • Sanderson JE , ChanSK, YipGet al.: β-blockade in heart failure: a comparison of carvedilol with metoprolol.J. Am. Coll. Cardiol.34(5), 1522–1528(1999).
  • Williams RV , TaniLY, ShaddyRE: Intermediate effects of treatment with metoprolol or carvedilol in children with left ventricular systolic dsyfunction.J. Heart Lung Transplant.21(8), 906–909(2002).
  • Bruns LA , ChrisantMK, LamourJMet al.: Carvedilol as a therapy in pediatric heart failure: an inital multicenter experience.J. Pediatr.138(4), 505–511(2001).
  • Gachara N , PrabhakaranS, SrinivasS, FarzanaF, KrishanU, ShahM: Efficacy and safety of carvedilol in infants with dilated cardiomyopathy: a prelimanary report.Indian Heart J.53(1), 74–78(2001).
  • Lee KJ : Carvedilol in heart failure management: a pediatric experience.Can. J. Cardiology17(Suppl. C), 100C (2001).
  • Rusconi P , Gomez-MarinO, Rossique-GonzalezMet al.: Carvedilol in children with cardiomyopathy: 3 -year experience at a single institution.J. Heart Lung Transplant.23(7), 832–838(2004).
  • Azeka E , Franchini Ramires JA, Valler C, Alcides Bocchi E: Delisting of infants and children from the heart transplantation waiting list after carvedilol treatment. J. Am. Coll. Cardiol.40(11), 2034–2038(2002).
  • Blume ED , CanterCE, SpicerR, GauvreauK, ColanS, JenkinsKJ: Prospective single-arm protocol of carvedilol in children with ventricular dysfunction.Pediatric Cardiol.27(3), 326–342(2006).
  • Shaddy RE , BoucekMM, HsuDTet al.: Carvedilol for children and adolescents with heart failure.JAMA298(10), 1171–1179(2007).
  • Bajcetic M , KokicA, DjukicMet al.: Effects of carvedilol on left ventricular function and oxidative stress in infants and children with idiopathic dilated cardiomyopathy: a 12-month, two-center, open-label study.Clin. Ther.30(4), 702–714(2008).
  • Vonder Muhll I , LiuP, WebbG: Applying standard therapies to new targets: the use of ACE inhibitors and β-blockers for heart failure in adults with congenital heart disease.Int. J. Cardiol.97(Suppl. 1), 25–33(2004).
  • Lindenfeld J , KellerK, CampbellDet al.: Improved systemic ventricular function afer carvedilol adminstration in a patient with congenitally corrected transposition of the great arteries.J. Heart Lung Transplant.22, 198–201(2003).
  • Josephson C , HowlettJ, JacksonSet al.: A case series of systemic right ventricular dysfunction post atrial switch for simple D-transposition of the great arteries: the impact of β-blockade.Can. J. Cardiol.22(9), 769–772(2006).
  • Doughan AR , McConnellME, BookWM: Effect of β-blockers (carvedilol or metroprolol XL) in patients with transposition of great Arteries and dysfunction of the systemic right ventricle.Am. J. Cardiol.99(5), 704–706(2007).
  • McAlister FA , EzekowitzJ, HootonNet al.: Cardiac resynchronization therapy for patients with left ventricular systolic dysfunction: a systemic review.JAMA297(22), 2502–2514(2007).
  • Veldtman GR , NishimotoA, SiuSet al.: The Fontan procedure in adults.Heart86, 330–335(2001).
  • Gelatt M , HamiltonRM, McCrindleBWet al.: Arrhythmia and mortality following the mustard procedure: a 30 year, single center experience.J. Am. Coll. Cardiol.29, 194–201(1997).
  • Grahram TP , BernardYD, MellenBGet al.: Long-term outcome in congenitally corrected transposition of the great arteries: a multi-institutional study.J. Am. Coll. Cardiol.36, 255–261(2000).
  • Millane T , BernardEJ, JaeggiEet al.: Role of ischemia and infarction in late right ventricular dysfunction after atrial repair of transposition of the great arteries.J. Am. Coll. Cardiol.35, 1661–1668(2000).
  • Piran S , VeldtmanG, SiuSet al.: Heart Failure and ventricular dysfunction in patients with single or systemic right ventricles.Circulation105, 1189–1194(2002).
  • Rutledge JM , NihillMR, FraserCDet al.: Outcome of 121 patients wtih congenitally corrected transposition of the great arteries.Pediatr. Cardiol.23, 137–145(2002).
  • Eicken A , FratzS, GutfriedCet al.: Hearts late after Fontan have normal mass, normal volume, and reduced systolic function.J. Am. Coll. Card.42(6), 1061–1065(2003).
  • Ishibashi N , ParkIS, TakahashiYet al.: Effectiveness of carvedilol for congestive heart failure that developed long after modified Fontan operation.Pediatr. Cardiol.27(4), 473–475(2006).
  • Norozi K , BahlmannJ, RaabBet al.: A prospective, randomized, double-blinded, placebo controlled trial of β-blockade in patients who have undergone surgical correction of Tetralogy of Fallot.Cardiol. Young.17, 372–379(2007).
  • Nororzi K , BuchhornR, WesselAet al.: β-blockade does not alter plasma cytokine concentrations and ventricular function in young adults with right ventricular dysfunction secondary to operated congenital heart disease.Circ. J.72, 747–752(2008).
  • Mukai Y , YoshidaT, NakaiakeRet al.: Five cases of anthracycline-induced cardiomyopathy effectively treated with carvedilol.Intern. Med.43(11), 1087–1088(2004).
  • Carreira RS , MonteiroLM, GoncalvesLM, ProvidenciaLA: Carvedilol: just another β-blocker or a powerful cardioprotector?Cardiovasc. Hematol. Disord. Drug Targets6, 257–266(2006).
  • Machado V , CabralA, MonteiroPet al.: Carvedilol as a protector againstthe cardiotoxicity induced by antracyclines (doxorubicin).Revista Portuguesa de Cardiologia27(10), 1277–1296(2008).
  • Ishikawa Y , BachJ, MinamiR: Cardioprotection for Duchenne‘s muscular dystrophy.Am. Heart J.137, 895–902(1999).
  • Kajimoto H , IshigakiK, OkumuraKet al.: β-blocker therapy for cardiac dysfunction in patients with muscular dystrophy.Circ. J.70, 991–994(2006).
  • Nishizawa T , YasumaF: The preventive efficacy of carvedilol on cardiac dysfunction in duchenne muscular dystrophy. clinicaltrials.gov indentifier: Current Study NCT00606775, 2007–2012.
  • Hunt SA , AbrahamWT, ChinMHet al.: 2009 Focused update incorporatedinto the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines.Circulation119, E391–E479 (2009).
  • Kaufman BD , ShaddyRE: β-adrenergic receptor blockade and pediatric dilated cardiomyopathy.Prog. Pediatr. Cardiol.24(1), 51–57(2007).

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