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Personalized Medicine Volume 14, 2017 - Issue 2
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Research Article

The Influence of a Gene-Expression Signature on the Treatment of Diagnostically Challenging Melanocytic Lesions

Clay Cockerell1 Cockerell Dermatopathology & University of Texas Southwestern Medical Center, 2110 Research Row #100, Dallas, TX 75235, USAView further author information
,
Jaime Tschen2 St Joseph Medical Center, 6909 Greenbriar Drive, Houston, TX 77030, USAView further author information
,
Steven D Billings3 Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44106, USAView further author information
,
Brent Evans4 Myriad Genetic Laboratories, Inc., 320 Wakara Way, Salt Lake City, UT 84108, USAView further author information
,
Krystal Brown4 Myriad Genetic Laboratories, Inc., 320 Wakara Way, Salt Lake City, UT 84108, USAView further author information
,
Colleen Rock4 Myriad Genetic Laboratories, Inc., 320 Wakara Way, Salt Lake City, UT 84108, USAView further author information
&
Loren E Clarke4 Myriad Genetic Laboratories, Inc., 320 Wakara Way, Salt Lake City, UT 84108, USACorrespondence[email protected]
View further author information
 show all
Pages 123-130 | Received 21 Nov 2016, Accepted 03 Jan 2017, Published online: 23 Jan 2017

References

  • Surveillance E, And End Results Program . SEER stat fact sheets: melanoma of the skin ( 2016 ). https://seer.cancer.gov/statfacts/html/melan.html .
  • Society AC . Survival rates for melanoma skin cancer, by stage ( 2016 ). www.cancer.org/cancer/skincancer-melanoma/detailedguide/melanoma-skin-cancer-survival-rates-by-stage .
  • Farmer ER , GoninR , HannaMP . Discordance in the histopathologic diagnosis of melanoma and melanocytic nevi between expert pathologists . Hum. Pathol.27 ( 6 ), 528 – 531 ( 1996 ).
  • Shoo BA , SagebielRW , Kashani-SabetM . Discordance in the histopathologic diagnosis of melanoma at a melanoma referral center . J. Am. Acad. Dermatol.62 ( 5 ), 751 – 756 ( 2010 ).
  • Hawryluk EB , SoberAJ , PirisAet al. Histologically challenging melanocytic tumors referred to a tertiary care pigmented lesion clinic . J. Am. Acad. Dermatol.67 ( 4 ), 727 – 735 ( 2012 ).
  • McGinnis KS , LessinSR , ElderDEet al. Pathology review of cases presenting to a multidisciplinary pigmented lesion clinic . Arch. Dermatol.138 ( 5 ), 617 – 621 ( 2002 ).
  • Veenhuizen KC , De WitPE , MooiWJ , SchefferE , VerbeekAL , RuiterDJ . Quality assessment by expert opinion in melanoma pathology: experience of the pathology panel of the Dutch Melanoma Working Party . J. Pathol.182 ( 3 ), 266 – 272 ( 1997 ).
  • Bastian BC , OlshenAB , LeboitPE , PinkelD . Classifying melanocytic tumors based on DNA copy number changes . Am. J. Pathol.163 ( 5 ), 1765 – 1770 ( 2003 ).
  • Clarke LE , WarfBM , FlakeDD2ndet al. Clinical validation of a gene-expression signature that differentiates benign nevi from malignant melanoma . J. Cutan. Pathol.42 ( 4 ), 244 – 252 ( 2015 ).
  • Gerami P , JewellSS , MorrisonLEet al. Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma . Am. J. Surg. Pathol.33 ( 8 ), 1146 – 1156 ( 2009 ).
  • Gerami P , LiG , PouryazdanparastPet al. A highly specific and discriminatory FISH assay for distinguishing between benign and malignant melanocytic neoplasms . Am. J. Surg. Pathol.36 ( 6 ), 808 – 817 ( 2012 ).
  • Administration FaD . Draft Guidance for Industry, Food and Drug Administration Staff, and Clinical Laboratories: Framework for Regulatory Oversight of Laboratory Developed Tests (LDTs) ( 2014 ). www.fda.gov/downloads/medicaldevices/deviceregulationandguidance/guidancedocuments/ucm416685.pdf .
  • Haddow JE , PalomakiGE . ACCE: a model process for evaluating data on emerging genetic tests . In : Human Genome Epidemiology: A Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease . Oxford University Press , 217 – 233 ( 2003 ).
  • Teutsch SM , BradleyLA , PalomakiGEet al. The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: methods of the EGAPP working group . Genet. Med.11 ( 1 ), 3 – 14 ( 2009 ).
  • Clarke LE , FlakeDD2nd , BusamKet al. An independent validation of a gene-expression signature to differentiate malignant melanoma from benign melanocytic nevi . Cancer doi: 10.1002/cncr.30385 ( 2016 ) ( Eub ahead of print ).
  • Warf MB , FlakeDD , AdamsDet al. Analytical validation of a melanoma diagnostic gene signature using formalin-fixed paraffin-embedded melanocytic lesions . Biomark. Med.27 , 1 – 10 ( 2015 ).
  • Cassarino DS , LewineN , ColeD , WadeB , GustavsenG . Budget impact analysis of a novel gene-expression assay for the diagnosis of malignant melanoma . J. Med. Econ.17 ( 11 ), 782 – 791 ( 2014 ).
  • Cockerell CJ , TschenJ , EvansBet al. The influence of a gene-expression signature on the diagnosis and recommended treatment of melanocytic tumors by dermatopathologists . Medicine95 ( 40 ), e4887 ( 2016 ).
  • Hayes DF , AllenJ , ComptonCet al. Breaking a vicious cycle . Sci. Transl. Med.5 ( 196 ), 196cm196 ( 2013 ).

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