4,550
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Primary Care Physician Experiences with Integrated Pharmacogenomic Testing in a Community Health System

, , , , , & show all
Pages 389-400 | Received 17 May 2017, Accepted 07 Jul 2017, Published online: 02 Aug 2017

References

  • van der Wouden CH , CarereDA , Maitland-van der ZeeAH , RuffinMT , RobertsJS , GreenRC . Consumer perceptions of interactions with primary care providers after direct-to-consumer personal genomic testing . Ann. Intern. Med.164 ( 8 ), 513 – 522 ( 2016 ).
  • U.S. Food & Drug Administration . Table of pharmacogenomic biomarkers in drug labeling ( 2017 ). www.fda.gov/Drugs/ScienceResearch/ResearchAreas/Pharmacogenetics/ucm083378.htm .
  • Stanek EJ , SandersCL , TaberKAet al. Adoption of pharmacogenomic testing by US physicians: results of a nationwide survey . Clin. Pharmacol. Ther.91 ( 3 ), 450 – 458 ( 2012 ).
  • Zhang G , NebertDW . Personalized medicine: genetic risk prediction of drug response . Pharmacol. Ther.175 , 75 – 90 ( 2017 ).
  • Haga SB , BurkeW , GinsburgGS , MillsR , AgansR . Primary care physicians’ knowledge of and experience with pharmacogenetic testing . Clin. Genet.82 ( 4 ), 388 – 394 ( 2012 ).
  • Selkirk CG , WeissmanSM , AndersonA , HulickPJ . Physicians’ preparedness for integration of genomic and pharmacogenetic testing into practice within a major healthcare system . Genet. Test. Mol. Biomarkers17 ( 3 ), 219 – 225 ( 2013 ).
  • Caudle KE , KleinTE , HoffmanJMet al. Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process . Curr. Drug Metab.15 ( 2 ), 209 – 217 ( 2014 ).
  • Relling MV , KleinTE . CPIC: clinical pharmacogenetics implementation consortium of the pharmacogenomics research network . Clin. Pharmacol. Ther.89 ( 3 ), 464 – 467 ( 2011 ).
  • Unertl KM , FieldJR , PriceL , PetersonJF . Clinician perspectives on using pharmacogenomics in clinical practice . Per. Med.12 ( 4 ), 339 – 347 ( 2015 ).
  • St Sauver JL , BielinskiSJ , OlsonJEet al. Integrating pharmacogenomics into clinical practice: promise vs reality . Am. J. Med.129 ( 10 ), 1093 – 1099 ( 2016 ).
  • Haga SB , TindallG , O’DanielJM . Professional perspectives about pharmacogenetic testing and managing ancillary findings . Genet. Test. Mol. Biomarkers16 ( 1 ), 21 – 24 ( 2012 ).
  • Dickmann LJ , WareJA . Pharmacogenomics in the age of personalized medicine . Drug Discov. Today Technol.21–22 , 11 – 16 ( 2016 ).
  • Haga SB . Challenges of development and implementation of point of care pharmacogenetic testing . Expert Rev. Mol. Diagn.16 ( 9 ), 949 – 960 ( 2016 ).
  • Johansen Taber KA , DickinsonBD . Pharmacogenomic knowledge gaps and educational resource needs among physicians in selected specialties . Pharmgenomics. Pers. Med.7 , 145 – 162 ( 2014 ).
  • Rosenman MB , DeckerB , LevyKD , HolmesAM , PrattVM , EadonMT . Lessons learned when introducing pharmacogenomic panel testing into clinical practice . Value Health20 ( 1 ), 54 – 59 ( 2017 ).
  • Moaddeb J , MillsR , HagaSB . Community pharmacists’ experience with pharmacogenetic testing . J. Am. Pharm. Assoc.55 ( 6 ), 587 – 594 ( 2015 ).
  • Dunnenberger HM , BiszewskiM , BellGCet al. Implementation of a multidisciplinary pharmacogenomics clinic in a community health system . Am. J. Health Syst. Pharm.73 ( 23 ), 1956 – 1966 ( 2016 ).
  • Haga SB , MoaddebJ , MillsR , PatelM , KrausW , Allen LaPointeNM . Incorporation of pharmacogenetic testing into medication therapy management . Pharmacogenomics16 ( 17 ), 1931 – 1941 ( 2015 ).
  • O’Donnell PH , WadhwaN , DanaheyKet al. Pharmacogenomics-based point-of-care clinical decision support significantly alters drug prescribing . Clin. Pharmacol. Ther. doi:10.1002/cpt.709 ( 2017 ) ( Epub ahead of print ).
  • Peterson JF , FieldJR , ShiYet al. Attitudes of clinicians following large-scale pharmacogenomics implementation . Pharmacogenomics J.16 ( 4 ), 393 – 398 ( 2015 ).
  • Abul-Husn NS , OwusuOA , SandersonSC , GottesmanO , ScottSA . Implementation and utilization of genetic testing in personalized medicine . Pharmgenomics. Pers. Med.7 , 227 – 240 ( 2014 ).
  • Bernhardt BA , ZayacC , GordonES , WawakL , PyeritzRE , GollustSE . Incorporating direct-to-consumer genomic information into patient care: attitudes and experiences of primary care physicians . Per. Med.9 ( 7 ), 683 – 692 ( 2012 ).
  • Goldsmith L , JacksonL , O’ConnorA , SkirtonH . Direct-to-consumer genomic testing from the perspective of the health professional: a systematic review of the literature . J. Community Genet.4 ( 2 ), 169 – 180 ( 2013 ).
  • Kaufman DJ , BollingerJM , DvoskinRL , ScottJA . Risky business: risk perception and the use of medical services among customers of DTC personal genetic testing . J. Genet. Couns.21 ( 3 ), 413 – 422 ( 2012 ).
  • Darst BF , MadlenskyL , SchorkNJ , TopolEJ , BlossCS . Characteristics of genomic test consumers who spontaneously share results with their health care provider . Health Commun.29 ( 1 ), 105 – 108 ( 2014 ).
  • Starks H , TrinidadSB . Choose your method: a comparison of phenomenology, discourse analysis, and grounded theory . Qual. Health Res.17 ( 10 ), 1372 – 1380 ( 2007 ).
  • Willis GB . Cognitive Interviewing: A Tool For Improving Questionnaire Design . Sage Publications, Inc. , CA, USA ( 2005 ).
  • Altas.ti ( 2012 ). http://atlasti.com .
  • Strauss A , CorbinJM . Basics of Qualitative Research: Techniques and Procedures For Developing Grounded Theory . Sage Publications, Inc. , CA, USA ( 1998 ).
  • Miles MB , HubermanAM , SaldañaJ . Qualitative Data Analysis: A Methods Sourcebook . Sage Publications, Inc. , CA, USA ( 2014 ).
  • Lerner B , MarshallN , OishiSet al. The value of genetic testing: beyond clinical utility . Genet. Med.19 ( 7 ), 763 – 771 ( 2017 ).
  • Burke W , LabergeAM , PressN . Debating clinical utility . Public Health Genomics13 ( 4 ), 215 – 223 ( 2010 ).
  • Dotson WD , BowenMS , KolorK , KhouryMJ . Clinical utility of genetic and genomic services: context matters . Genet. Med.18 ( 7 ), 672 – 674 ( 2016 ).
  • Joseph L , CankovicM , CaughronSet al. The spectrum of clinical utilities in molecular pathology testing procedures for inherited conditions and cancer: a report of the Association for Molecular Pathology . J. Mol. Diagn.18 ( 5 ), 605 – 619 ( 2016 ).
  • Kapoor R , Tan-KoiWC , TeoYY . Role of pharmacogenetics in public health and clinical health care: a SWOT analysis . Eur. J. Hum. Genet.24 ( 12 ), 1651 – 1657 ( 2016 ).
  • Patel HN , UrsanID , ZuegerPM , CavallariLH , PickardAS . Stakeholder views on pharmacogenomic testing . Pharmacotherapy34 ( 2 ), 151 – 165 ( 2014 ).
  • Vernez SL , SalariK , OrmondKE , LeeSS . Personal genome testing in medical education: student experiences with genotyping in the classroom . Genome Med.5 ( 3 ), 24 ( 2013 ).
  • Salari K , KarczewskiKJ , HudginsL , OrmondKE . Evidence that personal genome testing enhances student learning in a course on genomics and personalized medicine . PLoS ONE8 ( 7 ), e68853 ( 2013 ).
  • Frick A , BentonCS , ScolaroKLet al. Transitioning pharmacogenomics into the clinical setting: training future pharmacists . Front. Pharmacol.7 , 241 ( 2016 ).
  • Adams SM , AndersonKB , CoonsJCet al. Advancing pharmacogenomics education in the core pharmd curriculum through student personal genomic testing . Am. J. Pharm. Educ.80 ( 1 ), 3 ( 2016 ).
  • O’Brien TJ , LeLacheurS , WardC , LeeNH , CallierS , HarralsonAF . Impact of a personal CYP2D6 testing workshop on physician assistant student attitudes toward pharmacogenetics . Pharmacogenomics17 ( 4 ), 341 – 352 ( 2016 ).
  • Weitzel KW , CavallariLH , LeskoLJ . Preemptive panel-based pharmacogenetic testing: the time is now . Pharm. Res.34 ( 8 ), 1551 – 1555 ( 2017 ).
  • Luzum JA , PakyzRE , ElseyARet al. The pharmacogenomics research network translational pharmacogenetics program: outcomes and metrics of pharmacogenetic implementations across diverse healthcare systems . Clin. Pharmacol. Ther. doi:10.1002/cpt.630 ( 2017 ) ( Epub ahead of print ).
  • Dong D , OzdemirS , MongBY , TohSA , BilgerM , FinkelsteinE . Measuring high-risk patients’ preferences for pharmacogenetic testing to reduce severe adverse drug reaction: a discrete choice experiment . Value Health19 ( 6 ), 767 – 775 ( 2016 ).