161
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Increase in MEG3, MALAT1, NEAT1 Significantly Predicts the Clinical Parameters in Patients With Rheumatoid Arthritis

, , , , & ORCID Icon
Pages 445-457 | Received 23 Jan 2020, Accepted 28 Jul 2020, Published online: 07 Oct 2020

References

  • Firestein G S . Evolving concepts of rheumatoid arthritis. Nature423(6937), 356–361 (2003).
  • Cross M , SmithE, HoyD, CarmonaLet al. The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study. Ann. Rheum. Dis.73(7), 1316–1322 (2014).
  • Bernstein BE , BirneyE, DunhamI, GreenED, GunterC, SnyderM. Consortium EP. An integrated encyclopedia of DNA elements in the human genome. Nature489(7414), 57–74 (2012).
  • Mercer TR , MattickJS. Structure and function of long noncoding RNAs in epigenetic regulation. Nat. Struct. Mol. Biol.20(3), 300–307 (2013).
  • Sigdel KR , ChengA, WangY, DuanL, ZhangY. The emerging functions of long noncoding RNA in immune cells: autoimmune diseases. J. Immunol. Res. (Special issue 848790), 1–9 (2015).
  • Wu GC et al. Emerging role of long noncoding RNAs in autoimmune diseases. Autoimmun. Rev.14(9), 798–805 (2015).
  • Wu GC . Immunoregulation function of long noncoding RNA in rheumatic disease. Chin. J. Dis. Control. Prev.20(11), 1165–1171 (2016).
  • Messemaker TC et al. A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels. Genes. Immun.17(2), 85–92 (2016).
  • Liang J , ChenW, LinJ. LncRNA: an all-rounder in rheumatoid arthritis. J. Transl. Med.7(1), 3–9 (2019).
  • Song J , KimD, HanJ, KimY, LeeM, JinEJ. PBMC and exosome derived Hotair is a critical regulator and potent marker for rheumatoid arthritis. Clin. Exp. Med.15(1), 121–126 (2015).
  • Muller N , DoringF, KlapperMet al. Interleukin-6 and tumour necrosis factor-alpha differentially regulate lincRNA transcripts in cells of the innate immune system in vivo in human subjects with rheumatoid arthritis. Cytokine68(1), 65–68 (2014).
  • Zhang Y , XuYZ, SunNet al. Long noncoding RNA expression profile in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Res. Ther.18(227), 1–10 (2016).
  • Stuhlmuller B , KunischE, FranzJet al. Detection of oncofetal H19 RNA in rheumatoid arthritis synovial tissue. Am. J. Pathol.163(3), 901–911 (2003).
  • Yuan M , WangS, YuLet al. Long noncoding RNA profiling revealed differentially expressed lncRNAs associated with disease activity in PBMCs from patients with rheumatoid arthritis. PLoS ONE12(11), e0186795 (2017).
  • Arnett FC , EdworthySM, BlochDAet al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum-US31(3), 315–324 (1988).
  • Prevoo ML , Van'THof M, KuperHH, Van LeeuwenMA, VanDe Putte LB, Van RielPL. Modified disease activity scores that include twenty-eight-joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum-US38(1), 44–48 (1995).
  • Ramey DR , RaynauldJP, FriesJF. The health assessment questionnaire 1992. Status and review. Arthritis Rheum-US5(3), 119–129 (1992).
  • McInnes IB , SchettG. The pathogenesis of rheumatoid arthritis. New Engl. J. Med.365(23), 2205–2219 (2011).
  • Elshabrawy HA , ChenZ, VolinMV, RavellaS, VirupannavarS, ShahraraS. The pathogenic role of angiogenesis in rheumatoid arthritis. Angiogenesis18(4), 433–448 (2015).
  • Malemud C . Defective T-cell apoptosis and T-regulatory cell dysfunction in rheumatoid arthritis. Cells7(12), 223–233 (2018).
  • Prati C , DemougeotC, GuillotX, Godfrin-ValnetM, WendlingD. Endothelial dysfunction in joint disease. Joint Bone Spine81(5), 386–391 (2014).
  • Sattar N , McCareyDW, CapellH, McInnesIB. Explaining how & #x201C;high-grade” systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation108(24), 2957–2963 (2003).
  • Szcześniak MW , MakałowskaI. lncRNA-RNA interactions across the human transcriptome. PLoS ONE11(3), e0150353 (2016).
  • Huang JK , MaL, SongWHet al. LncRNA-MALAT1 promotes angiogenesis of thyroid cancer by modulating tumor-associated macrophage FGF2 protein secretion. J. Cell. Biochem.118(12), 4821–4830 (2017).
  • Ren L , WeiC, LiK, LuZ. LncRNA MALAT1 up-regulates VEGF-A and ANGPT2 to promote angiogenesis in brain microvascular endothelial cells against oxygen–glucose deprivation via targeting miR-145. Biosci. Rep.39(3), 1–30 (2019).
  • Michalik KM , YouX, ManavskiYet al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ. Res.114(9), 1389–1397 (2014).
  • Li X , SongY, LiuFet al. Long non-coding RNA MALAT1 promotes proliferation, angiogenesis, and immunosuppressive properties of mesenchymal stem cells by inducing VEGF and IDO. J. Cell. Biochem.118(9), 2780–2791 (2017).
  • Sun JY , ZhaoZW, LiWMet al. Knockdown of MALAT1 expression inhibits HUVEC proliferation by upregulation of miR-320a and downregulation of FOXM1 expression. Oncotarget8(37), 61499–61509 (2017).
  • Zhou ZW , ZhengLJ, RenX, LiAP, ZhouWS. LncRNA NEAT1 facilitates survival and angiogenesis in oxygen-glucose deprivation (OGD)-induced brain microvascular endothelial cells (BMECs) via targeting miR-377 and upregulating SIRT1, VEGFA, and BCL-XL. Brain Res.1707, 90–98 (2019).
  • Ding N , WuH, TaoT, PengE. NEAT1 regulates cell proliferation and apoptosis of ovarian cancer by miR-34a-5p/BCL2. OncoTargets Ther.10, 4905–4915 (2017).
  • He C , YangW, YangJet al. Long noncoding RNA MEG3 negatively regulates proliferation and angiogenesis in vascular endothelial cells. DNA Cell Biol.36(6), 475–481 (2017).
  • Lu X , QianJ. Downregulated MEG3 participates in rheumatoid arthritis via promoting proliferation of fibroblast-like synoviocytes. Exp. Ther. Med.17(3), 1637–1642 (2019).
  • Yan L , LiuZ, YinH, GuoZ, LuoQ. Silencing of MEG3 inhibited ox-LDL-induced inflammation and apoptosis in macrophages via modulation of the MEG3/miR-204/CDKN2A regulatory axis. Cell Biol. Int.43(4), 409–420 (2019).
  • Bai Y , ZhangQ, SuY, PuZ, LiK. Modulation of the proliferation/apoptosis balance of vascular smooth muscle cells in atherosclerosis by lncRNA-MEG3 via regulation of miR-26a/Smad1 Axis. Int. Heart J.2(60), 444–450 (2019).
  • Wållberg-Jonsson S , CaidahlK, KlintlandN, NybergG, Rantapää-DahlqvistS. Increased arterial stiffness and indication of endothelial dysfunction in long-standing rheumatoid arthritis. Scand. J. Rheumatol.37(1), 1–5 (2008).
  • Simion V , HaemmigS, FeinbergMW. LncRNAs in vascular biology and disease. Vascul. Pharmacol.114, 145–156 (2019).
  • Boon RA , HofmannP, MichalikKMet al. Long noncoding RNA Meg3 controls endothelial cell aging and function: implications for regenerative angiogenesis. J. Am. Coll. Cardiol.68(23), 2589–2591 (2016).
  • Igarashi H , HashimotoJ, TomitaT, YoshikawaH, IshiharaK. Tp53 mutations coincide with the ectopic expression of activation-induced cytidine-deaminase in the fibroblast-like synoviocytes derived from a fraction of patients with rheumatoid arthritis. Clin. Exp. Immunol.161(1), 71–80 (2010).
  • Shchetynsky K , Diaz-GalloLM, FolkersenLet al. Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis. Arthritis Res. Ther.19(1), 1–9 (2017).
  • Firestein GS , NguyenK, AupperleKR, YeoM, BoyleDL, ZvaiflerNJ. Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium. Am. J. Pathol.149(6), 2143–2151 (1996).
  • Helmchen B , WeckaufH, EhemannV, WittmannI, Meyer-ScholtenC, BergerI. Expression pattern of cell cycle-related gene products in synovial stroma and synovial lining in active and quiescent stages of rheumatoid arthritis. Histol. Histopathol.20(2), 365–372 (2005).
  • Müller-Ladner U , GayRE, GayS. Role of nuclear factor & #x03BA;B in synovial inflammation. Curr. Rheumatol. Rep.4(3), 201–207 (2002).
  • Liu T , ZhangL, JooD, SunSC. NF-κBsignaling in inflammation. Signal. Transduct. Tar.2(1), 1–9 (2017).
  • Pap T , Müller-LadnerU, GayRE, GayS. Fibroblast biology: role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res. Ther.2(5), 1–7 (2000).
  • Tang Y , ZhouT, YuX, XueZ, ShenN. The role of long non-coding RNAs in rheumatic diseases. Nat. Rev. Rheumatol.13(11), 657–669 (2017).
  • Mello SS , SinowC, RajNet al. Neat1 is a p53-inducible lincRNA essential for transformation suppression. Gene. Dev.31(11), 1095–1108 (2017).
  • Liu YR , YangL, XuQQet al. Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5. J. Cell. Physiol.234(8), 14270–14284 (2019).
  • Lu X , QianJ. Downregulated MEG3 participates in rheumatoid arthritis via promoting proliferation of fibroblast-like synoviocytes. Exp. Ther. Med.17(3), 1637–1642 (2019).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.