References
- Janssens AC , van Duijn CM. Genome-based prediction of common diseases: advances and prospects. Hum. Mol. Genet.17(R2) , R166–R173 (2008).
- van Hoek M , DehghanA, WittemanJC et al. Predicting Type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes 57(11) , 3122–3128 (2008).
- Lango H , PalmerCN, MorrisAD et al. Assessing the combined impact of 18 common genetic variants of modest effect sizes on Type 2 diabetes risk. Diabetes 57(11) , 3129–3135 (2008).
- Kathiresan S , MelanderO, AnevskiD et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N. Engl. J. Med. 358(12) , 1240–1249 (2008).
- Pharoah PD , AntoniouAC, EastonDF, PonderBA. Polygenes, risk prediction, and targeted prevention of breast cancer. N. Engl. J. Med.358(26) , 2796–2803 (2008).
- Gail MH . Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk. J. Natl Cancer Inst.100(14) , 1037–1041 (2008).
- Wacholder S , HartgeP, PrenticeR et al. Performance of common genetic variants in breast-cancer risk models. N. Engl. J. Med. 362(11) , 986–993 (2010).
- Zheng SL , SunJ, WiklundF et al. Cumulative association of five genetic variants with prostate cancer. N. Engl. J. Med. 358(9) , 910–919 (2008).
- Salinas CA , KoopmeinersJS, KwonEM et al. Clinical utility of five genetic variants for predicting prostate cancer risk and mortality. Prostate 69(4) , 363–372 (2009).
- Hingorani AD , ShahT, KumariM, SofatR, SmeethL. Translating genomics into improved healthcare. BMJ341 , C5945 (2010).
- Pashayan N , DuffySW, ChowdhuryS et al. Polygenic susceptibility to prostate and breast cancer: implications for personalised screening. Br. J. Cancer 104(10) , 1656–1663 (2011).
- Pashayan N , PharoahP. Translating genomics into improved population screening: hype or hope? Hum. Genet.130(1) , 19–21 (2011).
- Pharoah PD , AntoniouA, BobrowM, ZimmernRL, EastonDF, PonderBA. Polygenic susceptibility to breast cancer and implications for prevention. Nat. Genet.31(1) , 33–36 (2002).
- Risch N . The genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches. Cancer Epidemiol. Biomarkers Prev.10(7) , 733–741 (2001).
- Fredholm H , EakerS, FrisellJ, HolmbergL, FredrikssonI, LindmanH. Breast cancer in young women: poor survival despite intensive treatment. PLoS ONE4(11) , e7695 (2009).
- Lin DW , PorterM, MontgomeryB. Treatment and survival outcomes in young men diagnosed with prostate cancer: a population-based cohort study. Cancer115(13) , 2863–2871 (2009).
- Gray JA , PatnickJ, BlanksRG. Maximising benefit and minimising harm of screening. BMJ336(7642) , 480–483 (2008).
▪ Website
- Collaborative oncological gene–environment study (2012). http://cogseu.org