Advanced search
Publication Cover
Pain Management Volume 10, 2020 - Issue 5
Submit an article Journal homepage
100
Views
0
CrossRef citations to date
0
Altmetric
Drug Evaluation

Naldemedine for the Treatment of Opioid-Induced Constipation in Adults with Chronic Noncancer Pain

Joy J Liu1 Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USACorrespondence[email protected]
View further author information
,
Sarah E Quinton1 Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USAView further author information
&
Darren M Brenner1 Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USAORCID Iconhttps://orcid.org/0000-0002-8577-7278View further author information
ORCID Icon
Pages 301-306 | Received 15 Apr 2020, Accepted 22 May 2020, Published online: 19 Jun 2020

References

  • Han B , ComptonW , BlancoC. Prescription opioid use, misuse, and use disorders in U.S. adults: 2015 national survey on drug use and health. Ann. Int. Med.167, 293–201 (2017).
  • Benyamin R , TrescotAM , DattaSet.al Opioid complications and side effects. Pain Physician11(Suppl. 2), S105–S120 (2008).
  • Lacy BE , MearinF , ChangLet.al Bowel disorders. Gastroenterology150(6), 1393–1407 (2016).
  • Stern EK , BrennerDM. Spotlight on naldemedine in the treatment of opioid-induced constipation in adult patients with chronic noncancer pain: design, development, and place in therapy. J Pain Res.11, 195–199 (2018).
  • Kalso E , EdwardsJ , MooreR , McQuayH. Opioids in chronic noncancer pain: systematic review of efficacy and safety. Pain112(3), 372–380 (2004).
  • Bell T , PanchalS , MiaskowskiC , BolgeS , MilanovaT , WilliamsonR. The prevalence, severity, and impact of opioid-induced bowel dysfunction: results of a US and European Patient Survey (PROBE 1). Pain Med.10(1), 35–42 (2009).
  • Rauck RL , HongK-SJ , NorthJ. Opioid-induced constipation survey in patients with chronic noncancer pain. Pain Pract.17(3), 329–335 (2017).
  • Nokjov B , BakerJ , MeneesSet.al Is dyssynergic defecation an unrecognized cause of chronic constipation in patients using opioids? Am. J. Gastroenterol.114(11), 1772–1777 (2019).
  • Leppert W . Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction. Drug Des. Devel. Ther.9, 2215–2231 (2015).
  • Hanson B , SiddiqueSM , ScarlettY , SultanS. American Gastroenterological Association Institute technical review on the Medical Management of Opioid-Induced Constipation. Gastroenterology156(1), 229–253 (2019).
  • Crockett SD , GreerKB , HeidelbaughJJ , Falck-YtterY , HansonBJ , SultanS. American Gastroenterological Association Institute Guideline on the Medical Management of Opioid-Induced Constipation. Gastroenterology156(1), 218–226 (2019).
  • Brenner DM , HuY , DattoC , CreangaD , CamilleriM. A randomized, multicenter, prospective, crossover, open-label study of factors associated with patient preferences for naloxegol or PEG 3350 for opioid-induced constipation. Am. J. Gastroenterol.114(6), 954–963 (2019).
  • Brenner DM , SternE , CashBD. Opioid-related constipation in patients with noncancer pain syndromes: a review of evidence-based therapies and justification for a change in nomenclature. Curr. Gastroenterol. Rep.19(3), 12 (2017).
  • Chey WD , WebsterL , SostekM , LappalainenJ , BarkerPN , TackJ. Naloxegol for opioid-induced constipation in patients with noncancer pain. N. Engl. J. Med.370(35), 2387–2396 (2014).
  • Webster L , NagataT , YamadaT , FerreiraJA. A Phase IIa, randomized, double-blind, placebo-controlled, single ascending-dose study to evaluate the safety and efficacy of naldemedine in patients with chronic noncancer pain and opioid-induced bowel dysfunction. J. Pain17(4), S94 (2016).
  • Kanemasa T , JoikeK , AraiTet.al Pharmacologic effects of naldemedine, a peripherally acting μ-opioid receptor antagonist, in in vitro and in vivo models of opioid-induced constipation. Neurogastroenterol. Motil.31(5), e13563 (2019).
  • Blair HA . Naldemedine: a review in opioid-induced constipation. Drugs79(11), 1241–1247 (2019).
  • Webster LR , YamadaT , ArjonaFerreira JC. A Phase IIb, randomized, double-blind placebo-controlled study to evaluate the efficacy and safety of naldemedine for the treatment of opioid-induced constipation in patients with chronic noncancer pain. Pain Med.18(12), 2350–2360 (2017).
  • Webster LR , NalamachuS , MorlionBet.al Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled Phase III study. Pain159(5), 987–994 (2018).
  • Hale M , WildJ , ReddyJ , YamadaT , ArjonaFerreira JC. Naldemedine versus placebo for opioid-induced constipation (COMPOSE-1 and COMPOSE-2): two multi-centre, Phase III, double-blind, randomized, parallel-group trials. Lancet Gastroenterol. Hepatol.2(8), 555–564 (2017).
  • Nee J , ZakariM , SugarmanMAet.al Efficacy of treatments for opioid-induced constipation: systematic review and meta-analysis. Clin. Gastroenterol. Hepatol.16(10), 1569–1584 (2018).
  • Luthra P , BurrNE , BrennerDM , FordAC. Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis. Gut68(3), 434–444 (2019).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.