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Review

Mechanisms, Diagnosis, Prevention and Management of Perioperative Opioid-Induced Hyperalgesia

ORCID Icon, ORCID Icon, , ORCID Icon & ORCID Icon
Pages 405-417 | Received 17 Dec 2020, Accepted 03 Mar 2021, Published online: 29 Mar 2021

References

  • Treister R , EisenbergE , LawentalE , PudD. Is opioid-induced hyperalgesia reversible? A study on active and former opioid addicts and drug naive controls. J. Opioid Manag.8(6), 343–349 (2012).
  • Samuelsen PJ , NielsenCS , WilsgaardT , StubhaugA , SvendsenK , EggenAE. Pain sensitivity and analgesic use among 10,486 adults: the Tromso study. BMC Pharmacol. Toxicol.18(1), 45 (2017).
  • Sorensen J , SjogrenP. The clinical relevance of opioid-induced hyperalgesia remains unresolved. Ugeskr. Laeger173(13), 965–968 (2011).
  • Khomula EV , AraldiD , LevineJD. Invitro nociceptor neuroplasticity associated with in vivo opioid-induced hyperalgesia. J. Neurosci.39(36), 7061–7073 (2019).
  • Roeckel LA , UtardV , ReissDet al. Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide. Sci. Rep.7(1), 10406 (2017).
  • Higgins C , SmithBH , MatthewsK. Evidence of opioid-induced hyperalgesia in clinical populations after chronic opioid exposure: a systematic review and meta-analysis. Br. J. Anaesth.122(6), e114–e126 (2019).
  • Virani F , MillerM , GilmourJ. Opioid-induced hyperalgesia from alfentanil. BMJ Support Palliat. Care10(3), 310–311 (2020).
  • Fletcher D , MartinezV. Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis. Br. J. Anaesth.112(6), 991–1004 (2014).
  • Van Gulik L , AhlersSJ , VanDe Garde EMet al. Remifentanil during cardiac surgery is associated with chronic thoracic pain 1 yr after sternotomy. Br. J. Anaesth.109(4), 616–622 (2012).
  • Salengros JC , HuybrechtsI , DucartAet al. Different anesthetic techniques associated with different incidences of chronic post-thoracotomy pain: low-dose remifentanil plus presurgical epidural analgesia is preferable to high-dose remifentanil with postsurgical epidural analgesia. J. Cardiothorac. Vasc. Anesth.24(4), 608–616 (2010).
  • Crisostomo RA , SchmidtJE , HootenWM , KerkvlietJL , TownsendCO , BruceBK. Withdrawal of analgesic medication for chronic low-back pain patients: improvement in outcomes of multidisciplinary rehabilitation regardless of surgical history. Am. J. Phys. Med. Rehabil.87(7), 527–536 (2008).
  • Low Y , ClarkeCF , HuhBK. Opioid-induced hyperalgesia: a review of epidemiology, mechanisms and management. Singapore Med. J.53(5), 357–360 (2012).
  • Zylicz Z , TwycrossR. Opioid-induced hyperalgesia may be more frequent than previously thought. J. Clin. Oncol.26(9), 1564 (2008).
  • Kaneria A . Opioid-induced hyperalgesia: when pain killers make pain worse. BMJ Case Rep.2014, 1564 (2014).
  • Vargas-Schaffer G , PaquetS , NeronA , CoganJ. Opioid induced hyperalgesia, a research phenomenon or a clinical reality? Results of a Canadian survey. J. Pers. Med.10(2), 27 (2020).
  • Kum E , BuckleyN , DeLeon-Casasola O , LemaM , BusseJW. Attitudes towards and management of opioid-induced hyperalgesia: a survey of chronic pain practitioners. Clin. J. Pain36(5), 359–364 (2020).
  • Lee M , SilvermanSM , HansenH , PatelVB , ManchikantiL. A comprehensive review of opioid-induced hyperalgesia. Pain Physician14(2), 145–161 (2011).
  • Mercadante S , ArcuriE , SantoniA. Opioid-induced tolerance and hyperalgesia. CNS Drugs33(10), 943–955 (2019).
  • Weber L , YeomansDC , TzabazisA. Opioid-induced hyperalgesia in clinical anesthesia practice: what has remained from theoretical concepts and experimental studies?Curr. Opin. Anaesthesiol.30(4), 458–465 (2017).
  • Wittert G , HopeP , PyleD. Tissue distribution of opioid receptor gene expression in the rat. Biochem. Biophys. Res. Commun.218(3), 877–881 (1996).
  • Mason P . Medullary circuits for nociceptive modulation. Curr. Opin. Neurobiol.22(4), 640–645 (2012).
  • Azami J , LlewelynMB , RobertsMH. The contribution of nucleus reticularis paragigantocellularis and nucleus raphe magnus to the analgesia produced by systemically administered morphine, investigated with the microinjection technique. Pain12(3), 229–246 (1982).
  • Dickenson AH , OliverasJL , BessonJM. Role of the nucleus raphe magnus in opiate analgesia as studied by the microinjection technique in the rat. Brain Res.170(1), 95–111 (1979).
  • Ossipov MH , MorimuraK , PorrecaF. Descending pain modulation and chronification of pain. Curr. Opin. Support. Palliat. Care8(2), 143–151 (2014).
  • Hellman KM , MasonP. Opioids disrupt pro-nociceptive modulation mediated by raphe magnus. J. Neurosci.32(40), 13668–13678 (2012).
  • Vanderah TW , SuenagaNM , OssipovMH , MalanTPJr , LaiJ , PorrecaF. Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. J. Neurosci.21(1), 279–286 (2001).
  • Viisanen H , LiliusTO , SagalajevB , RauhalaP , KalsoE , PertovaaraA. Neurophysiological response properties of medullary pain-control neurons following chronic treatment with morphine or oxycodone: modulation by acute ketamine. J. Neurophysiol.124(3), 790–801 (2020).
  • Roeckel LA , LeCoz GM , Gaveriaux-RuffC , SimoninF. Opioid-induced hyperalgesia: cellular and molecular mechanisms. Neuroscience338, 160–182 (2016).
  • Hayashi Y , MorinagaS , ZhangJet al. BK channels in microglia are required for morphine-induced hyperalgesia. Nat. Commun.7, 11697 (2016).
  • Huang M , LuoL , ZhangYet al. Metabotropic glutamate receptor 5 signalling induced NMDA receptor subunits alterations during the development of morphine-induced antinociceptive tolerance in mouse cortex. Biomed. Pharmacother.110, 717–726 (2019).
  • Araldi D , FerrariLF , LevineJD. Repeated mu-opioid exposure induces a novel form of the hyperalgesic priming model for transition to chronic pain. J. Neurosci.35(36), 12502–12517 (2015).
  • Vardanyan A , WangR , VanderahTWet al. TRPV1 receptor in expression of opioid-induced hyperalgesia. J. Pain10(3), 243–252 (2009).
  • Lima LV , DesantanaJM , RasmussenLA , SlukaKA. Short-duration physical activity prevents the development of activity-induced hyperalgesia through opioid and serotoninergic mechanisms. Pain158(9), 1697–1710 (2017).
  • Raymond I , NielsenTA , LavigneG , ManziniC , ChoiniereM. Quality of sleep and its daily relationship to pain intensity in hospitalized adult burn patients. Pain92(3), 381–388 (2001).
  • Haack M , SimpsonN , SethnaN , KaurS , MullingtonJ. Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications. Neuropsychopharmacology45(1), 205–216 (2020).
  • Colvin LA , BullF , HalesTG. Perioperative opioid analgesia-when is enough too much? A review of opioid-induced tolerance and hyperalgesia. Lancet393(10180), 1558–1568 (2019).
  • Kim SH , StoiceaN , SoghomonyanS , BergeseSD. Remifentanil-acute opioid tolerance and opioid-induced hyperalgesia: a systematic review. Am. J. Ther.22(3), e62–e74 (2015).
  • Baron MJ , McdonaldPW. Significant pain reduction in chronic pain patients after detoxification from high-dose opioids. J. Opioid Manag.2(5), 277–282 (2006).
  • Compton P , CharuvastraVC , LingW. Pain intolerance in opioid-maintained former opiate addicts: effect of long-acting maintenance agent. Drug Alcohol Depend.63(2), 139–146 (2001).
  • Hay JL , WhiteJM , BochnerF , SomogyiAA , SempleTJ , RounsefellB. Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients. J. Pain10(3), 316–322 (2009).
  • Williams JT , IngramSL , HendersonGet al. Regulation of mu-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol. Rev.65(1), 223–254 (2013).
  • Cao JL , VialouVF , LoboMKet al. Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons. Proc. Natl Acad. Sci. USA107(39), 17011–17016 (2010).
  • Kosten TR , GeorgeTP. The neurobiology of opioid dependence: implications for treatment. Sci. Pract. Perspect.1(1), 13–20 (2002).
  • Rivat C , BallantyneJ. The dark side of opioids in pain management: basic science explains clinical observation. Pain Rep.1(2), e570 (2016).
  • World Health Organization. WHO guidelines . Clinical Guidelines for Withdrawal Management and Treatment of Drug Dependence in Closed Settings. Geneva, Switzerland (2009).www.ncbi.nlm.nih.gov/books/NBK310654/
  • Kosten TR , O’connorPG. Management of drug and alcohol withdrawal. N. Engl. J. Med.348(18), 1786–1795 (2003).
  • Mao J . Clinical diagnosis of opioid-induced hyperalgesia. Reg. Anesth. Pain Med.40(6), 663–664 (2015).
  • Beauchamp GA , NelsonLS , PerroneJ , LyonsMS. A theoretical framework and nomenclature to characterize the iatrogenic contribution of therapeutic opioid exposure to opioid induced hyperalgesia, physical dependence, and opioid use disorder. Am. J. Drug Alcohol Abuse46(6), 671–683 (2020).
  • Eisenberg E , SuzanE , PudD. Opioid-induced hyperalgesia (OIH): a real clinical problem or just an experimental phenomenon?J. Pain Symptom Manage.49(3), 632–636 (2015).
  • Syed UaM , AleemAW , WowkanechCet al. Neer Award 2018: the effect of pre-operative education on opioid consumption in patients undergoing arthroscopic rotator cuff repair: a prospective, randomized clinical trial. J. Shoulder Elbow Surg.27(6), 962–967 (2018).
  • Khorfan R , ShallcrossML , YuBet al. Pre-operative patient education and patient preparedness are associated with less postoperative use of opioids. Surgery167(5), 852–858 (2020).
  • Farley KX , AnastasioAT , KumarA , PremkumarA , GottschalkMB , XerogeanesJ. Association between quantity of opioids prescribed after surgery or pre-operative opioid use education with opioid consumption. JAMA321(24), 2465–2467 (2019).
  • Prabhu M , Mcquaid-HansonE , HoppSet al. A shared decision-making intervention to guide opioid prescribing after cesarean delivery. Obstet. Gynecol.130(1), 42–46 (2017).
  • Highland KB , GiordanoNA , KirkK , RojasW , Robinson-MorrisL , KrzyzekM. App-based pain management and opioid education program for patients in clinic waiting rooms. Pain Manag. Nurs. doi:10.1016/j.pmn.2020.10.007 (2020) ( Epub ahead of print).
  • Brock JL , JainN , PhillipsFM , MalikAT , KhanSN. Postoperative opioid cessation rates based on pre-operative opioid use: analysis of common orthopaedic procedures. Bone Joint J.101-B(12), 1570–1577 (2019).
  • Nguyen LC , SingDC , BozicKJ. Pre-operative reduction of opioid use before total joint arthroplasty. J. Arthroplasty31(Suppl. 9), 282–287 (2016).
  • Hassamal S , HaglundM , WittnebelK , DanovitchI. A pre-operative interdisciplinary biopsychosocial opioid reduction program in patients on chronic opioid analgesia prior to spine surgery: a preliminary report and case series. Scand. J. Pain13, 27–31 (2016).
  • Edwards DA , HedrickTL , JayaramJet al. American Society for Enhanced Recovery and Perioperative Quality Initiative joint consensus statement on perioperative management of patients on pre-operative opioid therapy. Anesth. Analg.129(2), 553–566 (2019).
  • Wasserman RA , BrummettCM , GoeslingJ , TsodikovA , HassettAL. Characteristics of chronic pain patients who take opioids and persistently report high pain intensity. Reg. Anesth. Pain Med.39(1), 13–17 (2014).
  • As-Sanie S , TillSR , MowersELet al. Opioid prescribing patterns, patient use, and postoperative pain after hysterectomy for benign indications. Obstet. Gynecol.130(6), 1261–1268 (2017).
  • Larach DB , SaharaMJ , As-SanieSet al. Patient factors associated with opioid consumption in the month following major surgery. Ann. Surg. doi:10.1097/SLA.0000000000003509 (2019) ( Epub ahead of print).
  • Rupniewska-Ladyko A , Malec-MilewskaM. A high dose of fentanyl may accelerate the onset of acute postoperative pain. Anesth. Pain Med.9(5), e94498 (2019).
  • Albrecht E , GrapeS , FrauenknechtJ , KilchoerL , KirkhamKR. Low- versus high-dose intraoperative opioids: a systematic review with meta-analyses and trial sequential analyses. Acta Anaesthesiol. Scand.64(1), 6–22 (2020).
  • Yu EH , TranDH , LamSW , IrwinMG. Remifentanil tolerance and hyperalgesia: short-term gain, long-term pain?Anaesthesia71(11), 1347–1362 (2016).
  • Comelon M , RaederJ , StubhaugA , NielsenCS , DraegniT , LenzH. Gradual withdrawal of remifentanil infusion may prevent opioid-induced hyperalgesia. Br. J. Anaesth.116(4), 524–530 (2016).
  • Han SS , DoSH , KimTH , ChoiWJ , YunJS , RyuJH. Stepwise tapering of remifentanil at the end of surgery decreased postoperative pain and the need of rescue analgesics after thyroidectomy. BMC Anesthesiol.15, 46 (2015).
  • Loftus RW , YeagerMP , ClarkJAet al. Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery. Anesthesiology113(3), 639–646 (2010).
  • Koppert W , SittlR , ScheuberK , AlsheimerM , SchmelzM , SchuttlerJ. Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans. Anesthesiology99(1), 152–159 (2003).
  • Mert T , OksuzH , TugtagB , KilincM , SenogluN , BilginR. Modulating actions of NMDA receptors on pronociceptive effects of locally injected remifentanil in diabetic rats. Pharmacol. Rep.66(6), 1065–1072 (2014).
  • Chaparro LE , SmithSA , MooreRA , WiffenPJ , GilronI. Pharmacotherapy for the prevention of chronic pain after surgery in adults. Cochrane Database Syst. Rev.2013(7), CD008307 (2013).
  • Bjorkman R , HallmanKM , HednerJ , HednerT , HenningM. Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P. Pain57(3), 259–264 (1994).
  • Crawley B , SaitoO , MalkmusS , FitzsimmonsB , HuaXY , YakshTL. Acetaminophen prevents hyperalgesia in central pain cascade. Neurosci. Lett.442(1), 50–53 (2008).
  • Baba H , KohnoT , MooreKA , WoolfCJ. Direct activation of rat spinal dorsal horn neurons by prostaglandin E2. J. Neurosci.21(5), 1750–1756 (2001).
  • Fayaz MK , AbelRJ , PughSC , HallJE , DjaianiG , MecklenburghJS. Opioid-sparing effects of diclofenac and paracetamol lead to improved outcomes after cardiac surgery. J. Cardiothorac. Vasc. Anesth.18(6), 742–747 (2004).
  • Wong I , StJohn-Green C , WalkerSM. Opioid-sparing effects of perioperative paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) in children. Paediatr. Anaesth.23(6), 475–495 (2013).
  • Malmberg AB , YakshTL. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science257(5074), 1276–1279 (1992).
  • Melander A , OlssonJ , LindbergGet al. 35th Annual Meeting of the European Association for the Study of Diabetes: Brussels, Belgium, 28 September-2 October 1999. Diabetologia42(Suppl. 1), A1–A330 (1999).
  • Jevtovic-Todorovic V , WozniakDF , PowellS , NardiA , OlneyJW. Clonidine potentiates the neuropathic pain-relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects. Brain Res.781(1-2), 202–211 (1998).
  • Zhang X , BaiX. New therapeutic uses for an alpha2 adrenergic receptor agonist–dexmedetomidine in pain management. Neurosci. Lett.561, 7–12 (2014).
  • Kamibayashi T , MazeM. Clinical uses of alpha2 -adrenergic agonists. Anesthesiology93(5), 1345–1349 (2000).
  • Martinez V , BeloeilH , MarretE , FletcherD , RavaudP , TrinquartL. Non-opioid analgesics in adults after major surgery: systematic review with network meta-analysis of randomized trials. Br. J. Anaesth.118(1), 22–31 (2017).
  • Memtsoudis SG , PoeranJ , ZubizarretaNet al. Association of multimodal pain management strategies with perioperative outcomes and resource utilization: a population-based study. Anesthesiology128(5), 891–902 (2018).
  • Beloeil H , AbabnehZ , ChungR , ZurakowskiD , MulkernRV , BerdeCB. Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (part 1): hyperalgesia, edema, and systemic cytokines. Anesthesiology105(1), 128–138 (2006).
  • Beloeil H , JiRR , BerdeCB. Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (part 2): cytokines and p38 mitogen-activated protein kinases in dorsal root ganglia and spinal cord. Anesthesiology105(1), 139–145 (2006).
  • Estebe JP , GentiliME , LeCorre P , LeVerge R , MoulinouxJP , EcoffeyC. Sciatic nerve block with bupivacaine-loaded microspheres prevents hyperalgesia in an inflammatory animal model. Can. J. Anaesth.49(7), 690–693 (2002).
  • Meleine M , RivatC , LaboureyrasE , CahanaA , RichebeP. Sciatic nerve block fails in preventing the development of late stress-induced hyperalgesia when high-dose fentanyl is administered perioperatively in rats. Reg. Anesth. Pain Med.37(4), 448–454 (2012).
  • Gomez-Brouchet A , BlaesN , MouledousLet al. Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice. J. Transl. Med.13, 208 (2015).
  • Senturk M , OzcanPE , TaluGKet al. The effects of three different analgesia techniques on long-term postthoracotomy pain. Anesth. Analg.94(1), 11–15 (2002).
  • Lavand’homme P , DeKock M , WaterloosH. Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery. Anesthesiology103(4), 813–820 (2005).
  • Barreveld A , WitteJ , ChahalH , DurieuxME , StrichartzG. Preventive analgesia by local anesthetics: the reduction of postoperative pain by peripheral nerve blocks and intravenous drugs. Anesth. Analg.116(5), 1141–1161 (2013).
  • Capdevila X , MoulardS , PlasseCet al. Effectiveness of epidural analgesia, continuous surgical site analgesia, and patient-controlled analgesic morphine for postoperative pain management and hyperalgesia, rehabilitation, and health-related quality of life after open nephrectomy: a prospective, randomized, controlled study. Anesth. Analg.124(1), 336–345 (2017).
  • Furutani K , IkomaM , IshiiH , BabaH , KohnoT. Bupivacaine inhibits glutamatergic transmission in spinal dorsal horn neurons. Anesthesiology112(1), 138–143 (2010).
  • Paganelli MA , PopescuGK. Actions of bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J. Neurosci.35(2), 831–842 (2015).
  • Mert T , GunesY , GunayI. Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy. Fundam. Clin. Pharmacol.27(2), 161–168 (2013).
  • Weibel S , JeltingY , PaceNLet al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults. Cochrane Database Syst. Rev.6, CD009642 (2018).
  • Minville V , FourcadeO , GirolamiJP , TackI. Opioid-induced hyperalgesia in a mice model of orthopaedic pain: preventive effect of ketamine. Br. J. Anaesth.104(2), 231–238 (2010).
  • Van Elstraete AC , SitbonP , BenhamouD , MazoitJX. The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction. Anesth. Analg.113(3), 634–640 (2011).
  • Laulin JP , MauretteP , CorcuffJB , RivatC , ChauvinM , SimonnetG. The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. Anesth. Analg.94(5), 1263–1269 (2002).
  • Davis AM , InturrisiCE. d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia. J. Pharmacol. Exp. Ther.289(2), 1048–1053 (1999).
  • Murphy GS , SzokolJW , AvramMJet al. Clinical effectiveness and safety of intraoperative methadone in patients undergoing posterior spinal fusion surgery: a randomized, double-blinded, controlled trial. Anesthesiology126(5), 822–833 (2017).
  • Komen H , BruntLM , DeychE , BloodJ , KharaschED. Intraoperative methadone in same-day ambulatory surgery: a randomized, double-blinded, dose-finding pilot study. Anesth. Analg.128(4), 802–810 (2019).
  • Machado FC , VieiraJE , DeOrange FA , AshmawiHA. Intraoperative methadone reduces pain and opioid consumption in acute postoperative pain: a systematic review and meta-analysis. Anesth. Analg.129(6), 1723–1732 (2019).
  • Vanderah TW , GardellLR , BurgessSEet al. Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance. J. Neurosci.20(18), 7074–7079 (2000).
  • Koppert W , IhmsenH , KorberNet al. Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model. Pain118(1-2), 15–22 (2005).
  • Freeman SC , ScottNW , PowellR , JohnstonM , SuttonAJ , CooperNJ. Component network meta-analysis identifies the most effective components of psychological preparation for adults undergoing surgery under general anesthesia. J. Clin. Epidemiol.98, 105–116 (2018).
  • Powell R , ScottNW , ManyandeAet al. Psychological preparation and postoperative outcomes for adults undergoing surgery under general anaesthesia. Cochrane Database Syst. Rev. doi:10.1002/14651858.CD008646.pub2(5) (2016) ( Epub ahead of print).
  • Szeverenyi C , KekecsZ , JohnsonA , ElkinsG , CsernatonyZ , VargaK. The use of adjunct psychosocial interventions can decrease postoperative pain and improve the quality of clinical care in orthopedic surgery: a systematic review and meta-analysis of randomized controlled trials. J. Pain19(11), 1231–1252 (2018).
  • Henry SG , PaternitiDA , FengBet al. Patients’ experience with opioid tapering: a conceptual model with recommendations for clinicians. J. Pain20(2), 181–191 (2019).
  • Berna C , KulichRJ , RathmellJP. Tapering long-term opioid therapy in chronic noncancer pain: evidence and recommendations for everyday practice. Mayo Clin. Proc.90(6), 828–842 (2015).
  • Smith HS , PeppinJF. Toward a systematic approach to opioid rotation. J. Pain Res.7, 589–608 (2014).
  • Sharan AD , RileyJ , FalowskiSet al. Association of opioid usage with spinal cord stimulation outcomes. Pain Med.19(4), 699–707 (2018).
  • Kapural L , KapuralM , BensitelT , SesslerDI. Opioid-sparing effect of intravenous outpatient ketamine infusions appears short-lived in chronic-pain patients with high opioid requirements. Pain Physician13(4), 389–394 (2010).
  • Patil S , AnitescuM. Efficacy of outpatient ketamine infusions in refractory chronic pain syndromes: a 5-year retrospective analysis. Pain Med.13(2), 263–269 (2012).
  • Mercadante S , FerreraP , ArcuriE , CasuccioA. Opioid-induced hyperalgesia after rapid titration with intravenous morphine: switching and re-titration to intravenous methadone. Ann. Palliat. Med.1(1), 10–13 (2012).
  • Axelrod DJ , RevilleB. Using methadone to treat opioid-induced hyperalgesia and refractory pain. J. Opioid Manag.3(2), 113–114 (2007).
  • Daitch J , FreyME , SilverD , MitnickC , DaitchD , PergolizziJJr. Conversion of chronic pain patients from full-opioid agonists to sublingual buprenorphine. Pain Physician15(Suppl. 3), ES59–ES66 (2012).
  • Berland DW , MalinoffHL , WeinerMA , PrzybylskiR. When opioids fail in chronic pain management: the role for buprenorphine and hospitalization. Am. J. Ther.20(4), 316–321 (2013).
  • Lundorff L , SjogrenP , HansenOB , JonssonT , NielsenPR , ChristrupL. Switching from high doses of pure mu-opioid agonists to transdermal buprenorphine in patients with cancer: a feasibility study. J. Opioid Manag.9(4), 255–262 (2013).
  • Wasserman RA , HassettAL , HarteSEet al. Pressure sensitivity and phenotypic changes in patients with suspected opioid-induced hyperalgesia being withdrawn from full mu agonists. J. Nat. Sci.3(2), e319 (2017).
  • Schug SA , BruceJ. Risk stratification for the development of chronic postsurgical pain. Pain Rep.2(6), e627 (2017).
  • Jiang S , XiaR , YanL , BaiJ. Successful reversal of opioid-induced hyperalgesia and allodynia with duloxetine. Pain Med. doi:10.1093/pm/pnaa184 (2020) ( Epub ahead of print).
  • Song L , WuC , ZuoY. Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors. BMC Anesthesiol.15, 12 (2015).
  • Turnaturi R , ChiechioS , SalernoLet al. Progress in the development of more effective and safer analgesics for pain management. Eur. J. Med. Chem.183, 111701 (2019).

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