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Management Perspective

Optimization of Ingredients, Procedures and Rehabilitation for Platelet-Rich Plasma Injections for Chronic Tendinopathy

Kenneth Mautner1 Department of Physical Medicine & Rehabilitation & Department of Orthopedics, Emory University, Atlanta, GA, USACorrespondence[email protected]
,
Gerard Malanga2 Department of Physical Medicine & Rehabilitation, University of Medicine & Dentistry, 30 Bergen Street, Newark, NJ, USA
&
Ricardo Colberg1 Department of Physical Medicine & Rehabilitation & Department of Orthopedics, Emory University, Atlanta, GA, USA
Pages 523-532 | Published online: 02 Nov 2011

Bibliography

  • Rees JD , WilsonAM, WolmanRL. Current concepts in the management of tendon disorders. Rheumatology45(5) , 508–521 (2006).
  • Maffulli N , WongJ, AlmekindersLC. Types and epidemiology of tendinopathy. Clin. Sports Med.22(4) , 675–692 (2003).
  • Tsai WC , HsuCC, ChangHN, LinYC, LinMS, PangJH. Ibuprofen upregulates expressions of matrix metalloproteinase-1, -8, -9, and -13 without affecting expressions of types I and III collagen in tendon cells. J. Orthop. Res.28(4) , 487–491 (2010).
  • Shen W , LiY, TangY, CumminsJ, HuardJ. NS-398, a cycloxoygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis. Am. J. Pathol.167(4) , 1105–1117 (2005).
  • Smidt N , AssendelftWJ, van der Windt DA, Hay EM, Buchbinder R, Bouter LM. Corticosteroid injections for lateral epicondylitis; a systematic review. Pain96 , 23–40 (2002).
  • Smidt N , van der Windt DA, Assendelft WJ, Deville´ WL, Korthals-deBos IB, Bouter LM. Corticosteroid injections, physiotherapy, or a wait-and-see policy for lateral epicondylitis: a randomised controlled trial. Lancet359 , 657–662 (2002).
  • Kleinman M , GrossAE. Achilles tendon rupture following steroid injection: report of three cases. J. Bone Joint Surg. Am.65 , 1345–1347 (1983).
  • Sharma P , MaffulliN. Tendinopathy and tendon injury: the future. Disabil. Rehabil.30(20–22) , 1733–1745 (2008).
  • Millar NL , HueberAJ, ReillyJH et al. Inflammation is present in early human tendinopathy. Am. J. Sports Med. 38(10) , 2085–2091 (2010).
  • Woodley BL , Newsham-WestRJ, BaxterGD. Chronic tendinopathy: effectiveness of eccentric exercise. Br. J. Sports Med.41(4) , 188–198 (2007).
  • Tyler TF , ThomasGC, NicholasSJ, McHughMP. Addition of isolated wrist extensor eccentric exercise to standard treatment for chronic lateral epicondylosis: a prospective randomized trial. J. Shoulder Elbow Surg.19(6) , 917–922 (2010).
  • Ohberg L , LorentzonR, AlfredsonH. Eccentric training in patients with chronic Achilles tendinosis: normalised tendon structure and decreased thickness at follow up. Br. J. Sports Med.38(1) , 8–11 (2004).
  • Fu SC , RolfC, CheukYC, LuiPP, ChanKM. Deciphering the pathogenesis of tendinopathy: a three-stages process. Sports Med. Arthrosc. Rehabil. Ther. Technol.2 , 30 (2010).
  • Alsousou J , ThompsonM, HulleyP, NobleA, WilletK. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J. Bone Joint Surg. Br.91(8) , 987–996 (2009).
  • Foster , TE, Puskas, BL, Mandelbaum, BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: from basic science to clinical applications. Am. J. Sports Med.37 , 2259–2272 (2009).
  • Hall MP , BandPA, MeislinRJ, JazrawiLM, CardoneDA. Platelet-rich plasma: current concepts and application in sports medicine. J. Am. Acad. Orthop. Surg.17(10) , 602–608 (2009).
  • Mehta S , WatsonJT. Platelet-rich concentrate: basic science and clinical applications. J. Orthop. Trauma.22(6) , 432–438 (2008).
  • Roback J , CombsM, GrossmanB, HillyerC. Technical Manual of the American Association of Blood Banks (16th Edition). American Association of Blood Banks (AABB), MD, USA (2008).
  • Ferrari M , ZiaS, ValbonesiM. A new technique for hemodilution, preparation of autologous platelet-rich plasma and intraoperative blood salvage in cardiac surgery. Int. J. Artif. Organs.10 , 47–50 (1987).
  • Mishra A , WoodallJ Jr, Vieira A. Treatment of tendon and muscle using platelet-rich plasma. Clin. Sports Med.28(1) , 113–125 (2009).
  • Molloy T , WangY, MurrellG. The roles of growth factors in tendon and ligament healing. Sports Med.33 , 381–394 (2003).
  • De Mos M , van der Windt AE, Jahr H et al. Can platelet rich plasma enhance tendon repair? A cell culture study. Am. J. Sports Med.36 , 1171–1178 (2008).
  • de Vos RJ , WeirA, van Schie HTM et al. Platelet-rich plasma injection for chronic achilles tendinopathy: a randomized controlled trial. JAMA303(2) , 144–149 (2010).
  • Filardo G , KonE, Della Villa S, Vincentelli F, Fornasari PM, Marcacci M. Use of platelet-rich plasma for the treatment of refractory jumper‘s knee. Int. Orthop.34(6) , 909–915 (2010).
  • Gaweda K , TarczynskaM, KrzyzanowskiW. Treatment of Achilles Tendinopathy with Platelet-Rich Plasma. Int. J. Sports Med.31(8) , 577–583 (2010).
  • Kon E , FilardoG, DelcoglianoM et al. Platelet-rich plasma: new clinical application: a pilot study for treatment of jumper‘s knee. Injury 40(6) , 598–603 (2009).
  • Mishra A , PavelkoT. Treatment of chronic elbow tendinosis with buffered platelet rich plasma. Am. J. Sports Med.34 , 1774–1778 (2006).
  • Peerbooms JC , SluimerJ, BruijnDJ, GosensT. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma vs corticosteroid injection with a 1-year follow up. Am. J. Sports Med.38 , 255–262 (2010).
  • Gosens T , PeerboomsJC, van Laar W, den Oudsten BL. Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. Am. J. Sports Med.39(6) , 1200–1208 (2011).
  • Mautner K , ColbergR, MalangaG et al. Platelet-rich plasma for chronic tendinopathies. Presented at: 6th World Congress of the International Society for Physical and Rehabilitation Medicine. San Juan, Puerto Rico, 11–16 June 2011.
  • Wang-Saegusa A , CugatR, AresO, SeijasR, CuscóX, Garcia-BalletbóM. Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life. Arch Orthop. Trauma Surg.131(3) , 311–317 (2011).
  • Nguyen RT , Borg-SteinJ, McInnisK. Applications of platelet-rich plasma in musculoskeletal and sports medicine: an evidence-based approach. PM R.3(3) , 226–250 (2011).
  • Kevy SV , JacobsonMS. Comparison of methods for point of care preparation of autologous platelet gel. J. Extra Corpor. Technol.36 , 28–35 (2004).
  • Pietrzak W , EppleyB. Scientific foundations platelet rich plasma: biology and new technology. J. Craniofac. Surg.16(6) , 1043–1054 (2005).
  • Marx RE . Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant. Dent.10 , 225–228 (2001)
  • Sampson S , GerhardtM, MandelbaumB. Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr. Rev. Musculoskelet. Med.1(3–4) , 165–174 (2008).
  • Graziani F , IvanovskiS, CeiS, DucciF, TonettiM, GabrieleM. The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts. Clin. Oral Implants. Res.17(2) , 212–219 (2006).
  • Weibrich G , HansenT, KleisW, BuchR, HitzlerWE. Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone34(4) , 665–671 (2004).
  • Giusti I , RughettiA, D‘AscenzoS et al. Identification of an optimal concentration of platelet gel for promoting angiogenesis in human endothelial cells. Transfusion 49(4) , 771–778 (2009).
  • Haynesworth SE , BruderSP et al. Mitogenic stimulation of human mesenchymal stem cells by platelet releasate. Presented at: The American Academy of Orthopedic Surgery. San Francisco, CA, USA, March 2001.
  • Kevy S , JacobsonM, MandleR. Defining the composition and healing effect of platelet-rich plasma. Presented at: Platelet-Rich Plasma Symposium. Hospital for Special Surgery, NY, USA, 5 August 2010.
  • Tidball JG . Inflammatory processes in muscle injury and repair. Am. J. Physiol. Regul. Integr. Comp. Physiol.288(2) , 345–353 (2005).
  • Pizza FX , McLoughlinTJ, McGregorSJ, CalomeniEP, GunningWT. Neutrophils injure cultured skeletal myotubes. Am. J. Physiol. Cell Physiol.281(1) , 335–341 (2001).
  • Pizza FX , PetersonJM, BaasJH, KohTJ. Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice. J. Physiol.562(3) , 899–913 (2005).
  • Schneider LA , KorberA, GrabbeS, DissemondJ. Influence of pH on wound-healing: a new perspective for wound-therapy? Arch Dermatol. Res.298(9) , 413–420 (2007).
  • El-Sharkawy H , KantarciA, DeadyJ et al. Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties. J. Periodontol. 78(4) , 661–669 (2007).
  • Tsay RC , VoJ, BurkeA, EisigSB, LuHH, LandesbergR. Differential growth factor retention by platelet-rich plasma composites. J. Oral Maxillofac. Surg.63(4) , 521–528 (2005).
  • Fufa D , ShealyB, JacobsonM, KevyS, MurrayMM. Activation of platelet-rich plasma using soluble type I collagen. J. Oral Maxillofac. Surg.66(4) , 684–690 (2008).
  • Roussy Y , Bertrand Duchesne MP, Gagnon G. Activation of human platelet-rich plasmas: effect on growth factors release, cell division and in vivo bone formation. Clin. Oral Implants Res.18(5) , 639–648 (2007).
  • Han B , Woodell-MayJ, PonticielloM, YangZ, NimniM. The effect of thrombin activation of platelet-rich plasma on demineralized bone matrix osteoinductivity. J. Bone Joint Surg. Am.91(6) , 1459–1470 (2009).
  • Edlow DW , SheldonWH. The pH of inflammatory exudates. Proc. Soc. Exp. Biol. Med.137(4) , 1328–1332 (1971).
  • Leveen HH , FalkG, BorekB et al. Chemical acidification of wounds. An adjuvant to healing and the unfavorable action of alkalinity and ammonia. Ann. Surg. 178(6) , 745–753 (1973).
  • Liu Y , KalénA, RistoO, WahlströmO. Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent. Wound Repair Regen.10(5) , 336–340 (2002).
  • Nilsson E , WendebergB. Effect of local anaesthetics on wound healing. An experimental study with special reference to carbocain. Acta Anaesthesiol. Scand.51(8) , 991–1003 (2007).
  • Scherb MB , HanSH, CourneyaJP, GuytonGP, SchonLC. Effect of bupivacaine on cultured tenocytes. Orthopedics32(1) , 26 (2009).
  • Fredberg U , BolvigL, Pfeiffer-JensenM, ClemmensenD, JakobsenBW, Stengaard-PedersenK. Ultrasonography as a tool for diagnosis, guidance of local steroid injection and, together with pressure algometry, monitoring of the treatment of athletes with chronic jumper‘s knee and achilles tendinitis: a randomized, double-blind, placebo-controlled study. Scand. J. Rheumatol.33(2) , 94–101 (2004).
  • Finnoff JT , NutzDJ, HenningPT, HollmanJH, SmithJ. Accuracy of ultrasound-guided versus unguided pes anserinus bursa injections. PM R2(8) , 732–739 (2010).
  • Peck E , LaiJK, PawlinaW, SmithJ. Accuracy of ultrasound-guided versus palpation-guided acromioclavicular joint injections: a cadaveric study. PM R2(9) , 817–821 (2010).
  • Finnoff JT , HurdleMF, SmithJ. Accuracy of ultrasound-guided versus fluoroscopically guided contrast-controlled piriformis injections: a cadaveric study. J. Ultrasound Med.27(8) , 1157–1163 (2008).
  • Naredo E , CaberoF, BeneytoP et al. A randomized comparative study of short term response to blind injection versus sonographic-guided injection of local corticosteroids in patients with painful shoulder. J. Rheumatol. 31(2) , 308–314 (2004).
  • Sibbitt WL Jr, Peisajovich A, Michael AA et al. Does sonographic needle guidance affect the clinical outcome of intraarticular injections? J. Rheumatol.36(9) , 1892–1902 (2009).
  • Smith J , FinnoffJT, Santaella-SanteB, HenningT, LevyBA, LaiJK. Sonographically guided popliteus tendon sheath injection: techniques and accuracy. J. Ultrasound Med.29(5) , 775–782 (2010).
  • Smith J , HurdleMF, WeingartenTN. Accuracy of sonographically guided intra-articular injections in the native adult hip. J. Ultrasound Med.28(3) , 329–335 (2009).
  • Zingas C , FaillaJM, Van Holsbeeck M. Injection accuracy and clinical relief of de Quervain‘s tendinitis. J. Hand Surg. Am.23(1) , 89–96 (1998).
  • Nissen NN , PolveriniPJ, KochAE, VolinMV, GamelliRL, DiPietroLA. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am. J. Pathol.152(6) , 1445–1452 (1998).
  • Virchenko O , AspenbergP. How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation. Acta Orthop.77(5) , 806–812 (2006).
  • Langberg H , EllingsgaardH, MadsenT et al. Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis. Scand. J. Med. Sci. Sports. 17(1) , 61–66 (2007).
  • Kjaer M , LangbergH, HeinemeierK et al. From mechanical loading to collagen synthesis, structural changes and function in human tendon. Scand. J. Med. Sci. Sports. 19(4) , 500–510 (2009).
  • Knobloch K . Eccentric training in Achilles tendinopathy: is it harmful to tendon microcirculation? Br. J. Sports Med.41(6) , (2007).
  • Nadler SF , MalangaGA, DePrinceM, StitikTP, FeinbergJH. The relationship between lower extremity injury, low back pain, and hip muscle strength in male and female collegiate athletes. Clin. J. Sport Med.10(2) , 89–97 (2000).
  • Rees JD , MaffulliN, CookJ. Management of tendinopathy. Am. J. Sports Med.37(9) , 1855–1867 (2009).
  • Alfredson H , PietiläT, JonssonP, LorentzonR. Heavy-load eccentric calf muscle training for the treatment of chronic Achilles tendinosis. Am. J. Sports Med.26(3) , 360–366 (1998).
  • Woodley BL , Newsham-WestRJ, BaxterGD. Chronic tendinopathy: effectiveness of eccentric exercise. Br. J. Sports Med.41(4) , 188–198 (2007).
  • Leadbetter WB . Cell-matrix response in tendon injury. Clin. Sports Med.11(3) , 533–578 (1992)
  • Witte MG , BarbulA. The process of wound repair. Surg. Clin. North Am.77 , 509–528 (1997)
  • Kumar V , AbbasA, FaustoN. Tissue renewal and repair: regeneration, healing, and fibrosis. In: Robbins and Cotran Pathologic Basis of Disease (7th Edition). Elsvier Saunders, PA, USA, 87–118 (2005).

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