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Commentary

Adenosine A3 Receptor Agonists: Do Recent Findings Offer New Hope in Chronic Pain Treatment?

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Pages 75-80 | Published online: 25 Mar 2015

References

  • Zylka MJ . Pain-relieving prospects for adenosine receptors and ectonucleotidases . Trends Mol. Med.17 ( 4 ), 188 – 196 ( 2011 ).
  • Sawynok J . Adenosine and ATP receptors . Handb. Exp. Pharmacol. ( 177 ), 309 – 328 ( 2007 ).
  • Fredholm BB , IJzermanAP , JacobsonKA , LindenJ , MullerCE . International union of basic and clinical pharmacology. LXXXI. Nomenclature and classification of adenosine receptors – an update . Pharmacol. Rev.63 ( 1 ), 1 – 34 ( 2011 ).
  • Sawynok J , LiuXJ . Adenosine in the spinal cord and periphery: release and regulation of pain . Prog. Neurobiol.69 ( 5 ), 313 – 340 ( 2003 ).
  • Sebastiao AM , RibeiroJA . Adenosine receptors and the central nervous system . Handb. Exp. Pharmacol. ( 193 ), 471 – 534 ( 2009 ).
  • Sneyd JR , LangtonJA , AllanLG , PeacockJE , RowbothamDJ . Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction . Br. J. Anaesth.98 ( 5 ), 672 – 676 ( 2007 ).
  • Hussey MJ , ClarkeGD , LedentC , HouraniSM , KitchenI . Reduced response to the formalin test and lowered spinal NMDA glutamate receptor binding in adenosine A2A receptor knockout mice . Pain129 ( 3 ), 287 – 294 ( 2007 ).
  • Li L , HaoJX , FredholmBB , SchulteG , Wiesenfeld-HallinZ , XuXJ . Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice . Neuroscience170 ( 3 ), 923 – 928 ( 2010 ).
  • Bilkei-Gorzo A , Abo-SalemOM , HayallahAM , MichelK , MullerCE , ZimmerA . Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia . Naunyn Schmiedebergs Arch. Pharmacol.377 ( 1 ), 65 – 76 ( 2008 ).
  • Abo-Salem OM , HayallahAM , Bilkei-GorzoA , FilipekB , ZimmerA , MullerCE . Antinociceptive effects of novel A2B adenosine receptor antagonists . J. Pharmacol. Exp. Ther.308 ( 1 ), 358 – 366 ( 2004 ).
  • Tavares C , SakataRK . Caffeine in the treatment of pain . Rev. Bras. Anestesiol.62 ( 3 ), 387 – 401 ( 2012 ).
  • Muller CE , JacobsonKA . Recent developments in adenosine receptor ligands and their potential as novel drugs . Biochim. Biophys. Acta1808 ( 5 ), 1290 – 1308 ( 2011 ).
  • Bar-Yehuda S , SilvermanMH , KernsWD , OchaionA , CohenS , FishmanP . The anti-inflammatory effect of A3 adenosine receptor agonists: a novel targeted therapy for rheumatoid arthritis . Expert Opin. Investig. Drugs16 ( 10 ), 1601 – 1613 ( 2007 ).
  • Ochaion A , Bar-YehudaS , CohenSet al. The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats . Biochem. Pharmacol.76 ( 4 ), 482 – 494 ( 2008 ).
  • Wu WP , HaoJX , Halldner-HenrikssonLet al. Decreased inflammatory pain due to reduced carrageenan-induced inflammation in mice lacking adenosine A3 receptors . Neuroscience114 ( 3 ), 523 – 527 ( 2002 ).
  • Sawynok J , ZarrindastMR , ReidAR , DoakGJ . Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine . Eur. J. Pharmacol.333 ( 1 ), 1 – 7 ( 1997 ).
  • Yoon MH , BaeHB , ChoiJI . Antinociception of intrathecal adenosine receptor subtype agonists in rat formalin test . Anesth. Analg.101 ( 5 ), 1417 – 1421 ( 2005 ).
  • Chen Z , JanesK , ChenCet al. Controlling murine and rat chronic pain through A3 adenosine receptor activation . FASEB J.26 ( 5 ), 1855 – 1865 ( 2012 ).
  • Janes K , EspositoE , DoyleTet al. A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways . Pain155 ( 12 ), 2560 – 2567 ( 2014 ).
  • Little JW , FordA , Symons-LiguoriAMet al. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states . Brain138 ( Pt 1 ), 28 – 35 ( 2015 ).
  • Mundell S , KellyE . Adenosine receptor desensitization and trafficking . Biochim. Biophys. Acta1808 ( 5 ), 1319 – 1328 ( 2011 ).
  • Trincavelli ML , TuscanoD , MarroniM , KlotzKN , LucacchiniA , MartiniC . Involvement of mitogen protein kinase cascade in agonist-mediated human A(3) adenosine receptor regulation . Biochim. Biophys. Acta1591 ( 1–3 ), 55 – 62 ( 2002 ).

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