Switching off Pain at the Source: Is This The End For Opioid Pain Relief?

References

• De Maeyer J , VanderplasschenW , BroekaertE . Quality of life among opiate-dependent individuals: a review of the literature . Int. J. Drug Policy21 ( 5 ), 364 – 380 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Feddern ML , JensenTS , LaurbergS . Chronic pain in the pelvic area or lower extremities after rectal cancer treatment and its impact on quality of life. A population-based, cross-sectional study . Pain156 ( 9 ), 1765 – 1771 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Ballantyne JC , LaforgeKS . Opioid dependence and addiction during opioid treatment of chronic pain . Pain129 ( 3 ), 235 – 255 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Pasternak GW . When it comes to opiates, just say NO . J. Clin. Invest.117 ( 11 ), 3185 – 3187 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Fornasari D . Pain mechanisms in patients with chronic pain . Clin. Drug Investig.32 ( Suppl 1 ), 45 – 52 ( 2012 ).
   Google Scholar
• Carinci AJ , MaoJ . Pain and opioid addiction: what is the connection?Curr. Pain Headache Rep.14 ( 1 ), 17 – 21 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Gyawali B , HayashiN , TsukuuraH , HondaK , ShimokataT , AndoY . Opioid-induced constipation . Scand. J. Gastroenterol.50 ( 11 ), 1331 – 1338 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Donner B , ZenzM . Transdermal fentanyl: a new step on the therapeutic ladder . Anticancer Drugs6 ( Suppl 3 ), 39 – 43 ( 1995 ).
   PubMedGoogle Scholar
• Brown J , SetnikB , LeeKet al. Assessment, stratification, and monitoring of the risk for prescription opioid misuse and abuse in the primary care setting . J. Opioid Manag.7 ( 6 ), 467 – 483 ( 2011 ).
   PubMedGoogle Scholar
• Mitra R . The utilization of opiates in pain management: use or abuse . Eur. J. Phys. Rehabil. Med.49 ( 1 ), 93 – 96 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Walwyn WM , MiottoKA , EvansCJ . Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions . Drug Alcohol Depend.108 ( 3 ), 156 – 165 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Cox JJ , ReimannF , NicholasAKet al. An SCN9A channelopathy causes congenital inability to experience pain . Nature444 ( 7121 ), 894 – 898 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Cregg R , MominA , RugieroF , WoodJN , ZhaoJ . Pain channelopathies . J. Physiol.588 ( Pt 11 ), 1897 – 1904 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Bennett DL , WoodsCG . Painful and painless channelopathies . Lancet Neurol.13 ( 6 ), 587 – 599 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Ho C , O’learyME . Single-cell analysis of sodium channel expression in dorsal root ganglion neurons . Mol. Cell. Neurosci.46 ( 1 ), 159 – 166 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Nassar MA , StirlingLC , ForlaniGet al. Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain . Proc. Natl Acad. Sci. USA101 ( 34 ), 12706 – 12711 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Weiss J , PyrskiM , JacobiEet al. Loss-of-function mutations in sodium channel Nav1.7 cause anosmia . Nature472 ( 7342 ), 186 – 190 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Gingras J , SmithS , MatsonDJet al. Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain . PLoS ONE9 ( 9 ), e105895 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Kotterman MA , SchafferDV . Engineering adeno-associated viruses for clinical gene therapy . Nat. Rev. Genet.15 ( 7 ), 445 – 451 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Bainbridge JW , AliRR . Keeping an eye on clinical trials in 2008 . Gene Ther.15 ( 9 ), 633 – 634 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Bainbridge JW , SmithAJ , BarkerSSet al. Effect of gene therapy on visual function in Leber’s congenital amaurosis . N. Engl. J. Med.358 ( 21 ), 2231 – 2239 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Jessup M , GreenbergB , ManciniDet al. Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a Phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure . Circulation124 ( 3 ), 304 – 313 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• LeWitt PA , RezaiAR , LeeheyMAet al. AAV2–GAD gene therapy for advanced Parkinson’s disease: a double-blind, sham-surgery controlled, randomised trial . Lancet Neurol.10 ( 4 ), 309 – 319 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Spencer NJ , KylohM , DuffieldM . Identification of different types of spinal afferent nerve endings that encode noxious and innocuous stimuli in the large intestine using a novel anterograde tracing technique . PLoS ONE9 ( 11 ), e112466 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Kyloh M , SpencerNJ . A novel anterograde neuronal tracing technique to selectively label spinal afferent nerve endings that encode noxious and innocuous stimuli in visceral organs . Neurogastroenterol. Motil.26 ( 3 ), 440 – 444 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Kyloh M , NicholasS , ZagorodnyukVP , BrookesSJ , SpencerNJ . Identification of the visceral pain pathway activated by noxious colorectal distension in mice . Front. Neurosci.5 , 16 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Muroi Y , RuF , KollarikMet al. Selective silencing of Na(V)1.7 decreases excitability and conduction in vagal sensory neurons . J. Physiol.589 ( Pt 23 ), 5663 – 5676 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Watkins LR , MilliganED , MaierSF . Spinal cord glia: new players in pain . Pain93 ( 3 ), 201 – 205 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Sun L , WuZ , HayashiYet al. Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain . J. Neurosci.32 ( 33 ), 11330 – 11342 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Storek B , ReinhardtM , WangCet al. Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain . Proc. Natl Acad. Sci. USA105 ( 3 ), 1055 – 1060 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Zagorodnyuk VP , KylohM , NicholasSet al. Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung’s disease . J. Physiol.589 ( Pt 7 ), 1691 – 1706 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Lee JH , ParkCK , ChenGet al. A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief . Cell157 ( 6 ), 1393 – 1404 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Pleticha J , HeilmannLF , EvansCH , AsokanA , SamulskiRJ , BeutlerAS . Preclinical toxicity evaluation of AAV for pain: evidence from human AAV studies and from the pharmacology of analgesic drugs . Mol. Pain10 , 54 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Beutler AS , ReinhardtM . AAV for pain: steps towards clinical translation . Gene Ther.16 ( 4 ), 461 – 469 ( 2009 ).
   PubMed Web of Science ®Google Scholar