Challenges in the Clinical Translation of Exosomal Therapy in Regenerative Medicine

References

• Fisher MB , MauckRL. Tissue engineering and regenerative medicine: recent innovations and the transition to translation. Tissue Eng. Part B Rev.19(1), 1–13 (2013).
   PubMed Web of Science ®Google Scholar
• Atala A . Tissue engineering and regenerative medicine: concepts for clinical application. Rejuvenation Res.7(1), 15–31 (2004).
   PubMed Web of Science ®Google Scholar
• Furth ME , AtalaA , Van DykeME. Smart biomaterials design for tissue engineering and regenerative medicine. Biomaterials28(34), 5068–5073 (2007).
   PubMed Web of Science ®Google Scholar
• Pina S , RibeiroVP , MarquesCFet al. Scaffolding strategies for tissue engineering and regenerative medicine applications. Materials12(11), 1824 (2019).
   PubMed Web of Science ®Google Scholar
• Muthu S , BapatA , JainR , JeyaramanN , JeyaramanM. Exosomal therapy-a new frontier in regenerative medicine. Stem Cell Investig.8, 7 (2021).
   PubMedGoogle Scholar
• Banerjee A , JainSM , SAbrar S , KumarMM , MathewC , PathakS. Sources, isolation strategies and therapeutic outcome of exosomes at a glance. Regen. Med.15(12), 2361–2378 (2020).
   PubMed Web of Science ®Google Scholar
• Liang B , HeX , ZhaoY-X , ZhangX-X , GuN. Advances in exosomes derived from different cell sources and cardiovascular diseases. BioMed Res. Intl2020, e7298687 (2020).
   PubMed Web of Science ®Google Scholar
• Akuma P , OkaguOD , UdenigweCC. Naturally occurring exosome vesicles as potential delivery vehicle for bioactive compounds. Front. Sustain. Food Syst.3, 23 (2019).
   Google Scholar
• Börger V , WeissDJ , AndersonJDet al. International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19. Cytotherapy22(9), 482–485 (2020).
   PubMed Web of Science ®Google Scholar
• Wang J , ChenD , HoEA. Challenges in the development and establishment of exosome-based drug delivery systems. J. Control. Rel.329, 894–906 (2021).
   PubMed Web of Science ®Google Scholar
• Chen Y-S , LinE-Y , ChiouT-W , HarnH-J. Exosomes in clinical trial and their production in compliance with good manufacturing practice. Tzu Chi Med. J.32(2), 113–120 (2019).
   Web of Science ®Google Scholar
• Gardiner C , DiVizio D , SahooSet al. Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey. J. Extracell. Vesicles5, 32945 (2016).
   PubMed Web of Science ®Google Scholar
• Tauro BJ , GreeningDW , MathiasRAet al. Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. Methods56(2), 293–304 (2012).
   PubMed Web of Science ®Google Scholar
• Van Deun J , MestdaghP , SormunenRet al. The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling. J. Extracell. Vesicles3(1), 24858 (2014).
   PubMedGoogle Scholar
• Riau AK , OngHS , YamGHF , MehtaJS. Sustained delivery system for stem cell-derived exosomes. Front Pharmacol.10, 1368 (2019).
   PubMed Web of Science ®Google Scholar
• Patel DB , GrayKM , SantharamY , LamichhaneTN , StrokaKM , JaySM. Impact of cell culture parameters on production and vascularization bioactivity of mesenchymal stem cell‐derived extracellular vesicles. Bioeng. Transl. Med.2(2), 170–179 (2017).
   PubMed Web of Science ®Google Scholar
• Meng W , HeC , HaoY , WangL , LiL , ZhuG. Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source. Drug Deliv.27(1), 585–598 (2020).
   PubMed Web of Science ®Google Scholar
• Elliott RO , HeM. Unlocking the power of exosomes for crossing biological barriers in drug delivery. Pharmaceutics13(1), 122 (2021).
   PubMed Web of Science ®Google Scholar
• Gutiérrez-Vázquez C , Villarroya-BeltriC , MittelbrunnM , Sánchez-MadridF. Transfer of extracellular vesicles during immune cell-cell interactions. Immunol. Rev.251(1), 125–142 (2013).
   PubMed Web of Science ®Google Scholar
• Prunevieille A , Babiker-MohamedMH , AslamiC , Gonzalez-NolascoB , MooneyN , BenichouG. T cell antigenicity and immunogenicity of allogeneic exosomes. Am. J. Transpl.21(7), 2583–2589 (2021).
   PubMed Web of Science ®Google Scholar
• Fuhrmann G , SerioA , MazoM , NairR , StevensMM. Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins. J. Control. Rel.205, 35–44 (2015).
   PubMed Web of Science ®Google Scholar
• Mendt M , KamerkarS , SugimotoHet al. Generation and testing of clinical-grade exosomes for pancreatic cancer. JCI Insight3(8), 99263 (2018).
   PubMed Web of Science ®Google Scholar
• Jeyaram A , JaySM. Preservation and storage stability of extracellular vesicles for therapeutic applications. AAPS J.20(1), 1 (2017).
   PubMed Web of Science ®Google Scholar
• Rezabakhsh A , SokulluE , RahbarghaziR. Applications, challenges and prospects of mesenchymal stem cell exosomes in regenerative medicine. Stem Cell Res. Ther.12(1), 521 (2021).
   PubMed Web of Science ®Google Scholar
• Kusuma GD , BarabadiM , TanJL , MortonDAV , FrithJE , LimR. To protect and to preserve: novel preservation strategies for extracellular vesicles. Front Pharmacol.9, 1199 (2018).
   PubMed Web of Science ®Google Scholar
• Xu M , FengT , LiuBet al. Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies. Theranostics11(18), 8926–8944 (2021).
   PubMed Web of Science ®Google Scholar
• Luan X , SansanaphongprichaK , MyersI , ChenH , YuanH , SunD. Engineering exosomes as refined biological nanoplatforms for drug delivery. Acta Pharmacol. Sin.38(6), 754–763 (2017).
   PubMed Web of Science ®Google Scholar