Regenerative Vs Flap-Based Limb Salvage: A Multi-Centered, Prospective, Randomized Controlled Trial

References

• Koshy J , SeruyaM. Reconstructive algorithms in the pediatric population. J. Surg. Oncol.113(8), 940–945 (2016).
   PubMed Web of Science ®Google Scholar
• Janis JE , KwonRK , AttingerCE. The new reconstructive ladder: modifications to the traditional model. Plast. Reconstr. Surg.127(Suppl. 1), S205–S212 (2011).
   PubMed Web of Science ®Google Scholar
• Gottlieb LJ , KriegerLM. From the reconstructive ladder to the reconstructive elevator. Plast. Reconstr. Surg.93(7), 1503–1504 (1994).
   PubMed Web of Science ®Google Scholar
• Pollak AN , McCarthyML , BurgessAR. Short-term wound complications after application of flaps for coverage of traumatic soft-tissue defects about the tibia. The Lower Extremity Assessment Project (LEAP) Study Group. J. Bone Joint Surg. Am.82(12), 1681–1691 (2000).
   PubMedGoogle Scholar
• Upton J , GuoL. Pediatric free tissue transfer: a 29-year experience with 433 transfers. Plast. Reconstr. Surg.121(5), 1725–1737 (2008).
   PubMed Web of Science ®Google Scholar
• Canales F , LineaweaverWC , FurnasHet al. Microvascular tissue transfer in paediatric patients: analysis of 106 cases. Br. J. Plast. Surg.44(6), 423–427 (1991).
   PubMedGoogle Scholar
• Torabi R , StrongA , HoganM , DupinC , TesslerO , LauF. Bone and Tendon Coverage via Dehydrated Human Amniotic/Chorionic Membrane and Split-Thickness Skin Grafting. J. Reconstr. Microsurg. Open01(01), 059–062 (2016).
   Google Scholar
• Saeg F , ChiccarelliEN , StHilaire H , LauFH. Regenerative Limb Salvage: A Novel Technique for Soft Tissue Reconstruction of Pediatric Extremities. J. Reconstr. Microsurg. Open05(02), e82–e89 (2020).
   Google Scholar
• Koob TJ , RennertR , ZabekNet al. Biological properties of dehydrated human amnion/chorion composite graft: implications for chronic wound healing. Int. Wound J.10(5), 493–500 (2013).
   PubMed Web of Science ®Google Scholar
• Zelen CM , SnyderRJ , SerenaTE , LiWW. The use of human amnion/chorion membrane in the clinical setting for lower extremity repair: a review. Clin. Podiatr. Med. Surg.32(1), 135–146 (2015).
   PubMed Web of Science ®Google Scholar
• Bosse MJ , MacKenzieEJ , KellamJFet al. An analysis of outcomes of reconstruction or amputation after leg-threatening injuries. N. Engl. J. Med.347(24), 1924–1931 (2002).
   PubMed Web of Science ®Google Scholar
• Sabino JM , SlaterJ , ValerioIL. Plastic Surgery Challenges in War Wounded I: Flap-Based Extremity Reconstruction. Adv. Wound Care5(9), 403–411 (2016).
   Web of Science ®Google Scholar
• Valerio IL , SabinoJM , DearthCL. Plastic Surgery Challenges in War Wounded II: Regenerative Medicine. Adv. Wound Care5(9), 412–419 (2016).
   Web of Science ®Google Scholar
• Sharif-Askary B , ZolperEG , DeldarRet al. Risk Factors for Loss to Follow-Up in the Lower Extremity Limb Salvage Population. Plast. Reconstr. Surg.148(4), 883–893 (2021).
   PubMed Web of Science ®Google Scholar
• Malik D , LuckJ , SmithOJ , MosahebiA. A Systematic Review of Autologous Fat Grafting in the Treatment of Acute and Chronic Cutaneous Wounds. Plast. Reconstr. surgery. Glob. open8(5), e2835 (2020).
   PubMedGoogle Scholar
• Piccinini P , deSousa Rebelato M , MasriM , UebelC , StümpfleR , de OliveiraM. Combined Regenerative Approach for a Complex Lower Extremity Wound: A Case Report. Wounds a Compend. Clin. Res. Pract.33(5), E34–E38 (2021).
   PubMedGoogle Scholar
• Smith OJ , JellG , MosahebiA. The use of fat grafting and platelet-rich plasma for wound healing: a review of the current evidence. Int. Wound J.16(1), 275–285 (2019).
   PubMed Web of Science ®Google Scholar
• Au AS , LeungWY , StavoskyJW. Efficacy of Dehydrated Human Amnion Chorion Membrane in the Treatment of Diabetic Foot Ulcers: A Review. J. Am. Podiatr. Med. Assoc.111(2), (2021).
   PubMed Web of Science ®Google Scholar
• Puyana S , RuizS , ElkbuliAet al. The Use of Dehydrated Human Amniotic Membrane Versus Amniotic/Chorionic Membrane Allografts to Treat Partial Thickness Facial Burns. J. Craniofac. Surg.31(1), 201–203 (2020).
   PubMed Web of Science ®Google Scholar
• Ahuja N , JinR , PowersC , BilliA , BassK. Dehydrated Human Amnion Chorion Membrane as Treatment for Pediatric Burns. Adv. wound care9(11), 602–611 (2020).
   Web of Science ®Google Scholar
• Schlanser V , DennisA , IvkovicKet al. Placenta to the Rescue: Limb Salvage Using Dehydrated Human Amnion/Chorion Membrane. J. Burn Care Res.39(6), 1048–1052 (2018).
   PubMed Web of Science ®Google Scholar
• Struebing F , XiongL , BigdeliAKet al. Microsurgical Strategies after Free Flap Failure in Soft Tissue Reconstruction of the Lower Extremity: A 17-Year Single-Center Experience. J. Pers. Med.12(10), 1563 (2022).
   PubMed Web of Science ®Google Scholar
• Culliford AT , SpectorJ , BlankA , KarpNS , KasabianA , LevineJP. The Fate of Lower Extremities With Failed Free Flaps. Ann. Plast. Surg.59(1), 18–22 (2007).
   PubMed Web of Science ®Google Scholar
• Park JE , RodriguezED , Bluebond-LangerRet al. The Anterolateral Thigh Flap is Highly Effective for Reconstruction of Complex Lower Extremity Trauma. J. Trauma Inj. Infect. Crit. Care62(1), 162–165 (2007).
   PubMedGoogle Scholar
• Fischer J , WinkJ , NelsonJet al. A Retrospective Review of Outcomes and Flap Selection in Free Tissue Transfers for Complex Lower Extremity Reconstruction. J. Reconstr. Microsurg.29(06), 407–416 (2013).
   PubMedGoogle Scholar
• Bekara F , HerlinC , SomdaS , de RunzA , GrolleauJL , ChaputB. Free versus perforator-pedicled propeller flaps in lower extremity reconstruction: what is the safest coverage? A meta-analysis. Microsurgery38(1), 109–119 (2018).
   PubMed Web of Science ®Google Scholar
• Khouri RK , ShawWW. Reconstruction of the lower extremity with microvascular free flaps: a 10-year experience with 304 consecutive cases. J. Trauma29(8), 1086–1094 (1989).
   PubMedGoogle Scholar
• Demirtas Y , KelahmetogluO , CifciM , TayfurV , DemirA , GunerenE. Comparison of free anterolateral thigh flaps and free muscle-musculocutaneous flaps in soft tissue reconstruction of lower extremity. Microsurgery30(1), 24–31 (2009).
   Web of Science ®Google Scholar