Advanced search
Publication Cover
Regenerative Medicine Volume 18, 2015 - Issue 12
Submit an article Journal homepage
79
Views
0
CrossRef citations to date
0
Altmetric
Case Report

Improved Neurological Function in a Patient with Complete Spinal Cord Injury Through Bone Marrow Mesenchymal Stem Cells Implantation: a Case Report

Ying-Chuan Kuan1 Department of Neurosurgery, Hualien Tzu Chi Hospital, Hualien, 970, Taiwan;2 Institute of Medical Sciences, Tzu Chi University, Hualien, 970, Taiwan
,
Shinn-Zong Lin1 Department of Neurosurgery, Hualien Tzu Chi Hospital, Hualien, 970, Taiwan;2 Institute of Medical Sciences, Tzu Chi University, Hualien, 970, Taiwan;3 Bioinnovation Center, Tzu Chi Foundation, Hualien, 970, Taiwan
,
Tsung-Lang Chiu1 Department of Neurosurgery, Hualien Tzu Chi Hospital, Hualien, 970, Taiwan;2 Institute of Medical Sciences, Tzu Chi University, Hualien, 970, Taiwan
&
Hsiang-Yi Hung1 Department of Neurosurgery, Hualien Tzu Chi Hospital, Hualien, 970, Taiwan;2 Institute of Medical Sciences, Tzu Chi University, Hualien, 970, TaiwanCorrespondence[email protected]
Pages 907-911 | Received 16 Jun 2023, Accepted 18 Sep 2023, Published online: 22 Nov 2023

References

  • Dvorak MF Noonan VK Fallah N The influence of time from injury to surgery on motor recovery and length of hospital stay in acute traumatic spinal cord injury: an observational Canadian cohort study. J. Neurotrauma32(9), 645–654 (2015).
  • Wilson JR Forgione N Fehlings MG . Emerging therapies for acute traumatic spinal cord injury. CMAJ185(6), 485–492 (2013).
  • Silva NA Sousa N Reis RL Salgado AJ . From basics to clinical: a comprehensive review on spinal cord injury. Prog. Neurobiol.114, 25–57 (2014).
  • Rowland JW Hawryluk GW Kwon B Fehlings MG . Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon. Neurosurg. Focus.25(5), E2 (2008).
  • McDonald JW Sadowsky C . Spinal-cord injury. Lancet (London, England).359(9304), 417–425 (2002).
  • Becker D McDonald JW 3rd . Approaches to repairing the damaged spinal cord: overview. Handb. Clinic. Neurol.109, 445–461 (2012).
  • Liu D Li X Xiao Z Different functional bio-scaffolds share similar neurological mechanism to promote locomotor recovery of canines with complete spinal cord injury. Biomaterials214, 119230 (2019).
  • Fehlings MG Hawryluk GW . Scarring after spinal cord injury. J. Neurosurg. Spine13(2), 165–167; discussion 167–168 (2010).
  • Bregman BS Coumans JV Dai HN Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury. Prog. Brain Res.137, 257–273 (2002).
  • Dasari VR Spomar DG Cady C Gujrati M Rao JS Dinh DH . Mesenchymal stem cells from rat bone marrow downregulate caspase-3-mediated apoptotic pathway after spinal cord injury in rats. Neurochem. Res.32(12), 2080–2093 (2007).
  • Emamhadi M Soltani B Babaei P Mashhadinezhad H Ghadarjani S . Influence of sexuality in functional recovery after spinal cord injury in rats. Arch. Bone Joint Surg.4(1), 56–59 (2016).
  • Medina RJ Barber CL Sabatier F Endothelial progenitors: a consensus statement on nomenclature. Stem Cells Translati. Med.6(5), 1316–1320 (2017).
  • Ray SK Samntaray S Banik NL . Future directions for using estrogen receptor agonists in the treatment of acute and chronic spinal cord injury. Neur. Regen. Res.11(9), 1418–1419 (2016).
  • Simcock JW Dunn JA Buckley NT Mohammed KD Beadel GP Rothwell AG . Identification of patients with cervical SCI suitable for early nerve transfer to achieve hand opening. Spinal Cord55(2), 131–134 (2017).
  • Oh SK Jeon SR . Current concept of stem cell therapy for spinal cord injury: a review. Korean J. Neurotr.12(2), 40–46 (2016).
  • Rossi F Perale G Papa S Forloni G Veglianese P . Current options for drug delivery to the spinal cord. Exp. Opin. Drug Deliv.10(3), 385–396 (2013).
  • Cizkova D Novotna I Slovinska L Repetitive intrathecal catheter delivery of bone marrow mesenchymal stromal cells improves functional recovery in a rat model of contusive spinal cord injury. J. Neurotrauma28(9), 1951–1961 (2011).
  • Liu WZ Ma ZJ Li JR Kang XW . Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury. Stem Cell Res. Ther.12(1), 102 (2021).
  • Yousefifard M Sarveazad A Babahajian A Growth factor gene-modified cells in spinal cord injury recovery: a systematic review. World Neurosurg.162, 150–162.e151 (2022).
  • Hou Y Liu X Guo Y Liu D Guo P Liu J . Strategies for effective neural circuit reconstruction after spinal cord injury: use of stem cells and biomaterials. World Neurosurg.161, 82–89 (2022).
  • Szymoniuk M Mazurek M Dryla A Kamieniak P . The application of 3D-bioprinted scaffolds for neuronal regeneration after traumatic spinal cord injury – a systematic review of preclinical in vivo studies. Exp. Neurol.363, 114366 (2023).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.