Which delivery model innovations can support sustainable HIV treatment?

References

• Allen, L., Williams, J., Townsend, N., Mikkelsen, B., Roberts, N., Foster, C., & Wickramasinghe, K. (2017). Socioeconomic status and non-communicable disease behavioural risk factors in low-income and lower-middle-income countries: A systematic review. The Lancet. Global Health, 5(3), e277–e289. https://doi.org/10.1016/S2214-109X(17)30058-X
   PubMed Web of Science ®Google Scholar
• Asiimwe, S., Ross, J. M., Arinaitwe, A., Tumusiime, O., Turyamureeba, B., Roberts, D. A., … Barnabas, R. V. (2017). Expanding HIV testing and linkage to care in southwestern Uganda with community health extension workers. Journal of the International AIDS Society, 20(Suppl 4), 80–87. https://doi.org/10.7448/IAS.20.5.21633
   Google Scholar
• Bärnighausen, T., Bloom, D. E., & Humair, S. (2007). Human resources for treating HIV/AIDS: Needs, capacities, and gaps. AIDS Patient Care and STDs, 21(11), 799–812. https://doi.org/10.1089/apc.2007.0193
   PubMed Web of Science ®Google Scholar
• Bärnighausen, T., Bloom, D. E., & Humair, S. (2010). Universal antiretroviral treatment: The challenge of human resources. Bulletin of the World Health Organization, 88(12), 951–952. https://doi.org/10.2471/BLT.09.073890
   PubMed Web of Science ®Google Scholar
• Bärnighausen, T., Bloom, D., & Humair, S. (2011). Going horizontal— Shifts in funding of global health interventions. The New England Journal of Medicine, 364(23), 2181–2183. https://doi.org/10.1056/NEJMp1014255
   PubMed Web of Science ®Google Scholar
• Bärnighausen, T., Bloom, D. E., & Humair, S. (2016). Human resources for treating HIV/AIDS: Are the preventive effects of antiretroviral treatment a game changer? PLoS One, 11(10), e0163960. https://doi.org/10.1371/journal.pone.0163960
   PubMed Web of Science ®Google Scholar
• Bärnighausen, T., Chaiyachati, K., Chimbindi, N., Peoples, A., Haberer, J., & Newell, M.-L. (2011). Interventions to increase antiretroviral adherence in sub-Saharan Africa: A systematic review of evaluation studies. The Lancet. Infectious Diseases, 11(12), 942–951. https://doi.org/10.1016/S1473-3099(11)70181-5
   PubMed Web of Science ®Google Scholar
• Bekker, L. G., Alleyne, G., Baral, S., Cepeda, J., Daskalakis, D., Dowdy, D., … Beyrer, C. (2018). Advancing global health and strengthening the HIV response in the era of the Sustainable Development Goals: The International AIDS Society—Lancet Commission. Lancet, 392(10144), 312–358. https://doi.org/10.1016/S0140-6736(18)31070-5
   PubMed Web of Science ®Google Scholar
• Bemelmans, M., Baert, S., Goemaere, E., Wilkinson, L., Vandendyck, M., van Cutsem, G., … Ford, N. (2014). Community-supported models of care for people on HIV treatment in sub-Saharan Africa. Tropical Medicine & International Health, 19(8), 968–977. https://doi.org/10.1111/tmi.12332
   PubMed Web of Science ®Google Scholar
• Bengtson, A. M., Pence, B. W., Gaynes, B. N., Quinlivan, E. B., Heine, A. D., & O’Donnell, J. K. … Mugavero, M. (2016). Improving depression among HIV-infected adults: Transporting the effect of a depression treatment intervention to routine care. Journal of Acquired Immune Deficiency Syndromes, 73(4), 482–488. https://doi.org/10.1097/QAI.0000000000001131
   PubMed Web of Science ®Google Scholar
• Chan, A. K., Mateyu, G., Jahn, A., Schouten, E., Arora, P., Mlotha, W., … van Lettow, M. (2010). Outcome assessment of decentralization of antiretroviral therapy provision in a rural district of Malawi using an integrated primary care model. Tropical Medicine & International Health, 15, 90–97. https://doi.org/10.1111/j.1365-3156.2010.02503.x
   PubMed Web of Science ®Google Scholar
• De Neve, J.-W., Garrison-Desany, H., Andrews, K. G., Sharara, N., Boudreaux, C., Gill, R., … Bossert, T. J. (2017). Harmonization of community health worker programs for HIV: A four-country qualitative study in Southern Africa. PLoS Medicine, 14(8), e1002374. https://doi.org/10.1371/journal.pmed.1002374
   PubMed Web of Science ®Google Scholar
• Diedrich, C. R., & Flynn, J. L. (2011). HIV-1/mycobacterium tuberculosis coinfection immunology: How does HIV-1 exacerbate tuberculosis? Infection and Immunity, 79(4), 1407–1417. https://doi.org/10.1128/IAI.01126-10
   PubMed Web of Science ®Google Scholar
• Dieleman, J. L., Haakenstad, A., Micah, A., Moses, M., Abbafati, C., Acharya, P., … Murray, C. J. L. (2018). Spending on health and HIV/AIDS: Domestic health spending and development assistance in 188 countries, 1995–2015. Lancet, 391(10132), 1799–1829. https://doi.org/10.1016/S0140-6736(18)30698-6
   PubMed Web of Science ®Google Scholar
• Duffy, M., Ojikutu, B., Andrian, S., Sohng, E., Minior, T., & Hirschhorn, L. R. (2017). Non-communicable diseases and HIV care and treatment: Models of integrated service delivery. Tropical Medicine & International Health, 22(8), 926–937. https://doi.org/10.1111/tmi.12901
   PubMed Web of Science ®Google Scholar
• Freeman, M. C., Patel, V., Collins, P. Y., & Bertolote, J. M. (2005). Integrating mental health in global initiatives for HIV/AIDS. The British Journal of Psychiatry, 187(1), 1–3. https://doi.org/10.1192/bjp.187.1.1
   PubMedGoogle Scholar
• Geldsetzer, P., Francis, J. M., Sando, D., Asmus, G., Lema, I. A., Mboggo, E., … Bärnighausen, T. (2018). Community delivery of antiretroviral drugs: A non-inferiority cluster-randomized pragmatic trial in Dar es Salaam, Tanzania. PLoS Medicine, 15(9), e1002659. https://doi.org/10.1371/journal.pmed.1002659
   PubMed Web of Science ®Google Scholar
• Geldsetzer, P., Francis, J. M., Ulenga, N., Sando, D., Lema, I. A., Mboggo, E., … Bärnighausen, T. (2017). The impact of community health worker-led home delivery of antiretroviral therapy on virological suppression: A non-inferiority cluster-randomized health systems trial in Dar es Salaam, Tanzania. BMC Health Services Research, 17(1), 160. https://doi.org/10.1186/s12913-017-2032-7
   PubMedGoogle Scholar
• Geldsetzer, P., Mboggo, E., Larson, E., Lema, I. A., Magesa, L., Machumi, L., … Bärnighausen, T. (2019). Community health workers to improve uptake of maternal healthcare services: A cluster-randomized pragmatic trial in Dar es Salaam, Tanzania. PLoS Medicine, 16(3), e1002768. https://doi.org/10.1371/journal.pmed.1002768
   PubMed Web of Science ®Google Scholar
• Genberg, B. L., Shangani, S., Sabatino, K., Rachlis, B., Wachira, J., Braitstein, P., & Operario, D. (2016). Improving engagement in the HIV care cascade: a systematic review of interventions involving people living with HIV/AIDS as peers. AIDS and Behavior, 20(10), 2452–2463. https://doi.org/10.1007/s10461-016-1307-z
   PubMed Web of Science ®Google Scholar
• Granich, R., Gupta, S., Hersh, B., Williams, B., Montaner, J., Young, B., & Zuniga, J. M. (2015). Trends in AIDS deaths, new infections and ART coverage in the top 30 countries with the highest AIDS mortality burden; 1990–2013. PLoS One, 10(7), e0131353. https://doi.org/10.1371/journal.pone.0131353
   PubMed Web of Science ®Google Scholar
• Haacker, M., Bärnighausen, T., & Atun, R. (2019). HIV and the growing health burden from noncommunicable diseases in Botswana: Modelling study. Journal of Global Health, 9(1), 010428. https://doi.org/10.7189/jogh.09.010428
   PubMed Web of Science ®Google Scholar
• Holmes, C. B., & Sanne, I. (2015). Changing models of care to improve progression through the HIV treatment cascade in different populations. Current Opinion in HIV and AIDS, 10(6), 447–450. https://doi.org/10.1097/COH.0000000000000194
   PubMed Web of Science ®Google Scholar
• Hontelez, J. A., de Vlas, S. J., Baltussen, R., Newell, M. L., Bakker, R., & Tanser, F. … Bärnighausen, T. (2012). The impact of antiretroviral treatment on the age composition of the HIV epidemic in sub-Saharan Africa. AIDS (London, England), 26(s1), s19–s30. https://doi.org/10.1097/QAD.0b013e3283558526
   Google Scholar
• Howard, A. A., & El-Sadr, W. M. (2010). Integration of tuberculosis and HIV services in sub-Saharan Africa: lessons learned. Clinical Infectious Diseases, 50(s3), S238–S244. https://doi.org/10.1086/651497
   PubMedGoogle Scholar
• Kaaya, S., Eustache, E., Lapidos-Salaiz, I., Musisi, S., Psaros, C., & Wissow, L. (2013). Grand challenges: improving HIV treatment outcomes by integrating interventions for co-morbid mental illness. PLoS Medicine, 10(5), e1001447. https://doi.org/10.1371/journal.pmed.1001447
   PubMed Web of Science ®Google Scholar
• Kates, J., Wexler, A, & Lie, E. (2017). Donor Government Funding to in Low- and Middle-Income Countries in 2016. Menlo Park CA: The Henry J Kaiser Family Foundation & UNAIDS.
   Google Scholar
• Kemp, C. G., Weiner, B. J., Sherr, K. H., Kupfer, L. E., Cherutich, P. K., Wilson, D., … Wasserheit, J. N. (2018). Implementation science for integration of HIV and non-communicable disease services in sub-Saharan Africa: A systematic review. AIDS (London, England), 32(May), S93–S105. https://doi.org/10.1097/QAD.0000000000001897
   Google Scholar
• Kim, J. Y., Farmer, P., & Porter, M. E. (2013). Redefining global health-care delivery. Lancet, 382(9897), 1060–1069. https://doi.org/10.1016/S0140-6736(13)61047-8
   PubMed Web of Science ®Google Scholar
• Koenig, S. P., Dorvil, N., Dévieux, J. G., Hedt-Gauthier, B. L., Riviere, C., Faustin, M., … Pape, J. W. (2017). Same-day HIV testing with initiation of antiretroviral therapy versus standard care for persons living with HIV: A randomized unblinded trial. PLoS Medicine, 14(7), e1002357. https://doi.org/10.1371/journal.pmed.1002357
   PubMed Web of Science ®Google Scholar
• Kredo, T., Adeniyi, F. B., Bateganya, M., & Pienaar, E. D. (2014). Task shifting from doctors to non-doctors for initiation and maintenance of antiretroviral therapy. Cochrane Database of Systematic Reviews, 7. https://doi.org/10.1002/14651858.CD007331.pub3
   Web of Science ®Google Scholar
• Larson, E., Geldsetzer, P., Mboggo, E., Lema, I. A., Sando, D., Ekström, A. M., … Bärnighausen, T. (2019). The effect of a community health worker intervention on public satisfaction: Evidence from an unregistered outcome in a cluster-randomized controlled trial in Dar es Salaam, Tanzania. Human Resources for Health, 17, 23. https://doi.org/10.1186/s12960-019-0355-7
   PubMed Web of Science ®Google Scholar
• Lema, I. A., Sando, D., Magesa, L., Machumi, L., Mungure, E., & Sando, M. M. … Bärnighausen, T.(2014). Community health workers to improve antenatal care and PMTCT uptake in Dar es Salaam, Tanzania: A quantitative performance evaluation. Journal of Acquired Immune Deficiency Syndromes, 67(s4), s195–s201. https://doi.org/10.1097/QAI.0000000000000371
   PubMedGoogle Scholar
• MacCarthy, S., Hoffmann, M., Ferguson, L., Nunn, A., Irvin, R., Bangsberg, D., … Dourado, I. (2015). The HIV care cascade: Models, measures and moving forward. Journal of the International AIDS Society, 18(1), 19395. https://doi.org/10.7448/IAS.18.1.19395
   PubMedGoogle Scholar
• MacKellar, D., Williams, D., Bhembe, B., Dlamini, M., Byrd, J., Dube, L., … Ryan, C. (2018). Peer-delivered linkage case management and same-day ART initiation for men and young persons with HIV infection—Eswatini, 2015–2017. Morbidity and Mortality Weekly Report, 67(23), 663–667. https://doi.org/10.15585/mmwr.mm6723a3
   PubMed Web of Science ®Google Scholar
• Mikkelsen, E., Hontelez, J. A. C., Jansen, M. P. M., Bärnighausen, T., Hauck, K., Johansson, K. A., … Baltussen, R. M. P. M. (2017). Evidence for scaling up HIV treatment in sub-Saharan Africa: A call for incorporating health system constraints. PLoS Medicine, 14(2), e1002240. https://doi.org/10.1371/journal.pmed.1002240
   PubMed Web of Science ®Google Scholar
• Murray, C. J. L., Ortblad, K. F., Guinovart, C., Lim, S. S., Wolock, T. M., Roberts, D. A., … Vos, T. (2014). Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet, 384(9947), 1005–1070. https://doi.org/10.1016/S0140-6736(14)60844-8
   PubMed Web of Science ®Google Scholar
• Naburi, H., Ekström, A. M., Mujinja, P., Kilewo, C., Manji, K., Biberfeld, G., … Bärnighausen, T. (2017). The potential of task-shifting in scaling up services for prevention of mother-to-child transmission of HIV: A time and motion study in Dar es Salaam, Tanzania. Human Resources for Health, 15(1), 35. https://doi.org/10.1186/s12960-017-0207-2
   PubMedGoogle Scholar
• Nakiwogga-Muwanga, A., Katabira, E., Kiragga, A., Kambugu, A., Nakibuuka-Lubwama, E., Manabe, Y. C., … Colebunders, R. (2014). Factors before enrolment are associated with being removed from a Pharmacy-only Refill Programme at a large urban HIV/AIDS clinic, Uganda. International Journal of STD & AIDS, 25(2), 105–112. https://doi.org/10.1177/0956462413492715
   PubMed Web of Science ®Google Scholar
• Nanni, M. G., Caruso, R., Mitchell, A. J., Meggiolaro, E., & Grassi, L. (2015). Depression in HIV infected patients: A review. Current Psychiatry Reports, 17(1), 530. https://doi.org/10.1007/s11920-014-0530-4
   PubMed Web of Science ®Google Scholar
• Oberth, G., & Whiteside, A. (2016). What does sustainability mean in the HIV and AIDS response? African Journal of AIDS Research, 15(1), 35–43. https://doi.org/10.2989/16085906.2016.1138976
   PubMed Web of Science ®Google Scholar
• Odeny, T. A., Penner, J., Lewis-Kulzer, J., Leslie, H. H., Shade, S. B., Adero, W., … Bukusi, E. A. (2013). Integration of HIV care with primary health care services: Effect on patient satisfaction and stigma in rural Kenya. AIDS Research and Treatment, 2013, 485715. https://doi.org/10.1155/2013/485715
   Google Scholar
• Oni, T., Youngblood, E., Boulle, A., McGrath, N., Wilkinson, R. J., & Levitt, N. S. (2015). Patterns of HIV, TB, and non-communicable disease multi-morbidity in peri-urban South Africa-a cross sectional study. BMC Infectious Diseases, 15(1), 20. https://doi.org/10.1186/s12879-015-0750-1
   PubMedGoogle Scholar
• Osetinsky, B., Hontelez, J. A. C., Lurie, M. N., McGarvey, S. T., Bloomfield, G. S., Pastakia, S. D., … Galárraga, O. (2019). Epidemiological and health systems implications of evolving HIV and hypertension in South Africa and Kenya. Health Affairs, 38(7), 1173–1181. https://doi.org/10.1377/hlthaff.2018.05287
   Web of Science ®Google Scholar
• Phillips, A., Shroufi, A., Vojnov, L., Cohn, J., Roberts, T., Ellman, T., … Revill, P. (2015). Sustainable HIV treatment in Africa through viral load-informed differentiated care. Nature, 528(7580), S68–S76. https://doi.org/10.1038/nature16046
   PubMed Web of Science ®Google Scholar
• Porter, M. E. (2001). The value chain and competitive advantage. Understanding Business Processes (pp. 50–66).
   Google Scholar
• Reuters. (2016). Drones could speed up HIV tests in remote areas. Health News, April 20. https://www.reuters.com/article/us-malawi-hiv-drones/drones-could-speed-up-hiv-tests-in-remote-areas-idUSKCN0XH1ZN
   Google Scholar
• Richter, L., Rotheram-Borus, M. J., Van Heerden, A., Stein, A., Tomlinson, M., Harwood, J. M., … Tang, Z. (2014). Pregnant women living with HIV (WLH) supported at clinics by peer WLH: A cluster randomized controlled trial. AIDS and Behavior, 18(4), 706–715. https://doi.org/10.1007/s10461-014-0694-2
   PubMed Web of Science ®Google Scholar
• Samb, B., Celletti, F., Holloway, J., Van Damme, W., De Cock, K. M., & Dybul, M. (2007). Rapid expansion of the health workforce in response to the HIV epidemic. The New England Journal of Medicine, 357(24), 2510–2514. https://doi.org/10.1056/NEJMsb071889
   PubMed Web of Science ®Google Scholar
• Schäferhoff, M., Martinez, S., Ogbuoji, O., Sabin, M. L., & Yamey, G. (2019). Trends in global health financing. BMJ, 365(12185), 19–20. https://doi.org/10.1136/bmj.l2185
   Google Scholar
• Smith, C. J., Ryom, L., Weber, R., Morlat, P., Pradier, C., Reiss, P., … Lundgren, J. D. (2014). Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration. Lancet, 384(9939), 241–248. https://doi.org/10.1016/S0140-6736(14)60604-8
   PubMed Web of Science ®Google Scholar
• Suthar, A. B., Lawn, S. D., del Amo, J., Getahun, H., Dye, C., Sculier, D., … Granich, R. M. (2012). Antiretroviral therapy for prevention of tuberculosis in adults with hiv: A systematic review and meta-analysis. PLoS Medicine, 9(7), e1001270. https://doi.org/10.1371/journal.pmed.1001270
   PubMed Web of Science ®Google Scholar
• Sweeney, S., Obure, C. D., Maier, C. B., Greener, R., Dehne, K., & Vassall, A. (2012). Costs and efficiency of integrating HIV/AIDS services with other health services: A systematic review of evidence and experience. Sexually Transmitted Infections, 88(2), 85–99. https://doi.org/10.1136/sextrans-2011-050199
   PubMed Web of Science ®Google Scholar
• UNAIDS. (2017). UNAIDS report 2017. Geneva: Joint United Nations Programme on HIV/AIDS. https://www.unaids.org/sites/default/files/media_asset/20170720_Data_book_2017_en.pdf
   Google Scholar
• United Nations. (2017). Transforming our World: The 2030 Agenda for Sustainable Development. Geneva: UNAIDS. https://sustainabledevelopment.un.org/post2015/transformingourworld
   Google Scholar
• Venter, W., Coleman, J., Chan, V. L., Shubber, Z., Phatsoane, M., Gorgens, M., … Fraser-Hurt, N. (2018). Improving linkage to HIV care through mobile phone apps: Randomized controlled trial. JMIR mHealth and uHealth, 6(7), e155. https://doi.org/10.2196/mhealth.8376
   PubMed Web of Science ®Google Scholar
• Warren, C. E., Hopkins, J., Narasimhan, M., Collins, L., Askew, I., & Mayhew, S. H. (2017). Health systems and the SDGs: Lessons from a joint HIV and sexual and reproductive health and rights response. Health Policy and Planning, 32(suppl_4), iv102–iv107. https://doi.org/10.1093/heapol/czx052
   Web of Science ®Google Scholar
• Zachariah, R., Ford, N., Philips, M., Lynch, S., Massaquoi, M., Janssens, V., & Harries, A. D. (2009). Task shifting in HIV/AIDS: Opportunities, challenges and proposed actions for sub-Saharan Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(6), 549–558. https://doi.org/10.1016/j.trstmh.2008.09.019
   PubMed Web of Science ®Google Scholar