Effects in vitro of progesterone and two 5α-reduced progestins, 5α-pregnane-3,20-dione and 5α-pregnane-3α-ol-20-one, on contracting human myometrium at term

References

• Thorburn G D. Past and present concepts on the initiation of parturition. Initiation of parturition: Prevention of prematurity. Reports from 4th Ross Conference on Obstetric Research, P C MacDonald. Ross Laboratories, Columbus, Ohio 1983; 2–9
   Google Scholar
• Liggin G C. Initiation of spontaneous labor. Clin Obstet Gynecol 1983; 26: 47–55
   Google Scholar
• Flint A P F. Regulations of placental enzymes. Initiation of parturition: Prevention of prematurity. Reports from 4th Ross Conference on Obstetric Research, P C Mac‐Donald. Ross Laboratories, Columbus, Ohio 1983; 27–34
   Google Scholar
• Saureau C, Germain G, Ferre F, . Therapeutic use of progesterone during the last two trimesters of pregnancy. Progesterone and progestins, C W Bardin, E Milgröm, P Mauvais‐Jarvis, et al. Raven Press, New York 1983; 247–8
   Google Scholar
• Beck P, Adler P, Szlachter N, Goldsmit L T, Steinetz B G, Weiss G. Synergistical effect of human relaxin and progesterone on human myometrial contractions. Int J Gynaecol Obstet 1982; 20: 141–4
   Google Scholar
• Barnafi L, Larraquibel R. The in vitro effect of progesterone and oestrogens on the spontaneous and oxytocin‐induced activity of the human myometrium. Acta Endocrinol 1974; 76: 172–7
   Google Scholar
• Bygdcman M, Swahn M. Progesterone receptor blockade. Effect on uterine contractility and early pregnancy. Contraception 1985; 32: 45–51
   Google Scholar
• Selinger M, Mackenzie I Z, Gillmer M D, Phipps S L, Ferguson J. Progesterone inhibition in mid‐trimester termination of pregnancy: physiological and clinical effects. Br J Obstet Gynaecol 1987; 94: 1218–22
   PubMedGoogle Scholar
• Cabrol D, Bouvier D'Yvoir M, Mermet E, Cédard L, Surean C, Baulieu E. Induction of labour with Mefepristonc (RU 486) after intrauterine fetal death. Letter. Lancet 1985; ii: 1019
   Google Scholar
• Landgren S, Aasly J, Bäckström T, Dubrovsky B, Daniclsson E. The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex. Acta Physiol Scand 1987; 131: 33–42
   PubMedGoogle Scholar
• Arafat E S, Hargrove J T, Maxson W S, Desiderio D M, Wentz A C, Andersen R N. Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites. Am J Obstet Gynecol 1988; 159: 1203–9
   PubMed Web of Science ®Google Scholar
• Norberg L, Wahlström G, Bäckström T. The anesthetic potency of 3α‐hydroxy‐5β‐Pregnan‐20‐one and 3α‐hydroxy‐5β‐Pregnan‐20‐one determined with an intravenous EEG‐threshold method in male rats. Acta Pharmacol Toxicol 1987; 61: 42–7
   Google Scholar
• Figdor S K, Kodet M J, Bloom B M, Agncllo E J, Plan S Y, Laubach G D. Central activity and structure in a series of water‐soluble steroids. J Pharmacol Exp Ther 1957; 119: 299–309
   Google Scholar
• Kubli‐Garfias C, Hoyo‐Vadillo C, López‐Nieto E, Ponce‐Monter H. Inhibition of spontaneous contractions of the rat pregnant uterus by progesterone metabolites. Proc West Pharmacol Soc 1983; 115–8
   Google Scholar
• Milewich L, Gomez‐Sanchez C, Madden J D, Mac‐Donald P C. Isolation and characterization of 5α‐preg‐nane‐3,20‐dione and progesterone in peripheral blood of pregnant women. Measurement throughout pregnancy. Gynecol Invest 1975; 6: 291–306
   PubMedGoogle Scholar
• Löfgren M, Bäckström T, Joclsson I. Decrease in serum concentration of 5α‐pregnane‐3,20‐dione prior to spontaneous labor. Acta Obstet Gynecol Scand 1988; 67: 467–70
   Web of Science ®Google Scholar
• Löfgren M, Bäckström T. Serum concentrations of progesterone and 5α‐pregnane‐3,20‐dione during labor and early post partum. Acta Obstet Gynecol Scand 1990; 69: 123–6
   Web of Science ®Google Scholar
• Bryman I, Nordström A, Lindblom B. Effects of PGE2 and PGF2a on the simulation by noradrenalin and oxytocin of human cervical muscle activity at term. Experientia 1985; 41: 1446–7
   Google Scholar
• Bäckström T, Andersson T, Baird D T, Selstam G. 5α‐pregnane‐3,20‐dione in peripheral and ovarian vein blood in women of different stages of the menstrual cycle. Acta Endocrinol 1986; 111: 116–21
   PubMedGoogle Scholar
• Wikland M, Lindblom B, Wilhelmson L, Wiquist N. Oxytocin, prostaglandins and contractility of the human uterus at term pregnancy. Acta Obstet Gynecol Scand 1982; 61: 467–72
   PubMed Web of Science ®Google Scholar
• Antonipillai I, Beverley E, Murphy P. Serum oestrogens and progesterone in mother and infant at delivery. Br J Obstet Gynaecol 1977; 84: 179–85
   PubMedGoogle Scholar
• Davidson B J, Murray R D, Challis J R, Valenzuela G J. Estrogen, progesterone, prolactin, prostaglandin E2, prostaglandin F2α‐13, 14‐dihydro‐15‐keto‐prostaglandin F2α and 6‐keto‐prostaglandin Flex gradients across the uterus in women in labor and not in labor. Am J Obstet Gynecol 1987; 157: 54–8
   Google Scholar