357
Views
27
CrossRef citations to date
0
Altmetric
INNER EAR

Gentamicin-induced spiral ganglion cell death: Apoptosis mediated by ROS and the JNK signaling pathway

, , , , &
Pages 670-678 | Received 25 Aug 2009, Accepted 18 Oct 2009, Published online: 18 Jan 2010

References

  • Guthrie OW. Aminoglycoside induced ototoxicity. Toxicology 2008;249:91–6.
  • Steinbach S, Lutz J. Glutamate induces apoptosis in cultured spiral ganglion explants. Biochem Biophys Res Commun 2007;357:14–19.
  • Ylikoski J, Wersäll J, Björkroth B. Degeneration of neural elements in the cochlea of the guinea-pig after damage to the organ of Corti by ototoxic antibiotics. Acta Otolaryngol Suppl 1974;326:23–41.
  • Dodson HC. Loss and survival of spiral ganglion neurons in the guinea pig after intracochlear perfusion with aminoglycosides. J Neurocytol 1997;26:541–56.
  • Bae WY, Kim LS, Hur DY, Jeong SW, Kim JR. Secondary apoptosis of spiral ganglion cells induced by aminoglycoside: Fas-Fas ligand signaling pathway. Laryngoscope 2008;118:1659–68.
  • Chandra J, Samali A, Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 2000;29:323–33.
  • Shen HM, Liu ZG. JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 2006;40:928–39.
  • Krammer PH. CD95(APO-1/Fas)-mediated apoptosis: live and let die. Adv Immunol 1999;71:163–210.
  • Bauer MK, Vogt M, Los M, Siegel J, Wesselborg S, Schulze-Osthoff K. Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression. J Biol Chem 1998;273:8048–55.
  • Chiba T, Takahashi S, Sato N, Ishii S, Kikuchi K. Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells. Eur J Immunol 1996;26:1164–9.
  • Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M, A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 1995;14:927–39.
  • Maroney AC, Finn JP, Bozyczko-Coyne D, O'Kane TM, Neff NT, Tolkovsky AM, CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults. J Neurochem 1999;73:1901–12.
  • Orrenius S. Reactive oxygen species in mitochondria-mediated cell death. Drug Metab Rev 2007;39:443–55.
  • Hibi M, Lin A, Smeal T, Minden A, Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993;7:2135–48.
  • Lin A. Activation of the JNK signaling pathway: breaking the brake on apoptosis. Bioessays 2003;25:17–24.
  • Song JJ, Lee YJ. Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1. Biochem J 2003;373:845-53.
  • Dragunow M, Young D, Hughes P, MacGibbon G, Lawlor P, Singleton K, Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury?. Brain Res Mol Brain Res 1993;18:347–52.
  • Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 2004;13:329–40.
  • Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K, Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell 2004;119:529–42.
  • Zamzami N, Marchetti P, Castedo M, Decaudin D, Macho A, Hirsch T, Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 1995;182:367–77.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.