11
Views
18
CrossRef citations to date
0
Altmetric
Original Article

Early Ultrastructural Effects of Gentamicin Cochleotoxicity

, &
Pages 273-280 | Published online: 08 Jul 2009

References

  • Poch Broto J, Merchan M, Ludena D. Toxilaberintopatias de origen medicamentoso. An Otorrin-olaringol Ibero Am 1980; 8: 189–236
  • Wersall J. Structural damage to the organ of Corti and the vestibular epithelia caused by aminoglycoside antibiotics in the guinea pig. Aminoglycoside ototoxicity, SA Lerner, GJ Matz, JE Hawkins. Little, Brown and Company, Boston 1981; 197–214
  • Lim DJ. Effects of noise and ototoxic drugs at the cellular level in the cochlea: A review. Am J Otolaryngol 1986; 7: 73–99
  • Theopold H-M. Comparative surface studies of ototoxic effects of various aminoglycoside antibiotics on the organ of Corti in the guinea pig. A scanning electron microscopic study. Acta Otolaryngol (Stockh) 1977; 84: 57–64
  • Yung MW. Comparative ototoxicity of kanamycin A and kanamycin B in the guinea pig. Acta Otolaryngol (Stockh) 1987; 103: 73–80
  • Furness D N, Hackney CM. Morphological changes to the stereociliary bundles in the guinea pig after kanamycin treatment. Br J Audiol 1986; 20: 253–9
  • Pickles J O, Comis S D, Osborne MP. The effect of chronic application of kanamycin on stereocilia and their tip links in hair cells of the guinea pig cochlea. Hear Res 1987; 29: 237–44
  • Takumida M, Bagger-Sjoback D, Wersall J, Harada Y. The effect of gentamicin on the glycocalyx and the ciliary interconnections in vestibular sensory cells: A high resolution scanning electron microscopic investigation. Hear Res 1989; 37: 163–70
  • Ylikoski J. Guinea-pig hair cell pathology from ototoxic antibiotics. Acta Otolaryngol (Stockh) 1974; 5–22, Suppl 326
  • Harpur E S, Bridges JB. An evaluation of the use of scanning and transmission electron microscopy in a study of the gentamicin-damaged guinea-pig organ of Corti. J Laryngol Otol 1979; 93: 7–23
  • Forge A. Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment. Hear Res 1985; 19: 171–82
  • Lenoir M, Puel J-L. Dose-dependent changes in the rat cochlea following aminoglycoside intoxication. II. Histological study. Hear Res 1987; 26: 199–209
  • Darrouzet J, Guilhaume A. Ototoxicity de la kanamycine au jour le jour. Etude experimental en microscopie electronique. Rev Laryngol 1974; 95: 601–21
  • Jarlstedt J, Bagger-Sjoback D. Gentamicin-induced changes in RNA content in sensory and ganglionic cells in the hearing organ of the lizard Calotes vesicolor. Acta Otolaryngol (Stockh) 1977; 84: 361–9
  • Postma D S, Pecorak J B, Prazma J, Logue S S, Fischer ND. Outer hair cell loss and alterations in glycogen due to tobramycin sulfate. Arch Otolaryngol 1978; 102: 154–9
  • Bagger-Sjoback D, Wersall J. Gentamicin-induced mitochondrial damage in inner ear sensory cells of the lizard Calotes versicolor. Acta Otolaryngol (Stockh) 1978; 86: 35–51
  • De Groot J CMJ, Veldman J E, Huizing EH. An improved fixation method for guinea pig cochlear tissues. Acta Otolaryngol (Stockh) 1987; 104: 234–2
  • De Groot J CMJ. Selective contrast-enhancement of the cochlear duct glycocalyx after OsCV KiRufCNls post-fixation. J Microsc 1986; 144: 223–7
  • Tange R A, Conijn E AJG, Van Zeijl J JPGM, Huizing EH. Pattern of gentamicin-induced cochlear degeneration in the guinea pig: A morphological and electrophysiological study. Arch Otorhino-laryngol 1982; 236: 173–84
  • Ohtani 1, Ohtsuki K, Aikawa T, Omata T, Ouchi J, Saito T. Individual variation and mechanism of kanamycin ototoxicity in rabbits. Acta Otolaryngol (Stockh) 1982; 94: 413–9
  • Tran Ba Huy P, Deffrennes D. Aminoglycoside ototoxicity: Influence of dosage regimen on drug uptake and correlation between membrane binding and some clinical features. Acta Otolaryngol (Stockh) 1988; 105: 511–5
  • De Groot J CMJ, Meeuwsen F, Ruizendaal W E, Veldman JE. Ultrastructural localization of gentamicin in the cochlea. Hear Res, in press
  • Lim DJ. Functional structure of the organ of Corti: A review. Hear Res 1986; 22: 117–46
  • De Groot J CMJ, Veldman JE. Early effects of gentamicin on inner ear glycocalyx cytochemistry. Hear Res 1988; 35: 39–46

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.