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Acta Oto-Laryngologica Volume 113, 1993 - Issue 2
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Original Article

Effects of Free Radicals on the Intracellular Calcium Concentration in the Isolated Outer Hair Cell of the Guinea Pig Cochlea

K. Ikeda Department of Otolaryngology, Laboratory of Cell Physiology and Biology, Tohoku University School of Medicine, Sendai, 980, Japan
,
H. Sunose Department of Otolaryngology, Laboratory of Cell Physiology and Biology, Tohoku University School of Medicine, Sendai, 980, Japan
&
T. Takasaka Department of Otolaryngology, Laboratory of Cell Physiology and Biology, Tohoku University School of Medicine, Sendai, 980, Japan
Pages 137-141 | Received 16 Oct 1992, Accepted 12 Dec 1992, Published online: 08 Jul 2009

References

  • Fridovich I. The biology of oxygen radicals. Science 1978; 201: 875–80
  • McCord J. M. Oxygen-derived radicals in post-ischemic tissue injury. N Engl J Med 1985; 312: 159–63
  • Simic M. G., Bergtold D. S., Karam L. R. Generation of oxy radicals in biosystems. Mutat Res 1989; 214: 3–12
  • Pacifici R. E., Davies K. JA. Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited. Gerontology 1991; 37: 166–80
  • Taylor M. D., Palmer G. C., Callaham A. S. Protective action by methylprednisolone, allopurinol and in-domethacin against stroke-induced damage to adenylate cyclase in gerbil cerebral cortex. Stroke 1984; 15: 329–35
  • Murphy J. G., Smith T. W., Marsh J. D. Mechanisms of reoxygenation-induced calcium overload in cultured chick embryo heart cells. Am J Physiol 1988; 254: 1133–41
  • Grover A. K., Samson S. E. Effect of superoxide radical on Ca2+ pumps of coronary artery. Am J Physiol 1988; 255: C297–303
  • Yamada Y., Yokota M., Furumichi T., Furui H., Yamauchi K., Saito H. Protective effects of calcium channel blockers on hydrogen peroxide induced increase in endothelial permeability. Cardiovasc Res 1990; 24: 993–7
  • Ashmore J. F., Meech R. W. Ionic basis of membrane potential in outer hair cells of guinea pig cochlea. Nature 1986; 322: 368–71
  • Zenner H. P. Motility of outer hair cells as an active, actin-mediated process. Acta Otolaryngol (Stockh) 1988; 105: 39–44
  • Ikeda K., Saito Y., Nishiyama A., Takasaka T. Effect of neuroregulators on the intracellular calcium level in the outer hair cell isolated from the guinea pig. ORL 1991; 53: 78–81
  • Ikeda K., Saito Y., Nishiyama A., Takasaka T. Effects of pH on intracellular calcium level in isolated cochlear outer hair cells of guinea pigs. Am J Physiol 1991; 261: C231–6
  • Ikeda K., Saito Y., Nishiyama A., Takasaka T. Intracellular pH regulation in isolated cochlear outer hair cells of the guinea-pig. J Physiol 1992; 447: 627–48
  • Ikeda K., Saito Y., Nishiyama A., Takasaka T. Na+-Ca2+ exchange in the isolated outer hair cells of the guinea-pig studied by fluorescence image microscopy. Pflügers Arch 1992; 420: 493–9
  • Grynkiewicz G., Poenie M., Tsien R. Y. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440–50
  • Pierson M. G., Gray B. H. Superoxide dismutase activity in the cochlea. Hear Res 1982; 6: 141–51
  • McCord J. M., Fridorich I. Superoxide dismutase: An enzymatic function for erythrocuprein (hemocuprein). J Biol Chem 1969; 244: 6049–55
  • Dulon D., Zajic G., Aran J. M., Schacht J. Aminoglycoside antibiotics impair calcium entry but not viability and mobility in isolated cochlear outer hair cells. J Neurosci Res 1989; 24: 338–46
  • Nakagawa T., Kakehata S., Akaike N., Komune S., Takasaka T., Uemura T. Calcium channel in isolated outer hair cells of guinea pig cochlea. Neurosci Lett 1991; 125: 81–4
  • Dulon D., Zajic G., Schacht J. Photo-induced irreversible shortening and swelling of isolated cochlear outer hair cells. Int J Radiat 1989; 57: 1007–14
  • Hoffman D. W., Whitworth C. A., Jones K. L., Rybak L. P. Nutritional status, glutathione levels, and ototoxicity of loop diuretics and aminoglycoside antibiotics. Hear Res 1987; 31: 217–22
  • Hoffman D. W., Whitworth C. A., Jones-King K. L., Rybak L. P. Potentiation of ototoxicity by glutathione depletion. Ann Otol Rhinol Laryngol 1988; 97: 36–41
  • Flock Å R., Flock B., Ulfendahl M. Mechanisms of movement in outer hair cells and a possible structural basis. Arch Otorhinolaryngol 1986; 243: 83–90
  • Ashmore J. F. A fast motile response in guinea-pig outer hair cells: The cellular basis of the cochlear amplifier. J Physiol 1987; 388: 323–47
  • Lipscombe D., Madison D. V., Poenie M., Reuter H., Tsien R. W., Tsien R. Y. Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons. Neuron 1988; 1: 355–65
  • Kuba K., Hua S. Y., Nohmi M. Spatial and dynamic changes in intracellular Ca2+ measured by confocal laser-scanning microscopy in bullfrog sympathetic ganglion cells. Neurosci Res 1991; 10: 245–59

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