References
- Bluestone C D, Stephenson J S, Martin L M. Ten-year review of otitis media pathogens. Pediatr Infect Dis J 1992; 11: S7–11
- Karma P, Palva T, Kouvalainen K, et al. Finnish approach to the treatment of acute otitis media. Report of the Finnish consensus conference. Ann Otol Rhinol Laryngol 1987; Suppl 129: 1–19
- Sloyer J L, Jr, Howie V M, Ploussard J H, Amman A J, Austrian R, Johnston R B, Jr. Immune response to acute otitis media in children. Infect Immun 1974; 9: 1028–32
- Koskela M, Luotonen J. Recurrent pneumococcal otitis media: presence of pneumococcal antigen and antibody in middle ear effusion compared with antibody levels in serum. Recent advances in otitis media with effusion, D J Lim, C D Bluestone, J O Klein, J D Nelson. BC Decker Inc, Philadelphia 1984; 251–5
- Karjalainen H, Koskela M, Luotonen J, Herva E, Sipila U P. Antibodies against Streptococcus pneumoniae, Haemophilus influenzae and Branhamella catarrhalis in middle ear effusion during early phase of acute otitis media. Acta Otolaryngol (Stockh) 1990; 109: 111–8
- Koskela M, Leinonen M, Luotonen J. Serum antibody response to pneumococcal otitis media. Pediatr Infect Dis J 1982; 1: 245–52
- Paton J C, Berry A M, Lock R A, Hansman D, Manning P A. Cloning and expression in Escherichia coli of the Streptococcus pneumoniae gene encoding pneumolysin. Infect Immun 1986; 54: 50–5
- Taira S, Jalonen E, Paton J C, Sarvas M, Runeberg-Nyman K. Production of the pneumococcal toxin pneumolysin in Bacillus subtilis. Gene 1989; 77: 211–8
- Jalonen E, Paton J C, Koskela M, Kerttula Y, Leinonen M. Measurement of antibody responses to pneumolysin—a promising method for the presumptive aetiological diagnosis of pneumococcal pneumonia. J Infect 1989; 19: 127–34
- Virolainen A, Jero J, Käyhty H, Karma P, Leinonen M, Eskola J. Nasopharyngeal antibodies to pneumococcal capsular polysaccharides in children with acute otitis media. J Infect Dis 1995, (in press)
- Salo P, örtqvist A R, Leinonen M. Diagnosis of bacteremic pneumococcal pneumonia by amplification of pneumolysin gene fragment in serum. J Infect Dis 1995; 171: 479–82
- Virolainen A, Salo P, Jero J, Karma P, Eskola J, Leinonen M. Comparison of PCR assay with bacterial culture for detecting Streptococcus pneumoniae in middle ear fluid of children with acute otitis media. J Clin Microbiol 1994; 32: 2667–70
- Alaluusua S, Gronblad E A, Tölo U H. Quantitation of IgA in human whole saliva: a comparison of three immunoassays. Acta Odontol Scand 1981; 39: 155–61
- Luotonen J, Herva E, Karma P, Timonen M, Leinonen M, Mäkelä P H. The bacteriology of acute otitis media in children with special reference to Streptococcus pneumoniae as studied by bacteriological and antigen detection methods. Scand J Infect Dis 1981; 13: 177–83
- Eskola J, Takala A, Kela E, Pekkanen E, Kalliokoski R, Leinonen M. Epidemiology of invasive pneumococcal infections in children in Finland. JAMA 1992; 268: 3323–7
- Koskela M. Serum antibodies to pneumococcal C polysaccharide in children: response to acute pneumococcal otitis media or to vaccination. Pediatr Infect Dis J 1987; 6: 519–26
- Pichichero M E, Hall C B, Insel R A. A mucosal antibody response following systemic Haemophilus influenzae type b infection in children. J Clin Invest 1981; 67: 1482–9
- Paparella M, Sipila U P, Juhn S K, Jung T TK. Subepithelial space in otitis media. Laryngoscope 1985; 95: 414–20
- Ogra P L, Bernstein J M, Yurchak A M, Coppola P R, Tomasi T B. Characteristics of secretory immune system in human middle ear: implications in otitis media. J Immunol 1974; 112: 488–95
- Watanabe N, Kato H, Mogi G. Induction of antigen spesific IgA-forming cells in the middle ear mucosa. Arch Otolaryngol Head Neck Surg 1988; 114: 758–62
- Ryan A F, Catanzaro A, Wasserman S, Harris J P. Secondary immune response in the middle ear: physiological, anatomical and immunological observations. Ann Otol Rhinol Laryngol 1986; 95: 242–9
- Ryan A F, Sharp P A, Harris J P. Lymphocyte circulation to the middle ear. Acta Otolaryngol (Stockh) 1990; 109: 278–87
- Paton J C, Lock R A, Hansman D J. Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae. Infect Immun 1983; 40: 548–52
- Shurin P A, Rehmus J M, Johnson C E, et al. Bacterial polysaccharide immune globulin for prophylaxis of acute otitis media in high-risk children. J Pediatr 1993; 123: 801–10
- Klein J O. Pneumococcal otitis media vaccine trials. Pediatr Infect Dis J 1989; 8: S82–3