References
- Bilder RM, Goldman RS, Robinson D . Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates. Am J Psychiatry 2000;157:549–559.
- Bozikas VP, Kosmidis MH, Kiosseoglou G, Karavatos A. Neuropsychological profile of cognitively impaired patients with schizophrenia. Compr Psychiatry 2006;47:136–143.
- Egan MF, Goldberg TE, Kolachana BS . Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001;98:6917–6922.
- Ma X, Wang Q, Sham PC . Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives. Am J Med Genet B Neuropsychiatr Genet 2007;144:407–416.
- Wang Q, Chan R, Sun J . Reaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: a study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controls. Schizophr Res 2007;89:293–298.
- Gold JM, Carpenter C, Randolph C, Goldberg TE, Weinberger DR. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch Gen Psychiatry 1997;54:159–165.
- Green MF, Nuechterlein KH. Should schizophrenia be treated as a neurocognitive disorder? Schizophr Bull 1999;25:309–319.
- Kern RS, Green MF, Nuechterlein KH, Deng BH. NIMH-MATRICS survey on assessment of neurocognition in schizophrenia. Schizophr Res 2004;72:11–19.
- Mitropoulou V, Harvey PD, Zegarelli G, New AS, Silverman JM, Siever LJ. Neuropsychological performance in schizotypal personality disorder: importance of working memory. Am J Psychiatry 2005;162:1896–1903.
- Nuechterlein KH, Dawson ME, Gitlin M . Developmental processes in schizophrenic disorders: longitudinal studies of vulnerability and stress. Schizophr Bull 1992;18:387–425.
- Nuechterlein KH, Barch DM, Gold JM, Goldberg TE, Green MF, Heaton RK. Identification of separable cognitive factors in schizophrenia. Schizophr Res 2004;72:29–39.
- Dempster EL, Toulopoulou T, McDonald C . Episodic memory performance predicted by the 2bp deletion in exon 6 of the ‘alpha 7-like’ nicotinic receptor subunit gene. Am J Psychiatry 2006;163:1832–1834.
- Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003;160:636–645.
- Dickinson D, Iannone VN, Wilk CM, Gold JM. General and specific cognitive deficits in schizophrenia. Biol Psychiatry 2004;55:826–833.
- Mohamed S, Paulsen JS, O'Leary D, Arndt S, Andreasen N. Generalized cognitive deficits in schizophrenia: a study of first-episode patients. Arch Gen Psychiatry 1999;56:749–754.
- Jaeger J, Czobor P, Berns SM. Basic neuropsychological dimensions in schizophrenia. Schizophr Res 2003;65:105–116.
- Gladsjo JA, McAdams LA, Palmer BW, Moore DJ, Jeste DV, Heaton RK. A six-factor model of cognition in schizophrenia and related psychotic disorders: relationships with clinical symptoms and functional capacity. Schizophr Bull 2004;30:739–754.
- Allen DN, Huegel SG, Seaton BE, Goldstein G, Gurklis JA Jr, van Kammen DP. Confirmatory factor analysis of the WAIS-R in patients with schizophrenia. Schizophr Res 1998;34:87–94.
- Genderson MR, Dickinson D, Diaz-Asper CM, Egan MF, Weinberger DR, Goldberg TE. Factor analysis of neurocognitive tests in a large sample of schizophrenic probands, their siblings, and healthy controls. Schizophr Res 2007;94:231–239.
- First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders: Clinician Version (SCID-CV): administration booklet. New York: American Psychiatric Publishing, 1996.
- American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th. Washington, DC: American Psychiatric Association, 1994.
- Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261–276.
- Chen EY, Wong AW, Chen RY, Au JW. Stroop interference and facilitation effects in first-episode schizophrenic patients. Schizophr Res 2001;48:29–44.
- Gong Y. Wechsler Adult Intelligence Scale–Revised in China. Hunan: Hunan Medical School Press, 1982.
- Gong Y. Wechsler Memory Scale–Revised in China. Hunan: Hunan Medical School Press, 1987.
- Humes GE, Welsh MC, Retzlaff P, Cookson N. Towers of Hanoi and London: reliability and validity of two executive function tasks. Assessment 1997;4:249–257.
- Lu L, Bigler ED. Performance on original and a Chinese version of Trail Making Test Part B: a normative bilingual sample. Appl Neuropsychol 2000;7:243–246.
- Chen YL, Chen YH, Lieh-Mak F. Semantic verbal fluency deficit as a familial trait marker in schizophrenia. Psychiatry Res 2000;95:133–148.
- Nelson HE. A modified card sorting task sensitive to frontal lobe defects. Cortex 1976;12:313–324.
- Spreen O, Strauss E. A compendium of neuropsychological tests: administration, norms, and commentary. New York: Oxford University Press, 1991.
- Jöreskog KG, Sorbom D. LISREL 8 User's Reference Guide, 2nd. Mooresville, IN: Scientific, Software International (Chicago, Illinois); 2004.
- Hu L-t, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Struct Equation Model 1999;6:1–55.
- Bentler PM, Bonett DG. Significance tests and goodness of fit in the analysis of covariance structures. Psychol Bull 1980;88:588–606.
- Bentler PM. Comparative fit indexes in structural models. Psychol Bull 1990; 107.
- Greenwood TA, Braff DL, Light GA . Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia. Arch Gen Psychiatry 2007;64:1242–1250.
- Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198–1211.
- Rice JP, Saccone NL, Rasmussen E. Definition of the phenotype. Adv Genet 2001;42:69–76.
- Winterer G, Egan MF, Radler T, Coppola R, Weinberger DR. Event-related potentials and genetic risk for schizophrenia. Biol Psychiatry 2001;50:407–417.
- Flint J, Munafò MR. The endophenotype concept in psychiatric genetics. Psychol Med 2007;37:163–180.
- Harvey P, Winters K, Weintraub S, Neale JM. Distractibility in children vulnerable to psychopathology. J Abnorm Psychol 1981;90:298–304.
- Harvey PD, Docherty NM, Serper MR, Rasmussen M. Cognitive deficits and thought disorder: II. An 8-month followup study. Schizophr Bull 1990;16:147–156.
- Baxter RD, Liddle PF. Neuropsychological deficits associated with schizophrenic syndromes. Schizophr Res 1998;30:239–249.
- Nuechterlein KH, Edell WS, Norris M, Dawson ME. Attentional vulnerability indicators, thought disorder, and negative symptoms. Schizophr Bull 1986;12:408–426.
- Jones P, Rodgers B, Murray R, Marmot M. Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet 1994;344:1398–1402.
- Cannon M, Huttunen MO, Tanskanen AJ, Arseneault L, Jones PB, Murray RM. Perinatal and childhood risk factors for later criminality and violence in schizophrenia. Longitudinal, population-based study. Br J Psychiatry 2002;180:496–501.
- Cornblatt BA. The New York high risk project to the Hillside recognition and prevention (RAP) program. Am J Med Genet 2002;114:956–966.
- Husted JA, Lim S, Chow EW, Greenwood C, Bassett AS. Heritability of neurocognitive traits in familial schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2009;150B:845–853.
- Hobart MP, Goldberg R, Bartko JJ, Gold JM. Repeatable battery for the assessment of neuropsychological status as a screening test in schizophrenia, II: convergent/discriminant validity and diagnostic group comparisons. Am J Psychiatry 1999;156:1951–1957.
- Green MF, Marder SR, Glynn SM . The neurocognitive effects of low-dose haloperidol: a two-year comparison with risperidone. Biol Psychiatry 2002;51:972–978.
- Kremen WS, Seidman LJ, Faraone SV, Pepple JR, Tsuang MT. Attention/information-processing factors in psychotic disorders. Replication and extension of recent neuropsychological findings. J Nerv Ment Dis 1992;180:89–93.
- Barnes TW, Vassallo R, Tazelaar HD, Hartman TE, Ryu JH. Diffuse bronchiolar disease due to chronic occult aspiration. Mayo Clin Proc 2006;81:172–176.
- Stuss DT, Shallice T, Alexander MP, Picton TW. A multidiscipli-nary approach to anterior attentional functions. Ann N Y Acad Sci 1995;769:191–211.
- Beck LH, Bransome ED Jr, Mirsky AF, Rosvold HE, Sarason I. A continuous performance test of brain damage. J Consult Psychol 1956;20:343–350.
- Spaulding W, Garbin CP, Dras SR. Cognitive abnormalities in schizophrenic patients and schizotypal college students. J Nerv Ment Dis 1989;177:717–728.
- Abi-Dargham A, Mawlawi O, Lombardo I . Prefrontal dopamine D1 receptors and working memory in schizophrenia. J Neurosci 2002;22:3708–3719.
- Addington J, Addington D. Neurocognitive functioning in schizophrenia: a trial of risperidone versus haloperidol. Can J Psychiatry 1997;42:983.
- Albus M, Hubmann W, Scherer J . A prospective 2-year follow-up study of neurocognitive functioning in patients with first-episode schizophrenia. Eur Arch Psychiatry Clin Neurosci 2002;252:262–267.
- Ho BC, Alicata D, Ward J . Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia. Am J Psychiatry 2003;160:142–148.