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Research Article

Phospholipase C beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illness

(Post-Doctoral Researcher) , (Post-Doctoral Fellow) , (Associate Professor) , (Associate Professor) & (Professor)
Pages 140-147 | Received 22 Jul 2010, Accepted 14 Oct 2010, Published online: 23 Nov 2010

References

  • Riley BP, McGuffin P. Linkage and associated studies of schizophrenia. Am J Med Genet 2000; 97:23–44.
  • Tsuang M. Schizophrenia: genes and environment. Biol Psychiatry 2000; 47:210–220.
  • Dean B. Signal transmission, rather than reception, is the underlying neurochemical abnormality in schizophrenia. Aust N Z J Psychiatry 2000; 34:560–569.
  • Hemby SE, Ginsberg SD, Brunk B, Arnold SE, Trojanowski JQ, Eberwine JH. Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortex. Arch Gen Psychiatry 2002; 59:631–640.
  • Mexal S, Frank M, Berger R . Differential modulation of gene expression in the NMDA postsynaptic density of schizophrenic and control smokers. Brain Res Mol Brain Res 2005; 139:317–332.
  • Vawter MP, Crook JM, Hyde TM . Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study. Schizophr Res 2002; 58:11–20.
  • Altar CA, Jurata LW, Charles V . Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts. Biol Psychiatry 2005; 58:85–96.
  • Mirnics K, Middleton FA, Marquez A, Lewis DA, Levitt P. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 2000; 28:53–67.
  • Mirnics K, Middleton FA, Stanwood GD, Lewis DA, Levitt P. Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol Psychiatry 2001; 6:293–301.
  • Hashimoto T, Volk DW, Eggan SM . Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. J Neurosci 2003; 23:6315–6326.
  • Middleton FA, Mirnics K, Pierri JN, Lewis DA, Levitt P. Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. J Neurosci 2002; 22:2718–2729.
  • Iwamoto K, Bundo M, Kato T. Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet 2005; 14:241–253.
  • Hakak Y, Walker JR, Li C . Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci USA 2001; 98:4746–4751.
  • Dean B, Keriakous D, Scarr E, Thomas EA. Gene expression profiling in Brodmann's area 46 from subjects with schizophrenia. Aust N Z J Psychiatry 2007; 41:308–320.
  • Narayan S, Tang B, Head SR . Molecular profiles of schizophrenia in the CNS at different stages of illness. Brain Res 2008; 1239:235–248.
  • Narayan S, Head SR, Gilmartin TJ, Dean B, Thomas EA. Evidence for disruption of sphingolipid metabolism in schizophrenia. J Neurosci Res 2009; 87:278–288.
  • Spires TL, Molnar Z, Kind PC . Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling. Cereb Cortex 2005; 15:385–393.
  • Hannan AJ, Blakemore C, Katsnelson A . PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex. Nat Neurosci 2001; 4:282–288.
  • Kind PC, Kelly GM, Fryer HJ, Blakemore C, Hockfield S. Phospholipase C-beta1 is present in the botrysome, an intermediate compartment-like organelle, and Is regulated by visual experience in cat visual cortex. J Neurosci 1997; 17:1471–1480.
  • Hannan AJ, Kind PC, Blakemore C. Phospholipase C-beta1 expression correlates with neuronal differentiation and synaptic plasticity in rat somatosensory cortex. Neuropharmacology 1998; 37:593–605.
  • Kim D, Jun KS, Lee SB . Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature 1997; 389:290–293.
  • Salles J, Wallace MA, Fain JN. Modulation of the phospholipase C activity in rat brain cortical membranes by simultaneous activation of distinct monoaminergic and cholinergic muscarinic receptors. Brain Res Mol Brain Res 1993; 20:111–117.
  • Wallace MA, Claro E. A novel role for dopamine: inhibition of muscarinic cholinergic-stimulated phosphoinositide hydrolysis in rat brain cortical membranes. Neurosci Lett 1990; 110:155–161.
  • Tandon R. Cholinergic aspects of schizophrenia. Br J Psychiatry Suppl 1999; (37):7–11.
  • Carlsson A. Does dopamine play a role in schizophrenia? Psychol Med 1977; 7:583–597.
  • Meltzer HY, Stahl SM. The dopamine hypothesis of schizophrenia: a review. Schizophr Bull 1976; 2:19–76.
  • Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 1991; 148:1301–1308.
  • Meltzer HY. Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology (Berl) 1989; 99 Suppl:S18–27.
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, fourth. Washington, DC: American Psychiatric Association, 1994.
  • Hill C, Keks N, Roberts S . Problem of diagnosis in postmortem brain studies of schizophrenia. Am J Psychiatry 1996; 153:533–537.
  • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29:e45.
  • Gliner JA, Morgan GA, Harmon RJ. Basic associational designs: analysis and interpretation. J Am Acad Child Adolesc Psychiatry 2002; 41:1256–1258.
  • Adams JW, Brown JH. G-proteins in growth and apoptosis: lessons from the heart. Oncogene 2001; 20:1626–1634.
  • Jalili T, Takeishi Y, Walsh RA. Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC. Cardiovasc Res 1999; 44:5–9.
  • Hashimoto K, Miyata M, Watanabe M, Kano M. Roles of phospholipase Cbeta4 in synapse elimination and plasticity in developing and mature cerebellum. Mol Neurobiol 2001; 23:69–82.
  • Litosch I. Novel mechanisms for feedback regulation of phospholipase C-beta activity. IUBMB Life 2002; 54:253–260.
  • Sorensen SD, Linseman DA, Fisher SK. Down-regulation of phospholipase C-beta1 following chronic muscarinic receptor activation. Eur J Pharmacol 1998; 346:R1–2.
  • Dwivedi Y, Pandey GN. Effects of treatment with haloperidol, chlorpromazine, and clozapine on protein kinase C (PKC) and phosphoinositide-specific phospholipase C (PI-PLC) activity and on mRNA and protein expression of PKC and PLC isozymes in rat brain. J Pharmacol Exp Ther 1999; 291(2):688–704.
  • Dwivedi Y, Agrawal AK, Rizavi HS, Pandey GN. Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC beta 1 isozyme in rat brain. Neuropharmacology 2002; 43:1269–1279.
  • Scarr E, Pavey G, Robinson PJ, Opeskin K, Copolov DL, Dean B. Decreased phorbol ester binding in the parahippocampal gyrus from subjects with schizophrenia is not associated with changes in protein kinase C. Mol Psychiatry 2002; 7:683–688.
  • Dean B, Opeskin K, Pavey G, Hill C, Keks N. Changes in protein kinase C and adenylate cyclase in the temporal lobe from subjects with schizophrenia. J Neural Transm 1997; 104:1371–1381.
  • Beasley C, Cotter D, Khan N . Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia. Neurosci Lett 2001; 302:117–120.
  • Nadri C, Dean B, Scarr E, Agam G. GSK-3 parameters in postmortem frontal cortex and hippocampus of schizophrenic patients. Schizophr Res 2004; 71:377–382.
  • Kozlovsky N, Belmaker RH, Agam G. Low GSK-3beta immunoreactivity in postmortem frontal cortex of schizophrenic patients. Am J Psychiatry 2000; 157:831–833.
  • Huber KM, Kayser MS, Bear MF. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science 2000; 288:1254–1257.
  • Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC. Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1). Biochim Biophys Acta 2000; 1517:63–72.
  • Grubb DR, Vasilevski O, Huynh H, Woodcock EA. The extreme C-terminal region of phospholipase Cbeta1 determines subcellular localization and function; the “b” splice variant mediates alpha1-adrenergic receptor responses in cardiomyocytes. Faseb J 2008; 22:2768–2774.
  • Lin XH, Kitamura N, Hashimoto T, Shirakawa O, Maeda K. Opposite changes in phosphoinositide-specific phospholipase C immunoreactivity in the left prefrontal and superior temporal cortex of patients with chronic schizophrenia. Biol Psychiatry 1999; 46:1665–1671.
  • Faenza I, Matteucci A, Manzoli L . A role for nuclear phospholipase C beta 1 in cell cycle control. J Biol Chem 2000; 275:30520–30524.
  • Conway RG, Routtenberg A. Endogenous phosphorylation in vitro: differential effects of brain state (anesthesia, post-mortem) on electrophoretically separated brain proteins. Brain Res 1979; 170:313–324.
  • Walaas SI, Perdahl-Wallace E, Winblad B, Greengard P. Protein phosphorylation systems in postmortem human brain. J Mol Neurosci 1989; 1:105–116.
  • Jope RS, Song L, Grimes CA . Selective increases in phosphoinositide signaling activity and G protein levels in postmortem brain from subjects with schizophrenia or alcohol dependence. J Neurochem 1998; 70:763–771.
  • Wallace MA, Claro E. Transmembrane signaling through phospholipase C in human cortical membranes. Neurochem Res 1993; 18:139–145.

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