80
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Atypical antipsychotics cause an acute increase in cutaneous hand blood flow in patients with schizophrenia and schizoaffective disorder

, , , , &
Pages 646-653 | Published online: 26 Aug 2011

References

  • Lambert TJ, Cock N, Alcock SJ, Kelly DL, Conley RR. Measurement of antipsychotic-induced side effects: support for the validity of a self-report (LUNSERS) versus structured interview (UKU) approach to measurement. Hum Psychopharmacol 2003;18:405–411.
  • Blessing WW, Seaman B. 5-hydroxytryptamine(2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats. Neuroscience 2003;117:939–948.
  • Blessing WW, Seaman B, Pedersen NP, Ootsuka Y. Clozapine reverses hyperthermia and sympathetically mediated cutaneous vasoconstriction induced by 3,4-methylenedioxymethamphetamine (ecstasy) in rabbits and rats. J Neurosci 2003;23:6385–6391.
  • Ootsuka Y, Blessing WW. 5-Hydroxytryptamine 1A receptors inhibit cold-induced sympathetically mediated cutaneous vasoconstriction in rabbits. J Physiol 2003;552:303–314.
  • Blessing WW. 5-hydroxytryptamine 1A receptor activation reduces cutaneous vasoconstriction and fever associated with the acute inflammatory response in rabbits. Neuroscience 2004;123:1–4.
  • Blessing WW. Clozapine and olanzapine, but not haloperidol, reverse cold-induced and lipopolysaccharide-induced cutaneous vasoconstriction. Psychopharmacol (Berl) 2004;175:487–493.
  • Blessing WW. BAT control shows the way: medullary raphe/parapyramidal neurons and sympathetic regulation of brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 2005; 288: R557–560 [comment].
  • Nalivaiko E, Ootsuka Y, Blessing WW. Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits. Am J Physiol Regul Integr Comp Physiol 2005;289:R596–604.
  • Blessing WW, Zilm A, Ootsuka Y. Clozapine reverses increased brown adipose tissue thermogenesis induced by 3,4-methylenedioxymethamphetamine and by cold exposure in conscious rats. Neuroscience 2006;141:2067–2073.
  • Ootsuka Y, Blessing WW, Nalivaiko E. Selective blockade of 5-HT2A receptors attenuates the increased temperature response in brown adipose tissue to restraint stress in rats. Stress 2008;11:125–133.
  • Mittelmann B, Wolf HG. Emotions and skin temperature: observations on patients during psychotherapeutic (psychoanalytic) interviews. Psychosom Med 1943;5:211–231.
  • Bleuler M, Bleuler R. Dementia praecox oder die Gruppe der Schizophrenien: Eugen Bleuler. Br J Psychiatry 1986;149:661–662.
  • Kraeplin E. Dementia praecox and paraphrenia. Chicago: Chicago Medical, 1919.
  • Klingmann T. Physical signs in schizophrenia. Am J Psychiatry 1946; 103:69–71.
  • Albus M, Ackenheil M, Engel RR, Muller F. Situational reactivity of autonomic functions in schizophrenic patients. Psychiatry Res 1982;6:361–370.
  • Williams M. Psychophysiological responsiveness to psychological stress in early chronic schizophrenic reactions. Psychosom Med 1953;15:456–462.
  • Dawson ME, Nuechterlein KH. Psychophysical dysfunctions in the developmental course of schizophrenic disorders. Schizophr Bull 1984;10:204–232.
  • Zahn TP, Pickar D. Autonomic effects of clozapine in schizophrenia: comparison with placebo and fluphenazine. Biol Psychiatry 1993;34:3–12.
  • Kistler A, Mariauzouls C, von Berlepsch K. Fingertip temperature as an indicator for sympathetic responses. Int J Psychophysiol 1998;29:35–41.
  • Kane J, Honigfeld G, Singer J, Meltzer H. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry 1988;45:789–796.
  • Blessing WW. Clozapine increases cutaneous blood flow and reduces sympathetic cutaneous vasomotor alerting responses (SCVARs) in rats: comparison with effects of haloperidol. Psychopharmacology (Berl) 2005;181:518–528.
  • Overall JE, Gorham DR. The Brief Psychiatric Rating Scale. Psychological Reports 1962;10:799–812.
  • Yu YH, Blessing WW. Cutaneous vasoconstriction in conscious rabbits during alerting responses detected by hippocampal theta-rhythm. Am J Physiol 1997;272:R208–216.
  • de Menezes RC, Ootsuka Y, Blessing WW. Sympathetic cutaneous vasomotor alerting responses (SCVARs) are associated with hippocampal theta rhythm in non-moving conscious rats. Brain Res 2009;1298:123–130.
  • Morrison SF, Sved AF, Passerin AM. GABA-mediated inhibition of raphe pallidus neurons regulates sympathetic outflow to brown adipose tissue. Am J Physiol 1999;276:R290–297.
  • Blessing WW. BAT control shows the way: medullary raphe/parapyramidal neurons and sympathetic regulation of brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 2005;288:R557–560.
  • Morrison SF, Nakamura K, Madden CJ. Central control of thermogenesis in mammals. Exp Physiol 2008;93:773–797.
  • Kulasekara KMKK, Menezes R, Ootsuka Y, Blessing WW. Amygdala mediates sympathetic cutaneous vasoconstrictor alerting responses (SCVARs) in rats: relevance of 5HT2a receptors. Canberra, Proceedings of the Australian Neuroscience Society, 2009;18:106.
  • Yu YH, Blessing WW. Amygdala co-ordinates sudden falls in ear pinna blood flow in response to unconditioned salient stimuli in conscious rabbits. Neuroscience 1999;93:135–141.
  • Vinkers CH, van Bogaert MJ, Klanker M . Translational aspects of pharmacological research into anxiety disorders: the stress-induced hyperthermia (SIH) paradigm. Eur J Pharmacol 2008;585:407–425.
  • Ackner B. Emotions and the peripheral vasomotor system: a review of previous work. J Psychosom Res 1956;1:3–20.
  • Ackner B. The relationship between anxiety and the level of peripheral vasomotor activity. J Psychosom Res 1956;1:21–48.
  • Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007;293:E444–452.
  • Saito M, Okamatsu-Ogura Y, Matsushita M . High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009;58:1526–1531.
  • van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM . Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009;360:1500–1508.
  • Abi-Saab W, Seibyl JP, D'Souza DC . Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms. Psychopharmacology (Berl) 2002;162:55–62.
  • Tauscher J, Kapur S, Verhoeff NP . Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635. Arch Gen Psychiatry 2002;59:514–520.
  • Meltzer HY, Li Z, Kaneda Y, Ichikawa J. Serotonin receptors: their key role in drugs to treat schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:1159–1172.
  • Meltzer HY, Arvanitis L, Bauer D, Rein W. Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder. Am J Psychiatry 2004;161:975–984.
  • Meltzer HY, Huang M. In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems. Prog Brain Res 2008;172:177–197.
  • Aghajanian GK, Marek GJ. Serotonin and hallucinogens. Neuropsychopharmacology 1999;21:16S–23S.
  • Lee HS, Bastani B, Friedman L, Ramirez L, Meltzer HY. Effect of the serotonin agonist, MK-212, on body temperature in schizophrenia. Biol Psychiatry 1992;31:460–470.
  • Blessing WW, Ootsuka Y. Activation of dopamine D2 receptors in the CNS inhibits sympathetic cutaneous vasomotor alerting responses (SCVARs), contributing to clozapine's SCVAR-inhibiting action. Prog Neuropsychopharmacol Biol Psychiatry 2007;31:328–336.
  • Shioda K, Nisijima K, Yoshino T . Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. Neurotoxicology 2008;9:1030–1036.
  • van Marum RJ, Wegewijs MA, Loonen AJ, Beers E. Hypothermia following antipsychotic drug use. Eur J Clin Pharmacol 2007;63:627–631.
  • Heh CW, Herrera J, DeMet E . Neuroleptic-induced hypothermia associated with amelioration of psychosis in schizophrenia. Neuropsychopharmacology 1988;1:149–156.
  • Shiloh R, Hermesh H, Weizer N, Dorfman-Etrog P, Weizman A, Munitz H. Acute antipsychotic drug administration lowers body temperature in drug-free male schizophrenic patients. Eur Neuropsychopharmacol 2000;10:443–445.
  • Cleare AJ, Forsling M, Bond AJ. Neuroendocrine and hypothermic effects of 5-HT1A receptor stimulation with ipsapirone in healthy men: a placebo-controlled study. Int Clin Psychopharmacol 1998;13:23–32.
  • Czobor P, Volavka J, Sheitman B . Antipsychotic-induced weight gain and therapeutic response: a differential association. J Clin Psychopharmacol 2002;22:244–251.
  • Bai YM, Lin CC, Chen JY, Lin CY, Su TP, Chou P. Association of initial antipsychotic response to clozapine and long-term weight gain. Am J Psychiatry 2006;163:1276–1279.
  • Stefanidis A, Verty AN, Allen AM, Owens NC, Cowley MA, Oldfield BJ. The role of thermogenesis in antipsychotic drug-induced weight gain. Obesity 2009;17:16–24.
  • Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 2003;28:519–526.
  • Chong TW, Castle DJ. Layer upon layer: thermoregulation in schizophrenia. Schizophr Res 2004;69:149–157.
  • Altschule MD, Sulzbach WM. Effect of carbon dioxide on acrocyanosis in schizophrenia. Arch Neurol Psychiatry 1949;61:44–55.
  • Tecce JJ, Cole JO. Psychophysiologic responses of schizophrenics to drugs. Psychopharmacologia 1972;24:159–200.
  • Bernstein AS, Taylor KW, Starkey P, Juni S, Lubowsky J, Paley H. Bilateral skin conductance, finger pulse volume, and EEG orienting response to tones of differing intensities in chronic schizophrenics and controls. J Nerv Ment Dis 1981;169:513–528.
  • Zahn TP, Carpenter WT Jr, McGlashan TH. Autonomic nervous system activity in acute schizophrenia: I. Method and comparison with normal controls. Arch Gen Psychiatry 1981;38:251–258.
  • Fuentes I, Garcia Merita M, Miquel M, Rojo J. Relationships between electrodermal activity and symptomatology in schizophrenia. Psychopathology 1993;26:47–52.
  • Lindstrom EM, Ohlund LS, Lindstrom LH, Ohman A. Symptomatology and electrodermal activity as predictors of neuroleptic response in young male schizophrenic inpatients. Psychiatry Res 1992;42:145–158.
  • Dawson ME, Nuechterlein KH, Schell AM, Gitlin M, Ventura J. Autonomic abnormalities in schizophrenia. State or trait indicators? Arch Gen Psychiatry 1994;51:813–824.
  • Kring AM, Neale JM. Do schizophrenic patients show a disjunctive relationship among expressive, experiential, and psychophysiological components of emotion? J Abnorm Psychol 1996; 105:249–257.
  • Shiloh R, Weizman A, Stryjer R, Kahan N, Waitman DA. Altered thermoregulation in ambulatory schizophrenia patients: a naturalistic study. World J Biol Psychiatry 2009;10:163–170.
  • Dawson ME, Schell AM, Rissling A, Ventura J, Subotnik KL, Nuechterlein KH. Psychophysiological prodromal signs of schizophrenic relapse: a pilot study. Schizophr Res 2010;123:64–67.
  • Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry 2003;160:13–23.
  • van Os J. A salience dysregulation syndrome. Br J Psychiatry 2009;194:101–103.
  • Schmidt K, Roiser JP. Assessing the construct validity of aberrant salience. Front Behav Neurosci 2009;3:58.
  • Roiser JP, Stephan KE, den Ouden HE, Barnes TR, Friston KJ, Joyce EM. Do patients with schizophrenia exhibit aberrant salience? Psychol Med 2009; 39:199–209.
  • Freedman R, Adler LE, Gerhardt GA . Neurobiological studies of sensory gating in schizophrenia. Schizophr Bull 1987;13:669–678.
  • Paradiso S, Johnson DL, Andreasen NC . Cerebral blood flow changes associated with attribution of emotional valence to pleasant, unpleasant, and neutral visual stimuli in a PET study of normal subjects. Am J Psychiatry 1999;156:1618–1629.
  • Laine CM, Spitler KM, Mosher CP, Gothard KM. Behavioral triggers of skin conductance responses and their neural correlates in the primate amygdala. J Neurophysiol 2009;101:1749–1754.
  • Lanteaume L, Khalfa S, Regis J, Marquis P, Chauvel P, Bartolomei F. Emotion induction after direct intracerebral stimulations of human amygdala. Cereb Cortex 2007;17:1307–1313.
  • Williams LM, Phillips ML, Brammer MJ . Arousal dissociates amygdala and hippocampal fear responses: evidence from simultaneous fMRI and skin conductance recording. Neuroimage 2001;14:1070–1079.
  • Satterthwaite TD, Wolf DH, Loughead J . Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophrenia. Am J Psychiatry 2010;167:418–426.
  • LeDoux JE. Emotion circuits in the brain. Annu Rev Neurosci 2000;23:155–184.
  • Taylor SF, Phan KL, Britton JC, Liberzon I. Neural response to emotional salience in schizophrenia. Neuropsychopharmacology 2005;30:984–995.
  • Holt DJ, Kunkel L, Weiss AP . Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia. Schizophr Res 2006;82:153–162.
  • Williams LM, Das P, Harris AW . Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. Am J Psychiatry 2004;161:480–489.
  • Williams LM, Das P, Liddell BJ . Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes. Psychiatry Res 2007;155:29–44.
  • Aleman A, Kahn RS. Strange feelings: do amygdala abnormalities dysregulate the emotional brain in schizophrenia? Prog Neurobiol 2005; 77:283–298.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.