Administration of Donepezil Does Not Rescue Galanin-Induced Spatial Learning Deficits

REFERENCES

• Fisone G, Wu CF, Consolo S, Nordstrom O, Brynne N, Bartfai T, Melander T, Hokfelt T. Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo, and in vitro studies. Proc Natl Acad Sci USA. 1987 Oct;84(20):7339–43.
   PubMed Web of Science ®Google Scholar
• Kinney GA, Emmerson PJ, Miller RJ. Galanin receptor-mediated inhibition of glutamate release in the arcuate nucleus of the hypothalamus. J Neurosci. 1998 May 15;18(10): 3489–500.
   PubMed Web of Science ®Google Scholar
• Pieribone VA, Xu ZQ, Zhang X, Grillner S, Bartfai T, Hokfelt T. Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice. Neuroscience. 1995 Feb;64(4):861–74.
   PubMed Web of Science ®Google Scholar
• Xu ZQ, Zhang X, Pieribone VA, Grillner S, Hokfelt T. Galanin-5-hydroxytryptamine interactions: electrophysiological, immunohistochemical and in situ hybridization studies on rat dorsal raphe neurons with a note on galanin R1 and R2 receptors. Neuroscience. 1998 Nov;87(1):79–94.
   PubMed Web of Science ®Google Scholar
• Karelson E, Langel U. Galaninergic signalling and adenylate cyclase. Neuropeptides. 1998 Jun;32(3):197–210.
   PubMed Web of Science ®Google Scholar
• Kinney JW, Starosta G, Holmes A, Wrenn CC, Yang RJ, Harris AP, Long KC, Crawley JN. Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice. Learn Mem. 2002 Jul-Aug;9(4):178–90.
   PubMed Web of Science ®Google Scholar
• Kinney JW, Starosta G, Crawley JN. Central galanin administration blocks consolidation of spatial learning. Neurobiol Learn Mem. 2003 Jul;80(1):42–54.
   PubMed Web of Science ®Google Scholar
• Ogren SO, Kehr J, Schott PA. Effects of ventral hippocampal galanin on spatial learning and on in vivo acetylcholine release in the rat. Neuroscience. 1996 Dec;75(4):1127–40.
   PubMed Web of Science ®Google Scholar
• Robinson JK, Crawley JN. Intraseptal galanin potentiates scopolamine impairment of delayed nonmatching to sample. J Neurosci. 1993 Dec;13(12):5119–25.
   PubMed Web of Science ®Google Scholar
• Rustay NR, Wrenn CC, Kinney JW, Holmes A, Bailey KR, Sullivan TL, Harris AP, Long KC, Saavedra MC, Starosta G, Innerfield CE, Yang RJ, Dreiling JL, Crawley JN. Galanin impairs performance on learning and memory tasks: findings from galanin transgenic and GAL-R1 knockout mice. Neuropeptides. 2005 Jun;39(3):239–43.
   PubMed Web of Science ®Google Scholar
• Steiner RA, Hohmann JG, Holmes A, Wrenn CC, Cadd G, Jureus A, Clifton DK, Luo M, Gutshall M, Ma SY, Mufson EJ, Crawley JN. Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7): 4184–9.
   PubMed Web of Science ®Google Scholar
• Beal MF, MacGarvey U, Swartz KJ. Galanin immunoreactivity is increased in the nucleus basalis of meynert in Alzheimer's disease. Ann Neurol. 1990 Aug;28(2):157–61.
   PubMed Web of Science ®Google Scholar
• Bowser R, Kordower JH, Mufson EJ. A confocal microscopic analysis of galaninergic hyperinnervation of cholinergic basal forebrain neurons in Alzheimer's disease. Brain Pathol. 1997 Apr;7(2):723–30.
   PubMed Web of Science ®Google Scholar
• Chan-Palay V. Galanin hyperinnervates surviving neurons of the human basal nucleus of meynert in dementias of Alzheimer's and Parkinson's disease: a hypothesis for the role of galanin in accentuating cholinergic dysfunction in dementia. J Comp Neurol. 1988 Jul 22;273(4):543–57.
   PubMed Web of Science ®Google Scholar
• Counts SE, He B, Che S, Ginsberg SD, Mufson EJ. Galanin fiber hyperinnervation preserves neuroprotective gene expression in cholinergic basal forebrain neurons in Alzheimer's disease. J Alzheimers Dis. 2009 Dec;18(4):885–96.
   PubMed Web of Science ®Google Scholar
• O'Meara G, Coumis U, Ma SY, Kehr J, Mahoney S, Bacon A, Allen SJ, Holmes F, Kahl U, Wang FH, Kearns IR, Ove-Ogren S, Dawbarn D, Mufson EJ, Davies C, Dawson G, Wynick D. Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons. Proc Natl Acad Sci USA. 2000 Oct 10;97(21):11569–74.
   PubMed Web of Science ®Google Scholar
• Elvander E, Schott PA, Sandin J, Bjelke B, Kehr J, Yoshitake T, Ogren SO. Intraseptal muscarinic ligands and galanin: influence on hippocampal acetylcholine and cognition. Neuroscience. 2004;126(3):541–57.
   PubMed Web of Science ®Google Scholar
• Ogren SO, Schott PA, Kehr J, Misane I, Razani H. Galanin and learning. Brain Res. 1999 Nov 27;848(1–2):174–82.
   PubMed Web of Science ®Google Scholar
• Palazzi E, Felinska S, Zambelli M, Fisone G, Bartfai T, Consolo S. Galanin reduces carbachol stimulation of phosphoinositide turnover in rat ventral hippocampus by lowering Ca2+ influx through voltage-sensitive Ca2+ channels. J Neurochem. 1991 Mar;56(3):739–47.
   PubMed Web of Science ®Google Scholar
• Kinney JW, Sanchez-Alavez M, Barr AM, Criado JR, Crawley JN, Behrens MM, Henriksen SJ, Bartfai T. Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation. Neurobiol Learn Mem. 2009 Oct;92(3):429–38.
   PubMed Web of Science ®Google Scholar
• Comb M, Birnberg NC, Seasholtz A, Herbert E, Goodman HM. A cyclic AMP- and phorbol ester-inducible DNA element. Nature. 1986 Sep 25-Oct 1;323(6086): 353–6.
   PubMed Web of Science ®Google Scholar
• Dash PK, Hochner B, Kandel ER. Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature. 1990 Jun 21;345(6277):718–21.
   PubMed Web of Science ®Google Scholar
• Rogers SL, Doody RS, Pratt RD, Ieni JR. Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease: final analysis of a US multicentre open-label study. Eur Neuropsychopharmacol. 2000 May;10(3):195–203.
   PubMed Web of Science ®Google Scholar
• Dong H, Csernansky CA, Martin MV, Bertchume A, Vallera D, Csernansky JG. Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl). 2005 Aug;181(1):145–52.
   PubMed Web of Science ®Google Scholar
• Van Dam D, Abramowski D, Staufenbiel M, De Deyn PP. Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model. Psychopharmacology (Berl). 2005 Jun;180(1):177–90.
   PubMed Web of Science ®Google Scholar
• Van Dam D, Coen K, De Deyn PP. Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer's disease. Psychopharmacology (Berl). 2008 Mar;197(1):37–43.
   PubMed Web of Science ®Google Scholar
• Chen Z, Xu AJ, Li R, Wei EQ. Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147. Acta Pharmacol Sin. 2002 Apr;23(4):355–60.
   PubMed Web of Science ®Google Scholar
• Dawson GR, Iversen SD. The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory. Behav Brain Res. 1993 Nov 30;57(2):143–53.
   PubMed Web of Science ®Google Scholar
• Tokita K, Yamazaki S, Yamazaki M, Matsuoka N, Mutoh S. Combination of a novel antidementia drug FK960 with donepezil synergistically improves memory deficits in rats. Pharmacol Biochem Behav. 2002 Oct;73(3):511–9.
   PubMed Web of Science ®Google Scholar
• Paxinos G, Watson C, editors. The rat brain in stereotaxic coordinates. 2nd ed. New York: Academic Press; 1986.
   Google Scholar
• Huang Y, Zhou W, Zhang Y. Bright lighting conditions during testing increase thigmotaxis and impair water maze performance in BALB/c mice. Behav Brain Res. 2012 Jan 1;226(1):26–31.
   PubMed Web of Science ®Google Scholar
• Treit D, Fundytus M. Thigmotaxis as a test for anxiolytic activity in rats. Pharmacol Biochem Behav. 1988 Dec;31(4):959–62.
   PubMed Web of Science ®Google Scholar