Advanced search
Publication Cover
International Journal of Neuroscience Volume 124, 2014 - Issue 12
Submit an article Journal homepage
188
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Association of IL-23 and its receptor gene single-nucleotide polymorphisms with multiple sclerosis in Chinese southern population

Meng LiuDepartment of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, China
,
Xueqiang HuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaCorrespondence[email protected]
,
Yuge WangDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
,
Xiaohong ChenDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
&
Jian WuDepartment of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, China
Pages 904-907 | Received 24 Nov 2013, Accepted 10 Feb 2014, Published online: 19 Mar 2014

References

  • Noseworthy JH, Lucchinetti C, Rodriguez M, Multiple sclerosis. N Engl J Med 2000;343:938–52.
  • Tan ZY, Bealgey KW, Fang Y, Interleukin-23: immunological roles and clinical implications. Int J Biochem Cell Biol 2009;41:733–5.
  • Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation. J Clin Invest 2006;116:1218–22.
  • Parham C, Chirica M, Timans J, A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 2002; 168:5699–708.
  • Duerr RH, Taylor KD, Brant SR, A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006;314:1461–3.
  • Glas J, Seiderer J, Wagner J, Analysis of IL12B gene variants in inflammatory bowel disease. PLoS One 2012;7:e34349.
  • Cargill M, Schrodi SJ, Chang M, A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 2007; 80:273–90.
  • Capon F, Di Meglio P, Szaub J, Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet 2007;122:201–206.
  • Karaderi T, Harvey D, Farrar C, Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series. Rheumatology (Oxford) 2009;48:386–9.
  • Wong RH, Wei JC, Huang CH, Association of IL-12B genetic polymorphism with the susceptibility and disease severity of ankylosing spondylitis. J Rheumatol 2012;39:135–40.
  • van Veen T, Crusius JBA, Schrijver HM, Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis. Ann Neurol 2001;50:275.
  • Alloza I, Heggarty S, Goris A, Interleukin-12 p40 polymorphism and susceptibility to multiple sclerosis. Ann Neurol 2002;52:524–5.
  • Illes Z, Safrany E, Peterfalvi A, 3'UTR C2370A allele of the IL-23 receptor gene is associated with relapsing-remitting multiple sclerosis. Neurosci Lett 2008;431:36–8.
  • Núñez C, Dema B, Cénit MC, IL23R: a susceptibility locus for celiac disease and multiple sclerosis? Genes Immun. 2008; 9:289–93.
  • Roos IM, Kockum I, Hillert J. The interleukin 23 receptor gene in multiple sclerosis: a case-control study. J Neuroimmunol 2008;194:173–80.
  • Hall MA, McGlinn E, Coakley G, Genetic polymorphism of IL-12 p40 gene in immune-mediated disease. Genes Immun 2000;1:219–24.
  • Begovich AB, Chang M, Caillier SJ, The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis. Hum Immunol 2007;68:934–7.
  • Forte GI, Ragonese P, Salemi G, Search for genetic factors associated with susceptibility to multiple sclerosis. Ann N Y Acad Sci 2006;1067:264–9.
  • McDonald WI, Compston A, Edan G, Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50:121–7.
  • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444–52.
  • Huber AK, Jacobson EM, Jazdzewski K, Interleukin(IL)-23 receptor is a major susceptibility gene for Graves'ophthalmopathy: the IL-23/T-helper 17 axis extends to thyroid autoimmunity. J Clin Endocrinol Metab 2008;93:1077–81.
  • Lincoln MR, Montpetit A, Cader MZ, A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat Genet 2005;37:1108–12.
  • Burton PR, Clayton DG, Cardon LR, Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007;39:1329–37.
  • International Multiple Sclerosis Genetics Conssortium (IMSGC). IL12A, PHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes Immun 2010;11:397–405.
  • Sawcer S, Hellenthal G, Pirinen M, Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011;476:214–9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.