The regulation of cardiovascular functions by monoamine neurotransmitters in the brain

References

• Antonaccio M. J. Neuropharmacology of central mechanisms governing the circulation. Cardiovascular Pharmacology, M. J. Antonaccio. Raven Press, New York 1977; 131–165
   Google Scholar
• Antonaccio M. J., Cavaliere T. A comparison of the effects of some inotropic and chronotropic agents on isolated atria from normotensive (NTR) and spontaneously hypertensive (SHR) rats. Archives internationales de Pharmacodynamie et de Thérapie 1974; 209: 273–282
   PubMedGoogle Scholar
• Antonaccio M. J., Kerwin L., Taylor D. G. Reductions in blood pressure, heart rate and renal sympathetic nerve discharge in cats after the central administration of muscimol, a GABA agonist. Neuropharmacology 1978; 17: 783–791
   PubMed Web of Science ®Google Scholar
• Baraban J. M., Wang R. Y., Aghajanian G. K. Reserpine suppression of dorsal raphe neuronal firing: mediation by the adrenergic system. European Journal of Pharmacology 1978; 52: 27–36
   PubMed Web of Science ®Google Scholar
• Baraban J. M., Aghajanian G. K. Supression of serotonergic neuronal firing by α‐adrenoceptor antagonists: Evidence against GABA mediation. European Journal of Pharmacology 1980; 66: 287–294
   PubMed Web of Science ®Google Scholar
• Baum T., Shropshire A. T. Reduction of sympathetic outflow by central administration of 1‐dopa, dopamine and norepinephrine. Neuropharmacology 1973; 12: 49–56
   PubMed Web of Science ®Google Scholar
• Baum T., Shropshire A. T. Inhibition of efferent sympathetic nerve activity by 5‐hydroxy‐tryptophan and centrally‐administered 5‐hydroxytryptamine. Neuropharmacology 1975; 14: 227–233
   PubMed Web of Science ®Google Scholar
• Bhargava K. P., Misra N., Tangri K. K. An analysis of central adrenoceptors for control of cardiovascular function. British Journal of Pharmacology 1972; 45: 596–602
   PubMed Web of Science ®Google Scholar
• Bhargava K. P., Jain I. P., Sazena A. K., Sinha J. N., Tangri K. K. Central adrenoceptors and cholinoceptors in cardiovascular control. British Journal of Pharmacology 1978; 63: 7–15
   PubMed Web of Science ®Google Scholar
• Bloom F. E., Hoffer B. J., Siggins G. R. Studies on norepinephrine containing afferents to Purkinje cells of rat cerebellum: I. Localization of the fibers and their synapses. Brain Research 1971; 25: 501–521
   PubMed Web of Science ®Google Scholar
• Bloom F. E., Battenberg E. L. F. A rapid, simple and more sensitive method for the demonstration of central catecholamine‐containing neurons and axons by glyoxylic acid induced fluorescence: II. A detailed description of methodology. Journal of Histochemistry and Cytochemistry 1976; 24: 561–571
   PubMed Web of Science ®Google Scholar
• Bobillier P., Seguin S., Petitjean F., Salvert D., Touret M., Jouvet M. The raphe nuclei of the cat brainstem: a topographical atlas of their efferent projections as revealed by auto‐radiography. Brain Research 1976; 113: 449–486
   PubMed Web of Science ®Google Scholar
• Bogdanski D. F., Weissbach H., Udenfriend S. Pharmacological studies with the serotonin precursor, 5‐hydroxytryptophan. Journal of Pharmacology & experimental Therapeutics 1958; 122: 182–194
   PubMed Web of Science ®Google Scholar
• Borkowski K. R., Finch L. Cardiovascular responses to intraventricular adrenaline in spontaneously hypertensive rats. European Journal of Pharmacology 1978; 47: 281–290
   PubMed Web of Science ®Google Scholar
• Bousquet P., Feldman J., Bloch R., Schwartz J. The central hypotensive action of baclofen in the anesthetized cat. European Journal of Pharmacology 1981; 76: 193–201
   PubMed Web of Science ®Google Scholar
• Bowery N. G., Hill D. R., Hudson A. L., Doble A., Middlemiss D. N., Shaw J., Turnbull M. Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature (Lond.) 1980; 283: 92–94
   PubMed Web of Science ®Google Scholar
• Breese G. R. Chemical and immunological lesions by specific neurotoxic substances and anti‐sera. Handbook of psychopharmacology, L. L. Iverson, D. S. Iverson, S. H. Snyder. Plenum Press, New York 1975; Vol. 1: 137–189
   Google Scholar
• Breese G. R., Howard J. L. Effect of central catecholamine alterations on the hypothermic response to 6‐hydroxydopamine in desipramine treated rats. British Journal of Pharmacology 1971; 43: 671–674
   PubMed Web of Science ®Google Scholar
• Brezenoff H. E., Caputi A. P. Intracerebroventricular injection of hemicholinium‐3 lowers blood pressure in conscious spontaneously hypertensive rats but not normotensive rats. Life Science 1980; 26: 1037–1045
   PubMed Web of Science ®Google Scholar
• Buccafusco J. J., Brezenoff H. E. The hypertensive response to injection of physostigmine into the hypothalamus of the unanesthetized rat. Clinical & Experimental Hypertension 1978; 1: 219–227
   PubMed Web of Science ®Google Scholar
• Calaresu F. R., Faiers A. A., Mogenson G. J. Central neuronal regulation of heart and blood vessels in mammals. Progress in Neurobiology 1975; 5: 1–35
   PubMedGoogle Scholar
• Carlsson A., Falck B., Hillarp M. ‐A. Cellular localization of brain monoamines. Acta Physiologica Scandinavica 1962; 56(Suppl. 196)1–28
   PubMedGoogle Scholar
• Chalmers J. P. Neuropharmacology of central mechanisms regulating blood pressure. Central action of drugs in blood pressure regulation, D. S. Davies, J. L. Reid. University Park Press, Baltimore 1975; 36–60
   Google Scholar
• Chalmers J. P., Reid J. L. Participation of central noradrenergic neurons in arterial baroreceptor reflexes in the rabbit: a study with intracisternally administered 6‐hydroxydopamine. Circulation Research 1972; 31: 789–804
   PubMed Web of Science ®Google Scholar
• Conrad L. C. A., Leonard C. M., Pfaff D. W. Connections of the median and dorsal raphe nuclei in the rat: An autoradiographic and degenerative study. Journal of Comparative Neurology 1974; 156: 179–206
   PubMed Web of Science ®Google Scholar
• Corrodi H., Masuoka D. T., Clark W. G. Effects of 6‐hydroxydopamine on rat heart noradrenaline. European Journal of Pharmacology 1971; 15: 160–163
   PubMed Web of Science ®Google Scholar
• Creese I., Sibley D. R. Receptor adaptations to centrally acting drugs. Annual Review of Pharmacology & Toxicology 1981; 21: 357–391
   PubMed Web of Science ®Google Scholar
• Crow T. J. Neurotransmitter related pathways: The structure and function of central monoamine neurones. Biochemical correlates of brain structure and function, A. N. Davidson. Academic Press, London 1977; 137–174
   Google Scholar
• Dahlstrom A., Fuxe K. Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brainstem neurons. Acta Physiologica Scandinavica 1964; 62(Suppl. 232)1–55
   PubMedGoogle Scholar
• Dahlstrom A., Fuxe K. Evidence for the existence of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine level of bulbospinal neuron systems. Acta Physiologica Scandinavica 1965; 64(Suppl. 247)1–36
   PubMedGoogle Scholar
• Day M. D., Roach A. G. β‐adrenergic receptors in the central nervous system of the cat concerned with the control of arterial blood pressure and heart rate. Nature New Biology 1973; 242: 30–31
   PubMedGoogle Scholar
• Day M. D., Roach A. G. Central α‐ and β‐adrenoceptors modifying arterial blood pressure and heart rate in conscious cats. British Journal of Pharmacology 1974; 51: 325–333
   PubMed Web of Science ®Google Scholar
• Day M. D., Roach A. G. Cardiovascular effects of dopamine after central administration into conscious cats. British Journal of Pharmacology 1976; 58: 505–515
   PubMed Web of Science ®Google Scholar
• Day M. D., Roach A. G. Cardiovascular effects of carbachol and other cholinomimetics administered into the cerebral ventricles of conscious cats. Clinical & Experimental Pharmacology & Physiology 1977; 4: 431–442
   PubMed Web of Science ®Google Scholar
• De Jong W., Nijkamp F. P., Bohus B. Role of noradrenaline and serotonin in the central control of blood pressure in normotensive and spontaneously hypertensive rats. Archives internationales de Pharmacodynamie et de Thérapie 1975; 213: 272–284
   PubMedGoogle Scholar
• Descarries L., Leger L. Serotonin nerve terminals in the locus coeruleus of the adult rat. Interactions between putative neurotransmitters in the brain, S. Garattini, J. F. Pujol, R. Samanin. Raven Press, New York 1978; 355–367
   Google Scholar
• Descarries L., Saucier G. Disappearance of the locus coeruleus in the rat after intraventricular 6‐hydroyxdopamine. Brain Research 1972; 37: 310–316
   PubMed Web of Science ®Google Scholar
• DiMicco J. A., Hamilton B. L., Gillis R. A. Central nervous system sites involved in the cardiovascular effects of picrotoxin. Journal of Pharmacology & experimental Therapeutics 1977a; 203: 64–71
   PubMed Web of Science ®Google Scholar
• DiMicco J. A., Prestel T., Pearle D. L., Gillis R. A. Mechanism of cardiovascular changes produced by activation of the central nervous system with picrotoxin. Circulation Research 1977b; 41: 446–451
   PubMed Web of Science ®Google Scholar
• DiMicco J. A., Gillis R. A. Neuro‐cardiovascular effects produced by bicuculline in the cat. Journal of Pharmacology & experimental Therapeutics 1979; 210: 1–6
   PubMed Web of Science ®Google Scholar
• DiMicco J. A., Gale K., Hamilton B. L., Gillis R. A. GABA receptor control of para‐sympathetic outflow of the heart: characterization and brain stem localization. Science 1979; 204: 1106–1109
   PubMed Web of Science ®Google Scholar
• Doha N., Reis D. J. Acute fulminating neurogenic hypertension produced by brainstem lesions in the rat. Circulation Research 1973; 32: 584–593
   PubMed Web of Science ®Google Scholar
• Doba N., Reis D. J. Role of central and peripheral adrenergic mechanisms in neurogenic hypertension produced by brainstem lesions in rat. Circulation Research 1974; 34: 294–302
   Web of Science ®Google Scholar
• Dunkley B., Sanghvi I., Friedman E., Gershon S. Comparison of behavioural and cardiovascular effects of L‐DOPA and 5‐HTP in conscious dogs. Psychopharmacologia 1972; 26: 161–172
   PubMedGoogle Scholar
• Falck B., Hillarp N. ‐A., Thieme G., Torp A. Fluorescence of catecholamines and related compounds with formaldehyde. Journal of Histochemistry & Cytochemistry 1962; 10: 348–354
   Web of Science ®Google Scholar
• Fallon J. H., Koizell D. A., Moore R. Y. Catecholamine innervation of the basal forebrain. II. Amygdala, suprarhinal coretx and autorhinal cortex. Journal of Comparative Neurology 1978; 180: 509–532
   PubMed Web of Science ®Google Scholar
• Fallon J. H., Moore R. Y. Catecholamine innervation of the basal forebrain. III. Olfactory bulb, anterior olfactory nuclei, olfactory tubercle and piriform cortex. Journal of Comparative Neurology 1978; 180: 533–544
   PubMed Web of Science ®Google Scholar
• Feigl E. O. Vasoconstriction resulting from diencephalic stimulation. Acta Physiologica Scandinavica 1964; 60: 372–380
   PubMedGoogle Scholar
• Forsyth R. P. Hypothalamic control of the distribution of cardiac output in the unanaesthetized rhesus monkey. Circulation Research 1970; 26: 783–794
   PubMed Web of Science ®Google Scholar
• Fuxe K. Evidence for the existence of monoamine containing neurons in the csntral nervous system. III. The monoamine nerve terminal. Zeitschrift für Zellforschung 1965a; 65: 572–596
   Google Scholar
• Fuxe K. Evidence for the existence of monoamine neurons in the central nervous system. IV. Distribution of monoamine nerve terminals in the central nervous system. Acta Physiologica Scandinavica 1965b; 64(Suppl. 247)39–85
   Google Scholar
• Fuxe K., Hamberger B., Hokfelt T. Distribution of noradrenaline nerve terminals in cortical areas of the rat. Brain Research 1968; 8: 125–131
   PubMedGoogle Scholar
• Fuxe K., Hokfelt T., Bolme P., Goldstein M., Johansson O., Jonsson G., Lidbrink P., Ljungdahl A., Sachs C. The topography of central catecholamine pathways in relation to their possible role in blood pressure control. Central action of drugs in blood pressure regulation, D. S. Davies, J. L. Reid. University Park Press, Baltimore 1975; 8–23
   Google Scholar
• Gallager D. W., Aghajanian G. K. Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. The role of the adrenergic system. European Journal of Pharmacology 1976; 39: 341–355
   PubMed Web of Science ®Google Scholar
• Gianutsos G., Moore K. E. Epinephrine contents of sympathetic ganglia and brain regions of spontaneously hypertensive rats of different ages. Proceedings of the Society of Experimental Biology & Medicine 1978; 158: 45–49
   PubMed Web of Science ®Google Scholar
• Grobecker H., Roizen M. F., Weise V., Saavedra J. M., Kopin I. J. Sympathoadrenal medullary activity in young spontaneously hypertensive rats. Nature 1975; 258: 267–268
   PubMed Web of Science ®Google Scholar
• Guyton A. C., Coleman T. G., Cowley A. W., Jr., Scheel K. W., Manning R. D., Jr., Norman R. A., Jr. Arterial pressure regulation. Overriding dominance of the kidneys in long‐term regulation and in hypertension. Hypertension mechanisms, J. H. Laragh. DunDonnelley Publ. Co., New York 1975
   Google Scholar
• Haeusler G., Gerold M., Thoenen T. Cardiovascular effects of 6‐hydroxydopamine injected into a lateral brain ventricle of the rat. Naunyn‐Schmiedeberg's Archiv für Pharmacologie 1972; 274: 211–228
   PubMed Web of Science ®Google Scholar
• Helke C. J., Muth E. A., Jacobowitz D. M. Changes in central cholinergic neurons in the spontaneously hypertensive rat. Brain Research 1980; 188: 425–436
   PubMed Web of Science ®Google Scholar
• Hoffman W. E. Central cardiovascular and antidiuretic action of adrenergic drugs. Neuropharmacology 1979a; 18: 7–12
   PubMed Web of Science ®Google Scholar
• Hoffman W. E. Central cholinergic receptors in cardiovascular and anti‐diuretic effects in rats. Clinical & Experimental Pharmacology & Physiology 1979b; 6: 373–380
   PubMed Web of Science ®Google Scholar
• Hoffman W. E., Phillips M. I., Schmid P. G., Falcon J., Weet J. F. Antidiuretic hormone release and the pressor response to central angiotensin II and cholinergic stimulation. Neuro‐pharmacology 1977; 16: 463–472
   Google Scholar
• Hoffman W. E., Schmid P. G., Phillips M. I. Central cholinergic and noradrenergic stimulation in spontaneously hypertensive rats. Journal of Pharmacology & experimental Therapeutics 1978; 206: 644–651
   PubMed Web of Science ®Google Scholar
• Hokfelt T., Fuxe K., Goldstein M., Joh T. H. Immunohistochemical studies of three catecholamine synthesizing enzymes: aspects on methodology. Histochemistry 1973a; 33: 231–254
   PubMedGoogle Scholar
• Hokfelt T., Fuxe K., Goldstein M., Johansson O. Evidence for adrenaline neurons in the rat brain. Acta Physiologica Scandinavica 1973b; 89: 286–288
   PubMedGoogle Scholar
• Hokfelt T., Fuxe K., Goldstein M., Johansson O. Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain. Brain Research 1974; 66: 235–251
   Web of Science ®Google Scholar
• Howe P. R. C., Provis J. C., West M. J., Chalmers J. P. Changes in cardiac norepinephrine in spontaneously hypertensive and stroke‐prone rats. Journal of Cardiovascular Pharmacology 1979; 1: 115–122
   PubMed Web of Science ®Google Scholar
• Iijima T., Philippu A. Failure of isoprenaline and beta‐receptor blocking drugs to modify depressor response and bradycardia induced by electrical stimulation of the anterior hypothalamus of cats. Naunyn‐Schmiedeberg's Archiv für Pharmacologie 1980; 312: 27–30
   PubMed Web of Science ®Google Scholar
• Ito A., Schanberg S. M. Central nervous system mechanisms responsible for blood pressure elevation induced by p‐chlorophenylalanine. Journal of Pharmacology & experimental Therapeutics 1972; 181: 65–74
   PubMedGoogle Scholar
• Iversen L. L. The uptake and storage of noradrenaline in sympathetic nerves. Cambridge University Press, Cambridge 1967
   Google Scholar
• Jacobowitz D. M. Monoaminergic pathways in the central nervous system. Psychopharmacology: a generation of progress, M. A. Lipton, A. DiMascio, K. F. Killam. Raven Press, New York 1979; 119–129
   Google Scholar
• Joh T. H., Shikimi T., Pickel V. M., Reis D. J. Brain tryptophan hydroxylase: Purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of the rat midbrain. Proceedings of the National Academy of Science USA 1975; 72: 3575–3579
   PubMed Web of Science ®Google Scholar
• Jones B. E., Moore R. Y. Ascending projections of the locus coeruleus in the rat. II. Autoradiographic study. Brain Research 1977; 127: 23–53
   Web of Science ®Google Scholar
• Jonsson G., Fuxe K., Hokfelt T., Goldstein M. Resistance of central phenylethanolamine‐N‐methyl transferase containing neurons to 6‐hydroxydopamine. Medical Biology 1976; 54: 421–426
   PubMedGoogle Scholar
• Juskevich J. C., Robinson D. S., Whitehorn D. Effect of hypothalamic stimulation in spontaneously hypertensive and Wistar‐Kyoto rats. European Journal of Pharmacology 1978; 51: 429–439
   PubMed Web of Science ®Google Scholar
• Kaneko Y., McCubbin J. W., Page I. H. Mechanism by which serotonin, norepinephrine and reserpine cause central vasomotor inhibition. Circulation Research 1960; 8: 849–858
   PubMed Web of Science ®Google Scholar
• Kobayashi R. M., Palkovits M., Kopin I. J., Jacobowitz D. M. Biochemical mapping of nor‐adrenergic nerves arising from the rat locus coeruleus. Brain Research 1974; 77: 269–279
   PubMed Web of Science ®Google Scholar
• Kobinger W. Central α‐adrenergic systems as targets for hypotensive drugs. Reviews of Physiology Biochemistry & Pharmacology 1978; 81: 39–100
   PubMed Web of Science ®Google Scholar
• Korner P. I., Oliver J. R., Reynoldson J. A., Head G. A., Carson V. J., Mc Walker D. Cardiovascular and behavioral effects of intracisternal 6‐hydroxydopamine in the rabbit. European Journal of Pharmacology 1978; 53: 83–93
   PubMed Web of Science ®Google Scholar
• Koslow S. H., Schlumpf M. Quantitation of adrenaline in rat brain nuclei and areas by mass fragmentography. Nature (Lond) 1974; 251: 530–531
   PubMed Web of Science ®Google Scholar
• Kostrzewa R. M., Jacobowitz D. M. Pharmacological actions of 6‐hydroxydopamine. Pharmacology Review 1974; 26: 199–288
   PubMed Web of Science ®Google Scholar
• Kristic M. K., Djurkovic D. Cardiovascular response to intracerebroventricular administration of acetylcholine in rats. Neuropharmacology 1978; 17: 341–347
   PubMed Web of Science ®Google Scholar
• Kubo T., Hashimoto M. Effects of intraventricular and intraspinal 6‐hydroxydopamine on blood pressure of spontaneously hypertensive rats. Archives internationales de Pharmacodynamie et de Thérapie 1978; 232: 176–176
   Google Scholar
• Kuhar M. J., Atweh S. F. Distribution of some suspected neurotransmitters in the central nervous system. Reviews of neuroscience, S. Ehrenpreis, I. Kopin. Raven Press, New York 1978; Vol. 3: 35–76
   Google Scholar
• Lang W. J., Woodman O. L. Cardiovascular responses produced by the injection of dopamine into the cerebral ventricles of the unanaesthetized dog. British Journal of Pharmacology 1979; 66: 235–240
   PubMed Web of Science ®Google Scholar
• Langer S. Z., Enero M. A., Adler‐Graschinsky E., Dubocovich M. L., Celuchi S. M. Presynaptic regulatory mechanisms for noradrenaline release by nerve stimulation. Central actions of drugs in blood pressure regulation, D. S. Davies, J. L. Reid. Pitman, Tun‐bridge Wells 1975; 133–150
   Google Scholar
• Laverty R., Aharman D. E., Vogt M. Action of 2, 4, 5‐trihydroxyphenylethylamine on the storage and release of noradrenaline. British Journal of Pharmacology 1965; 24: 549–560
   Web of Science ®Google Scholar
• Leger L., Descarries L. Serotonin nerve terminals in the locus coeruleus of adult rat: A radioautographic study. Brain Research 1978; 145: 1–13
   PubMed Web of Science ®Google Scholar
• Levitt P., Moore R. Y. Noradrenaline neuron innervation of the neocortex in the rat. Brain Research 1978; 139: 219–232
   PubMed Web of Science ®Google Scholar
• Lewis B. D., Renaud B., Buda M., Pujol J. Time‐course variations in tryosine hydroxylase activity in the rat locus coeruleus after electrolytic destruction of the nuclei raphe dorsalis or raphe centralis. Brain Research 1976; 108: 339–349
   PubMed Web of Science ®Google Scholar
• Lewis P. J., Rawlins M. D., Reid J. L. Acute thermoregulatory and cardiovascular effects of 6‐hydroxydopamine administration centrally in rabbits and cats. British Journal of Pharmocology 1972; 44: 559P
   Google Scholar
• Ljungdahl A., Hokfelt T., Jonsson G., Sachs C. Autoradiographic demonstration of uptake and accumulation of H3–6‐hydroxydopamine in adrenergic nerves. Experientia 1971; 27: 297–299
   PubMedGoogle Scholar
• Loewy A. D., McKellar S. The neuroanatomical basis of central cardiovascular control. Federation Proceedings 1980; 39: 2495–2503
   PubMedGoogle Scholar
• Loizou L. A. Projections of the nucleus locus coeruleus in the albino rat. Brain Research 1969; 15: 563–566
   PubMed Web of Science ®Google Scholar
• Lorens S. A., Guldberg H. C. Regional 5‐hydroxytryptamine following selective midbrain raphe lesions in the rat. Brain Research 1974; 78: 45–56
   PubMed Web of Science ®Google Scholar
• Louis W. J. Turnover of catecholamines in experimental hypertension. Circulation Research 1970; 26 and 27(Suppl. II)49
   Google Scholar
• Louis W. J., Spector S., Tabei R., Sjoerdsma A. Synthesis and turnover of norepinephrine in the heart of the spontaneously hypertensive rat. Circulation Research 1969a; 24: 85–91
   PubMed Web of Science ®Google Scholar
• Louis W. J., Tabei R., Spector S., Sjoerdsma A. Studies on the spontaneously hypertensive rat. Genealogy, effects of varying salt intake, and kinetics of catecholamine metabolism. Circulation Research 1969b; 24 and 25(Suppl. I)93–102
   Google Scholar
• Louis W. J., Krauss K. R., Kopin I. J., Sjoerdsma A. Catecholamine metabolism in hypertensive rats. Circulation Research 1970; 27: 589–594
   PubMed Web of Science ®Google Scholar
• Maeda T., Shimizu N. (Ascending amine fibers from locus coeruleus and other pontine amine neurons to forebrain of rat) (in French). Brain Research 1972; 36: 19–35
   PubMed Web of Science ®Google Scholar
• Maeda T., Pin C., Salvert D., Ligier M., Jouvet M. (Catecholamine containing neurons in pontine tegmentum and their pathways in cat) (in French). Brain Research 1973; 57: 119
   PubMed Web of Science ®Google Scholar
• Malmfors T., Sachs C. Degeneration of adrenergic nerves produced by 6‐hydroxydopamine. European Journal of Pharmacology 1968; 3: 89–92
   PubMed Web of Science ®Google Scholar
• McCubbin J. W., Kaneko Y., Page I. H. Ability of serotonin and norepinephrine to mimic the central effects of reserpine on vasomotor activity. Circulation Research 1960; 8: 849–858
   PubMed Web of Science ®Google Scholar
• McGregor D. D., Smirk F. H. Vascular responses to 5‐hydroxytryptamine in genetic and renal hypertensive rats. American Journal of Physiology 1970; 219: 687–690
   PubMed Web of Science ®Google Scholar
• Minneman K. P., Hedstrand L. R., Molinoff P. B. Simultaneous determination of beta‐1 and beta‐2‐adrenergic receptors in tissues containing both receptor subtypes. Molecular Pharmacology 1979; 16: 34–46
   PubMed Web of Science ®Google Scholar
• Miura M., Reis D. J. Role of the solitary and paramedian reticular nuclei in mediating cardiovascular reflex responses from carotid baro‐ and chemoreceptors. Journal of Physiology (Lond.) 1972; 223: 525–548
   PubMed Web of Science ®Google Scholar
• Morgane P. J., Jacobs M.S. Raphe projections to the locus coeruleus in the rat. Brain Research Bulletin 1979; 4: 519–534
   PubMed Web of Science ®Google Scholar
• Nagaoka A., Lovenberg W. Plasma norepinephrine and dopamine‐β‐hydroyxlase in genetic hypertensive rats. Life Science 1976; 59: 29–34
   Google Scholar
• Nagatsu T., Kato T., Numata(sudo) Y., Ikuta K., Sano M., Nagatsu I., Umezawa H., Matsuzaki M., Takeuchi T. Norepinephrine‐synthesizing enzymes in brain, adrenals and peripheral sympathetic nerves of spontaneously hypertensive rats. Japanese Journal of Pharmacology 1977; 27: 531–535
   PubMedGoogle Scholar
• Nahorski S. R. Heterogeneity of cerebral β‐adrenoceptor binding sites in various vertebrate species. European Journal of Pharmacology 1978; 51: 199–209
   PubMed Web of Science ®Google Scholar
• Nathan M. A., Reis D. J. Fulminating arterial hypertension with pulmonary edema from release of adrenomedeullary catecholamines after lesions of the anterior hypothalamus in the rat. Circulation Research 1975; 37: 226–256
   PubMed Web of Science ®Google Scholar
• Oberg B. Overall cardiovascular regulation. Annual Review of Physiology 1976; 38: 537–570
   PubMed Web of Science ®Google Scholar
• Ogawa M. Interaction between noradrenergic and serotonergic mechanisms on the central regulation of blood pressure in the rat: A study using experimental central hypertension produced by chemical lesions of the locus coeruleus. Japanese Circulation Journal 1978; 42: 581–597
   PubMedGoogle Scholar
• Okamoto K. Spontaneous hypertension in rats. International Review of experimental Pathology 1969; 7: 227–270
   PubMedGoogle Scholar
• Okamoto K., Nosaka S., Yamori Y., Matsumoto M. Participation of neural factors in the pathogenesis of hypertension in the spontaneously hypertensive rat. Japanese Heart Journal 1967; 8: 168–180
   PubMedGoogle Scholar
• Palkovits M., Zaborszky L. Neuroanatomy of central cardiovascular control. Nucleus tractus solitarii: afferent and efferent neuronal connections in relation to the baroreceptor reflex arc. Progress in Brain Research 1977; 37: 9–34
   Google Scholar
• Persson B. Cardiovascular effects of intracerebroventricular GABA, glycine and muscimol in the rat. Naunyn‐Schmiedeberg's Archiv für Pharmacologie 1980; 133: 225–236
   Google Scholar
• Persson B., Henning M. Central cardiovascular and biochemical effects of baclofen in the conscious rat. Journal of Pharmacy & Pharmacology 1980; 32: 417–422
   PubMed Web of Science ®Google Scholar
• Philippu A., Przuntek H., Roensberg W. Superfusion of the hypothalamus with gamma‐amino butyric acid: effect on release of noradrenaline and blood pressure. Naunyn‐Schmiedeberg's Archiv für Pharmacologie 1973a; 276: 103–118
   PubMed Web of Science ®Google Scholar
• Philippu A., Roensberg W., Przuntek H. Effects of adrenergic drugs on pressor responses to hypothalamic stimulation. Naunyn‐Schmiedeberg's Archiv für Pharmacologie 1973b; 278: 373–386
   PubMed Web of Science ®Google Scholar
• Philippu A., Demmeler R., Roensberg G. Effects of centrally applied drugs on pressor response to hypothalamic stimulation. Naunyn‐Schmiedeberg's Archiv für Pharmacologie 1974; 282: 389–400
   PubMed Web of Science ®Google Scholar
• Philippu A., Bohuschke N. Hypothalamic superfusion with muscarinic drugs; their effects on pressor responses to hypothalamic stimulation. Naunyn‐Schmiedeber's Archiv für Pharmacologie 1976; 292: 1–7
   PubMed Web of Science ®Google Scholar
• Philippu A., Schartner P. Inhibition by locally applied alpha‐adrenoreceptor blocking drugs of the depressor response to stimulation of the anterior hypothalamus. Naunyn‐Schmiedeberg's Archiv für Pharmacologie 1976; 295: 1–7
   PubMed Web of Science ®Google Scholar
• Philippu A., Kittel E. Presence of beta‐adrenoreceptors in the hypothalamus; their importance for the pressor response to hypothalamic stimulation. Naunyn‐Schmiedeberg's Archiv für Pharmacologie 1977; 297: 219–225
   PubMed Web of Science ®Google Scholar
• Philippu A., Stroehl U. Beta‐adrenoreceptors of the posterior hypothalamus. Clinical & Experimental Hypertension 1978; 1: 25–38
   PubMed Web of Science ®Google Scholar
• Pittman R. N., Minneman K. P., Molinoff P. B. Ontogeny of β1 and β2‐adrenergic receptors in rat cerebellum and cerebral cortex. Brain Research 1980; 188: 357–368
   PubMed Web of Science ®Google Scholar
• Porter C. C., Totaro J. A., Stone C. A. Effect of 6‐hydroxydopamine and some other compounds on the concentration of norepinephrine in the hearts of mice. Journal of Pharmacology & experimental Therapeutics 1963; 140: 308–316
   PubMed Web of Science ®Google Scholar
• Reis D. J. Central neuronal mechanisms governing the circulation with particular reference to the lower brainstem and cerebellum. Renal and psychological mechanisms in cardiovascular disease, A. Zanchetti. Casa Editrice Il Ponte, Milano 1972; 255–280
   Google Scholar
• Reis D. J., Doba N. The central nervous system and neurogenic hypertension. Progress in Cardiovascular Disease 1974; 17: 51–71
   PubMed Web of Science ®Google Scholar
• Reis D. J., Doba N., Snyder D. W., Nathan M. A. Brain lesions and hypertension: Chronic lability and elevation of arterial pressure produced by electrolytic lesions and 6‐hydroxydopamine treatment of nucleus tractus solitarii (NTS) in rat and cat. Progress in Brain Research 1977; 47: 169–188
   PubMedGoogle Scholar
• Renaud B., Buda M., Lewis B. D., Pujol J. F. Effects of 5, 6‐dihydroxytryptamine on tryosine‐hydroxylase activity in central catecholaminergic neurons of the rat. Biochemistry & Pharmacology 1975; 24: 1739–1742
   Web of Science ®Google Scholar
• Renaud B., Fouriere S., Denoroy L., Vincent M., Pujol J. F., Sassard J. Early increase in phenylethanolamine‐n‐methyl transferase activity in a new strain of spontaneously hypertensive rats. Brain Research 1978; 159: 149–159
   PubMed Web of Science ®Google Scholar
• Richardson J. S., Lamprecht F., Kazic T., Kopin I. J. Reduction in brain tryosine hydroxylase activity following acetylcholinesterase blockade in rats. Canadian Journal of Physiology & Pharmacology 1976; 54: 774–778
   PubMed Web of Science ®Google Scholar
• Richardson J. S., Richardson A. K. The biphasic dose‐response effect of baclofen on haloperidol catalepsy in the rat. Pharmacology Biochemistry & Behavior 1982; 17: 855–856
   PubMed Web of Science ®Google Scholar
• Russell G. V. The locus coeruleus (dorsolateralis tegmenti). Texas Report Biology & Medicine 1955; 13: 938–988
   Google Scholar
• Saavedra J. M., Palkovits M., Brownstein M. J., Axelrod J. Localization of phenylethanolamine N‐methyltransferase in rat brain nuclei. Nature (Lond.) 1974; 248: 695–696
   PubMed Web of Science ®Google Scholar
• Saavedra J. M., Grobecker H., Axelrod J. Changes in central catecholaminergic neurons in the spontaneously (genetic) hypertensive rat. Circulation Research 1978; 42: 529–534
   PubMed Web of Science ®Google Scholar
• Sakai K., Touret M., Salvert D., Leger L., Jouvet M. Afferent projections to the cat locus coeruleus as visualized by the horseradish peroxidase technique. Brain Research 1977a; 119: 21–41
   PubMed Web of Science ®Google Scholar
• Sakai K., Salvert D., Touret M., Jouvet M. Afferent connections of the nucleus raphe dorsalis in the cat as visualized by the horseradish peroxidase technique. Brain Research 1977b; 137: 11–35
   PubMed Web of Science ®Google Scholar
• Scriabine A., Clineschmidt B. V., Sweet C. S. Central noradrenergic control of blood pressure. Annual Review of Pharmacology & Toxicology 1976; 16: 113–123
   PubMed Web of Science ®Google Scholar
• Smith O. A. Reflex and central mechanisms involved in the control of the heart and circulation. Annual Review of Physiology 1974; 36: 93–124
   PubMed Web of Science ®Google Scholar
• Snyder D. W., Nathan M. A., Reis D. J. Chronic lability of arterial pressure produced by selective destruction of the catecholamine innervation of the nucleus tractus solitarii in the rat. Circulation Research 1978; 43: 662–671
   PubMed Web of Science ®Google Scholar
• Starke K. Regulation of noradrenaline release by presynaptic receptor systems. Review of Physiology, Biochemistry & Pharmacology 1977; 77: 1–124
   PubMed Web of Science ®Google Scholar
• Starke K. Presynaptic receptors. Annual Review of Pharmacology & Toxicology 1981; 21: 7–30
   PubMed Web of Science ®Google Scholar
• Stone C. A., Porter C. C., Stavorski J. M., Ludden C. T., Totaro J. A. Antagonism of certain effects of catecholamine‐depleting agents by antidepressants and related drugs. Journal of Pharmacology & experimental Therapeutics 1964; 144: 196–204
   PubMed Web of Science ®Google Scholar
• Struyker Boudier H. A. J., Smeets G. W. M., Brower G. M., van Rossum J. M. Hypothalamic alpha adrenergic receptors in cardiovascular regulation. Neuropharmacology 1974a; 13: 837–846
   PubMed Web of Science ®Google Scholar
• Struyker Boudier H. A. J., Smeets G. W. M., Brower G. M., van Rossum J. M. Central and peripheral alpha adrenergic activity of imidazoline derivatives. Life Sciences 1974b; 15: 887–899
   PubMed Web of Science ®Google Scholar
• Struyker Boudier H. A. J., Smeets G. W. M., Brower G., van Rossum J. M. Central nervous system α‐adrenergic mechanisms and cardiovascular regulation in rats. Archives internationales de Pharmacodynamie et de Thérapie 1975a; 213: 285–293
   PubMedGoogle Scholar
• Struyker Boudier H. A. J., de Boer J., Smeets G. W. M., Lien E. J., van Rossum J. M. Structure activity for central and peripheral alpha adrenergic activities of imidazoline derivatives. Life Sciences 1975b; 17: 377–386
   PubMed Web of Science ®Google Scholar
• Swanson L. W., Hartman B. K. The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine‐β‐hydroxylase as a marker. Journal of Comparative Neurology 1975; 163: 467–506
   PubMed Web of Science ®Google Scholar
• Takahashi H., Bunag R. D. Augmentation of centrally induced alpha‐adrenergic vaso‐depression in spontaneously hypertensive rats. Hypertension 1980; 2: 198–206
   PubMed Web of Science ®Google Scholar
• Takahashi Y., Satoh K., Sakumoto T., Tohyama M., Shimizu N. A major source of catecholamine terminals in the nucleus tractus solitarii. Brain Research 1979; 172: 372–377
   PubMed Web of Science ®Google Scholar
• Thoenen H., Tranzer J. P. The pharmacology of 6‐hydroxydopamine. Annual Review of Pharmacology 1973; 13: 169–180
   PubMedGoogle Scholar
• Thomas M. R., Calaresu F. R. Hypothalamic inhibition of chemoreceptor‐induced bradycardia in the cat. American Journal of Physiology 1973; 225: 201–208
   PubMedGoogle Scholar
• Tranzer J. P., Thoenen H. An electron microscopic study of selective acute degeneration of sympathetic nerve terminals after administration of 6‐hydroxydopamine. Experientia 1968; 24: 155–156
   PubMedGoogle Scholar
• Tranzer J. P., Thoenen H. Selective destruction of adrenergic nerve terminals by chemical analogues of 6‐hydroxydopamine. Experientia 1973; 29: 314–315
   PubMedGoogle Scholar
• Unger T., Ganten D., Lang R. E., Rascher W. Brain peptides and blood pressure control. Trends in Pharmacological Sciences 1981; 2: 289–292
   Web of Science ®Google Scholar
• Ungerstedt U. Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiologica Scandinavica 1971; 82(Suppl. 367)1–48
   PubMedGoogle Scholar
• Van Der Gugten J., Palkovits M., Wijnen H. L. J. M., Versteeg D. H. G. Regional distribution of adrenaline in rat brain. Brain Research 1976; 107: 171–175
   PubMed Web of Science ®Google Scholar
• Versteeg D. H. G., Palkovits M., Van der Gugten J., Wijnen H. J. L. M., Smeets G. W. M., De Jong W. The spontaneously hypertensive rat: Catecholamine levels in individual brain regions. Progress in Brain Research 1977; 47: 111–116
   PubMedGoogle Scholar
• Ward D. G., Baertschi A. J., Gunn D. S. Activation of solitary nucleus neurons from the locus coeruleus and vicinity. Neuroscience Abstracts 1975; 1: 424
   Google Scholar
• Wijnen H. J. L. M., Palkovits M., De Jong W., Versteeg D. H. G. Elevated adrenaline content in nuclei of the medulla oblongata and the hypothalamus during the development of spontaneous hypertension. Brain Research 1978; 157: 191–195
   PubMed Web of Science ®Google Scholar
• Wilkening D., Dvorkin B., Makman M. H., Lew J. Y., Matsumoto J., Baba Y., Goldstein M., Fuxe K. Catecholamine‐stimulated cyclic AMP formation in phenylethanolamine N‐methyltransferase containing brain stem nuclei of normal rats and rats with spontaneous genetic hypertension. Brain Research 1980; 186: 133–143
   PubMed Web of Science ®Google Scholar
• Williford D. J., DiMicco J. A., Gillis R. A. Evidence for the presence of a tonically active forebrain GABA system influencing central sympathetic outflow in the cat. Neuropharmacology 1980; 19: 245–250
   PubMed Web of Science ®Google Scholar
• Wing L. M. H., Chalmers J. P. Effects of p‐chlorophenylalanine on blood pressure and heart rate in normal rabbits and with neurogenic hypertension. Clinical & Experimental Pharmacology & Physiology 1974a; 1: 219–229
   PubMed Web of Science ®Google Scholar
• Wing L. M. H., Chalmers J. P. Participation of central serotonergic neurons in control of circulation of unanesthetized rabbit study using 5, 6‐dihydroxytryptamine in experimental neurogenic and renal hypertension. Circulation Research 1974b; 35: 504–513
   PubMed Web of Science ®Google Scholar
• Yamori Y. Contribution of cardiovascular factors to the development of hypertension in the spontaneously hypertensive rats. Japanese Heart Journal 1974; 15: 194–196
   PubMedGoogle Scholar
• Yamori Y. Neural and non‐neural mechanisms in spontaneous hypertension. Clinical Science & Molecular Medicine 1976; 51: 431s–434s
   Google Scholar
• Yamori Y., Okamoto K. Hypothalamic tonic regulation of blood pressure in spontaneously hypertensive rats. Japanese Circulation Journal 1969; 33: 509–519
   PubMedGoogle Scholar
• Yamori Y., Nakada T., Lovenberg W. Effect of antihypertensive therapy on lysine incorporation into vascular protein of the spontaneously hypertensive rat. European Journal of Pharmacology 1976; 38: 349–355
   PubMed Web of Science ®Google Scholar
• Zandberg P., Palkovits M., De Jong W. Effect of various lesions in the nucleus tractus solitarii of the rat on blood pressure, heart rate and cardiovascular reflex responses. Clinical & Experimental Hypertension 1978; 1: 355–379
   PubMed Web of Science ®Google Scholar