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Original Article

The Relationship of Negative Schizophrenia to Parkinsonism

&
Pages 1-59 | Received 16 Jul 1990, Published online: 07 Jul 2009

References

  • Abramsky O., Litvin O. Autoimmune response to dopamine as a possible mechanism in the pathogenesis of Parkinson's disease and schizophrenia. Perspectives in Biology and Medicine 1978; 24: 104–114
  • Agid Y., Javoy-Agid F., Ruberg M., Pillon B., Dubois B., Duyckaerts C., Hauw J. J., Baron J. C., Scatton B. Progressive supranuclear palsy; Anatomoclinical and biochemical considerations. Advances in Neurology, M. D. Vahr, K. J. Bergmann, 1986; vol. 45: 191–206
  • Albrech P., Torrey E. F., Boone E. Raised cytomegalovirus antibody level in cerebrospinal fluid of schizophrenic patients. Lancet 1980; 2: 769–772
  • Alexopolous G. S. Complaints in schizophrenics with tardive dyskinesia. Journal of Nervous and Mental Disorders 1979; 167: 125–127
  • Alizan T. S., Terasaki P. I., Yahr M. D. HLA-B14 antigen and postencephalitic Parkinson's disease: their association in an American Jewish ethnic group. Archives of Neurology 1980; 37: 542–544
  • Alpert M., Diamond F., Weisenfreund J., Taleporos E., Friedhoff A. J. The neuroleptic hypothesis: Study of the covariation of the extrapyramidal and therapeutic drug effect. British Journal of Psychiatry 1978; 133: 169–175
  • Alpert M., Rush M. Comparison of affects in Parkinson's disease and schizophrenia. Psychopharmacology Bulletin 1983; 196: 118–120
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 3rd edition. APA, Washington, DC 1980
  • Andreasen N. C. Thought, language, and communication disorders: I. Clinical assessment, definition of terms, and evaluation of their reliability. Archives of General Psychiatry 1979; 36: 1315–1321
  • Andreasen N. C. Scale for the Assessment of Negative Symptoms (SANS). University of Iowa., Iowa City 1981
  • Andreasen N. C. Negative symptoms in schizophrenia: Definition and reliability. Archives of General Psychiatry 1982; 39: 784–788
  • Andreasen N. C., Olsen S. A., Dennert J. W., Smith M. R. Ventricular enlargement in schizophrenia: Definition and prevalence. American Journal of Psychiatry 1982; 139: 292–296
  • Andreasen N. C. Positive vs. negative schizophrenia: A critical evaluation. Schizophrenia Bulletin 1985; 11: 380–389
  • Angrist B., Rotrosen J., Gershon S. Differential effects of amphetamine and neuroleptics on negative vs. positive symptoms in schizophrenia. Psychopharmacology 1980; 72: 17–19
  • Angrist B., Peselow E., Rubinstein M. Partial improvement in negative schizophrenic symptoms after amphetamine. Psychopharmacology 1982; 78: 128–130
  • Angst J., Stassen H. H., Woggon B. Effect of neuroleptics on positive and negative symptoms and the deficit state. Psychopharmacology 1989; 99: S41–S46
  • Appenzeller O., Goss J. E. Autonomic deficits in Parkinson's syndrome. Archives of Neurology 1971; 24: 50–57
  • Arregui A., MacKay A. V. P., Iversen L. L., Spokes E. G. S. Reduction of angiotensin-converting enzyme in substantia nigra in early-onset schizophrenia. New England Journal of Medicine 1979; 300: 502–503
  • Ashcroft G. W., Crawford T. B. B., Eccelson D., Sharman D. F., Macdougall E. G., Stanton J. B., Binnis J. K. 5-hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurologic diseases. Lancet 1966; 2: 1049–1052
  • Asso D. WAIS scores in a group of Parkinson patients. British Journal of Psychiatry 1969; 115: 555–556
  • Ayd F. J. A survey of drug-induced extrapyramidal reactions. Journal of the American Medical Association 1961; 175: 1054–1060
  • Baldessarini R. J., Tarsy D. Relationship of the action of neuroleptic drugs to the pathophysiology of tardive dyskinesia. International Review of Neurobiology, J. R. Smythes, R. J. Bradley. Academic Press, New York 1979
  • Barbeau A., Porcher E. New data on the genetics of Parkinson's disease. Canadian Journal of Neurological Sciences 1982; 9: 53–66
  • Baron J. A. Cigarette smoking and Parkinson's disease. Neurology 1986; 36: 1490–1496
  • Barr M. L. The Human Nervous System, 3rd ed. Harper & Row, Hagerstown, MD 1979
  • Becker H., Grau H., Schneider E. CT examination series of Parkinson patients. Cranial Computerized Tomography, W. Lauksch, E. Kazner. Springer Verlag, New York 1976; 249–251
  • Benedek L. Zwangmassiges Schreien in Anfallen als postencephalitische Hyperkinesie. Zeitschrift fur die Gesamte Neurologie und Psychiatrie 1925; 98: 17–26
  • Bentin S., Silverberg R., Gordon H. W. Asymmetrical cognitive deterioration in demented and Parkinson patients. Cortex 1981; 17: 533–544
  • Berger L., Gauthier S., Leblanc R. Akinetic mutism and Parkinsonism associated with obstructive hydrocephalus. Canadian Journal of Neurological Sciences 1985; 12: 255–258
  • Bernheimer H., Birkmayer W., Hornykiewicz O., Jellinger K., Seitelberger F. Brain dopamine and syndromes of Parkinson and Huntington: clinical, morphological and neurochemical correlations. Jorunal of Neurological Sciences 1973; 20: 415–455
  • Bes A., Guell A., Fabre N. Cerebral blood flow studied by Xenon-133 inhalation technique in Parkinsonism: Loss of hyperfrontal pattern. Journal of Cerebral Blood Flow and Metabolism, 3: 33–37
  • Birkmayer W., Dannielzyk W., Neumacher E., Riedere P. Nucleus ruber and L-DOPA psychosis: biochemical postmortem findings. Journal of Neural Transmission 1974; 35: 93–116
  • Birkmayer W., Knoll J., Riederer P., Youdim M. G. H., Hars V., Marton J. Increased life expectancy resulting from addition of L-deprenyl to madopar treatment in Parkinson's disease: A longterm study. Journal of Neural Transmission 1985; 64: 113–127
  • Bitton V., Melamed E. Coexistence of severe Parkinsonism and tardive dyskinesia as side-effects of neuroleptic therapy. Journal of Clinical Psychiatry 1984; 45: 28–30
  • Bjorklund A., Lindvall O. Regeneration of normal terminal innervation patterns by central noradrenergic neurons after 5,7-dihydroxytryptoamine-induced axotomy in the adult rat. Brain Research 1979; 171: 271–294
  • Bleuler E. Dementia Praecox or The Group of Schizophrenias, J. Zinkin. International Universities Press, New York 1950, Translated by
  • Blumer D., Benson D. F. Personality changes with frontal and temporal lobe lesions. Psychiatric Aspects of Neurologic Disease, D. F. Benson, D. Blumer. Grune & Stratton, New York 1975; 151–170
  • Bogerts B., Meertz E., Schonfeldt-Bausch R. Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage. Archives of General Psychiatry 1985; 42: 784–791
  • Boller F., Passafiume D., Keefe N. C., Rogers K., Morrow L., Kim Y. Visuospatial impairment in Parkinson's disease. Role of perceptual and motor factors. Archives of Neurology 1984; 41: 485–490
  • Borison R. The recognition and management of drug-induced movement disorders (reversible type). Presented at the 137th Annual Meeting of the American Psychiatric Association, Los Angeles, CA, 1984
  • Bowen F. P., Hoehn M. M., Yahr M. D. Parkinsonism: Alterations in spatial orientation as determined by a route-walking test. Neuropsychologia 1972; 10: 355–361
  • Bowers M. B., Goodman E., Sim V. M. Some behavior changes in man following anticholines-terase administration. Journal of Nervous and Mental Disease 1964; 138: 383–389
  • Bowers M. B. Central dopamine turnover in schizophrenic syndromes. Archives of General Psychiatry 1974; 31: 50–54
  • Bowman M., Lewis M. S. Sites of subcortical damage in diseases which resemble schizophrenia. Neuropsychologia 1980; 18: 597–601
  • Boyd A. E., Lebovitz H. E., Feldman J. M. Endocrine function and glucose metabolism in patients with Parkinson's disease and their alteration by L-dopa. Journal of Clinical Endocrinology and Metabolism 1971; 33: 829–837
  • Brambilla F., Guastalla A., Guerrini A. Glucose-insulin metabolism in chronic schizophrenia. Diseases of the Nervous System 1976; 37: 98–103
  • Breier A., Wolkowitz O. M., Doran A. R., Roy A., Hommer D. W., Pickar D. Neuroleptic responsivity of negative and positive symptoms in schizophrenia. American Journal of Psychiatry 1987; 144: 1549–1555
  • Burton J. L., Cartlidge M., Cartlidge N. E. F., Shuster F. Sebum secretion in Parkinsonism. British Journal of Dermatology 1973; 88: 263–266
  • Buscaino V. M. Le cause anatoma-pathologiche della manifetatione schizophrenica della demenza precoce. Ric Pathologia Nervus Mental 1920; 25: 193–226
  • Butterworth R. F., Belanger F., Barveau A. Hypokinesia produced by anterolateral hypothalamic 6-hydroxydopamine lesions and its reversal by some antiparkinson drugs. Pharmacology, Biochemistry & Behavior 1977; 8: 41–45
  • Calne D. B. Pharmacology of Parkinsonism. Parkinsonism: Physiology, pharmacology and treatment, D. B. Calne. Edward Arnold Publishers, London 1970; 49–67
  • Cannon T. D., Fuhrmann M., Mednick S. A., Machon R. A., Parnas J., Schulsinger F. Third ventricular enlargement and reduced electrodermal responsivenss. Psychophysiology 1988; 25: 153–156
  • Carpenter W. T., Heinrichs D. W., Alphs L. D. Treatment of negative schizophrenia. Schizophrenia Bulletin 1985; 11: 440–452, 1985
  • Cash R., Dennis T., L'Heureux R., Raisman R., Javoy-Agid F., Scatton B. Parkinson's disease and dementia: Norepinephrine and dopamine in locus coeruleus. Neurology 1987; 37: 42–46
  • Chase T. N. Catecholamine metabolism and neurologic disease. Biochemical Pharmacology 1974; 23(suppl)941–946
  • Chien C., DiMascio A., Cole J. O. Antiparkinson agents and depot phenothiazines. American Journal of Psychiatry 1974; 131: 86–90
  • Chouinard G., Jones B. D. Schizophrenia as a dopamine deficiency disease. Lancet 1978; 1: 99–100
  • Cornblatt B. A., Lenzenweger M. F., Dworkin R. H., Erlenmeyer-Kimling L. Positive and negative schizophrenic symptoms, attention, and information processing. Schizophrenia Bulletin 1985; 11: 397–408
  • Costall B., Naylor R. J. The role of telencephalic dopaminergic systems in the mediation of apomorphine-stereotypes behavior. European Journal of Pharmacology 1973; 24: 8–24
  • Costall B., Naylor R. J. The hypothesis of different dopamine receptor mechanisms. Life Sciences 1981; 28: 215–229
  • Cox S. M., Ludwig A. M. Neurological soft signs and psychopathology: Findings in schizophrenia. Journal of Nervous and Mental Disease 1979; 167: 161–165
  • Crane G. E. Pseudoparkinsonism and tardive dyskinesia. Archives of Neurology 1972; 27: 426–430
  • Crow T. J. Molecular pathology of schizophrenia: More than one disease process?. British Medical Journal 1980; 280: 66–68
  • Crow T. J. Positive and negative schizophrenic symptoms and the role of dopamine. British Journal of Psychiatry 1980a; 137: 383–386
  • Crow T. J. Is schizophrenia an infectious disease?. Lancet 1983; 1: 173–175
  • Crow T. J. The two-syndrome concept: Origins and current status. Schizophrenia Bulletin 1985; 11: 471–486
  • Crow T. J., Johnstone E. C., McClelland H. A. The coincidence of schizophrenia and Parkinsonism: some neurochemical implications. Psychological Medicine 1976; 6: 227–233
  • Cummings J. L., Frankel M. Gilles de la Tourette's syndrome and the neurological basis for obsessions and compulsions. Biological Psychiatry 1985; 20: 1117–1126
  • D'Antona R., Baron J. C., Samson Y., Serdaru M., Viader F., Agid Y., Cambier J. Subcortical dementia: Frontal cortex hypometabolism detected by positron tomography in patients with progressive supranuclear palsy. Brain 1985; 108: 785–799
  • Davis J. M. Comparative doses and costs of antipsychotic medication. Archives of General Psychiatry 1976; 33: 858–861
  • Davis K. L., Hollister L. E., Overall J., Johnson A., Train K. Physostigmine: effects on cognition and affect in normal subjects. Psychopharmacology 1976; 51: 23–27
  • DeFraites E. G., Davis K. L., Berger P. A. Coexisting tardive dyskinesia and Parkinsonism. Biological Psychiatry 1977; 12: 267–272
  • Den Hartog Jager W. A., Bethlem J. The distribution of Lewy bodies in the central and autonomic nervous system in idiopathic paralysis agitans. Journal of Neurology, Neurosurgery and Psychiatry 1960; 23: 283–290
  • De Jong D. Parkinson's disease: statistics. Journal of Neurosurgery 1966; 24(suppl)149–155
  • De Lancy-Horne D. J. Performance on delayed response task by patients with Parkinsonism. Journal of Neurology, Neurosurgery and Psychiatry 1971; 34: 192–194
  • Dening T. R. Blinking and essential blepharospasm. Comprehensive Psychiatry 1987; 28: 83–92
  • Desai N. G., Ganghadar B. N., Pradhan N., Chanabasavanna S. M. Treatment of negative schizophrenia with d-amphetamine. American Journal of Psychiatry 1984; 141: 723–724
  • Dewan M. J., Pandurangi A. K., Lee S. H., Ramachandran T., Levy B., Boucher M., Voza witz A., Major L. F. Central brain morphology in chronic schizophrenic patients: A controlled CT study. Biological Psychiatry 1983; 18: 1133–1140
  • Dide M. M. Les syndromes hypothalamiques et al dyspsychogenese. Review Neurologique 1934; 6: 941–943
  • Domino E. F., Olds M. E. Cholinergic inhibition of self-stimulation behavior. Journal of Pharmacology 1968; 164: 202–211
  • Donlong P. T., Stenson R. L. Neuroleptic-induced extrapyramidal symptoms. Diseases of the Nervous System 1976; 37: 629–635
  • Eaton W. E. Epidemiology of schizophrenia. Epidemiology Reviews 1985; 7: 105–126
  • Economo C. Encephalitis Lethargica–Its sequelae and Treatment, K. O. Newman. University Press, Oxford 1931, Translated by
  • Ehringer H., Hornykiewicz O. Verteilung von noradrenalin und dopamin im Gehirn des Menschen und ihre Verhalten beim Erkrankungen des Extrapyramidaler Systems. Wiener Klinische Wochenschrift 1960; 38: 1236–1239
  • Elner A. M., Kandel E. I. Study of the carbohydrate metabolism in Parkinsonism. ZH Nerypathology Psikhiatry IM SS Korsakova 1965; 65: 46–50
  • Endicott J. E., Spitzer R. L. Diagnostic interview: The schedule for affective disorders and schizophrenia. Archives of General Psychiatry 1978; 35: 837–844
  • Fahn S., Mayeux R. Unilateral Parkinson's disease and contralateral tardive dyskinesia: A unique case with successful therapy that may explain the pathophysiology of these two disorders. Journal of Neural Transmission 1980; 16(suppl)179–185
  • Fairweather D. S. Psychiatric aspects of the postencephalitic syndrome. Journal of Mental Science 1974; 93: 201–254
  • Fanget F., Claustrat B., Dalery J., Brun J., Terra J. L., Marie-Cardine M., Guyotat J. Nocturnal plasma melatonin levels in schizophrenic patients. Biological Psychiatry 1989; 25: 499–501
  • Fann W. E., Lake C. R. On the coexistence of Parkinsonism and tardive dyskinesia. Diseases of the Nervous System 1974; 35: 324–326
  • Fayen M., Goldman M. G., Moulthrop M. A., Luchins D. J. Differential memory function with dopaminergic versus anticholinergic treatment of drug-induced extrapyramidal symptoms. American Journal of Psychiatry 1988; 145: 483–496
  • Ferrier I. N., Arendt J., Johnstone E. C., Crow T. J. Reduced nocturnal melatonin secretion in chronic schizophrenia: Relationship to body weight. Clinical Endocrinology 1982; 17: 181–187
  • Ferrier I. N., Roberts G. W., Crow T. J., Johnstone E. C., Owens D. G. C., Lee V. C., O'Shaughnessy D., Adrian T. E., Polak J. M., Bloom S. R. Reduced cholecytokinin-like and somatostatin-like immureactivity is associated with negative symptoms in schizophrenia. Life Sciences 1983; 33: 475–492
  • Fishman M. The brain stem in psychosis. British Journal of Psychiatry 1975; 126: 414–422
  • Fleischhaker W. W., Barnas C., Stuppack C., Unterweger B., Hinterhuber H. Zotepine in the treatment of negative symptoms in chronic schizophrenia. Pharmacopsychiatry 1987; 20: 58–60
  • Flint A. The skin in Parkinson's disease. Primary Care 1977; 4: 475–480
  • Flint A. J., Wastwood R. Frontal lobe syndrome and depression in old age. Journal of Geriatric Psychiatry and Neurology 1988; 1: 53–55
  • Forno L. S. Pathology of Parkinsonism: A preliminary report of 24 cases. Journal of Neurosurgery 1966; 24(Suppl)266–271
  • Forno L. S. The Lewy body in Parkinson's disease. Advances in Neurology, M. D. Vahy, K. J. Bergmann, 1986; vol. 45: 35–43
  • Friedhoff A. J. A strategy for developing novel drugs for the treatment of schizophrenia. Schizophrenia Bulletin 1983; 9: 555–562
  • Friedman J. H., Max J., Swift R. Idiopathic Parkinson's disease in a chronic schizophrenic patient: Long term treatment with clozapine and L-dopa. Clinical Neuropharmacology 1987; 10: 470–475
  • Friedman J. H., Lannon M. C. Clozapine in the treatment of psychosis in Parkinson's disease. Neurology 1989; 39: 1219–1221
  • Fuxe K., Goldstein M., Hokfelt T., Johnson T., Lidbrik P. Dopaminergic involvement in hypothalamic function: Extrahypothalamic and hypothalamic control. A neuroanatomical analysis. Advances in Neurology 1974; 5: 405–419
  • Gath J., Jorgensen A., Sjaastad O. Pneumencephalographic findings in Parkinsonism. Archives of Neurology 1975; 32: 769–773
  • George L., Neufeld R. W. J. Cognition and symptomatology in schizophrenia. Schizophrenia Bulletin 1985; 11: 264–285
  • Gerlach J., Luhdorf K. The effect of L-dopa on young patients with simple schizophrenia treated with neuroleptic drugs: A double-blind cross-over trial, with madopar and placebo. Psychopharmacologia 1975; 44: 105–110
  • Gerlach J. Pathophysiological mechanisms underlying tardive dyskinesia. Dyskinesia: Research and Treatment, D. E. Casey, T. N. Chase, A. V. Christensen, J. Gerlach. Springer-Verlag, Berlin 1985; 98–103
  • Gibb W. R. G., Lees A. J. Prevalence of Lewy body in Alzheimer's disease. Annals of Neurology 1989; 26: 691–692
  • Goetz C. G. Drug-induced Parkinsonism and idiopathic Parkinson's disease. Archives of Neurology 1983; 40: 325–326
  • Goldberg E. Akinesia, tardive dysmentia, and frontal lobe disorder in schizophrenia. Schizophrenia Bulletin 1985; 11: 255–263
  • Goldberg T. E., Weinberger D. R., Berman K. F., Pliskin N. H., Podd M. H. Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test. Archives of General Psychiatry 1987; 44: 1008–1014
  • Grasset N., Brun R. Etude du film sebace de sujets sains et de patients atteints d'epilepsie ou de maladie de Parkinson. Dermatologica 1959; 119: 232–237
  • Green M., Walker E. Neuropsychological performance and positive and negative symptoms in schizophrenia. Journal of Abnormal Psychology 1985; 94: 460–469
  • Greenfield J. G., Bosanquet F. D. The brainstem in Parkinsonism. Journal of Neurology, Neurosurgery and Psychiatry 1953; 16: 213–226
  • Gross M., Bannister R., Godwin-Austen R. Orthostatic hypotension in Parkinson's disease. Lancet 1972; 1: 174–176
  • Growdon J. H., Corkin S. Cognitive impairments in Parkinson's disease. Advances in Neurology, M. D. Yahr, K. J. Bergmann, 1986; vol. 45: 383–392
  • Gruzelier J. H., Hammond M. V. The effect of chlorpromazine upon psychophysiological, endocrine, and information processing measures in schizophrenia. Journal of Psychiatric Research 1978; 14: 167–182
  • Gubbay S. S., Barwick D. D. Two cases of accidental hypothermia in Parkinson's disease with unusual EEG findings. Journal of Neurology, Neurosurgery and Psychiatry 1966; 29: 459–466
  • Gureje O. Topographic subtypes of tardive dyskinesia in schizophrenic patients aged less than 60 years: Relationship to demographic, clinical, treatment, and neuropsychological variables. Journal of Neurology, Neurosurgery and Psychiatry 1988; 51: 1525–1530
  • Hall A. The origin and purpose of blinking. British Journal of Ophpthalmology 1945; 29: 445–467
  • Hoehn M. M., Crowley T. J., Rutledge C. O. Dopamine correlates of neurological and psychological status in untreated Parkinsonism. Journal of Neurology, Neurosurgery, and Psychiatry 1976; 39: 941–951
  • Hoffman W. F., Labs S. M., Casey D. E. Neuroleptic-induced Parkinsonism in older schizophrenics. Biological Psychiatry 1987; 22: 427–439
  • Holden J. M. C., Itil T. M., Keskiner A. The treatment of lobotomized schizophrenic patients with butaperazine. Current Therapeutic Research 1969; 11: 418–428
  • Hollister L. E., Glazener F. S. Concurrent paralysis agitans and schizophrenia. Diseases of the Nervous System 1961; 22: 187–189
  • Honigfeld G., Patin J., Singer J. Clozapine: antipsychotic activity in treatment-resistant schizophrenics. Advances in Therapy 1984; 1: 77–97
  • Hopf A. Uber histopathologische veranderungen im Pallidum und Striatum bei Schizophrenie. Proceedings of the International Congress of Neuropathology. Rosenberg & Sellinger, TurinItaly 1952; vol. 3: 629–635
  • Horn S. Some psychological factors in Parkinsonism. Journal of Neurology, Neurosurgery and Psychatry 1974; 37: 27–31
  • Hornykiewicz O. Brain neurotransmitter changes in Parkinson's disease. Movement Disorders, C. D. Marsden, S. Fahn. Butterworths Publishers, Boston 1982; 41–58
  • Hornykiewicz O., Kish S. J. Biochemical pathophysiology of Parkinson's disease. Advances in Neurology, M. D. Yahr, K. J. Bergmann, 1986; vol. 45: 19–34
  • Houston J. P., Maas J. W., Bowden C. L., Contreras S. A., McIntyre K. L., Javors M. A. Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia. Psychiatry Research 1986; 19: 207–214
  • Howard R. S., Lees A. J. Encephalitis lethargica. A report of four recent cases. Brain 1987; 110: 19–33
  • Huber S. J., Paulson G. W. Relationship between primitive reflexes and severity in Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry 1986; 49: 1298–1300
  • Hurst J. H., LeWitt P. A., Burns R. S., Foster N. L., Lovenberg W. CSF dopamine-beta-hydroxylase activity in Parkinson's disease. Neurology 1985; 35: 565–568
  • Jackson J. H. Remarks on evolution and dissolution of the nervous system. Journal of Mental Sciences 1887; 33: 25–48
  • Jackson J. A., Free G. B. M., Pike H. V. The psychic manifestations in paralysis agitans. Archives of Neurology and Psychiatry 1923; 10: 680–684
  • Jankovic J. Pathophysiology and clinical assessment of motor symptoms in Parkinson's disease. Handbook of Parkinson's disease, W. C. Killer. Marcel Dekker, New York 1987; 99–126
  • Javoy-Agid F., Agid F. Is the mesocortical dopaminergic system involved in Parkinson's disease?. Neurology 1980; 30: 1326–1330
  • Javoy-Agid F., Pique L., Bertagna X., Taquet H., Studler J. M., Cesselin F., Epelbaum J., Agid Y. Biochemistry of the Hypothalamus in Parkinson disease. Neurology 1984; 34: 672–675
  • Javoy-Agid F., Ruberg M., Hirsch E., Cash R., Raisman R., Taquet H., epelbaum J., Scatton B., Duyckaerts C., Agid Y. Recent progress in the neurochemistry of Parkinson's disease. Recent Developments in Parkinson's Disease, S. Fahn, C. D. Marsden, P. Jenner, P. Teychenne. Raven Press, New York 1986; 67–83
  • Jellife S. E. The mental pictures in schizophrenia and in epidemic encephalitis. American Journal of Psychiatry 1927; 6: 413–465
  • Jellinger K. Overview of morphological changes in Parkinson's disease. Advances in Neurology, M. D. Yahr, K. J. Bergmann, 1986; vol. 45: 1–18
  • Jellinger K. Pathology of Parkinsonism. Recent development in Parkinson's disease, S. Fahn, C. D. Marsden, P. Jenner, P. Teychenne. Raven Press, New York 1986; 33–66
  • Jenkyn L. R., Walsh D. B., Culver C. M., Reeves A. G. Clinical signs in diffuse cerebral dysfunction. Journal of Neurology, Neurosurgery and Psychiatry 1977; 40: 956–966
  • Jernigan T. Anatomic and CT studies of psychiatric disorders. American Handbook of Psychiatry, P. Berger, H. K. H. Brodie. Basic Books Inc Publishers, New York 1986; vol. 8: 213–235
  • Johnstone E. C., Crow T. J., Frith C. D., Stevens M., Kreel I., Husband J. The dementia of dementia praecox. Acta Psychiatrica Scandinavica 1976; 57: 305–324
  • Johnstone E. C., Crow T. J., Frith C. D., Husband J., Kreel I. Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet 1976a; 2: 924–926
  • Johnstone E. C., Crow T. J., Ferrier I. N., Frith C. D., Owens D. G. C., Bourne R. C., Gamble S. J. Adverse effects of anticholinergic medication on positive schizophrenic symptoms. Psychological Medicine 1983; 13: 513–527
  • Johnstone E. C., Owens D. G. C., Frith C. D., Crow T. J. The relative stability of positive and negative features in chronic schizophrenia. British Journal of Psychiatry 1987; 150: 60–64
  • Kaminsky R., Moriarty T. M., Bodine J., Wolf D. E., Davidson M. Effect of famotidine on deficit symptoms of schizophrenia. Lancet 1990; 335: 1351–1352
  • Kanazawa I. Clinical pathophysiology of basal ganglia disease. Handbook of Clinical Neurology, P. J. Vinken, G. W. Bruyn, H. L. Klawans. Elsevier Science Publishers, Amsterdam 1986; vol. 5: 65–85
  • Kane J., Honigfeld G., Singer J., Meltzer H. Y. Clozapine in treatment resistant schizophrenia. Archives of General Psychiatry 1988; 45: 789–796
  • Karson C. N., Stabu R., Kleinman J. E. Drug effect on blink rates in rhesus monkey. Biological Psychiatry 1981; 16: 249–254
  • Karson C. N. Spontaneous eye blink rates and dopaminergic systems. Brain 1983; 106: 643–653
  • Kastin A. J., Redding T. W., Schally A. V. MSH activity in rat pituitaries after pinealectomy. Proceedings of the Society of Experimental Biology and Medicine 1967; 124: 1275–1277
  • Kastin A. J., Viosca S., Nair R. M. G., Schally A. V., Miller M. C. Interactions between pineal, hypothalamus and pituitary involving melatonin, MSH release inhibiting factor and MSH. Endocrinology 1972; 91: 1323–1328
  • Kaufman C. A., Jeste D. V., Shelton R. C., Linnoila M., Kafka M. S., Wyatt R. J. Noradrenergic and neuroradiological abnormalities in tardive dyskinase. Biological Psychiatry 1986; 21: 799–812
  • Kawamura T., Kinoshita M., Iwasaki Y., Nemoto H. Low-dose dexamethasone suppression test in Japanese patients with Parkinson's disease. Journal of Neurology 1987; 234: 264–265
  • Kay S. R. Positive and Negative Syndromes in Schizophrenia: Assessment and Research. Brunner/Mazel, New York, (in press).
  • Kay S. R., Sandyk R. Interpretation of the positive-negative distinction. Positive and Negative Syndromes in Schizophrenia: Assessment and Research, S. R. Kay. Brunner/Mazel., New York, (in press)
  • Kay S. R., Sevy S. Pyramidal model of schizophrenia. Schizophrenia Bulletin, (in press)
  • Kay S. R., Singh M. M. The positive-negative distinction in drug-free schizophrenic patients: Stability, response to neuroleptics, and prognostic significance. Archives of General Psychiatry, (in press)
  • Kay S. R., Singh M. M. Cognitive abnormality in schizophrenia: A dual process model. Biological Psychiatry 1979; 14: 155–176
  • Kay S. R. Arousal and schizophrenia: Toward a dual-process model and framework for research. JSAS Catalog of Selected Documents in Psychology 1981; 11: 35–36, (Whole No. 2256)
  • Kay S. R., Opler L. A. L-dopa in the treatment of negative schizophrenic symptoms. International Journal of Psychiatry in Medicine 1985; 15: 293–298
  • Kay S. R., Opler L. A., Fiszbein A. Significance of positive and negative syndromes in chronic schizophrenia. British Journal of Psychiatry 1986; 149: 439–448
  • Kay S. R., Fiszbein A., Opler L. A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 1987; 13: 261–275
  • Kay S. R., Sandyk R. Negative symptoms in schizophrenia: Clinical relevance and biological significance. Presented at the Collegium International Neuropsychopharmacologicum, KyotoJapan, 1990
  • Keshavan M. S., Yeragani V. K. Primitive reflexes in psychiatry. Lancet 1987; 1: 1264
  • Kizer J. S., Palkovits M., Brownstein M. J. The projections of the A8, A9 and A10 dopaminergic cell bodies: evidence for anigral-hypothalamic-median eminence dopaminergic pathway. Brain Research 1976; 108: 363–370
  • Klawans H. L. The pharmacology of tardive dyskinesia. American Journal of Psychiatry 1973; 130: 82–86
  • Klawans H. L. Psychiatric side effects during the treatment of Parkinson's disease. Journal of Neural Transmission 1988; 27(suppl)117–122
  • Knoll J., Dallo J., Yen T. T. Striatal dopamine, sexual activity and lifespan. Longevity of rats treated with (–) deprenyl. Life Sciences 1989; 45: 525–531
  • Kolb B., Whishaw I. Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal or parietal function in neurological patients. Journal of Nervous and Mental Disease 1983; 171: 435–443
  • Krawiecka M., Goldberg D., Vaughan M. A. Standardized psychiatric assessment for rating chronic patients. Acta Psychiatrica Scandinavica 1977; 55: 299–308
  • Kvorning S. A. Excretion of skin lipids in patients with Parkinson's syndrome. Acta Dermatologica Venerica 1952; 32(supp, 28–29)201–203
  • Langston J. W., Forno L. S. The hypothalamus in Parkinson disease. Annals of Neurology 1978; 3: 129–133
  • Lesch A., Bogerts B. The diencephalon in schizophrenia: Evidence for reduced thickness of the periventricular grey matter. European Archives of Psychiatry and Neurological Sciences 1984; 234: 212–219
  • Lewy F. H. Die Lehre vom Tonus und der Bewegung. Springer., Berlin 1923
  • Lidsky T. I., Weinhold P. M., Levine F. M. Implications of basal ganglionic dysfunction for schizophrenia. Biological Psychiatry 1979; 14: 3–12
  • Lindstrom L. H. Low HVA and normal 5-HIAA CSF level in drug free schizophrenic patients compared to healthy volunteers: Correlations to symptomatology and family history. Psychiatry Research 1985; 14: 265–273
  • Lindvall O., Bjorklund A., Moore R. Y., Stevevi U. Mesencephalic dopamine neurons projecting to neocortex. Brain Research 1974; 81: 325–331
  • Lipman I. J., Boykin M. E., Flora R. E. Glucose intolerance in Parkinson's disease. Journal of Chronic Diseases 1974; 27: 573–579
  • Luchins D. J., Jackman H., Meltzer H. Y. Lateral ventricular size and drug-induced Parkinsonism. Psychiatry Research 1983; 9: 9–16
  • Luria A. R. Higher Cortical Functions in Man. Basic Books., New York 1966
  • MacKay A. V. P. Positive and negative schizophrenic symptoms and the role of dopamine. Discussion, 1. British Journal of Psychiatry 1980; 137: 379–383
  • MacKay A. V. P., Iversen L. L., Rossor M., Spokes E., Bird E., Arregui A., Creese I., Synder S. H. Increased brain dopamine and dopamine receptors in schizophrenia. Archives of General Psychiatry 1982; 39: 991–997
  • Malarkey W. B., Cyrus J., Paulson G. W. Dissociation of growth hormone and prolactin secretion in Parkinson's disease following L-dopa therapy. Journal of Clinical Endocrinology and Metabolism 1974; 34: 229–235
  • Markianos M., Tripodianakis J. Low plasma dopamine beta-hydroxylase in demented schizophrenics. Biological Psychiatry 1985; 20: 94–119
  • Marsden C. D., Jenner P. The pathophysiology of extrapyramidal side-effects of neuroleptic drugs. Psychological Medicine 1980; 10: 55–72
  • Marshall J. F., Richardson J. S., Teitelbaum P. Nigrostriatal bundle damage and the lateral hypothalamic syndrome. Journal of Comparative Psychology 1974; 87: 808–830
  • Marttila R. J., Eskola J., Paivarina M., Rinne U. K. Immune functions in Parkinson's disease. Advances in Neurology, R. G. Hassler, J. F. Christ. Raven Press, New York 1984; vol. 40: 315–323
  • Maser J. D., Keith S. J. CT scan and schizophrenia–report on a workshop. Schizophrenia Bulletin 1983; 9: 265–273
  • Mason S. T. Noradrenaline and behavior. Trends in Neuroscience 1979; 2: 82–84
  • Maudsley H. The Pathology of the Mind, 3rd ed. Appleton, New York 1899; 113
  • Mayeux R. Depression and dementia in Parkinson's disease. Movement Disorders, C. D. Marsden, S. Fahn. Butterworths International Medical Reviews, London 1982; 75–95
  • McCowan P. K., Cook L. C. The mental aspect of chronic epidemic encephalitis. Lancet 1928; I: 1316–1320
  • Meltzer H. Y., Busch D., Fang V. S. Hormones, dopamine receptors and schizophrenia. Psychoneuroendocrinology 1981; 6: 17–36
  • Meltzer H. Y., Sommers A. A., Luchins D. J. The effect of neuroleptics and other psychotrophic drugs on negative symptoms in schizophrenia. Journal of Clinical Psychopharmacology 1986; 6: 329–338
  • Meltzer H. Y. Biological studies in schizophrenia. Schizophrenia Bulletin 1987; 13: 77–111
  • Merriam A. E., Kay S. R., Opler L. A., Kushner S., van Praag H. M. Neurological signs and the positive-negative distinction in schizophrenia. Biological Psychiatry, (in press)
  • Mettler F. A. Perceptual capacity, functions of the corpus striatum and schizophrenia. Psychiatric Quarterly 1955; 29: 89–97
  • Mettler F. A., Crandell A. Relation between Parkinsonism and psychiatric disorder. Journal of Nervous and Mental Disease 1959; 129: 551–557
  • Mindham R. H. S. Psychiatric symptoms in Parkinsonism. Journal of Neurology, Neurosurgery and Psychiatry 1970; 32: 188–191
  • Miwa S., Inagaki C., Fujewara M., Takaori S. The activities of noradenergic and dopaminergic neurons systems in experimental hydrocephalus. Journal of Neurosurgery 1982; 57: 67–73
  • Morel-Maroger A. Effects of levodopa on frontal signs in Parkinsonism. British Medical Journal 1977; 2: 1543
  • Morgan L. O., Gregory H. S. Pathological changes in the tuber cinerum in a group of psychoses. Journal of Nervous and Mental Disease 1935; 82: 286–298
  • Morris J. C., Drazer M., Fulling K., Grant E. A., Goldring J. Clinical and pathological aspects of Parkinsonism in Alzheimer's disease. A role for extranigral factors?. Archives of Neurology 1989; 46: 651–657
  • Mortimer J. A., Pirozzolo F. J., Hansch E. C., Webster D. D. Relationship of motor symptoms to intellectual deficits in Parkinson's disease. Neurology 1982; 32: 133–137
  • Moylan J. J., Saldias C. A. Developmental reflexes and cortical atrophy. Annals of Neurology 1979; 5: 499–500
  • Mukherjee S., Rosen A. M., Cardenas C., Varia V., Olarte S. Tardive dyskinesia in psychiatric outpatients. Archives of General Psychiatry 1982; 39: 466–469
  • Myers R. D. Temperature regulation: neurochemical systems in the hypothalamus. The Hypothalamus, W. Haymaker, E. Andersen, W. J. H. Nauta. Charles C. Thomas., Springfield, Illinois 1969
  • Narabayashi H., Kondo T., Nagatsu T., Hayashi A., Suzuki T. DL-thereo-3,4-dihydroxyph-enylserine for freezing symptom in Parkinsonism. Advances in Neurology, R. G. Hassler, J. F. Christ. Raven Press, New York 1984; vol. 40: 497–502
  • Nasrallah H. A., Jacoby C. G., McCalley-Whitters M., Kuperman S. Cerebral ventricular enlargement in subtypes of chronic schizophrenia. Archives of General Psychiatry 1982; 39: 774–777
  • Nasrallah H. A., Kuperman S., Jacoby C. G., McCalley-Whitters M., Hamra B. Clinical correlates of sulcal widening in chronic schizophrenia. Psychiatry Research 1983; 10: 237–242
  • National Institute of Mental Health. Abnormal Involuntary Movement Scale (AIMS). Department of Health, Education, and Welfare, Washington, DC 1974
  • Nieto D., Escobar A. Major Psychoses. Pathology of the Nervous System, J. Minckler. McGraw-Hill Book Co., New York 1972; vol. 3: 2654–2665
  • Nieto A., Nieto D. The red nucleus, the substantia nigra and the pineal gland responsible for mental illness. International Journal of Neuroscience 1988; 32: 277–278
  • Nyback H., Berggren B. M., Nyman H., Sedvall G., Wiesel F. A. Cerebroventricular volume, cerebrospinal fluid monoamine metabolites, and intellectual performance in schizophrenic patients. Neurology and Neurobilogy–Catecholamine. Part C: Neuropharmacology and Central Nervous System–Therapeutic Aspects, E. Usdin, A. Carlson, A. Dahlstrom, J. Engel. Alan R Liss Inc., New York 1984; 161–165
  • Ohama E., Ikuta F. Parkinson's disease: Distribution of Lewy bodies and monoamine neuron system. Acta Neuropathologica 1976; 34: 311–319
  • Opler L. A., Kay S. R., Rosado V., Lindemayer J. P. Positive and negative syndromes in chronic schizophrenic inpatients. Journal of Nervous and Mental Disease 1984; 172: 317–325
  • Overall J. E., Gorham D. R. Brief Psychiatric Rating Scale. Psychological Reports 1962; 10: 799–812
  • Owens D. G. C., Johnstone E. C., Crow T. J., Frith C. D., Jagoe J. R., Kreel L. Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations. Psychological Medicine 1985; 15: 27–41
  • Pandurangi A. K., Dewan M. J., Lee S. H., Ramachandran T., Levy B. F., boucher M., Yoz awitz A., Major L. The ventricular system in chronic schizophrenic patients. A controlled computed tomography study. British Journal of Psychiatry 1984; 144: 172–176
  • Paulson G., Gottleib G. Developmental reflexes: The reappearance of fetal and neonatal reflexes in aged patients. Brain 1968; 91: 37–52
  • Payne R. W. Cognitive abnormalities. Handbook of Abnormal Psychology, H. J. Eysenck. Pitman Medical Press, London 1973; 420–483
  • Pearce J., Hassan A., Gallagher H. Primitive reflex activity in primary and symptomatic Parkinsonism. Journal of Neurology, Neurosurgery and Psychiatry 1968; 31: 501–504
  • Pearce J. M. S., Flowers K., Pearce I., Pratt A. E. Clinical, psychometric and CAT scan correlations in Parkinson's disease. Research Progress in Parkinson's disease, F. Cliford Rose, R. Capildeo. Pitman Medical, Kent 1981; 43–52
  • Perutz A., Lustig B. Zur physiologie der Fettausscheidung und der Hautoberflache. Biochemische Zentraschrift 1933; 261: 128–131
  • Peuskins J., De Cuyper H. J. A., Bollen J., Eneman M., Wilms G. Risperidone: A new approach in the treatment of schizophrenia. Treatment of Negative Symptoms in Schizophrenia. Oxford Clinical Communications, Oxford 1989
  • Pfeiffer R. F., Hsieh H. H., Diercks M. J., Glaeske C., Jefferson A., Cheng S. C. Examethasone suppression test in Parkinson's disease. Advances in Neurology, M. D. Yahr, K. J. Bergmann. Raven Press, New York 1986; vol. 45: 439–442
  • Pique L., Jegou S., Bertagna X., Javoy-Agid F., Seurin D., Proeschel M. F., Girard F., Agid Y., Vaudry H., Luton J. P. Pro-opiomelanocortin peptides in the human hypothalamus: Comparative studies between normal subjects and Parkinson patients. Neuroscience Letters 1985; 54: 141–146
  • Pirozzolo F. J., Hansch E. C., Mortimer J. A. Dementia in Parkinson disease: A neuropsychological analysis. Brain and Cognition 1982; 1: 71–83
  • Pochi P. E., Strauss J. S., Mescon H. Sebum production and fractional 17 ketosteroid excretion in parkinsonism. Journal of Investigative Dermatology 1962; 38: 45–51
  • Pogue-Geile M. F., Harrow M. Negative and positive symptoms in schizophrenia and depression: A Followup. Schizophrenia Bulletin 1984; 10: 371–387
  • Pogue-Geile M. F., Harrow M. Negative symptoms in schizophrenia: Their longitudinal course and prognostic significance. Schizophrenia Bulletin 1985; 11: 427–439
  • Pogue-Geile M. F., Zubin J. Negative symptoms in schizophrenia: A conceptual and empirical review. International Journal of Mental Health 1988; 16: 3–45
  • Poirier L. J. The development of animal models for studies in Parkinson's disease. Recent Advances in Parkinson's Disease, F. H. McDowell, C. H. Markham. FA Davis, Philadelphia 1971; 83–117
  • Portin R., Raininko R., Rinne U. K. Neuropsychological disturbances and cerebral atrophy determined by computerized tomography in parkinsonian patients with long-term levodopa treatment. Advances in Neurology, R. G. Hassler, J. F. Christ. Raven Press, New York 1984; vol. 40: 219–227
  • Post F. Persistent Persecutory States of the Elderly. Pergamon Press, London 1966
  • Potkin S. G., Weinberger D. R., Linnoila M., Wyatt R. J. Low CSF 5-hydroxyindioleacetic acid in schizophrenic patients with enlarged cerebral ventricles. American Journal of Psychiatry 1983; 140: 21–25
  • Pouplard A., Emile J. Autoimmunity in Parkinson's disease. Advances in Neurology, R. G. Hassler, J. F. Christ. Raven Press, New York 1984; vol. 40: 307–313
  • Proctor F., Riklan M., Cooper S. T., Teuber H. L. Judgement of visual and postural vertical by parkinsonism patients. Neurology 1964; 14: 287–293
  • Rabins P. V., Pauker S., Thomas J. Can schizophrenia begin after age 44?. Comprehensive Psychiatry 1984; 25: 290–294
  • Rabins P., Pearlson G., Jayaram G., Steele C., Tune L. Increased ventricle-to-brain ratio in late-onset schizophrenia. American Journal of Psychiatry 1987; 144: 1216–1218
  • Rafal R. D., Posner M. I., Walker J. A., Friedrich F. J. Cognition and the basal ganglia. Separating mental and motor components of performance in Parkinson's disease. Brain 1984; 107: 1083–1094
  • Rainero I., Kaye A., May C., Durso R., Katz D. I., Albert M. L., Wolfe N., Pinessi L., Friedland R. P., Rapoport S. I. Alpha-melanocyte stimulating hormonelike immunoreactivity is increased in cerebrospinal fluid of patients with Parkinson's disease. Archives of Neurology 1988; 45: 1224–1227
  • Rajput A. H., Rozdilsky B., Hornykiewicz O., Shannak K., Lee T., Seeman P. Reversible drug-induced parkinsonism. Clinicopathologic study of two cases. Archives of Neurology 1982; 39: 644–646
  • Redmond D. E., Maas J. W., Kling A., Dekirmenjian H. Changes in primate social behavior after treatment with alpha-methyl-para-tyrosine. Psychosomatic Medicine 1971; 33: 97–113
  • Richardson M. A., Craig T. J. The coexistence of Parkinsonism-like symptoms and tardive dyskinesia. American Journal of Psychiatry 1982; 139: 341–343
  • Rieder R. O., Donnely E. F., Herdt J. R., Waldman I. N. Sulcal prominence in young chronic schizophrenic patients: CT scan findings associated with impairment on neuropsychological tests. Psychiatry Research 1979; 1: 1–8
  • Rifkin A., Quitkin F., Klein D. F. Akinesia: A poorly recognized drug-induced extrapyramidal behavioral disorder. Archives of General Psychiatry 1975; 32: 672–674
  • Rifkin A. The risks of longterm neuroleptic treatment of schizophrenia: Especially depressive and akinesia. Acta Psychiatrica Scandinavica 1981; 63(supp)129–134
  • Rogers D., Lees A. J., Trimble M., Stern G. M. Concept of bradyphernia: A neuropsychiatric approach. Advances in Neurology, M. D. Yahr, K. J. Bergmann, 1986; vol. 45: 447–455
  • Rose R. M., Sachar E. Endocrine disturbances in psychiatric disorders. Textbook of Endocrinology, R. H. Williams. Saunders, Philadelphia 1981
  • Rosen A. M., Mukherjee S., Olarte S., Varia V., Cardenas C. C. Perception of tardive dyskinesia in outpatients receiving maintenance neuroleptics. American Journal of Psychiatry 1982; 139: 372–373
  • Rosen J., Silk K. R., Rice H. E., Smith C. B. Platelet alpha-2 adrenergic dysfunction in negative symptom schizophrenia: A preliminary study. Biological Psychiatry 1985; 20: 539–545
  • Ross E. D., Stewart R. M. Akinetic mutism from hypothalamic damage: successful treatment with dopamine agonists. Neurology 1981; 31: 1435–1439
  • Roth M. The natural history of mental disorder in old age. Journal of Mental Science 1955; 101: 281–301
  • Roy M., Boyer L., Barbeau A. A prospective study of 50 cases of familial Parkinson's disease. Canadian Journal of Neurological Sciences 1983; 10: 37–42
  • Saffer D., Metcalfe M., Coopen A. Abnormal dexamethasone suppression test in Type II schizophrenia?. British Journal of Psychiatry 1985; 147: 721–723
  • Sandyk R., Decina P., Caracci G., Scapicchio P. Seborrhea and melanocyte stimulating hormone in drug-induced parkinsonism. International Journal of Neuroscience, (in press).
  • Sandyk R., Iacono R. P. Early vs. late onset Parkinson's disease: The role of the locus coeruleus. International Journal of Neuroscience, (in press)
  • Sandyk R., Kay S. R., Iacono R. P. Diabetes mellitus as a risk factor for drug-induced Parkinsonism in schizophrenia. International Journal of Neuroscience, (in press)
  • Sandyk R., Kay S. R. Interpretation of the positive-negative distinction. Positive and Negative Syndromes in Schizophrenia: Assessment and Research, S. R. Kay. Brunner/Mazel, New York, (in press a).
  • Sandyk R., Kay S. R. Sulcal prominence and neuroleptic-induced akathisia. Biological Psychiatry, (in press b)
  • Sandyk R., Kay S. R. Pineal calcification: Relationship to age of onset of schizophrenia. International Journal of Neuroscience, (in press c)
  • Sandyk R., Kay S. R. Parkinsonian tremor in schizophrenia is associated with cortical atrophy. International Journal of Neuroscience, (in press d)
  • Sandyk R., Kay S. R. Tardive dyskinesia is not associated with features of negative schizophrenia. International Journal of Neuroscience, (in press e)
  • Sandyk R., Kay S. R. Subjective awareness of abnormal involuntary movements in schizophrenic patients with tardive dyskinesia. International Journal of Neuroscience, (in press f)
  • Sandyk R., Kay S. R. Tardive dyskinesia is associated with positive schizophrenia. International Journal of Neuroscience, (in press g)
  • Sandyk R., Kay S. R. Diabetes mellitus as a clinical marker of idiopathic Parkinson's disease in schizophrenic patients with neuroleptic-induced parkinsonism. International Journal of Neuroscience, (in press h).
  • Sandyk R., Kay S. R. The role of pineal melatonin functions in the pathophysiology of schizophrenia: A review and hypothesis. Schizophrenia Bulletin, (in press i)
  • Sandyk R., Kay S. R. Pineal calcification is related to drug-induced parkinsonism. International Journal of Neuroscience, (in press j)
  • Sandyk R. Mechanisms of recovery in MPTP-induced parkinsonism. Neuroscience 1988; 27: 727–729
  • Sandyk R. Pro-opiomelanocortin (POMC) processing in Parkinson's disease. International Journal of Neuroscience 1989; 46: 201–204
  • Sandyk R. Autoimmune mechanisms in Parkinson's disease. International Journal of Neuroscience 1989; 48: 369–372
  • Sandyk R. Melanocyte stimulating hormone and tardive dyskinesia. Biological Psychiatry 1990; 27: 677–678
  • Sandyk R. Pineal melatonin functions: Possible relevance to Parkinson's disease. International Journal of Neuroscience 1990; 50: 37–53
  • Sandyk R., Fleming J., Brennan M. J. W. The head retraction reflex–its specificity in Parkinson's disease. Clinical Neurology and Neurosurgery 1982; 84: 159–162
  • Sandyk R., Fisher H. Serotonin in involuntary movement disorders. International Journal of Neuroscience 1988; 42: 185–205
  • Sandyk R., Iacono R. P. Hypothalamic-mediated immune mechanisms and their relevance to the pathoetiology of Parkinson's disease. International Journal of Neuroscience 1986; 32: 979–981
  • Sandyk R., Iacono R. P., Bamford C. R. The hypothalamus in Parkinson's disease. Italian Journal of Neurological Sciences 1987; 8: 227–234
  • Schooler N. R., Kane J. M. Research diagnoses of tardive dyskinesia. Archives of General Psychiatry 1982; 39: 486–487
  • Schwartz L., Munoz R. Blood sugar levels in patients treated with chlorpromazine. American Journal of Psychiatry 1968; 125: 253–255
  • Seidman L. J. Schizophrenia and brain dysfunction: An integration of recent neurodiagnostic findings. Psychological Bulletin 1983; 94: 195–238
  • Selby G. Cerebral atrophy and parkinsonism. Journal of the Neurological Sciences 1968; 6: 517–559
  • Serrati B. Influenza del sistema nervoso sull secrezione sebacea; osservazioni e ricerche cliniche. Rivera di Patholgia Nervosa 1938; 52: 377–423
  • Shelton R. C., Karson K. N., Doran A. R., Pickar D., Bigelow L. B., Weinberger D. R. Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical defect. American Journal of Psychiatry 1988; 145: 154–163
  • Sheppard M. A., Merlis S. Drug-induced extrapyramidal symptoms: Their incidence and treatment. American Journal of Psychiatry 1967; 123: 886–889
  • Shuster S., Thody A. J., Plummer N., Goolamali S. K., Bates D. Melanocyte stimulating hormone and parkinsonism. Lancet 1973; 1: 463–465
  • Silman R. E., Leone R. M., Hooper R. J. L., Preece M. A. Melatonin, and pineal gland and human puberty. Nature 1979; 282: 301–303
  • Simpson G. M., Angus J. W. S. Drug-induced extrapyramidal disorders. Acta Psychiatrica Scandinavica 1970; 212(suppl)1–58
  • Simpson G. M., Lee J. H., Zoubok B., Gardos G. A rating scale for tardive dyskinesia. Psychopharmacology 1979; 64: 171–179
  • Singh M. M., Kay S. R., Opler L. A. Anticholinergic-neuroleptic antagonism in terms of positive and negative symptoms of schizophrenia: implications for psychobiological subtyping. Psychological Medicine 1987; 17: 39–48
  • Sommers A. A. “Negative symptoms”: conceptual and methodological problems. Schizophrenia Bulletin 1985; 11: 364–379
  • Spiegel E. A., Wycis H. T., Schor H., Schwartz H., Fabiani F. R. (1968) The incidence of vegetative symptoms in Parkinson patients with and without bradykinesia. 3rd Parkinson Symposium, Edinburgh, May, 1968
  • Spitzer R. L., Endicott J. E., Robins E. Research Diagnostic Criteria (RDC) for a Select Group of Functional Disorders (3rd ed.). New York State Psychiatric Institute, Biometrics Research, New York 1978
  • Spokes E. G. S., Garrett N. J., Rosser M. N., Iversen L. L. Distribution of GABA in post-mortem brain tissue from control, psychotic and Huntington's chorea subjects. Journal of Neurological Sciences 1980; 48: 303–313
  • Sroka H., Elizan T. S., Yahr M. D., Burger A., Mendoza M. R. Organic mental syndrome and confusional states in Parkinson's disease. Relationship to computerized tomographic signs of cerebral atrophy. Archives of Neurology 1981; 38: 339–342
  • Stein L., Wise C. D. Possible etiology of schizophrenia: Progressive damage to the noradrenergic reward system by 6-hydroxydopamine. Science 1971; 171: 1032–1036
  • Steiner I., Gomori G. M., Melamed E. Features of brain atrophy in parkinson's disease. A CT scan study. Neuradiology 1985; 27: 158–160
  • Stephen P. J., Williamson J. Drug-induced parkinsonism in the elderly. Lancet 1984; 2: 1082–1083
  • Stevens J. R. Neuropathology of schizophrenia. Archives of General Psychiatry 1982; 39: 1131–1139
  • Strauss J. S., Carpenter W. T., Bartko J. J. An approach to the diagnosis and understanding of schizophrenia: Speculations on the process that underlie schizophrenic symptoms and signs. Schizophrenia Bulletin 1974; 1: 61–69
  • Studler J. M., Javoy-Agid F., Cesselin F., Legrand J. C., Agid Y. CCK-8 immunoreactivity distribution in human brain: selective decrease in the substantia nigra from parkinsonian patients. Brain Research 1982; 243: 176–179
  • Synek V., Reuben J. R. The ventricular brain ratio using planimetric measurements of EMI scans. British Journal of Radiology 1976; 49: 233–237
  • Tandon R., Greden J. F. Trihexyphenidyl treatment of negative schizophrenic symptoms. Acta Psychiatrica Scandinavica 1987; 76: 732
  • Tandon R., Greden J. F. & K. R. Treatment of negative schizophrenic symptoms with trihexyphenidyl. Journal of Clinical Psychopharmacology 1988; 8: 212–215
  • Tandon R., Greden J. F. Cholinergic hyperactivity and negative schizophrenic symptoms. A model of cholinergic/dopaminergic interactions in schizophrenia. Archives of General Psychiatry 1989; 46: 745–753
  • Tandon R., Goodson J., Silk K. R., Kronfol Z., Hariharan M., Greden J. F. Positive and negative symptoms in schizophrenia and the dexamethasone suppression test. Biological Psychiatry 1989; 25: 788–791
  • Taylor A. E., Saint-Cyr J. A., Lang A. E. Frontal dysfunction in Parkinson's disease: The cortical focus of neostriatal outflow. Brain 1986; 109: 845–883
  • Tetrud J. W., Langston J. W. The effects of deprenyl (selegiline) on the natural history of Parkinson's disease. Science 1989; 245: 519–522
  • Teuber H. L. The riddle of frontal lobe function in man. The frontal granular cortex and behavior, J. M. Warren, K. Akert. McGraw-Hill, New York 1964; 410–444
  • Todd N. Scottish first episode schizophrenia study: Two-year follow-up. Psychiatry Today: Accomplishments and Promises, C. N. Stefanis, C. R. Soldatos, A. D. Rabavilas. Excerpta Medica, Amsterdam 1989; 287
  • Tonnard-Neuman E. Phenothiazines and diabetes in hospitalized women. American Journal of Psychiatry 1968; 124: 978–982
  • Tweedy J., Reding M., Garcia C., Schulman P., Deutsch G., Antin S. Significance of cortical disinhibition signs. Neurology 1982; 32: 169–173
  • Tyrrell D. A. J., Parry R. P., Crow T. J., Johnstone E., Ferrier I. M. Possible virus in schizophrenia and some neurological disorders. Lancet 1979; 2: 839–841
  • U'Prichard D. C., Bechtel W. D., Rouot B. M., Synder S. H. Multiple apparent alpha-noradrenergic receptor binding sites in rat brain. Effect of 6-hydroxydopamine. Molecular Pharmacology 1971; 16: 47–60
  • Ungerstedt U. Is interruption of the nigrostriatal dopamine system producing the “lateral hypothalamic syndrome”?. Acta Physiologica Scandinavica 1970; 80: 35A–36A
  • Ungerstedt U. Adipsia and aphagia after 6-hydroxydopamine induced degeneration of nigrostriatal dopamine system. Acta Physiologica Scandinavica 1971; 367(suppl)95–122
  • Van Dongen P. A. M. The human locus coeruleus in neurology and psychiatry. Progress in Neurobiology 1981; 17: 97–139
  • Van Kammen D. P., Mann L. S., Sternberg D. E., Ninan P. T., Marder S. r., van Kammen W. B., Rieder R. O., Linnoila M. Dopamine beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy. Science 1983; 220: 974–977
  • Van Kammen D. P., van Kammen W. B., Mann L. S., Seppala T., Linnoila M. Dopamine metabolism in the cerebrospinal fluid of drug-free schizophrenic patients with and without cortical atrophy. Archives of General Psychiatry 1986; 43: 978–983
  • Van Praag H. M., Korf J. Retarded depression and the dopamine metabolism. Psychopharmacologica 1971; 19: 199–203
  • Van Putten T., May P. R. A. “Akinetic depression” in schizophrenia. Archives of General Psychiatry 1978; 35: 1101–1107
  • Van Putten T., May P. R. A., Willkins J. N. Importance of akinesia: Plasma chlorpromazine and prolactin levels. American Journal of Psychiatry 1980; 137: 1446–1448
  • Venables P. H. The psychophysiological aspects of schizophrenia. British Journal of Medical Psychology 1966; 39: 289–297
  • Von Buttlar-Brentano K. Pathohistologische Feststellungen am basalkern Schizophrener. Journal of Nervous and Mental Disease 1952; 116: 646–653
  • Waddington J. L., Youssef H. A. An unusual cluster of tardive dyskinesia in schizophrenia: Association with cognitive dysfunction and negative symptoms. American Journal of Psychiatry 1986; 143: 1162–1165
  • Waddington J. L., Youssef H. A., Dolphin C., Kinsella A. Cognitive dysfunction, negative symptoms, and tardive dyskinesia in schizophrenia. Their association in relation to topography of involuntary movements and criterion of their abnormality. Archives of General Psychiatry 1987; 44: 907–912
  • Waldhauser F., Weiszenbacher G., Frisch H., Zeitelhuber U., Waldhauser M., Wurtman R. J. Fall in nocturnal serum melatonin during prepuberty and pubescence. Lancet 1984; 2: 362–365
  • Waziri R. Lateralization of neuroleptic-induced dyskinesia indicates pharmacologic asymmetry in the brain. Psychopharmacology 1980; 68: 51–53
  • Weinberger D. R., Torrey E. F., Neophytides A. N. Lateral cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry 1979; 36: 735–739
  • Weinberger D. R., Wyatt R. J. Structural brain abnormalities in chronic schizophrenia: Computed tomography findings. Perspectives in Schizophrenia Research, C. Baxter, T. Melnuchek. Raven Press, New York 1980
  • Weinberger D. R., Cannon-Spoor E., Potkin S. G., Wyatt R. J. Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia. American Journal of Psychiatry 1980; 137: 1410–1413
  • Weinberger D. R. Computed tomographic (CT) findings in schizophrenia: Speculations on the meaning of it all. Journal of Psychiatric Research 1984; 18: 477–490
  • Weinberger D. R. Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 1987; 44: 660–669
  • Weigant V. M., Verhoef C. J., Burbach P. H., de Wied D. Increased concentration of alpha and sigma-endorphin in post mortem hypothalamic tissue of schizophrenic patients. Life Sciences 1988; 42: 1733–1742
  • Willkinson D. G. Psychiatric aspects of diabetes mellitus. British Journal of Psychiatry 1981; 138: 1–9
  • Wise C. D., Stein L. Dopamine beta-hydroxylase deficit in the brain of schizophrenic patients. Science 1973; 181: 344–347
  • Wise R. A. Neuroleptics and operant behavior: The anhedonia hypothesis. Behavioral and Brain Sciences 1982; 5: 39–87
  • Woodard J. C. Concentric hyaline inclusion body formation in mental disease: Analysis of 27 cases. Journal of Neuropathology and Experimental Neurology 1962; 21: 442–449
  • Zigmond M. J., Acheson A. L., Stachowiak M. K., Strickerm E. M. Neurochemical compensation after nigrostriatal bundle injury in an animal model of preclinical parkinsonism. Archives of Neurology 1984; 41: 856–861

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