258
Views
4
CrossRef citations to date
0
Altmetric
Research Articles

L-thyroxine treatment in primary hypothyroidism does not increase the content of free triiodothyronine in cerebrospinal fluid: A pilot study

, , , &
Pages 63-67 | Received 30 Aug 2010, Accepted 09 Nov 2010, Published online: 10 Jan 2011

References

  • Segerson TP, Kauer J, Wolfe HC, Mobtaker H, Wu P, Jackson IM, Lechan RM. Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus. Science 1987;238:78–80.
  • Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocrine Rev 2002;23:38–89.
  • Kakuscka I, Rand W, Lechan RM. Thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is dependent upon feedback regulation by both triiodothyronine and thyroxine. Endocrinology 1992;130: 2845–50.
  • Chopra IJ, Solomon DH, Chua Teco GN Thyroxine: just a prohormone or a hormone too? JCEM 1973;36:1050–7.
  • Crantz FR, Silva JE, Larsen PR. An analysis of the sourses and quantity of 3,5,3′-triiodothyronine specifically bound to nuclear recptors in rat cerebral cortex and cerebellum. Endocrinology 1982;110:367–75.
  • Sjöberg S, Eriksson M, Nordin C. L-thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients: a pilot study. Eur J Endocrinol 1998; 139:493–7.
  • Gunnarsson T, Sjöberg S, Eriksson M, Nordin C. Cholecystokinin peptides in cerebrospinal fluid: a pilot study in hypothyroid patients. Hum Psychopharmacol 1999;14:113–7.
  • Hagen GA, Solberg LA Jr. Brain and cerebrospinal fluid permeability to intravenous thyroid hormones. Endocrinology 1974;95:1398–10.
  • Bertilsson L, Åsberg M. Amine metabolites in the cerebrospinal fluid as a measure of central neurotransmitter function: methodological aspects. Usdin E, Åsberg M, Bertilsson L, Sjöqvist F. Frontiers in biochemical and pharmacological research in depression. New York: Raven Press; 1984, 27–34.
  • Burman P, Hetta J, Wide L, Månsson J-E, Ekman R, Karlsson FA. Growth hormone treatment affects brain neurotransmittors and throxine. Clinical Endocrinology. 1996;44:319–24.
  • Kirkegard C, Faber J. Free thyroxine and 3,3′,5′-triiodothyronine levels in cerebrospinal fluid in patients with endogenous depression. Acta Endocrinol 1991;124:166–72.
  • Malin J-P, Ködding R, Fuhrmann H, von zur Mühlen A. T4, T3 and r T3 levels in serum and cerebrospinal fluid of patients with amylotrophic lateral sclerosis. J Neurol 1989;236:57–9.
  • Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ. Identifcation of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 2003;278:40128–35.
  • Heuer J, Maier MK, Iden S. Mittag J, Friesema EC, Visser TJ, Bauer K. The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations. Endocrinology 2005;146:1701–6.
  • Jansen J, Friesema EC, Milici C, Visser TJ. Thyroid hormone transporters in health and disease. Thyroid 2005;15:757–68.
  • Bernal J. The significance of thyroid hormone transporters in the brain. Endocrinology 2005;146:1698–00.
  • Larsen PR, Silva JE, Kaplan MM. Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocrinol Rev 1981;2: 87–102.
  • Köhrle J, Schomburg L, Drescher S, Fekete E, Bauer K. Rapid stimulation of type I 5´-deoidinase in rat pituitaries by 3, 3´,5-triiodo-L-thyronine. Mol Cell Endocrinol 1995; 108:17–21.
  • Braverman LE, Ingbar SH, Sterling K. Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects. J Clin Invest 1970;49: 855–64.
  • Surks MI, Schadlow AR, Stock JM, Oppenheimer JH. Determination of iodothyronine absorption and conversion of L-thyroxine (T4) to L-triiodothyronine (T3) using turnover rate techniques. J Clin Invest 1973;52:805–11.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.