Deletion of the aquaporin-4 gene alters expression and phosphorylation of protective kinases in the mouse heart

References

• Butler TL, Au CG, Yang B, Egan JR, Tan YM, Hardeman EC, North KN, Verkman AS, Winlaw DS. Cardiac aquaporin expression in humans, rats, and mice. Am J Physiol Heart Circ Physiol 2006;291:H705–13.
   Web of Science ®Google Scholar
• Hibuse T, Maeda N, Nakatsuji H, Tochino Y, Fujita K, Kihara S, Funahashi T, Shimomura I. The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator. Cardiovasc Res 2009;83:34–41.
   PubMed Web of Science ®Google Scholar
• Rutkovskiy A, Stenslokken KO, Mariero LH, Skrbic B, Amiry-Moghaddam M, Hillestad V, Valen G, Perreault MC, Ottersen OP, Gullestad L, Dahl CP, Vaage J. Aquaporin-4 in the heart: expression, regulation and functional role in ischemia. Basic Res Cardiol 2012;107:280.
   PubMed Web of Science ®Google Scholar
• Rutkovskiy A, Mariero LH, Nygard S, Stenslokken KO, Valen G, Vaage J. Transient hyperosmolality modulates expression of cardiac aquaporins. Biochem Biophys Res Commun 2012;425:70–5.
   PubMed Web of Science ®Google Scholar
• Amiry-Moghaddam M, Otsuka T, Hurn PD, Traystman RJ, Haug FM, Froehner SC, Adams ME, Neely JD, Agre P, Ottersen OP, Bhardwaj A. An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc Natl Acad Sci USA 2003;100:2106–11.
   PubMed Web of Science ®Google Scholar
• Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 2000;6:159–63.
   PubMed Web of Science ®Google Scholar
• Ovize M, Baxter GF, Di Lisa F, Ferdinandy P, Garcia- Dorado D, Hausenloy DJ, Heusch G, Vinten-Johansen J, Yellon DM, Schulz R. Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology.Cardiovasc Res 2010; 87:406–23.
   PubMed Web of Science ®Google Scholar
• Hausenloy DJ, Yellon DM. Survival kinases in ischemic preconditioning and postconditioning. Cardiovasc Res 2006;70:240–53.
   PubMed Web of Science ®Google Scholar
• Churchill EN, Mochly-Rosen D. The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury. Biochem Soc Trans 2007;35:1040–2.
   PubMed Web of Science ®Google Scholar
• Gateau-Roesch O, Argaud L, Ovize M. Mitochondrial permeability transition pore and postconditioning. Cardiovasc Res 2006;70:264–73.
   PubMed Web of Science ®Google Scholar
• Dyck JR, Lopaschuk GD. AMPK alterations in cardiac physiology and pathology: enemy or ally?J Physiol 2006; 574:95–112.
   PubMed Web of Science ®Google Scholar
• McCoy ES, Haas BR, Sontheimer H. Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion. Neuroscience 2010;168:971–81.
   PubMed Web of Science ®Google Scholar
• Nakahama K, Nagano M, Fujioka A, Shinoda K, Sasaki H. Effect of TPA on aquaporin 4 mRNA expression in cultured rat astrocytes. Glia 1999;25:240–6.
   PubMed Web of Science ®Google Scholar
• Qi LL, Fang SH, Shi WZ, Huang XQ, Zhang XY, Lu YB, Zhang WP, Wei EQ. CysLT2 receptor-mediated AQP4 up-regulation is involved in ischemic-like injury through activation of ERK and p38 MAPK in rat astrocytes. Life Sci 2011;88:50–6.
   PubMed Web of Science ®Google Scholar
• Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, DC: National Academies Press; 2011.
   Google Scholar
• Sorbo JG, Moe SE, Ottersen OP, Holen T. The molecular composition of square arrays. Biochemistry 2008;47: 2631–7.
   PubMed Web of Science ®Google Scholar
• Hausenloy DJ, Yellon DM. Preconditioning and postconditioning: united at reperfusion. Pharmacol Ther 2007; 116:173–91.
   PubMed Web of Science ®Google Scholar
• Fenton RA, Moeller HB, Zelenina M, Snaebjornsson MT, Holen T, MacAulay N. Differential water permeability and regulation of three aquaporin 4 isoforms. Cell Mol Life Sci 2010;67:829–40.
   PubMed Web of Science ®Google Scholar
• Tsang A, Hausenloy DJ, Mocanu MM, Yellon DM. Postconditioning: a form of ‘modified reperfusion’ protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res 2004;95:230–2.
   PubMed Web of Science ®Google Scholar
• Miyamoto S, Howes AL, Adams JW, Dorn GW 2nd, Brown JH. Ca2 + dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2 + exchanger and AKT. J Biol Chem 2005;280:38505–12.
   PubMed Web of Science ®Google Scholar
• Mullonkal CJ, Toledo-Pereyra LH. Akt in ischemia and reperfusion. J Invest Surg 2007;20:195–203.
   PubMed Web of Science ®Google Scholar
• Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129:1261–74.
   PubMed Web of Science ®Google Scholar
• Hua Y, Zhang Y, Ceylan-Isik AF, Wold LE, Nunn JM, Ren J. Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy. Basic Res Cardiol 2011;106:1173–91.
   PubMed Web of Science ®Google Scholar
• Cheng YS, Tang YQ, Dai DZ, Dai Y. AQP4 knockout mice manifest abnormal expressions of calcium handling proteins possibly due to exacerbating pro-inflammatory factors in the heart. Biochem Pharmacol 2012;83:97–105.
   PubMed Web of Science ®Google Scholar
• Fazzina G, Amorini AM, Marmarou CR, Fukui S, Okuno K, Dunbar JG, Glisson R, Marmarou A, Kleindienst A. The protein kinase C activator phorbol myristate acetate decreases brain edema by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat. J Neurotrauma 2010;27:453–61.
   PubMed Web of Science ®Google Scholar
• Moeller HB, Fenton RA, Zeuthen T, Macaulay N. Vasopressin- dependent short-term regulation of aquaporin 4 expressed in Xenopus oocytes. Neuroscience 2009;164:1674–84.
   PubMed Web of Science ®Google Scholar
• Gupta RK, Kanungo M. Glial molecular alterations with mouse brain development and aging: up-regulation of the Kir4.1 and aquaporin-4. Age (Dordr) 2013;35:59–67.
   PubMed Web of Science ®Google Scholar
• Quek AM, McKeon A, Lennon VA, Mandrekar JN, Iorio R, Jiao Y, Costanzi C, Weinshenker BG, Wingerchuk DM, Lucchinetti CF, Shuster EA, Pittock SJ. Effects of age and sex on aquaporin-4 autoimmunity. Arch Neurol 2012;69: 1039–43.
   PubMedGoogle Scholar
• Peart JN, Pepe S, Reichelt ME, Beckett N, Hoe LS, Ozberk V, Niesman IR, Patel HH, Headrick JP. Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium. Exp Gerontol 2014;50:72–81.
   PubMed Web of Science ®Google Scholar
• Wu ZK, Pehkonen E, Laurikka J, Kaukinen L, Honkonen EL, Kaukinen S, Laippala P, Tarkka MR. The protective effects of preconditioning decline in aged patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg 2001;122:972–8.
   PubMed Web of Science ®Google Scholar