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Scandinavian Journal of Clinical and Laboratory Investigation Volume 26, 1970 - Issue 1
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Original Article

Dependency on Acid-base Status of Oxyhemoglobin Dissociation and 2, 3-Diphosphoglycerate Level in Human Erythrocytes: II. In Vivo Studies

P. Astrup Dept. of Clinical Chemistry A and of Anesthesiology, Rigshospitalet, Copenhagen, Denmark
,
M. Rörth Dept. of Clinical Chemistry A and of Anesthesiology, Rigshospitalet, Copenhagen, Denmark
&
C. Thorshauge Dept. of Clinical Chemistry A and of Anesthesiology, Rigshospitalet, Copenhagen, Denmark
Pages 47-52 | Received 14 Jan 1970, Accepted 12 Apr 1970, Published online: 08 Jul 2009

References

  • Astrup P. Oxygen dissociation curves in some diseases. Försvarsmedicin 1969; 5: 199
  • Astrup P., Rorth M., Mellemgaard K., Lund- gren C., Mulhausen R. O. Changes of oxygen affinity of blood at low and high pressures. Lancet 1968; ii: 732
  • Benesch R., Benesch R. E., Yu C. I. Reciprocal binding of oxygen and diphospho- glycerate by human hemoglobin. Proc. not. Acad. Sci. (Wash.) 1968; 59: 526
  • De Verdier C.-H., Garby L., Hjelm M. The role of 2,3-diphosphoglycerate in the erythro- cyte as a regulator of tissue oxygen tension,. Försvarsmedicin 1969; 5: 258
  • Eaton J. W., Brewer G. J. The relationship between red cell 2,3-diphosphoglycerate and levels of hemoglobin in the human. Proc. nat. Acad. Sci. (Wash.) 1968; 61: 756
  • Garby L., Gerber G., de Verdier C.-H. Binding of 2,3-diphosphoglycerate and ade- nosine triphosphate to human hemoglobin A. Europ. J. Biochem. 1969; 10: 110
  • Hartmann G., Rörth M. Unpublished results
  • Hjelm M. The content of 2,3-diphosphoglycerate and some other phosphocompounds in human erythrocytes from healthy adults and subjects with different types of anemia. Försvarsmedicin 1969; 5: 219
  • Kennedy A. C., Valtis D. J. The oxygen dissociation curve in anemia of various types. J. clin. Invest. 1954; 33: 1372
  • Keys A., Hall F. G., Barron E. S. G. The position of the oxygen dissociation curve of human blood at high altitude. Amer. J. Physiol. 1936; 115: 292
  • Kjeldsen K., Damgaard F. Influence of prolonged carbon monoxide exposure and high altitude on the composition of blood and urine in man. Scand. 1. clin. Lab. Invest. 1968; 22: 20, Suppl. 103
  • Lenfant C., Torrance J., English E., Finch C. A., Reynafarje C., Ramos J., Faura J. Effect of altitude on oxygen binding hemoglobin and on organic phosphate levels. J. clin. Invest. 1968; 47: 2652
  • Mulhausen R. O., Astrup P., Kjeldsen K. Oxygen affinity of hemoglobin in patients with cardiovascular diseases, anemia and cirrhosis of the liver. Scand. J. clin. Lab. Invest. 1967; 19: 291
  • Mulhausen R. O., Astrup P., Mellemgaard K. Oxygen affinity and acid-base status of human blood during exposure to hypoxia and carbon monoxide. Scand. J. clin. Lab. Invest. 1968; 22: 9, Suppl. 103
  • Nygaard S. F., Rorth M. An enzymatic assay of 2,3-diphosphoglycerate in blood. Scand. J. clin Lab. Invest. 1969; 24: 199
  • Rapoport S. Über Phosphorglycerinsäure als Transportsubstanz des Blutphosphors und ihr Verhalten bei experimenteller Ammonchlori- dazidose. I und II. Biochem. Z. 1937; 289: 411
  • Rörth M. Dependency on acid-base status of blood of oxyhemoglobin dissociation and 2,3- diphosphoglycerate level in human erythrocytes. I. In vitro studies on reduced and oxygenated blood. Scand. J. clin. Lab. Invest. 1970; 26: 43
  • Valeri C. R., Fortier N. L. Red-cell-mass deficits and erythrocyte 2,3-DPG levels. Försvarsmedicin 1969; 5: 212

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