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Scandinavian Journal of Clinical and Laboratory Investigation Volume 30, 1972 - Issue 3
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Original Article

The Effect of Hypercapnia upon the Energy Metabolism of the Brain during Arterial Hypoxemia

V. Macmillan Brain Research Laboratory, E-blocket, University Hospital, Lund, Sweden
&
B. K. Siesjö Brain Research Laboratory, E-blocket, University Hospital, Lund, Sweden
Pages 237-244 | Received 08 Jun 1972, Accepted 08 Sep 1972, Published online: 08 Jul 2009

References

  • Atkinson D. E. The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry 1968; 7: 4030
  • Eklöf B., MacMillan V., Siesjö B. K. Cerebral energy state and cerebral venous PÖ2in experimental hypotension caused by bleeding. Acta physiol. scand 1972, In press
  • Eklöf B., MacMillan V., Siesjö B. K. The effect of hypercapnic acidosis upon the energy metabolism of the brain in arterial hypotension caused by bleeding. Acta physiol. scand 1972, In press
  • Folbergrová J., MacMillan V., Siesjö B. K. The effect of moderate and marked hyper-capnia upon the energy state and upon the cytoplasmatic NADH/NAD+ratio of the rat brain. J. Neurochem 1972, In press
  • Folbergrová J., MacMillan V., Siesjö B. K. The effect of hypercapnic acidosis upon some glycolytic and Krebs cycle-associated intermediates in the rat brain. J. Neurochem 1972, In press
  • Gottesfeld Z., Miller A. T. Metabolic response of rat brain to acute hypoxia: influence of polycythemia and hypercapnia. Amer. J. Physiol. 1969; 216: 1374
  • MacMillan V., Siesjö B. K. Intracellular pH of the brain in arterial hypoxemia, evaluated with the CO2method and from the creatine phosphokinase equilibrium. Scand. J. clin. Lab. Invest. 1972; 30: 117
  • MacMillan V., Siesjö B. K. Brain energy metabolism in hypoxemia. Scand. J. clin. Lab. Invest. 1972; 30: 127
  • Rose I. A. The state of magnesium in cells as estimated from the adenylate kinase equilibrium. Proc. nat. Acad. Sci. 1968; 80: 235
  • Siesjö B. K., Nilsson L. The influence of arterial hypoxemia upon labile phosphates and upon extra- and intracellular lactate and pyruvate concentrations in the rat brain. Scand. J. clin. Lab. Invest. 1971; 27: 83
  • Siesjö B. K., Folbergrová J., MacMillan V. The effect of hypercapnia upon intracellular pH in the brain, evaluated with the bicarbonate-carbonic acid method and from the creatine phosphokinase equilibrium. J. Neurochem 1972, In press
  • Siggaard-Andersen O. Blood acid-base alignment nomogram. Scand. J. clin. Lab. Invest. 1963; 15: 211

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