The Effect of Acute Ammonia Intoxication upon the Brain Energy State in Rats Pretreated with L-Methionine D-L-Sulphoximine

References

• Atkinson D. E. The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochem. 1968; 7: 4030
   PubMed Web of Science ®Google Scholar
• Bessman S. P. Ammonia and coma. Chemical Pathology of the Nervous System, J. Folch-Pi. Pergamon Press. 1961; 370–376
   Google Scholar
• Bessman S. P., Bessman A. N. The cerebral and peripheral uptake of ammonia in liver disease, with an hypothesis for the mechanism of hepatic coma. J. clin. Invest. 1955; 34: 622
   PubMed Web of Science ®Google Scholar
• Bücher T. H., Klingenberg M. Wege des Wasserstoffs in der lebendigen Organisation. Angew. Chem. 1958; 70: 552
   Web of Science ®Google Scholar
• Fazekas J. F., Ticktim H. E., Ehrmantraut W. R., Alman R. W. Cerebral metabolism in hepatic insufficiency. Amer. J. Med. 1956; 21: 843
   PubMed Web of Science ®Google Scholar
• Folbergrová J. Free glutamine level in the rat brain in vivo after methionine sulphoximine administration. Physiol. bohemoslov. 1964; 13: 21
   PubMedGoogle Scholar
• Folbergrová J., MacMillan V., Siesjö B. K. The effect of moderate and marked hypercapnia upon the energy state and upon the cytoplasmatic NADH/NAD+ ratio of the rat brain. J. Neurochem. 1972, to be published
   Web of Science ®Google Scholar
• Folbergrová J., Passoneau I. V., Lowry O. H., Schulz D. W. Glycogen, ammonia and related metabolites in the brain during seizures evoked by methionine sulphoximine. J. Neurochem. 1969; 16: 191
   PubMed Web of Science ®Google Scholar
• Gabuzda G. I. Hepatic coma: clinical considerations, pathogenesis, and management. Advanc. intern. Med. 1962; 11: 11
   PubMedGoogle Scholar
• Gaitonde M. K. Rate of utilization of glucose and ‘compartmentation’ of α-oxoglutarate and glutamate in rat brain. Biochem. J. 1965; 95: 803
   PubMed Web of Science ®Google Scholar
• Ghittoni N. E., Ohlsson W. G., Sellinger O. Z. The effect of methionine on the regional and intracellular disposition of [3H]-methionine sulphoximine in rat brain. J. Neurochem. 1970; 17: 1057
   PubMed Web of Science ®Google Scholar
• Goldberg N. E., Passonneau J. V., Lowry G. H. Effects of changes in brain metabolism on the levels of citric acid cycle intermediates. J. biol. Chem. 1966; 10: 3997
   Google Scholar
• Hindfelt B. The effect of sustained hyper-ammonemia upon the metabolic state of the brain. Scand. J. clin. Lab. Invest. 1972; 30: 245
   PubMed Web of Science ®Google Scholar
• Hindfelt B., Siesjö B. K. Cerebral effects of acute ammonia intoxication. I. The influence on intracellular and extracellular acid-base parameters. Scand. J. clin. Lab. Invest. 1971; 28: 353
   PubMed Web of Science ®Google Scholar
• Hindfelt B., Siesjö B. K. Cerebral effects of acute ammonia intoxication. II. The effect upon energy metabolism. Scand. J. clin. Lab. Invest. 1971; 28: 365
   PubMed Web of Science ®Google Scholar
• Hohorst H. J. Der Reduktionszustand des Diphosphopyridin-Nucleotid-systems in lebendem Gewebe. Dissertation. Phil. Fakultät, Marburg 1960
   Google Scholar
• Kaasik A. E., Nilsson L., Siesjö B. K. The effect of asphyxia upon the lactate, pyruvate and bicarbonate concentrations of brain tissue and cisternal CSF, and upon the tissue concentrations of phosphocreatine and adenine nucleotides in anesthetized rats. Acta physiol. scand. 1970; 78: 433
   PubMedGoogle Scholar
• Kuby S. A., Noltman E. A. ATP-creatine transphosphorylase. The Enzymes 1962; 6: 515
   Google Scholar
• Lowry O. H., Passonneau J. V. Kinetic evidence for multiple binding sites on phosphofructokinase. J. biol. Chem. 1966; 241: 2268
   PubMed Web of Science ®Google Scholar
• Lowry O. H., Passonneau J. V., Hasselberger F. X., Schultz D. W. Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain. J. biol. chem. 1964; 239: 18
   PubMed Web of Science ®Google Scholar
• McKhann G. M., Tower D. B. Ammonia toxicity and cerebral oxidative metabolism. Amer. J. Physiol. 1961; 200: 420
   PubMed Web of Science ®Google Scholar
• Meister A. The specificity of glutamine synthetase and its relationship to substrate conformation at the active site. Advanc. Enzymol. 1968; 31: 183
   PubMedGoogle Scholar
• Milne M. D., Scribner B. H., Crawford M. A. Non-ionic diffusion and excretion of weak acid and base. Amer. J. Med. 1958; 24: 709
   PubMed Web of Science ®Google Scholar
• Minard F. N., Davis R. V. The effects of electroshock on the acid-soluble phosphates of rat brain. J. biol. Chem. 1962; 237: 1283
   Web of Science ®Google Scholar
• Navazio F., Geritsen T., Weight G. I. Relationship of ammonia intoxication to convulsions and coma in rats. J. Neurochem. 1961; 8: 146
   PubMed Web of Science ®Google Scholar
• Nilsson L., Siesjö B. K. The effect of anesthetics upon labile phosphates and upon extra- and intracellular lactate, pyruvate and bicarbonate concentrations in the rat brain. Acta physiol. scand. 1970; 80: 235
   PubMedGoogle Scholar
• Pace I., McDermott E. E. Methionine sulphoximine and some enzyme systems involving glutamine. Nature (Lond.) 1952; 169: 415
   PubMed Web of Science ®Google Scholar
• Pontén U., Siesjö B. K. Gradients of CO2 tension in the brain. Acta physiol. scand. 1966; 67: 129
   PubMedGoogle Scholar
• Pontén U., Siesjö B. K. A method for determination of the total carbon dioxide content of frozen tissues. Acta physiol. scand. 1964; 60: 297
   PubMedGoogle Scholar
• Posner J. B., Plum F. The toxic effects of carbon dioxide and by azetazolamide in hepatic encephalopathy. J. clin. Invest. 1960; 39: 1246
   PubMed Web of Science ®Google Scholar
• Schenker S., McCandless D. W., Brophy E., Lewis M. S. Studies on the intracerebral toxicity of ammonia. J. clin. Invest. 1967; 46: 838
   PubMed Web of Science ®Google Scholar
• Siesjö B. K. Metabolism and flow in the hypoxic brain, in Cerebral Blood Flow and Intracranial Pressure. Proc. 5th Int. Symp., Roma-Siena 1971, part I. Europ. Neurol. 1971; 6: 43
   PubMedGoogle Scholar
• Siesjö B. K., Messeter K. Factors determining intracellular pH. Ion Homeostasis of the Brain, B. K. Siesjö, S. C. Sörensen. Munksgaard, Copenhagen 1971
   Google Scholar
• Siggaard-Andersen O. Blood acid-base alignment nomogram. Scand. J. clin. Lab. Invest. 1963; 15: 211
   PubMed Web of Science ®Google Scholar
• Van der Berg C. I. Glutamate and glutamine. Handbook of Neurochemistry, A. Lajtha. Plenum Press, New York 1970; vol. 3: 355
   Google Scholar
• Warren K. S., Schenker S. Effect of an inhibition of glutamine synthesis (methionine sulphoximine) on ammonia toxicity and metabolism. J. Lab. clin. Med. 1964; 64: 442
   PubMed Web of Science ®Google Scholar
• Weil-Malherbe H. Ammonia metabolism in the brain. Neurochemistry2nd ed., K. A. C. Elliott, I. H. Page, J. H. Quastel. Charles C. Thomas, Springfield 1962; III: 321
   Google Scholar
• Williamson D. H., Lund P., Krebs H. A. The redox state of free nicotinamide-adeninedinucleotide in the cytoplasm and mitochondria of rat liver. Biochem. J. 1967; 103: 514
   PubMed Web of Science ®Google Scholar
• Williamson J. R., Clark J. B., Nicklas W. J., Safer B. Control of glycolysis and oxidative metabolism in tissue. Ion Homeostasis of the Brain, B. K. Siesjö, S. C. Sörensen. Munksgaard, Copenhagen 1971; 381
   Google Scholar
• Worcel A., Erecinska M. Mechanism of inhibitory action of ammonia on the respiration of rat liver mitochondria. Biochem. biophys. Acta (Amst.) 1962; 65: 27
   PubMed Web of Science ®Google Scholar