7
Views
11
CrossRef citations to date
0
Altmetric
Miscellaneous Article

Effect of Long-Term Administration of Ethanol to the Rat: Lipids, Collagen and Other Proteins, and Mallory Bodies in the Liver

, &
Pages 753-765 | Received 15 Feb 1975, Accepted 13 Aug 1975, Published online: 08 Jul 2009

References

  • Aalto M., Lampiaho K., Pikkarainen J., Kulonen E. Amino acid metabolism of experimental granulation tissue in vitro. Biochem. J. 1973; 132: 663
  • Baraona E., Lieber C. S. Effects of chronic ethanol feeding on serum lipoprotein metabolism in the rat. J. Clin. Invest. 1970; 49: 769
  • Belfrage P., Berg B., Cronholm T., Elmqvist D., Hägerstrand I., Johansson B., Nilsson-Ehle P., Nordin G., Sjívall J., Wiebe T. Prolonged administration of ethanol to young healthy volunteers: effects on biochemical, morphological and neurophysiological parameters. Acta med. scand. 1973, Suppl. 552: 13
  • Bode C, Kono H., Goebell H., Bode C., Martini G. A. Zur Pathogenese der Fetteinlagerung in die Leber durch Alkohol. III. Ef-fekt von Äthanol auf Metabolite und Coenzyme des energieliefernden Stoffwechsels in der Leber und im Blut bei Standardkost und proteinarmer Ernährung. Klin. Wschr. 1970; 48: 1180
  • Christoffersen P., Braendstrup O., Juhl E., Poulsen H. Lipogranulomas in human liver biopsies with fatty change. Acta path, microbial, scand. A 1971; 79: 150
  • Cohen P. P. Suspending media for animal tissues. Manometric Techniques and Tissue Metabolism, W. W. Umbreit, R. H. Burns, J. F. Stauffer. Burgess Publ. Co., Minneapolis, Minn. 1951; 118–119
  • Comstock J. P., Udenfriend S. Effect of lactate on collagen proline hydroxylase activity in cultured L-929 fibroblasts. Proc. Nat. Acad. Sci. (Wash.) 1970; 66: 552
  • Feinman L., Lieber C. S. Hepatic collagen metabolism: effects of alcohol consumption in rats and baboons. Science 1972; 176: 795
  • Finerman G. A. M., Downing S., Rosenberg S. E. Amino acid transport in bone. II. Regulation of collagen synthesis by perturbation of proline transport. Biochim. Biophys. Acta (Amst.) 1967; 135: 1008
  • Folch J., Lees M., Sloane-Stanley G. H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1957; 226: 497
  • French S. W. Ethanol-induced liver injury. The Biology of Alcoholism Vol. 1: Biochemistry, B. Kissin, H. Begleiter. Plenum Press, New York-London 1971; 482–484
  • Häkkinen H.-M., Kulonen E. Effect of ethanol on the metabolism of alanine, glutamic acid, and proline in rat liver. Biochem. Pharmacol. 1975; 24: 199
  • Harinasuta U., Chomet B., Ishak K., Zimmerman H. J. Steatonecrosis—Mallory body type. Medicine (Baltimore) 1967; 46: 141
  • Hartroft W. S. Nutritional factors in the pathogenesis of alcoholic fatty liver. Alkohol und Leber, W. Gerok, K. Sickinger, H. H. Hennekeuser. F. K. Schattauer Verlag, Stuttgart-New York 1971; 169–178, Internationales Symposion
  • Hillbom M. E., Pösö A. R., Eriksson C. J. P., Franssila K., Häkkinen H.-M. Metabolic effects of prolonged ethanol administration in rats treated with clofibrate. Research Laboratories of the Finnish State Alcohol Monopoly (Alko), Helsinki 1974, Report 7536
  • Hirayama C, Morotoni I., Hiroshige K. Quantitative and metabolic changes of hepatic collagens in rats after carbon tetrachloride poisoning. Biochem. J. 1970; 118: 229
  • Huberman A., Soberon G. Albumin synthesis in liver slices of cirrhotic rats. Clin, chim. Acta 1970; 29: 121
  • Isselbacher K. J., Greenberger N. J. Metabolic effects of alcohol on the liver. New Engl. J. Med. 1964; 270: 351, 402
  • Jeejeebhoy K. N., Phillips M. J., Bruce-Robertson A., Ho J., Sodtke U. The acute effect of ethanol on albumin, fibrinogen and transferrin synthesis in the rat. Biochem. 1972; 126: 1111
  • Juva K., Prockop D. J. Modified procedure for the assay of H3- or C14-labeled hydroxyproline. Anal. Biochem. 1966; 15: 11
  • Kershenobich D., Fierro F. F., Rojkind M. The relationship between the free pool of proline and collagen content in human liver cirrhosis. J. Clin. Invest. 1970; 49: 2246
  • Koch O. R., Porta E. A., Hartroft W. S. A new experimental approach in the study of chronic alcoholism. III. Role of alcohol versus sucrose or fat-derived calories in hepatic damage. Lab. Invest. 1968; 18: 379
  • Kuriyama K., Sze P. Y., Rauscher G. E. Effects of acute and chronic ethanol administration on ribosomal protein synthesis in mouse brain and liver. Life Sci. 1971; 10: 181
  • Lampiaho K., Kulonen E. Metabolic phases during the development of granulation tissue. Biochem. J. 1967; 105: 333
  • Lieber C. S. Origin and pathogenesis of fatty acid accumulation in the liver during prolonged ethanol consumption. Metabolic Changes Induced by Alcohol, G. A. Martini, C. Bode. Springer Verlag, Berlin 1971; 212–216
  • Lieber C. S., Rubin E., De Carli L. M. Pathogenesis and prevention of the alcoholic fatty liver. The Biology of Alcoholism Vol. 1: Biochemistry, B. Kissin, H. Begleiter. Plenum Press, New York-London 1971; 287–298
  • Lillie R. D. Histologic Technic and Practical Histochemistry. McGraw-Hill Book Co., New York 1965
  • Lowry O. H., Rosebrough N. I., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951; 193: 265
  • Mallory F. B. Cirrhosis of the liver. Five different types of lesions from which it may arise. Bull. Johns Hopkins Hosp. 1911; 22: 69
  • Marsh J. B., Drabkin D. L. Metabolic channeling in experimental nephrosis. IV. Net synthesis of plasma albumin by liver slices from normal and nephrotic rats. J. Biol. Chem. 1958; 230: 1073
  • Mörland J. Effect of chronic ethanol treatment on tryptophan oxygenase, tyrosine aminotransferase and general protein metabolism. Biochem. Pharmacol. 1974; 23: 21
  • Patrick R. S. Alcohol as a stimulus to hepatic fibrogenesis. J. Alc. 1973; 8: 13
  • Popper H., Schaffner F. Structural studies in alcohol and drug induced liver injury. Alcoholic Cirrhosis and Other Toxic Hepatopathias, Skandia international symposia, A. Engel, T. Larsson. Nordiska Bokhandelns Förlag, Stockholm 1970; 15–42
  • Popper H., Udenfriend S. Hepatic fibrosis. Correlation of biochemical and morphologic investigations. Amer. J. Med. 1970; 49: 707
  • Porta E. A., Koch O. R., Hartroft W. S. A new experimental approach in the study of chronic alcoholism. IV. Reproduction of alcoholic cirrhosis in rats and the role of lipotropes versus vitamins. Lab. Invest. 1969; 20: 562
  • Rothschild M. A., Oratz M., Mongelli I., Schreiber S. S. Alcohol-induced depression of albumin synthesis: reversal by tryptophan. J. Clin. Invest. 1971; 50: 1812
  • Rubin E., Lieber C. S. Fatty liver, alcoholic hepatitis and cirrhosis produced by alcohol in primates. New Engl. J. Med. 1974; 290: 128
  • Ruebner B. H., Brayton M. A., Freedland R. A., Kanayama R., Tsao M. Production of fatty liver by ethanol in rhesus monkey. Lab. Invest. 1972; 27: 71
  • Scheig R. The fatty liver: clinical and basic considerations. R. I. med. J. 1965; 48: 659
  • Stegemann H., Stalder K. Determination of hydroxyproline. Clin. Chim. Acta 1967; 18: 267
  • Takeuchi J., Takada A., Kato Y., Hasumura Y., Ikegami F., Matsuda Y. Hepatic changes in chronic alcoholic rats following periodic acute alcoholic intoxications. Amer. J. clin. Nutr. 1971; 24: 628
  • Troll W., Lindsley J. A photometric method for the determination of proline. J. Biol. Chem. 1955; 215: 655
  • Wallgren H., Ahlqvist J. A, Rhman K., Suomalainen H. Repeated alcoholic intoxication compared with continued consumption of dilute ethanol in experiments with rats on a marginal diet. Brit. J. Nutr. 1967; 21: 643
  • Wallgren H., Ahlqvist J., Salaspuro M. Biochemical and morphological alterations in liver of rats fed high alcohol and high fat diets with ample protein and vitamin supply. Research Laboratories of the Finnish State Alcohol Monopoly (Alko), Helsinki 1967, Report 7269
  • Wallgren H., Barry H., III. Actions of Alcohol. Elsevier, Amsterdam-London-New York 1970; 482–489
  • Zinker S., Rojkind M. Collagen biosynthesis in the chick embryo. I. The source of free proline and collagen hydroxyproline. Connect. Tiss. Res. 1972; 1: 275

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.